OncoImmunology, Volume 13, Issue 1 (2024)

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OncoImmunology, Volume 13, Issue 1 (2024)

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Issue In Progress

Original research

Article
HUNK as a key regulator of tumor-associated macrophages in triple negative breast cancer
Nicole Ramos Solis, Anthony Cannon, Tinslee Dilday, Melissa Abt, Adrian L. Oblak, Adam C. Soloff, Mark H. Kaplan & Elizabeth S. Yeh
Article: 2364382
Published online: 05 Jun 2024
AbstractforHUNK as a key regulator of tumor-associated macrophages in triple negative breast cancer | Full Text | References | PDF (4.6 MB) | EPUB | Supplemental
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Open Access
Article
CD20 expression regulates CD37 levels in B-cell lymphoma – implications for immunotherapies
Malgorzata Bobrowicz, Aleksandra Kusowska, Marta Krawczyk, Andriy Zhylko, Christopher Forcados, Aleksander Slusarczyk, Joanna Barankiewicz, Joanna Domagala, Matylda Kubacz, Michal Šmída, Lenka Dostalova, Katsiaryna Marhelava, Klaudyna Fidyt, Monika Pepek, Iwona Baranowska, Anna Szumera-Cieckiewicz, Else Marit Inderberg, Sébastien Wälchli, Monika Granica, Agnieszka Graczyk-Jarzynka, Martyna Majchrzak, Marcin Poreba, Carina Lynn Gehlert, Matthias Peipp, Malgorzata Firczuk, Monika Prochorec-Sobieszek & Magdalena Winiarska
Article: 2362454
Published online: 04 Jun 2024
AbstractforCD20 expression regulates CD37 levels in B-cell lymphoma – implications for immunotherapies | Full Text | References | PDF (3 MB) | EPUB | Supplemental
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Open Access
Article
β-Lapachone promotes the recruitment and polarization of tumor-associated neutrophils (TANs) toward an antitumor (N1) phenotype in NQO1-positive cancers
Soumya Tumbath, Lingxiang Jiang, Xiaoguang Li, Taolan Zhang, Kashif Rafiq Zahid, Ye Zhao, Hao Zhou, Zhijun Yin, Tao Lu, Shu Jiang, Yaomin Chen, Xiang Chen, Yang-Xin Fu & Xiumei Huang
Article: 2363000
Published online: 04 Jun 2024
Abstractforβ-Lapachone promotes the recruitment and polarization of tumor-associated neutrophils (TANs) toward an antitumor (N1) phenotype in NQO1-positive cancers | Full Text | References | PDF (5.7 MB) | EPUB | Supplemental
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Open Access

Commentary

Comment
Immunogenic oncolysis by tigilanol tiglate
Jonathan G. Pol, Manuela Lizarralde-Guerrero & Guido Kroemer
Article: 2360230
Published online: 27 May 2024
AbstractforImmunogenic oncolysis by tigilanol tiglate | Full Text | References | PDF (747.5 KB) | EPUB
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Open Access
Comment
Clinically relevant GABARAP deficiency abrogates bortezomib-induced immunogenic cell death in multiple myeloma
Liwei Zhao, Zhe Shen, Guido Kroemer & Oliver Kepp
Article: 2360275
Published online: 27 May 2024
AbstractforClinically relevant GABARAP deficiency abrogates bortezomib-induced immunogenic cell death in multiple myeloma | Full Text | References | PDF (619.6 KB) | EPUB
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Open Access

