Statistics in Biopharmaceutical Research, Volume 12, Issue 1 (2020)

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Statistics in Biopharmaceutical Research, Volume 12, Issue 1 (2020)

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Estimands and Missing Data

Article
A General Framework for Treatment Effect Estimators Considering Patient Adherence
Yongming Qu, Haoda Fu, Junxiang Luo & Stephen J. Ruberg
Pages: 1-18
Published online: 21 Jan 2020
AbstractforA General Framework for Treatment Effect Estimators Considering Patient Adherence | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 1016 Views
  • 14 CrossRef citations
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Article
Estimating the Treatment Effect in a Subgroup Defined by an Early Post-Baseline Biomarker Measurement in Randomized Clinical Trials With Time-To-Event Endpoint
Björn Bornkamp & Georgina Bermann
Pages: 19-28
Published online: 08 May 2019
AbstractforEstimating the Treatment Effect in a Subgroup Defined by an Early Post-Baseline Biomarker Measurement in Randomized Clinical Trials With Time-To-Event Endpoint | Full Text | References | PDF (1.4 MB) | EPUB
  • 1049 Views
  • 20 CrossRef citations
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Article
A New Principal Stratum Estimand Investigating the Treatment Effect in Patients Who Would Comply, If Treated With a Specific Treatment
Klaus Groes Larsen & Mette Krog Josiassen
Pages: 29-38
Published online: 13 Dec 2019
AbstractforA New Principal Stratum Estimand Investigating the Treatment Effect in Patients Who Would Comply, If Treated With a Specific Treatment | Full Text | References | PDF (1.1 MB) | EPUB
  • 577 Views
  • 7 CrossRef citations
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Article
Estimands in a Chronic Pain Trial: Challenges and Opportunities
Francesca Callegari, Mouna Akacha, Peter Quarg, Shaloo Pandhi, Florian von Raison & Emmanuel Zuber
Pages: 39-44
Published online: 22 Jul 2019
AbstractforEstimands in a Chronic Pain Trial: Challenges and Opportunities | Full Text | References | PDF (798.1 KB) | EPUB
  • 718 Views
  • 15 CrossRef citations
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Article
Do Covariates Change the Estimand?
Thomas Permutt
Pages: 45-53
Published online: 26 Aug 2019
AbstractforDo Covariates Change the Estimand? | Full Text | References | PDF (787.6 KB) | EPUB
  • 1481 Views
  • 12 CrossRef citations
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Article
Causal Inference and Estimands in Clinical Trials
Ilya Lipkovich, Bohdana Ratitch & Craig H. Mallinckrodt
Pages: 54-67
Published online: 23 Jan 2020
AbstractforCausal Inference and Estimands in Clinical Trials | Full Text | References | PDF (1.2 MB) | EPUB
  • 5461 Views
  • 37 CrossRef citations
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Article
Methods for Missing Data Handling in Phase III Clinical Trials with Nonnormal Endpoints and Nonnormal Covariates
Chunpeng Fan, Lynn Wei & Gary G. Koch
Pages: 68-78
Published online: 19 Feb 2019
AbstractforMethods for Missing Data Handling in Phase III Clinical Trials with Nonnormal Endpoints and Nonnormal Covariates | Full Text | References | PDF (964.7 KB) | EPUB
  • 326 Views
  • 2 CrossRef citations
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Article
Model Averaging Using Likelihoods That Reflect Poor Outcomes for Clinical Trial Dropouts
G. Frank Liu, Fang Liu & Devan V. Mehrotra
Pages: 79-89
Published online: 14 Jan 2020
AbstractforModel Averaging Using Likelihoods That Reflect Poor Outcomes for Clinical Trial Dropouts | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 157 Views
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Original Articles

Article
Extended Rank Tests for Analyzing Recurrent Event Data
Qiang Zhao, Bin Zhang, Michael P. LaValley, Joseph M. Massaro, Kathryn L. Lunetta & Mark Chang
Pages: 90-98
Published online: 24 Jun 2019
AbstractforExtended Rank Tests for Analyzing Recurrent Event Data | Full Text | References | PDF (1,022.2 KB) | EPUB | Supplemental
  • 179 Views
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Article
The Win Ratio: On Interpretation and Handling of Ties
Gaohong Dong, David C. Hoaglin, Junshan Qiu, Roland A. Matsouaka, Yu-Wei Chang, Jiuzhou Wang & Marc Vandemeulebroecke
Pages: 99-106
Published online: 25 Apr 2019
AbstractforThe Win Ratio: On Interpretation and Handling of Ties | Full Text | References | PDF (751.5 KB) | EPUB
  • 1003 Views
  • 33 CrossRef citations
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Article
Methods for Using Aggregate Historical Control Data in Meta-Analyses of Clinical Trials With Time-to-Event Endpoints
Björn Holzhauer
Pages: 107-116
Published online: 05 Jul 2019
AbstractforMethods for Using Aggregate Historical Control Data in Meta-Analyses of Clinical Trials With Time-to-Event Endpoints | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 430 Views
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Article
Family-Wise Error Rate Controlling Procedures for Discrete Data
Yalin Zhu & Wenge Guo
Pages: 117-128
Published online: 16 Sep 2019
AbstractforFamily-Wise Error Rate Controlling Procedures for Discrete Data | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 302 Views
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