Upregulation of MUC8 and Downregulation of MUC5AC by Inflammatory Mediators in Human Nasal Polyps and Cultured Nasal Epithelium

Je-Kyung Seong From the 1Division of Laboratory Animal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 2Department of Thoracic :Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, 3Division of Molecular Life Science, Ewha Womans University, Seoul, South Korea and the 4Department of Otorhinolaryngolog y and 5BK 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea

Ja Seok Koo From the 1Division of Laboratory Animal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 2Department of Thoracic :Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, 3Division of Molecular Life Science, Ewha Womans University, Seoul, South Korea and the 4Department of Otorhinolaryngolog y and 5BK 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea

Won Jae Lee From the 1Division of Laboratory Animal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 2Department of Thoracic :Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, 3Division of Molecular Life Science, Ewha Womans University, Seoul, South Korea and the 4Department of Otorhinolaryngolog y and 5BK 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea

Hee-Nam Kim From the 1Division of Laboratory Animal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 2Department of Thoracic :Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, 3Division of Molecular Life Science, Ewha Womans University, Seoul, South Korea and the 4Department of Otorhinolaryngolog y and 5BK 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea

Ji-Young Park From the 1Division of Laboratory Animal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 2Department of Thoracic :Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, 3Division of Molecular Life Science, Ewha Womans University, Seoul, South Korea and the 4Department of Otorhinolaryngolog y and 5BK 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea

Kyoung Seob Song From the 1Division of Laboratory Animal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 2Department of Thoracic :Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, 3Division of Molecular Life Science, Ewha Womans University, Seoul, South Korea and the 4Department of Otorhinolaryngolog y and 5BK 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea

Ji Hun Hong From the 1Division of Laboratory Animal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 2Department of Thoracic :Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, 3Division of Molecular Life Science, Ewha Womans University, Seoul, South Korea and the 4Department of Otorhinolaryngolog y and 5BK 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea

Joo-Heon Yoon From the 1Division of Laboratory Animal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 2Department of Thoracic :Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, 3Division of Molecular Life Science, Ewha Womans University, Seoul, South Korea and the 4Department of Otorhinolaryngolog y and 5BK 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea

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Abstract

Polyps are believed to be the source of mucus hypersecretion in chronic inflammation of the sinus. However, it is not clear which mucins are responsible for the hypersecretion of mucus by nasal polyps. We describe the over-expression of MUC8 mRNA in nasal polyps and the upregulation of MUC8 mRNA expression and downregulation of MUC5AC mRNA expression by inflammatory mediators. We found that the level of MUC8 mRNA, but not the level of MUC5AC mRNA, increased in nasal polyps. We also found that there was an increase in intracellular mucin in nasal polyps, compared to the normal nasal inferior turbinate. A mixture of inflammatory mediators increased MUC8 mRNA expression and decreased MUC5AC mRNA expression in cultured normal human nasal epithelial cells. Among inflammatory mediators, IL-4 is responsible for the decrease in MUC5AC mRNA and MUC5AC mucin secretion. These results indicate that MUC8 may be one of the major mucins secreted from the polyp epithelium and that it may play an important role in the pathogenesis of mucus hypersecretion in chronic sinusitis with polyps.

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Upregulation of MUC8 and Downregulation of MUC5AC by Inflammatory Mediators in Human Nasal Polyps and Cultured Nasal Epithelium

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Upregulation of MUC8 and Downregulation of MUC5AC by Inflammatory Mediators in Human Nasal Polyps and Cultured Nasal Epithelium

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