Original Research

Article
CXCL10 and IL15 co-expressing chimeric antigen receptor T cells enhance anti-tumor effects in gastric cancer by increasing cytotoxic effector cell accumulation and survival
Siyue Nie, Yujie Song, Kun Hu, Wei Zu, Fengjiao Zhang, Lixia Chen, Qiang Ma, Zishan Zhou & Shunchang Jiao
Article: 2358590
Published online: 24 May 2024
AbstractforCXCL10 and IL15 co-expressing chimeric antigen receptor T cells enhance anti-tumor effects in gastric cancer by increasing cytotoxic effector cell accumulation and survival | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 387 Views
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Open Access
Article
Peripheral CX3CR1+ T cells combined with PD-1 blockade therapy potentiates the anti-tumor efficacy for lung cancer
Congcong Li, Zhen Zhang, Qianfeng Cai, Qitai Zhao, Han Wu, JunRu Li, Yaqing Liu, Xuan Zhao, Jinyan Liu, Yu Ping, Jiqi Shan, Shengli Yang & Yi Zhang
Article: 2355684
Published online: 22 May 2024
AbstractforPeripheral CX3CR1+ T cells combined with PD-1 blockade therapy potentiates the anti-tumor efficacy for lung cancer | Full Text | References | PDF (5 MB) | EPUB | Supplemental
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Open Access
Article
HIF2A mediates lineage transition to aggressive phenotype of cancer-associated fibroblasts in lung cancer brain metastasis
Muyuan You, Minjie Fu, Zhewei Shen, Yuan Feng, Licheng Zhang, Xianmin Zhu, Zhengping Zhuang, Ying Mao & Wei Hua
Article: 2356942
Published online: 20 May 2024
AbstractforHIF2A mediates lineage transition to aggressive phenotype of cancer-associated fibroblasts in lung cancer brain metastasis | Full Text | References | PDF (9.7 MB) | EPUB | Supplemental
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Open Access
Article
Characterization of innate lymphoid cell subsets infiltrating melanoma and epithelial ovarian tumors
Douglas C. Chung, Maryam Ghaedi, Kathrin Warner, Azin Sayad, Samuel D. Saibil, Marcus Q. Bernardini, Blaise A. Clarke, Patricia A. Shaw, Marcus O. Butler, Alexandra Easson, Sorana Morrissy, Ben X. Wang, Linh Nguyen, Pamela S. Ohashi & Nicolas Jacquelot
Article: 2349347
Published online: 10 May 2024
AbstractforCharacterization of innate lymphoid cell subsets infiltrating melanoma and epithelial ovarian tumors | Full Text | References | PDF (5.2 MB) | EPUB | Supplemental
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Open Access
Article
CPT1C-positive cancer-associated fibroblast facilitates immunosuppression through promoting IL-6-induced M2-like phenotype of macrophage
Rongyuan Wei, Junquan Song, Hongda Pan, Xiaowen Liu & Jianpeng Gao
Article: 2352179
Published online: 10 May 2024
AbstractforCPT1C-positive cancer-associated fibroblast facilitates immunosuppression through promoting IL-6-induced M2-like phenotype of macrophage | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
  • 505 Views
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Open Access
Article
Expression of CD39 is associated with T cell exhaustion in ovarian cancer and its blockade reverts T cell dysfunction
Witt Marius, Oliveira-Ferrer Leticia, Koch-Nolte Friedrich, Menzel Stephan, Hell Louisa, Sturmheit Tabea, Seubert Elisa, Weimer Pauline, Ding Yi, Minyue Qi, Schmalfeldt Barbara, Bokemeyer Carsten, Fiedler Walter, Wellbrock Jasmin & Brauneck Franziska
Article: 2346359
Published online: 09 May 2024
AbstractforExpression of CD39 is associated with T cell exhaustion in ovarian cancer and its blockade reverts T cell dysfunction | Full Text | References | PDF (10.2 MB) | EPUB | Supplemental
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Open Access

Brief report

Article
Distinct autoantibody profiles across checkpoint inhibitor types and toxicities
Hong Mu-Mosley, Mitchell S. von Itzstein, Farjana Fattah, Jialiang Liu, Chengsong Zhu, Yang Xie, Edward K. Wakeland, Jason Y. Park, Brad S. Kahl, Catherine S. Diefenbach & David E. Gerber
Article: 2351255
Published online: 09 May 2024
AbstractforDistinct autoantibody profiles across checkpoint inhibitor types and toxicities | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 549 Views
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Open Access

Original Research

Article
Memory-like differentiation enhances NK cell responses against colorectal cancer
Nancy D. Marin, Michelle Becker-Hapak, Wilbur M. Song, Quazim A. Alayo, Lynne Marsala, Naomi Sonnek, Melissa M. Berrien-Elliott, Mark Foster, Jennifer A. Foltz, Jennifer Tran, Pamela Wong, Celia C. Cubitt, Patrick Pence, Kimberly Hwang, Alice Y. Zhou, Miriam T. Jacobs, Timothy Schappe, David A. Russler-Germain, Ryan C. Fields, Matthew A. Ciorba & Todd A. Fehniger
Article: 2348254
Published online: 07 May 2024
AbstractforMemory-like differentiation enhances NK cell responses against colorectal cancer | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
  • 995 Views
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Open Access

