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Acta Oto-Laryngologica Volume 122, 2002 - Issue 4
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Research Article

Upregulation of MUC8 and Downregulation of MUC5AC by Inflammatory Mediators in Human Nasal Polyps and Cultured Nasal Epithelium

Je-Kyung Seong From the 1Division of Laboratory Animal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 2Department of Thoracic :Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, 3Division of Molecular Life Science, Ewha Womans University, Seoul, South Korea and the 4Department of Otorhinolaryngolog y and 5BK 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea
,
Ja Seok Koo From the 1Division of Laboratory Animal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 2Department of Thoracic :Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, 3Division of Molecular Life Science, Ewha Womans University, Seoul, South Korea and the 4Department of Otorhinolaryngolog y and 5BK 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea
,
Won Jae Lee From the 1Division of Laboratory Animal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 2Department of Thoracic :Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, 3Division of Molecular Life Science, Ewha Womans University, Seoul, South Korea and the 4Department of Otorhinolaryngolog y and 5BK 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea
,
Hee-Nam Kim From the 1Division of Laboratory Animal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 2Department of Thoracic :Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, 3Division of Molecular Life Science, Ewha Womans University, Seoul, South Korea and the 4Department of Otorhinolaryngolog y and 5BK 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea
,
Ji-Young Park From the 1Division of Laboratory Animal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 2Department of Thoracic :Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, 3Division of Molecular Life Science, Ewha Womans University, Seoul, South Korea and the 4Department of Otorhinolaryngolog y and 5BK 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea
,
Kyoung Seob Song From the 1Division of Laboratory Animal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 2Department of Thoracic :Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, 3Division of Molecular Life Science, Ewha Womans University, Seoul, South Korea and the 4Department of Otorhinolaryngolog y and 5BK 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea
,
Ji Hun Hong From the 1Division of Laboratory Animal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 2Department of Thoracic :Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, 3Division of Molecular Life Science, Ewha Womans University, Seoul, South Korea and the 4Department of Otorhinolaryngolog y and 5BK 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea
&
Joo-Heon Yoon From the 1Division of Laboratory Animal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 2Department of Thoracic :Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, 3Division of Molecular Life Science, Ewha Womans University, Seoul, South Korea and the 4Department of Otorhinolaryngolog y and 5BK 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, South Korea
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Pages 401-407 | Published online: 08 Jul 2009

  • Groves RW, Allen MH, Ross EL, Barker JM, MacDonald DM. Tumor necrosis factor alpha is pro-inflammatory in normal human skin and modulates cutaneous adhesion molecule expressioa Br J Dermatol 1995 132: 345-52.
  • Hamilos DL, Leung DYM, Wood R, et al. Evidence of distinct cytokine expression in allergic versus nonallergjc chronic sinusitis. J Allergy Clin Immunol 1995; 96: 537-44.
  • Yoon JH, Kim KS, Kim HU, Linton JA, Lee JG. Effects of TNF-a and IL-1ß on mucin, lysozyme, IL-6 and IL-8 in passage-2 normal human nasal epithelial cells. Acta Otolaryngol (Stockh) 1999; 119: 905-10.
  • Yoon JH, Park IY. Mucin gene expression and mucin secretion in human airway epithelium. Rhinology 1998; 36: 146-52.
  • Lapensee L, Paquette Y, Bleau G. Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9). Fertil Steril 1997; 68: 702-8.
  • Williams SJ, McGucklin MA, Gotley DC, Eyre HJ, Sutherland GR, Antalis TM. Two novel mucin genes down-regulated in colorectal cancer identified by differential display. Cancer Res 1999; 59: 4083-9.
  • Willams SJ, Wreschner DH, Tran M, Eyre HJ, Sutherland GR, McGuckin MA. MUC13-a novel human cell surface mucin expressed by epithelial and hemopoietic cells. J Biol Chem 2001; 276: 18327-36.
  • Thornton DJ, Devine PL, Hanski C, Howard M, Sheehan JK. Identification of two major populations of mucins in respiratory secretions. Am J Respir Crit Care Med 1994; 150: 823-32.
  • Buisine MP, Devisme L, Copin MC, et al. Developmental mucin gene expression in the human respiratory tract. Am J Respir Cell Mol Biol 1999; 20: 209-18.
  • Sharma P, Dudus L, Nielsen PA, et al. MUC5B and MUC7 are differentially expressed in mucous and serous cells of submucosal glands in human bronchial airways. Am J Respir Cell Mo1 Biol 1998; 19: 30-7.
  • Reid CJ, Gould S, Harris A. Developmental expression of mucin genes in the human respiratory tract. Am J Respir Cell MoI Biol 1997; 17: 592-8.
  • Levine SJ, Larivee P, Logun C, Angus CW, Ognibene FP, Shelhamer JH. Tumor necrosis factor-alpha induces mucin hypersecretion and MUC-2 gene expression by human airway epithelial cells. Am J Respir Cell MoI Biol 1995; 12: 196-204.
  • Li JD, Feng W, Gallup M, et al. Activation of NFkappaB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells. Proc Natl Acad Sei USA 1998; 95: 5718-23.
  • Temann UA, Prasad B, Gallup MW, et al. A novel role of murine IL-4 in vivo: induction of MUC5AC gene expression and mucin hypersecretioa Am J Respir Cell MoI Biol 1997; 16: 471-8.
  • Lou YP, Takeyama K, Grattan KM, et al. Platelet-activating factor induces goblet cell hyperplasia and mucin gene expression in airways. Am J Respir Crit Care Med 1998; 157: 1927-34.
  • Longphre M, Li D, Gallup M, et al. Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells. J Clin Invest 1999; 104: 1375-82.
  • Yoon JH, Kim KS, Kirn SS, Lee JG, Park IY. Secretory differentiation of serially-passaged normal human nasal epithelial cells by retinoic acid: expression of mucin and lysozyme. Ann Otol Rhinol Laryngol 2000; 109: 594-601.
  • Yoon JH, Gray T, Guzman K, Koo JS, Nettesheim P. Regulation of the secretory phenotype of human airway epithelium by retinoic acid, triiodothyronine, andextracellular matrix. Am J Respir Cell MoI Biol 1997; 16: 724-31.
  • Kirn SS, Kirn KS, Lee JG, Park IY, Koo JS, Yoon JH. Levels of intracellular protein and mRNA of mucin and lysozyme in normal human nasal and polyp epithelium. Laryngoscope 2000; 110: 276-80.
  • Dabbagh K, Takeyama K, Lee HM, Ueki IF, Lausier JA, Nadel JA. IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J Immunol 1999; 162: 6233-7.
  • Voynow JA, Young LR, Wang Y, Borger T, Rose MC, Fischer BM. Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. Am J Physiol 1999; 276: L835-43.
  • Jayawickreme SP, Gray T, Nettesheim P, Eling T. Regulation of 15-lipoxygenase expression and mucus secretion by IL-4 in human bronchial epithelial cells. Am J Physiol 1999; 276: L596-603.
  • Kirn CH, Song KS, Kirn HU, Seong JK, Yoon JH. Expression of MUC5AC mRNA in the goblet cells of human nasal mucosa. Laryngoscope 2000; 110: 21103.
  • Borchers MT, Wert SE, Leikauf GD. Acrolein-induced MUC5AC expression in rat airway. Am J Physiol 1998; 274: L573-81.
  • Li D, Gallup M, Fan N, Szymkowski DE, Basbaum C. Cloning of the amino-terminal and 5-flanking region of the human MUCSAC mucin gene and transcriptional upregulation by bacterial exoproducts. J Biol Chem 1998; 273: 6812-20.

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