Cancer Biology & Therapy, Volume 7, Issue 6 (2008)

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Cancer Biology & Therapy, Volume 7, Issue 6 (2008)

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Editor's Corner

Editorial
Cover Caption
Page: i
Published online: 01 Jul 2008
AbstractforCover Caption | PDF (8.9 MB)
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Review

Review Article
Hsp60 expression, new locations, functions, and perspectives for cancer diagnosis and therapy
Francesco Cappello, Everly Conway de Macario, Lorenzo Marasà, Giovanni Zummo & Alberto J. L. Macario
Pages: 801-809
Published online: 01 Jul 2008
AbstractforHsp60 expression, new locations, functions, and perspectives for cancer diagnosis and therapy | PDF (899.1 KB)
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Bedside to Bench Report

Article
Metastatic chest wall malignant schwannoma responding to sorafenib: case report and literature review
Vinay Gudena, Nitin Verma, Ginell Post, Michael Kizziah, Robert Fenning & Alberto J. Montero
Pages: 810-813
Published online: 01 Jul 2008
AbstractforMetastatic chest wall malignant schwannoma responding to sorafenib: case report and literature review | PDF (1 MB)
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Research Paper

Article
Static magnetic fields induce blood flow decrease and platelet adherence in tumor microvessels
Sebastian Strieth, Donata Strelczyk, Martin E. Eichhorn, Marc Dellian, Siiri Luedemann, Jürgen Griebel, Matthias Bellemann, Alexander Berghaus & Gunnar Brix
Pages: 814-819
Published online: 01 Jul 2008
AbstractforStatic magnetic fields induce blood flow decrease and platelet adherence in tumor microvessels | PDF (1,010.7 KB)
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Commentary

Static magnetic fields, blood and genes: an intriguing relationship
Marco Ruggiero
Pages: 820-821
Published online: 01 Jul 2008
AbstractforStatic magnetic fields, blood and genes: an intriguing relationship | PDF (485.9 KB)
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Research Paper

Article
Altered expression of cell proliferation-related and interferon-stimulated genes in colon cancer cells resistant to SN38
Céline Gongora, Laurent Candeil, Nadia Vezzio, Virginie Copois, Vincent Denis, Corinne Bareil, Franck M. Molina, Caroline Fraslon, Caroline Fraslon, Emmanuel Conseiller, Bernard Pau, Pierre Martineau & Maguy Del Rio
Pages: 822-832
Published online: 01 Jul 2008
AbstractforAltered expression of cell proliferation-related and interferon-stimulated genes in colon cancer cells resistant to SN38 | PDF (1.2 MB)
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Article
Reduced expression of PNUTS leads to activation of Rb-phosphatase and caspase-mediated apoptosis
Gabriel De Leon, Tara C. Sherry & Nancy A. Krucher
Pages: 833-841
Published online: 01 Jul 2008
AbstractforReduced expression of PNUTS leads to activation of Rb-phosphatase and caspase-mediated apoptosis | PDF (1.8 MB)
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Commentary

Downregulation of the Phosphatase Nuclear Targeting Subunit (PNUTS) triggers pRB dephosphorylation and apoptosis in pRB positive tumor cell lines
Xavier Graña
Pages: 842-844
Published online: 01 Jul 2008
AbstractforDownregulation of the Phosphatase Nuclear Targeting Subunit (PNUTS) triggers pRB dephosphorylation and apoptosis in pRB positive tumor cell lines | PDF (497.2 KB)
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Research Paper

Article
A small molecule that disrupts Mdm2-p53 binding activates p53, induces apoptosis, and sensitizes lung cancer cells to chemotherapy
Steven H. Sun, Min Zheng, Ke Ding, Shaomeng Wang & Yi Sun
Pages: 845-852
Published online: 01 Jul 2008
AbstractforA small molecule that disrupts Mdm2-p53 binding activates p53, induces apoptosis, and sensitizes lung cancer cells to chemotherapy | PDF (2.1 MB)
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Commentary

Inhibition of MDM2-p53 feedback loop by various small molecules for potential cancer chemotherapy
Arif Khan & Hua Lu
Pages: 853-855
Published online: 01 Jul 2008
AbstractforInhibition of MDM2-p53 feedback loop by various small molecules for potential cancer chemotherapy | PDF (513.2 KB)
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Research Paper