Review

Review Article
Principles of risk assessment in colon cancer: immunity is key
Assia Hijazi & Jérôme Galon
Article: 2347441
Published online: 30 Apr 2024
AbstractforPrinciples of risk assessment in colon cancer: immunity is key | Full Text | References | PDF (913.8 KB) | EPUB
  • 412 Views
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Open Access

Original Research

Article
Immune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes
Joel Kidman, Rachael M. Zemek, John-William Sidhom, Debora Correa, Nicola Principe, Fezaan Sheikh, Vanessa S. Fear, Catherine A. Forbes, Abha Chopra, Louis Boon, Ayham Zaitouny, Emma de Jong, Robert A. Holt, Matt Jones, Michael J. Millward, Timo Lassmann, Alistair R.R. Forrest, Anna K. Nowak, Mark Watson, Richard A. Lake, W. Joost Lesterhuis & Jonathan Chee
Article: 2345859
Published online: 26 Apr 2024
AbstractforImmune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 837 Views
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Open Access
Article
The potential role of CMC1 as an immunometabolic checkpoint in T cell immunity
Yuwen Chen, Jie Gao, Mingyue Ma, Ke Wang, Fangming Liu, Feiyu Yang, Xin Zou, Zhouli Cheng & Duojiao Wu
Article: 2344905
Published online: 23 Apr 2024
AbstractforThe potential role of CMC1 as an immunometabolic checkpoint in T cell immunity | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
  • 612 Views
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Open Access
Article
Combination of T cell-redirecting strategies with a bispecific antibody blocking TGF-β and PD-L1 enhances antitumor responses
Antonio Tapia-Galisteo, Iñigo Sánchez-Rodríguez, Javier Narbona, Patricia Iglesias-Hernández, Saray Aragón-García, Anaïs Jiménez-Reinoso, Marta Compte, Shaukat Khan, Takeshi Tsuda, Patrick Chames, Javier Lacadena, Luis Álvarez-Vallina & Laura Sanz
Article: 2338558
Published online: 13 Apr 2024
AbstractforCombination of T cell-redirecting strategies with a bispecific antibody blocking TGF-β and PD-L1 enhances antitumor responses | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Open Access
Article
Redoxhigh phenotype mediated by KEAP1/STK11/SMARCA4/NRF2 mutations diminishes tissue-resident memory CD8+ T cells and attenuates the efficacy of immunotherapy in lung adenocarcinoma
Xue-Wu Wei, Chang Lu, Yi-Chen Zhang, Xue Fan, Chong-Rui Xu, Zhi-Hong Chen, Fen Wang, Xiao-Rong Yang, Jia-Yi Deng, Ming-Yi Yang, Qing Gou, Shi-Qi Mei, Wei-Chi Luo, Ri-Wei Zhong, Wen-Zhao Zhong, Jin-Ji Yang, Xu-Chao Zhang, Hai-Yan Tu, Yi-Long Wu & Qing Zhou
Article: 2340154
Published online: 09 Apr 2024
AbstractforRedoxhigh phenotype mediated by KEAP1/STK11/SMARCA4/NRF2 mutations diminishes tissue-resident memory CD8+ T cells and attenuates the efficacy of immunotherapy in lung adenocarcinoma | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
  • 988 Views
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Open Access

Author’s View

Reply
PD-L1+ macrophages suppress T cell-mediated anticancer immunity
Peng Liu, Liwei Zhao, Guido Kroemer & Oliver Kepp
Article: 2338951
Published online: 04 Apr 2024
AbstractforPD-L1+ macrophages suppress T cell-mediated anticancer immunity | Full Text | References | PDF (777.7 KB) | EPUB
  • 786 Views
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Open Access

