Synthesis, spectral analysis, antibacterial and antifungal activities of some 4,6-diaryl-4,5-dihydro-3-hydroxy-2[H]-indazole—a novel fused indazole derivative

Abstract

A novel class of 4,6-diaryl-4,5-dihydro-3-hydroxy-2[H]-indazoles 25-32 were synthesized and evaluated for their in vitro antibacterial and antifungal activities. Four Compounds, which all possessed electron withdrawing functional groups (–Cl, –NO₂, –Br) 27, 28, 30 and 32 were more potent against the tested bacterial/fungal strains than the standard bacterial and fungal drugs ciprofloxacin and fluconazole respectively.

Keywords::

• 6-Carbethoxy-3,5-diarylcyclohex-2-enone
• 4,6-diaryl-4,5-dihydro-3-hydroxy-2[H]-indazole
• hydrazine hydrate
• antibacterial activity
• antifungal activity