A quantitative structure-activity relationship study on matrix metalloproteinase inhibitors: Piperidine sulfonamide aryl hydroxamic acid analogs

Abstract

A quantitative structure-activity relationship (QSAR) study has been made on a series of piperidine sulfonamide aryl hydroxamic acid analogs acting as matrix metalloproteinase (MMP) inhibitors. The inhibitory potencies of the compounds against two MMPs, MMP-2 and MMP-13, are found to be significantly correlated with the hydrophobic properties of the molecules, suggesting that in both enzymes the hydrophobic interaction is playing a dominant role.

Keywords::

• Quantitative structure-activity relationship (QSAR)
• matrix metalloproteinase (MMP)
• inhibitors
• piperidine sulfonamide aryl hydroxamic acids

Acknowledgements

One of the authors, S. Kumaran, is thankful to CSIR, New Delhi, for providing him with an SRF.