Original Research

Article
CCR2 and CCR5 co-inhibition modulates immunosuppressive myeloid milieu in glioma and synergizes with anti-PD-1 therapy
Ayush Pant, Brandon Hwa-Lin Bergsneider, Siddhartha Srivastava, Timothy Kim, Aanchal Jain, Sadhana Bom, Pavan Shah, Nivedha Kannapadi, Kisha Patel, John Choi, Kwang Bog Cho, Rohit Verma, Caren Yu-Ju Wu, Henry Brem, Betty Tyler, Drew M. Pardoll, Christina Jackson & Michael Lim
Article: 2338965
Published online: 04 Apr 2024
AbstractforCCR2 and CCR5 co-inhibition modulates immunosuppressive myeloid milieu in glioma and synergizes with anti-PD-1 therapy | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 1012 Views
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Open Access
Article
STING is significantly increased in high-grade glioma with high risk of recurrence
Meishi Zhong, Manmei Long, Chenjie Han, Saiyan Ji & Qingyuan Yang
Article: 2327682
Published online: 20 Mar 2024
AbstractforSTING is significantly increased in high-grade glioma with high risk of recurrence | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
  • 702 Views
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Open Access
Article
Lymphatic endothelial cell-mediated accumulation of CD177+Treg cells suppresses antitumor immunity in human esophageal squamous cell carcinoma
Min Ma, Liang Li, Shu-Han Yang, Chuan Huang, Weitao Zhuang, Shujie Huang, Xin Xia, Yong Tang, Zijun Li, Zhi-Bin Zhao, Qingyun Chen, Guibin Qiao & Zhe-Xiong Lian
Article: 2327692
Published online: 20 Mar 2024
AbstractforLymphatic endothelial cell-mediated accumulation of CD177+Treg cells suppresses antitumor immunity in human esophageal squamous cell carcinoma | Full Text | References | PDF (6.1 MB) | EPUB | Supplemental
  • 1064 Views
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Open Access
Article
Co-inhibition of TGF-β and PD-L1 pathways in a metastatic colorectal cancer mouse model triggers interferon responses, innate cells and T cells, alongside metabolic changes and tumor resistance
Reshmi Nair, Tamsin R. M. Lannagan, Rene Jackstadt, Anna Andrusaite, John Cole, Caitlin Boyne, Robert J. B. Nibbs, Owen J. Sansom & Simon Milling
Article: 2330194
Published online: 20 Mar 2024
AbstractforCo-inhibition of TGF-β and PD-L1 pathways in a metastatic colorectal cancer mouse model triggers interferon responses, innate cells and T cells, alongside metabolic changes and tumor resistance | Full Text | References | PDF (4.4 MB) | EPUB | Supplemental
  • 1184 Views
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Open Access

Trial Watch

News
Trial watch: local anesthetics in cancer therapy
Killian Carnet Le Provost, Oliver Kepp, Guido Kroemer & Lucillia Bezu
Article: 2308940
Published online: 17 Mar 2024
AbstractforTrial watch: local anesthetics in cancer therapy | Full Text | References | PDF (874.1 KB) | EPUB
  • 619 Views
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Open Access

Original Research

Article
Intratumoral T-cell receptor repertoire composition predicts overall survival in patients with pancreatic ductal adenocarcinoma
Vikram S. Pothuri, Graham D. Hogg, Leah Conant, Nicholas Borcherding, C. Alston James, Jacqueline Mudd, Greg Williams, Yongwoo David Seo, William G. Hawkins, Venu G. Pillarisetty, David G. DeNardo & Ryan C. Fields
Article: 2320411
Published online: 15 Mar 2024
AbstractforIntratumoral T-cell receptor repertoire composition predicts overall survival in patients with pancreatic ductal adenocarcinoma | Full Text | References | PDF (8.4 MB) | EPUB | Supplemental
  • 1691 Views
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Open Access
Article
Humoral complementomics – exploration of noninvasive complement biomarkers as predictors of renal cancer progression
Margot Revel, Mikel Rezola Artero, Houcine Hamidi, Anne Grunenwald, Loris Blasco, Yann A. Vano, Stephane Marie Oudard, Rafael Sanchez-Salas, Petr Macek, Lara Rodriguez Sanchez, Xavier Cathelineau, Benoit Vedié, Catherine Sautes-Fridman, Wolf Herman Fridman, Lubka T. Roumenina & Marie-Agnes Dragon-Durey
Article: 2328433
Published online: 13 Mar 2024
AbstractforHumoral complementomics – exploration of noninvasive complement biomarkers as predictors of renal cancer progression | Full Text | References | PDF (6.5 MB) | EPUB | Supplemental
  • 947 Views
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Open Access

Author’s View

Reply
Transmembrane TNF-TNFR2 signaling as a critical immunoregulatory node in pancreatic cancer
Erin M. Dickey, Anna Bianchi, Haleh Amirian, Peter J. Hosein, Denise Faustman, Roberta Brambilla & Jashodeep Datta
Article: 2326694
Published online: 12 Mar 2024
AbstractforTransmembrane TNF-TNFR2 signaling as a critical immunoregulatory node in pancreatic cancer | Full Text | References | PDF (1.4 MB) | EPUB
  • 765 Views
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Open Access

