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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 23, 2008 - Issue 1
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Research Article

Lipoxygenase inhibiting and antioxidant iridoids from Buddleja crispa

IJAZ AHMAD
,
SHILIN CHEN Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100094, China
,
YONG PENG Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100094, China
,
SIBAO CHEN State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen, 518057, China
&
LIJIA XU Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100094, China
Pages 140-143 | Received 30 Nov 2006, Accepted 24 Jan 2007, Published online: 04 Oct 2008
 
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Abstract

Phytochemical investigations on the ethyl acetate-soluble fraction of the whole plant of Buddleja crispa led to the isolation of the iridoids 1–7. Compound 2 displayed significant inhibitory potential against enzyme lipoxygenase in a concentration-dependant fashion with IC50 value of 39.7 ± 0.02μM, along with DPPH radical scavenging activity with IC50 value 0.638 mM.

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