Statistics in Biopharmaceutical Research, Volume 6, Issue 1 (2014)

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Statistics in Biopharmaceutical Research, Volume 6, Issue 1 (2014)

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Original Articles

Article
Estimating and Testing the Variation of a Binary Treatment Effect Over Clusters in a Proportional Hazard Frailty Model
Shibao Feng & Lei Nie
Pages: 1-8
Published online: 01 Feb 2014
AbstractforEstimating and Testing the Variation of a Binary Treatment Effect Over Clusters in a Proportional Hazard Frailty Model | Full Text | References | PDF (348.2 KB)
  • 109 Views
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Article
Optimal Designs for Estimating the ED50 When Response Functions Have a Downturn
Seung Won Hyun
Pages: 9-15
Published online: 01 Feb 2014
AbstractforOptimal Designs for Estimating the ED50 When Response Functions Have a Downturn | Full Text | References | PDF (196.9 KB)
  • 132 Views
  • 1 CrossRef citations
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Article
Statistical Methods for Selecting Maximum Effective Dose and Evaluating Treatment Effect When Dose–Response is Monotonic
Maiying Kong, Shesh N. Rai & Roberto Bolli
Pages: 16-29
Published online: 01 Feb 2014
AbstractforStatistical Methods for Selecting Maximum Effective Dose and Evaluating Treatment Effect When Dose–Response is Monotonic | Full Text | References | PDF (304.8 KB)
  • 473 Views
  • 4 CrossRef citations
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Article
Empirical Likelihood Approaches to Two-Group Comparisons of Upper Quantiles Applied to Biomedical Data
Jihnhee Yu, Albert Vexler, Alan D. Hutson & Heinz Baumann
Pages: 30-40
Published online: 01 Feb 2014
AbstractforEmpirical Likelihood Approaches to Two-Group Comparisons of Upper Quantiles Applied to Biomedical Data | Full Text | References | PDF (214.1 KB)
  • 104 Views
  • 2 CrossRef citations
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Article
Sensitivity Analysis for Withdrawals in Grouped Time-to-Event Data
Yue Zhao, John S. Preisser & Gary G. Koch
Pages: 41-54
Published online: 01 Feb 2014
AbstractforSensitivity Analysis for Withdrawals in Grouped Time-to-Event Data | Full Text | References | PDF (301.5 KB)
  • 133 Views
  • 2 CrossRef citations
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Article
Identification of the Minimum Effective Dose for Normally Distributed Endpoints Using a Model Selection Approach
Rebecca M. Kuiper, Daniel Gerhard & Ludwig A. Hothorn
Pages: 55-66
Published online: 01 Feb 2014
AbstractforIdentification of the Minimum Effective Dose for Normally Distributed Endpoints Using a Model Selection Approach | Full Text | References | PDF (256.6 KB) | Supplemental
  • 147 Views
  • 6 CrossRef citations
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Article
A Quantitative Process for Enhancing End of Phase 2 Decisions
Tony Sabin, James Matcham, Sarah Bray, Andrew Copas & Mahesh K. B. Parmar
Pages: 67-77
Published online: 01 Feb 2014
AbstractforA Quantitative Process for Enhancing End of Phase 2 Decisions | Full Text | References | PDF (579.4 KB) | Supplemental
  • 2663 Views
  • 17 CrossRef citations
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Open Access
Article
Identifying a Subpopulation for a Tailored Therapy: Bridging Clinical Efficacy From a Laboratory-Developed Assay to a Validated In Vitro Diagnostic Test Kit
Jonathan S. Denne, Gene Pennello, Luping Zhao, Shao-Chun Chang & Sandra Althouse
Pages: 78-88
Published online: 01 Feb 2014
AbstractforIdentifying a Subpopulation for a Tailored Therapy: Bridging Clinical Efficacy From a Laboratory-Developed Assay to a Validated In Vitro Diagnostic Test Kit | Full Text | References | PDF (249.8 KB)
  • 388 Views
  • 12 CrossRef citations
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Article
A General AUC-Type Measure and Biomarker Selection
Zhanfeng Wang & Yuan-Chin Ivan Chang
Pages: 89-103
Published online: 01 Feb 2014
AbstractforA General AUC-Type Measure and Biomarker Selection | Full Text | References | PDF (380.8 KB)
  • 225 Views
  • 1 CrossRef citations
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Article
Design and Analysis of Diabetes Prevention Trials for Glucose-Lowering Drugs
Björn Holzhauer
Pages: 104-114
Published online: 01 Feb 2014
AbstractforDesign and Analysis of Diabetes Prevention Trials for Glucose-Lowering Drugs | Full Text | References | PDF (210.4 KB) | Supplemental
  • 361 Views
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Article
Exact Methods for Testing the Equality of Proportions for Binary Clustered Data From Otolaryngologic Studies
Guogen Shan & Changxing Ma
Pages: 115-122
Published online: 01 Feb 2014
AbstractforExact Methods for Testing the Equality of Proportions for Binary Clustered Data From Otolaryngologic Studies | Full Text | References | PDF (1.8 MB)
  • 138 Views
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