News

News
Trial watch: dexmedetomidine in cancer therapy
Killian Carnet Le Provost, Oliver Kepp, Guido Kroemer & Lucillia Bezu
Article: 2327143
Published online: 11 Mar 2024
AbstractforTrial watch: dexmedetomidine in cancer therapy | Full Text | References | PDF (3.2 MB) | EPUB
  • 1328 Views
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Open Access

Original Research

Article
Prognostic impact of the bone marrow tumor microenvironment, HLA-I and HLA-Ib expression in MDS and CMML progression to sAML
Marcus Bauer, Nadja Jäkel, Andreas Wilfer, Anja Haak, Markus Eszlinger, Katalin Kelemen, Monika Haemmerle, Haifa Kathrin Al-Ali, Barbara Seliger & Claudia Wickenhauser
Article: 2323212
Published online: 06 Mar 2024
AbstractforPrognostic impact of the bone marrow tumor microenvironment, HLA-I and HLA-Ib expression in MDS and CMML progression to sAML | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 543 Views
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Open Access
Article
Are tumor-associated carbohydrates the missing link between the gut microbiome and response to immune checkpoint inhibitor treatment in cancer?
Zoltan Szallasi, Aurel Prosz, Zsofia Sztupinszki & Judit Moldvay
Article: 2324493
Published online: 04 Mar 2024
AbstractforAre tumor-associated carbohydrates the missing link between the gut microbiome and response to immune checkpoint inhibitor treatment in cancer? | Full Text | References | PDF (745.3 KB) | EPUB
  • 611 Views
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Open Access

Trial Watch

News
Trial watch: bispecific antibodies for the treatment of relapsed or refractory large B-cell lymphoma
Giulio Cassanello, Alejandro Luna de Abia & Lorenzo Falchi
Article: 2321648
Published online: 03 Mar 2024
AbstractforTrial watch: bispecific antibodies for the treatment of relapsed or refractory large B-cell lymphoma | Full Text | References | PDF (773.1 KB) | EPUB
  • 1995 Views
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Open Access

Original Research

Article
Expression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8+T cell function and its impact against pancreatic ductal adenocarcinoma
Wei Wei, Linqing Tian, Xiaoyan Zheng, Lei Zhong, Yuan Chen, Hui Dong, Guibing Zhang, Shibing Wang & Xiangmin Tong
Article: 2322173
Published online: 27 Feb 2024
AbstractforExpression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8+T cell function and its impact against pancreatic ductal adenocarcinoma | Full Text | References | PDF (7.5 MB) | EPUB | Supplemental
  • 921 Views
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Open Access
Article
Lactate/GPR81 recruits regulatory T cells by modulating CX3CL1 to promote immune resistance in a highly glycolytic gastric cancer
Jin Su, Xinyuan Mao, Lingzhi Wang, Zhian Chen, Weisheng Wang, Cuiyin Zhao, Guoxin Li, Weihong Guo & Yanfeng Hu
Article: 2320951
Published online: 26 Feb 2024
AbstractforLactate/GPR81 recruits regulatory T cells by modulating CX3CL1 to promote immune resistance in a highly glycolytic gastric cancer | Full Text | References | PDF (9.5 MB) | EPUB | Supplemental
  • 994 Views
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Open Access

Brief Report

Brief Report
Arginase-1 specific CD8+ T cells react toward malignant and regulatory myeloid cells
Hannah Jorinde Glöckner, Evelina Martinenaite, Thomas Landkildehus Lisle, Jacob Grauslund, Shamaila Ahmad, Özcan Met, Per Thor Straten & Mads Hald Andersen
Article: 2318053
Published online: 22 Feb 2024
AbstractforArginase-1 specific CD8+ T cells react toward malignant and regulatory myeloid cells | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
  • 795 Views
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Open Access

Special Report

Report
A bispecific anti-PD-1 and PD-L1 antibody induces PD-1 cleavage and provides enhanced anti-tumor activity
Diana I. Albu, Benjamin J. Wolf, Yan Qin, Xianzhe Wang, Amy Daniel Ulumben, Mei Su, Vivian Li, Eirene Ding, Jose Angel Gonzalo, Jason Kong, Ruturaj Jadhav, Nelly Kuklin, Alberto Visintin, Bing Gong & Thomas J. Schuetz
Article: 2316945
Published online: 16 Feb 2024
AbstractforA bispecific anti-PD-1 and PD-L1 antibody induces PD-1 cleavage and provides enhanced anti-tumor activity | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
  • 2043 Views
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Open Access

