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Volume 2, Issue 3

Statistics in Biopharmaceutical Research

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Statistics in Biopharmaceutical Research, Volume 2, Issue 3 (2010)

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Statistics in Biopharmaceutical Research, Volume 2, Issue 3 (2010)

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International Symposium on Biopharmaceutical Statistics Special Issue II

Article

Measuring Study-Specific Heterogeneity in Meta-Analysis: Application to an Antecedent Biomarker Study of Alzheimer’s Disease

Chengjie Xiong, J. Philip Miller & John C. Morris

Pages: 300-309

Published online: 01 Jan 2012

AbstractforMeasuring Study-Specific Heterogeneity in Meta-Analysis: Application to an Antecedent Biomarker Study of Alzheimer’s Disease | PDF (138.7 KB)

73 Views
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Article

Optimal Adaptive Designs for Binary Response Trials With Three Treatments

Youngsook Jeon & Feifang Hu

Pages: 310-318

Published online: 01 Jan 2012

AbstractforOptimal Adaptive Designs for Binary Response Trials With Three Treatments | PDF (152.5 KB)

125 Views
11 CrossRef citations
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Article

Sample Size Analysis for Pharmacogenetic Studies

Chi-hong Tseng & Yongzhao Shao

Pages: 319-328

Published online: 01 Jan 2012

AbstractforSample Size Analysis for Pharmacogenetic Studies | PDF (163 KB)

122 Views
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Article

Stratified Wilson and Newcombe Confidence Intervals for Multiple Binomial Proportions

Xin Yan & Xiao Gang Su

Pages: 329-335

Published online: 01 Jan 2012

AbstractforStratified Wilson and Newcombe Confidence Intervals for Multiple Binomial Proportions | PDF (111.6 KB)

514 Views
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Article

A Comparison of Testing Parameters and the Implementation of a Group Sequential Design for Equivalence Studies Using Paired-Sample Analysis

Yunda Huang & Steven G. Self

Pages: 336-347

Published online: 01 Jan 2012

AbstractforA Comparison of Testing Parameters and the Implementation of a Group Sequential Design for Equivalence Studies Using Paired-Sample Analysis | PDF (162.6 KB)

49 Views
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Article

Optimal Two-Stage Design for the Phase II Cancer Clinical Trials With Responses and Early Progression as Co-primary Endpoints

Xianming Tan, Glen Takahara & Dongsheng Tu

Pages: 348-354

Published online: 01 Jan 2012

AbstractforOptimal Two-Stage Design for the Phase II Cancer Clinical Trials With Responses and Early Progression as Co-primary Endpoints | PDF (114.5 KB)

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Article

Where Statisticians can Contribute to Address Future Challenges for Drug Regulatory Agencies: A View from the European Medicines Agency (EMEA)

Hans-Georg Eichler, Robert J. Hemmings & Spiros Vamvakas

Pages: 355-358

Published online: 01 Jan 2012

AbstractforWhere Statisticians can Contribute to Address Future Challenges for Drug Regulatory Agencies: A View from the European Medicines Agency (EMEA) | PDF (76.7 KB)

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Article

Marking the Ends of ECG T-Waves for Assessing Cardiac Safety: Algorithms and Experts

Yingchun Zhou & Nell Sedransk

Pages: 359-367

Published online: 01 Jan 2012

AbstractforMarking the Ends of ECG T-Waves for Assessing Cardiac Safety: Algorithms and Experts | PDF (694.6 KB)

42 Views
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Article

Multiple Comparisons in Microarray Data Analysis

Donghui Zhang & Li Liu

Pages: 368-382

Published online: 01 Jan 2012

AbstractforMultiple Comparisons in Microarray Data Analysis | PDF (162.9 KB)

67 Views
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Article

A Web-Based Tool for Finding Optimal Designs for the Michaelis–Menten Model and an Overview

Holger Dette, Christine Kiss & Weng Kee Wong

Pages: 383-393

Published online: 01 Jan 2012

AbstractforA Web-Based Tool for Finding Optimal Designs for the Michaelis–Menten Model and an Overview | PDF (167.4 KB)

64 Views
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Article

Stopping Boundaries of Flexible Sample Size Design With Flexible Trial Monitoring

Yi He, Zhenming Shun & Yijia Feng

Pages: 394-407

Published online: 01 Jan 2012

AbstractforStopping Boundaries of Flexible Sample Size Design With Flexible Trial Monitoring | PDF (204.6 KB)

58 Views
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Article

Tests for Normality Based on Entropy Divergences

Jiqiang Guo, Demissie Alemayehu & Yongzhao Shao

Pages: 408-418

Published online: 01 Jan 2012

AbstractforTests for Normality Based on Entropy Divergences | PDF (142.8 KB)

68 Views
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Article

Genomic Biomarkers for Depression: Feature-Specific and Joint Biomarkers

Abel Tilahun, Dan Lin, Ziv Shkedy, Helena Geys, Ariel Alonso, Pieter Peeters, Willem Talloen, Wilhelmus Drinkenburg, Hinrich Göhlmann, Evian Gorden, Luc Bijnens & Geert Molenberghs

Pages: 419-434

Published online: 01 Jan 2012

AbstractforGenomic Biomarkers for Depression: Feature-Specific and Joint Biomarkers | PDF (188 KB)

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