Synthesis, characterization and biological aspects of novel five-coordinated dimeric-Cu(II) systems

Abstract

The structural and spectroscopic properties of novel five-coordinated dimeric-Cu(II) system have been investigated. The biocidal activities of all eight compounds, ligands, cupric nitrate and standard drugs against six bacteria and three fungi were determined. The DNA interaction activity of complexes was studied using spectrophotometry and electrophoresis. The superoxide dismutase (SOD)-like activity of the complexes was compared with previously reported monomeric- and dimeric copper complexes. The results support the five-coordinated dimeric square pyramidal geometry for the quinolone-Cu(II) system.

Keywords::

• Dimeric-Cu(II) system
• fluoroquinolone
• DNA binding
• SOD activity
• biocidal activity

Acknowledgements

We thank the Prof. J. S. Parmar, Head, Department of Chemistry, and Prof. D. Madammvar, Head, Department of Biosciences, for providing the laboratory facilities. The authors wish to acknowledge the help of Dr. V. Thakkar and Mr. Pinakin Dhandhukia of the Department of Biochemistry of Sardar Patel University.