Original Research

Article
Noninvasive radiomic biomarkers for predicting pseudoprogression and hyperprogression in patients with non-small cell lung cancer treated with immune checkpoint inhibition
Yikun Li, Peiliang Wang, Junhao Xu, Xiaonan Shi, Tianwen Yin & Feifei Teng
Article: 2312628
Published online: 07 Feb 2024
AbstractforNoninvasive radiomic biomarkers for predicting pseudoprogression and hyperprogression in patients with non-small cell lung cancer treated with immune checkpoint inhibition | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
  • 887 Views
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Open Access

Brief Report

Brief Report
Immune checkpoint blockade improves the activation and function of circulating mucosal-associated invariant T (MAIT) cells in patients with non-small cell lung cancer
Patrik Sundström, Nikita Dutta, William Rodin, Andreas Hallqvist, Sukanya Raghavan & Marianne Quiding Järbrink
Article: 2312631
Published online: 06 Feb 2024
AbstractforImmune checkpoint blockade improves the activation and function of circulating mucosal-associated invariant T (MAIT) cells in patients with non-small cell lung cancer | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 818 Views
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Open Access

Original Research

Article
Platelet-derived microparticles adoptively transfer integrin β3 to promote antitumor effect of tumor-infiltrating T cells
Mimi Zhou, Yali Feng, Xiaoli Zhang, Jianguo Chen, Naijuan Yao, Shan Fu, Tianzhi Ni, Yi Chen, Fei Xie, Sahasrabda Roy, Jinfeng Liu, Yuan Yang, Yingli He, Yingren Zhao & Nan Yang
Article: 2304963
Published online: 16 Jan 2024
AbstractforPlatelet-derived microparticles adoptively transfer integrin β3 to promote antitumor effect of tumor-infiltrating T cells | Full Text | References | PDF (9.4 MB) | EPUB | Supplemental
  • 963 Views
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Open Access
Article
An oncogene regulating chromatin favors response to immunotherapy
Oncogene CHAF1A and immunotherapy outcomes
Leqian Ying, Zhangmin Hu, Yi Lu, Qing Tao, Fen Xiong, Yongqian Shu, Yufei Yang, Xuehan Qiao, Chen Peng, Yuchun Jiang, Miao Han, Min Xu, Xiaoqin Li & Deqiang Wang
Article: 2303195
Published online: 09 Jan 2024
AbstractforAn oncogene regulating chromatin favors response to immunotherapy | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 806 Views
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Open Access
Article
Targeting the activin receptor 1C on CD4+ T cells for cancer immunotherapy
Ying Zheng, Andriana Lebid, Liam Chung, Juan Fu, Xiaoxu Wang, Andrea Otrocol, Jelani C. Zarif, Hong Yu, Nicolas J. Llosa & Drew M. Pardoll
Article: 2297503
Published online: 08 Jan 2024
AbstractforTargeting the activin receptor 1C on CD4+ T cells for cancer immunotherapy | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 1598 Views
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Open Access
Article
Extracellular vesicles released by cancer-associated fibroblast-induced myeloid-derived suppressor cells inhibit T-cell function
Carlo P. Ramil, Handan Xiang, Peng Zhang, Aileen Cronin, Lisia Cabral, Zhizhang Yin, Josephine Hai, Huijun Wang, Benjamin Ruprecht, Yanlin Jia, Dongyu Sun, Hongmin Chen & An Chi
Article: 2300882
Published online: 05 Jan 2024
AbstractforExtracellular vesicles released by cancer-associated fibroblast-induced myeloid-derived suppressor cells inhibit T-cell function | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 1613 Views
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Open Access

Editorial

Editorial
Single-cell analysis of T lymphocytes infiltrating colorectal carcinoma: the dilemma of specificity
Manuela Lizarralde-Guerrero, Laura Zucaro, Guido Kroemer & Jonathan G. Pol
Article: 2300520
Published online: 04 Jan 2024
AbstractforSingle-cell analysis of T lymphocytes infiltrating colorectal carcinoma: the dilemma of specificity | Full Text | References | PDF (764.9 KB) | EPUB
  • 1126 Views
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Open Access