Article
C. elegans as a model organism for in vivo screening in cancer: effects of human c-Met in lung cancer affect C. elegans vulva phenotypes
Shahid S. Siddiqui, Sivakumar Loganathan, Soundararajan Krishnaswamy, Leonardo Faoro, Ramasamy Jagadeeswaran & Ravi Salgia
Pages: 856-863
Published online: 01 Jul 2008
AbstractforC. elegans as a model organism for in vivo screening in cancer: effects of human c-Met in lung cancer affect C. elegans vulva phenotypes | PDF (1 MB)
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Article
A chemotherapy-associated senescence bystander effect in breast cancer cells
Xu Di, Andrew Taylor Bright, Ricardo Bellott, Elizabeth Gaskins, Jacques Robert, Shawn Holt, David A. Gewirtz & Lynne Elmore
Pages: 864-872
Published online: 01 Jul 2008
AbstractforA chemotherapy-associated senescence bystander effect in breast cancer cells | PDF (2.3 MB)
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Article
Functions of p21 and p27 in the regenerating epithelial linings of the mouse small and large intestine
Yu Zheng, Wenjun Bie, Ruyan Yang, Ansu O. Perekatt, Aleksandra J. Poole & Angela L. Tyner
Pages: 873-879
Published online: 01 Jul 2008
AbstractforFunctions of p21 and p27 in the regenerating epithelial linings of the mouse small and large intestine | PDF (2.4 MB)
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Commentary

Normal intestinal epithelial cell differentiation in the absence of p21 and p27: new insights from old knock-out mice
James E. Butler & Brett T. Spear
Pages: 880-881
Published online: 01 Jul 2008
AbstractforNormal intestinal epithelial cell differentiation in the absence of p21 and p27: new insights from old knock-out mice | PDF (482.3 KB)
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Research Paper

Article
Pancreatic cancer associated fibroblasts display normal allelotypes
Kimberly Walter, Noriyuki Omura, Seung-Mo Hong, Margaret Griffith & Michael Goggins
Pages: 882-888
Published online: 01 Jul 2008
AbstractforPancreatic cancer associated fibroblasts display normal allelotypes | PDF (2.1 MB)
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Article
Iron chelator-based amplification strategy for improved targeting of transferrin receptor with SPIO
Clare Y. Zhang, Jing Lu & Andrew Tsourkas
Pages: 889-895
Published online: 01 Jul 2008
AbstractforIron chelator-based amplification strategy for improved targeting of transferrin receptor with SPIO | PDF (1.1 MB)
  • 346 Views
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Open Access
Article
Application of combination of short hairpin RNA segments for silencing VEGF, TERT, and Bcl-xl expression in laryngeal squamous carcinoma
Yan Wang, Ze-Zhang Tao, Shi-Ming Chen, Bo-Kui Xiao, Xu-Hong Zhou & Jun-Ping Liu
Pages: 896-901
Published online: 01 Jul 2008
AbstractforApplication of combination of short hairpin RNA segments for silencing VEGF, TERT, and Bcl-xl expression in laryngeal squamous carcinoma | PDF (1.1 MB)
  • 200 Views
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Article
The BH3-only protein PUMA is involved in green tea polyphenol induced apoptosis in colorectal cancer cell lines
Xi Wang, Rui Wang, Miao-Wang Hao, Ke Dong, San-Hua Wei, Fang Lin, Ji-Hong Ren & Hui-Zhong Zhang
Pages: 902-908
Published online: 01 Jul 2008
AbstractforThe BH3-only protein PUMA is involved in green tea polyphenol induced apoptosis in colorectal cancer cell lines | PDF (1.8 MB)
  • 244 Views
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Commentary

Green tea and PUMA: A deadly combination?
Crissy Dudgeon & Jian Yu
Pages: 909-910
Published online: 01 Jul 2008
AbstractforGreen tea and PUMA: A deadly combination? | PDF (530.3 KB)
  • 140 Views
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Research Paper

