Cancer Biology & Therapy, Volume 9, Issue 7 (2010)

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Cancer Biology & Therapy, Volume 9, Issue 7 (2010)

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Editor's Corner

Editorial
Cover caption
Page: i
Published online: 01 Apr 2010
AbstractforCover caption | PDF (62.3 MB)
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News

News
UNMC Names Dr. Vimla Band to Head Genetics, Cell Biology and Anatomy
Tom O'Connor
Pages: 479-478
Published online: 01 Apr 2010
AbstractforUNMC Names Dr. Vimla Band to Head Genetics, Cell Biology and Anatomy | PDF (204.3 KB)
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News
Cancer Biology and Therapy Editor Wafik El-Deiry named as Chief of Hematology/Oncology at Penn State
Pages: 479-478
Published online: 01 Apr 2010
AbstractforCancer Biology and Therapy Editor Wafik El-Deiry named as Chief of Hematology/Oncology at Penn State | PDF (204.3 KB)
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Review

Review Article
MicroRNAs and cancer therapy: The next wave or here to stay?
Sirigiri Divijendra Natha Reddy, Rajendra P. Gajula, Suresh B. Pakala & Rakesh Kumar
Pages: 479-482
Published online: 01 Apr 2010
AbstractforMicroRNAs and cancer therapy: The next wave or here to stay? | PDF (480 KB)
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Review Article
Growth hormone- secreting pituitary adenomas: from molecular basis to treatment options in acromegaly
Simone Magnavita Sabino, Paulo Augusto Carvalho Miranda & Antonio Ribeiro-Oliveira
Pages: 483-492
Published online: 01 Apr 2010
AbstractforGrowth hormone- secreting pituitary adenomas: from molecular basis to treatment options in acromegaly | PDF (755 KB)
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Research Paper

Article
An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo
Craig Cherrin, Kathleen Haskell, Bonnie Howell, Raymond Jones, Karen Leander, Ronald Robinson, Aubrey Watkins, Mark Bilodeau, Jacob Hoffman, Philip Sanderson, George Hartman, Elizabeth Mahan, Thomayant Prueksaritanont, Guoqiang Jiang, Qing-Bai She, Neal Rosen, Laura Sepp-Lorenzino, Deborah Defeo-Jones & Hans E. Huber
Pages: 493-503
Published online: 01 Apr 2010
AbstractforAn allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo | PDF (2.9 MB)
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Commentary

Allosteric AKT inhibitors as a targeted cancer therapy
Jihye Yun
Pages: 504-506
Published online: 01 Apr 2010
AbstractforAllosteric AKT inhibitors as a targeted cancer therapy | PDF (167.1 KB)
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Research Paper

Article
KLF4 inhibition of lung cancer cell invasion by suppression of SPARC expression
Yanbin Zhou, Wayne L. Hofstetter, Yong He, Wenxian Hu, Abujiang Pataer, Li Wang, Ji Wang, Yihong Zhou, Liping Yu, Bingliang Fang & Stephen G. Swisher
Pages: 507-513
Published online: 01 Apr 2010
AbstractforKLF4 inhibition of lung cancer cell invasion by suppression of SPARC expression | PDF (701.1 KB)
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Article
MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil
Hiroshi Hirai, Tsuyoshi Arai, Megumu Okada, Toshihide Nishibata, Makiko Kobayashi, Naoko Sakai, Kazuhide Imagaki, Junko Ohtani, Takumi Sakai, Takashi Yoshizumi, Shinji Mizuarai, Yoshikazu Iwasawa & Hidehito Kotani
Pages: 514-522
Published online: 01 Apr 2010
AbstractforMK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil | PDF (1.4 MB)
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Commentary

Targeting the checkpoint kinase WEE1: Selective sensitization of cancer cells to DNA-damaging drugs
Paola Indovina & Antonio Giordano
Pages: 523-525
Published online: 01 Apr 2010
AbstractforTargeting the checkpoint kinase WEE1: Selective sensitization of cancer cells to DNA-damaging drugs | PDF (317.6 KB)
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Research Paper

Article
OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins
Hossein A. Hamed, Adly Yacoub, Margaret A. Park, Patrick J. Eulitt, Devanand Sarkar, Igor P. Dimitrie, Ching-Shih Chen, Steven Grant, David T. Curiel, Paul B. Fisher & Paul Dent
Pages: 526-536
Published online: 01 Apr 2010
AbstractforOSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins | PDF (1.4 MB)
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Commentary

The role of autophagy as a mechanism of cytotoxicity by the clinically used agent MDA-7/IL-24.
Stacey Lehman & Constantinos Koumenis
Pages: 537-538
Published online: 01 Apr 2010
AbstractforThe role of autophagy as a mechanism of cytotoxicity by the clinically used agent MDA-7/IL-24. | PDF (162.1 KB)
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Research Paper

Article
Combined therapy with the RANKL inhibitor RANK-Fc and rhApo2L/TRAIL/dulanermin reduces bone lesions and skeletal tumor burden in a model of breast cancer skeletal metastasis
Pamela M. Holland, Robert Miller, Jon Jones, Heather Douangpanya, Julia Piasecki, Martine Roudier & William C. Dougall
Pages: 539-550
Published online: 01 Apr 2010
AbstractforCombined therapy with the RANKL inhibitor RANK-Fc and rhApo2L/TRAIL/dulanermin reduces bone lesions and skeletal tumor burden in a model of breast cancer skeletal metastasis | PDF (2.4 MB)
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Commentary

Breast cancer bone metastases: Combination therapy targeting cancer cells and the tumor microenvironment
Rachel L. de Kluyver & Thomas J. Sayers
Pages: 551-553
Published online: 01 Apr 2010
AbstractforBreast cancer bone metastases: Combination therapy targeting cancer cells and the tumor microenvironment | PDF (168.8 KB)
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Research Paper

Article
Expression of miR-122 mediated by adenoviral vector induces apoptosis and cell cycle arrest of cancer cells.
Leina Ma, Jia Liu, Junjie Shen, Li Liu, Jia Wu, Wei Li, Jingjing Luo, Qing Chen & Cheng Qian
Pages: 554-561
Published online: 01 Apr 2010
AbstractforExpression of miR-122 mediated by adenoviral vector induces apoptosis and cell cycle arrest of cancer cells. | PDF (1.4 MB)
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