Original Research

Article
Interferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis
Jochen T. Frueh, Julia Campe, Daniele Yumi Sunaga-Franze, Nikita A. Verheyden, Sakhila Ghimire, Elisabeth Meedt, Denise Haslinger, Sabine Harenkamp, Daniel Staudenraus, Sascha Sauer, Andreas Kreft, Ralf Schubert, Michael Lohoff, Andreas Krueger, Halvard Bonig, Andreas G. Chiocchetti, Robert Zeiser, Ernst Holler & Evelyn Ullrich
Article: 2296712
Published online: 27 Dec 2023
AbstractforInterferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis | Full Text | References | PDF (13.4 MB) | EPUB | Supplemental
  • 973 Views
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Open Access
Article
Salmonella immunotherapy engineered with highly efficient tumor antigen coating establishes antigen-specific CD8+ T cell immunity and increases in antitumor efficacy with type I interferon combination therapy
Suyang Wang, Michelle Cheng, Chao-Cheng Chen, Chia-Yu Chang, Ya-Chea Tsai, Jr-Ming Yang, TC Wu, Chuan-Hsiang Huang & Chien-Fu Hung
Article: 2298444
Published online: 27 Dec 2023
AbstractforSalmonella immunotherapy engineered with highly efficient tumor antigen coating establishes antigen-specific CD8+ T cell immunity and increases in antitumor efficacy with type I interferon combination therapy | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 981 Views
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Open Access

Brief Report

Brief Report
The anti-inflammatory cytokine IL-37 improves the NK cell-mediated anti-tumor response
Nadine Landolina, Francesca Romana Mariotti, Andrea Pelosi, Valentina D’Oria, Tiziano Ingegnere, Claudia Alicata, Paola Vacca, Lorenzo Moretta & Enrico Maggi
Article: 2297504
Published online: 26 Dec 2023
AbstractforThe anti-inflammatory cytokine IL-37 improves the NK cell-mediated anti-tumor response | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 992 Views
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Open Access

Original Research

Article
Unbiased high-dimensional flow cytometry identified NK and DC immune cell signature in Luminal A-type and triple negative breast cancer
Lukas Heger, Gordon F. Heidkamp, Lukas Amon, Falk Nimmerjahn, Tobias Bäuerle, Andreas Maier, Ramona Erber, Arndt Hartmann, Carolin C. Hack, Matthias Ruebner, Hanna Huebner, Peter Fasching, Matthias W. Beckmann & Diana Dudziak
Article: 2296713
Published online: 22 Dec 2023
AbstractforUnbiased high-dimensional flow cytometry identified NK and DC immune cell signature in Luminal A-type and triple negative breast cancer | Full Text | References | PDF (8.3 MB) | EPUB | Supplemental
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Article
CD3-CD8 immune score associated with a clinical score stratifies PDAC prognosis regardless of adjuvant or neoadjuvant chemotherapy
Coralie Schoumacher, Valentin Derangère, Gwladys Gaudillière-Le Dain, Titouan Huppe, David Rageot, Alis Ilie, Angélique Vienot, Christophe Borg, Franck Monnien, Frederic Bibeau, Caroline Truntzer, François Ghiringhelli & For the CGE-Pancreas investigators
Article: 2294563
Published online: 21 Dec 2023
AbstractforCD3-CD8 immune score associated with a clinical score stratifies PDAC prognosis regardless of adjuvant or neoadjuvant chemotherapy | Full Text | References | PDF (3 MB) | EPUB | Supplemental
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Original research