Article
Paclitaxel-loaded poly(D,L-lactide-co-glycolide) nanoparticles for radiotherapy in hypoxic human tumor cells in vitro
Cheng Jin, Ling Bai, Hong Wu, Junye Liu, Guozhen Guo & Jingyuan Chen
Pages: 911-916
Published online: 01 Jul 2008
AbstractforPaclitaxel-loaded poly(D,L-lactide-co-glycolide) nanoparticles for radiotherapy in hypoxic human tumor cells in vitro | PDF (1 MB)
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Article
MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors
Adly Yacoub, Hossein A. Hamed, Luni Emdad, Wagner Dos Santos, Pankaj Gupta, William C. Broaddus, Viswanathan Ramakrishnan, Devanand Sarkar, Khalid Shah, David T. Curiel, Steven Grant, Paul B. Fisher & Paul Dent
Pages: 917-933
Published online: 01 Jul 2008
AbstractforMDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors | PDF (13.5 MB)
  • 420 Views
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Open Access
Article
Poly (ADP-ribose) polymerase activity regulates apoptosis in HeLa cells after alkylating DNA damage
Xuesong Liu, Xu Luo, Yan Yan Shi, Gui-dong Zhu, Thomas Penning, Vincent L Giranda & Yan Luo
Pages: 934-941
Published online: 01 Jul 2008
AbstractforPoly (ADP-ribose) polymerase activity regulates apoptosis in HeLa cells after alkylating DNA damage | PDF (1.1 MB)
  • 427 Views
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Commentary

PARP inhibitor tilts cell death from necrosis to apoptosis in cancer cells
Keqiang Ye
Pages: 942-944
Published online: 01 Jul 2008
AbstractforPARP inhibitor tilts cell death from necrosis to apoptosis in cancer cells | PDF (543.4 KB)
  • 451 Views
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Research Paper

Article
Development of a bidirectional caspase-3 expression system for the induction of apoptosis
Martyn K. White, Shohreh Amini, Kamel Khalili & Nune Darbinian
Pages: 945-954
Published online: 01 Jul 2008
AbstractforDevelopment of a bidirectional caspase-3 expression system for the induction of apoptosis | PDF (7.9 MB)
  • 390 Views
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Commentary

Inducing the uptake of the deadly executioner in cancer cells
Francesca Pentimalli & Antonio Giordano
Pages: 955-957
Published online: 01 Jul 2008
AbstractforInducing the uptake of the deadly executioner in cancer cells | PDF (717.4 KB)
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Research Paper

Article
Quantitative detection of methylated ESR1 and 14-3-3-σ gene promoters in serum as candidate biomarkers for diagnosis of breast cancer and evaluation of treatment efficacy
Joaquina Martínez-Galán, Blanca Torres, Rosario del Moral, José Antonio Muñoz-Gámez, David Martín-Oliva, Mercedes Villalobos, María Isabel Núñez, Juan de Dios Luna, Francisco Javier Oliver & José Mariano Ruiz de Almodóvar,
Pages: 958-965
Published online: 01 Jul 2008
AbstractforQuantitative detection of methylated ESR1 and 14-3-3-σ gene promoters in serum as candidate biomarkers for diagnosis of breast cancer and evaluation of treatment efficacy | PDF (1.5 MB)
  • 772 Views
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Open Access
Article
Apoptotic effect of citrus fruit extract nobiletin on lung cancer cell line A549 in vitro and in vivo
Gang Luo, Xiaoling Guan & Liming Zhou
Pages: 966-973
Published online: 01 Jul 2008
AbstractforApoptotic effect of citrus fruit extract nobiletin on lung cancer cell line A549 in vitro and in vivo | PDF (3.7 MB)
  • 1414 Views
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Article
Characterization of a targeted nanoparticle functionalized with a urea-based inhibitor of prostate-specific membrane antigen (PSMA)
Sachin S. Chandran, Sangeeta R. Banerjee, Ron C. Mease, Martin G. Pomper & Samuel R. Denmeade
Pages: 974-982
Published online: 01 Jul 2008
AbstractforCharacterization of a targeted nanoparticle functionalized with a urea-based inhibitor of prostate-specific membrane antigen (PSMA) | PDF (1.4 MB)
  • 898 Views
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