Article
A phase 2, multicenter, open-label study of anti-LAG-3 ieramilimab in combination with anti-PD-1 spartalizumab in patients with advanced solid malignancies
Chia-Chi Lin, Elena Garralda, Patrick Schöffski, David S. Hong, Lillian L. Siu, Miguel Martin, Michela Maur, Rina Hui, Ross A Soo, Joanne Chiu, Tian Zhang, Brigette Ma, Chrisann Kyi, Daniel SW Tan, Philippe A. Cassier, John Sarantopoulos, Andrew Weickhardt, Richard D. Carvajal, Jennifer Spratlin, Taito Esaki, Fréderic Rolland, Wallace Akerley, Barbara Deschler-Baier, Lawrence Rispoli, Tanay S. Samant, Niladri Roy Chowdhury, Daniel Gusenleitner, Eunice L. Kwak, Vasileios Askoxylakis & Filippo De Braud
Article: 2290787
Published online: 20 Dec 2023
AbstractforA phase 2, multicenter, open-label study of anti-LAG-3 ieramilimab in combination with anti-PD-1 spartalizumab in patients with advanced solid malignancies | Full Text | References | PDF (1 MB) | EPUB | Supplemental
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Article
Clusterin protects mature dendritic cells from reactive oxygen species mediated cell death
Alvaro López Malizia, Antonela Merlotti, Pierre-Emmanuel Bonte, Melina Sager, Yago Arribas De Sandoval, Christel Goudot, Fernando Erra Díaz, Pehuén Pereyra-Gerber, Ana Ceballos, Sebastian Amigorena, Jorge Geffner & Juan Sabatte
Article: 2294564
Published online: 18 Dec 2023
AbstractforClusterin protects mature dendritic cells from reactive oxygen species mediated cell death | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
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Article
LFA-1 regulated by IL-2/STAT5 pathway boosts antitumor function of intratumoral CD8+ T cells for improving anti-PD-1 antibody therapy
Jiqi Shan, Wei Jing, Yu Ping, Chunyi Shen, Dong Han, Fengsen Liu, Yaqing Liu, Congcong Li & Yi Zhang
Article: 2293511
Published online: 14 Dec 2023
AbstractforLFA-1 regulated by IL-2/STAT5 pathway boosts antitumor function of intratumoral CD8+ T cells for improving anti-PD-1 antibody therapy | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
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Brief report

Brief Report
MHCII restriction demonstrates B cells have very limited capacity to activate tumour-specific CD4+ T cells in vivo
Thomas V. Guy, Alexandra M. Terry, Helen M. McGuire, Elena Shklovskaya & Barbara Fazekas de St Groth
Article: 2290799
Published online: 10 Dec 2023
AbstractforMHCII restriction demonstrates B cells have very limited capacity to activate tumour-specific CD4+ T cells in vivo | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Original research

Article
Cerebrospinal fluid immunological cytokines predict intracranial tumor response to immunotherapy in non-small cell lung cancer patients with brain metastases
Meichen Li, Jing Chen, Hui Yu, Baishen Zhang, Xue Hou, Honghua Jiang, Dan Xie & Likun Chen
Article: 2290790
Published online: 07 Dec 2023
AbstractforCerebrospinal fluid immunological cytokines predict intracranial tumor response to immunotherapy in non-small cell lung cancer patients with brain metastases | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
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Article
LTX-315 and adoptive cell therapy using tumor-infiltrating lymphocytes generate tumor specific T cells in patients with metastatic soft tissue sarcoma
Morten Nielsen, Tine Monberg, Vibeke Sundvold, Benedetta Albieri, Dorrit Hovgaard, Michael Mørk Petersen, Anders Krarup-Hansen, Özcan Met, Ketil Camilio, Trevor Clancy, Richard Stratford, Baldur Sveinbjornsson, Øystein Rekdal, Niels Junker & Inge Marie Svane
Article: 2290900
Published online: 07 Dec 2023
AbstractforLTX-315 and adoptive cell therapy using tumor-infiltrating lymphocytes generate tumor specific T cells in patients with metastatic soft tissue sarcoma | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Article
PD-L1-expressing natural killer cells predict favorable prognosis and response to PD-1/PD-L1 blockade in neuroblastoma
Mengjia Song, Yue Huang, Ye Hong, Juan Liu, Jia Zhu, Suying Lu, Juan Wang, Feifei Sun, Junting Huang, Jiaqian Xu, Yan Tang, Jian-Chuan Xia & Yizhuo Zhang
Article: 2289738
Published online: 01 Dec 2023
AbstractforPD-L1-expressing natural killer cells predict favorable prognosis and response to PD-1/PD-L1 blockade in neuroblastoma | Full Text | References | PDF (6.7 MB) | EPUB | Supplemental
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Article
Activation of endogenous glucocorticoids by HSD11B1 inhibits the antitumor immune response in renal cancer
Hélène Poinot, Eloïse Dupuychaffray, Grégoire Arnoux, Montserrat Alvarez, Jérémie Tachet, Ounss Ezzar, Jonathan Moore, Olivia Bejuy, Eulalia Olesti, Gioele Visconti, Víctor González-Ruiz, Serge Rudaz, Jean-Christophe Tille, Clarissa D. Voegel, Patrycja Nowak-Sliwinska, Carole Bourquin & Aurélien Pommier
Article: 2286820
Published online: 30 Nov 2023
AbstractforActivation of endogenous glucocorticoids by HSD11B1 inhibits the antitumor immune response in renal cancer | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
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