Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 23, Issue 6 (2008)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 23, Issue 6 (2008)

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Research Article

Article
Oleanolic acid and related derivatives as medicinally important compounds
Nighat Sultana & Athar Ata
Pages: 739-756
Published online: 20 Oct 2008
AbstractforOleanolic acid and related derivatives as medicinally important compounds | Full Text | References | PDF (679.8 KB)
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Article
QSAR studies on peptide α-ketoamides and α-ketohydroxamate derivatives as calpain I inhibitors
Jesse S. Dondapati, Sudhakar Godi & Ajay P. Babu
Pages: 757-762
Published online: 20 Oct 2008
AbstractforQSAR studies on peptide α-ketoamides and α-ketohydroxamate derivatives as calpain I inhibitors | Full Text | References | PDF (125.6 KB)
  • 420 Views
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Article
QSAR of aromatic substances: EGFR inhibitory activity of quinazoline analogues
Omar Deeb & Brian W. Clare
Pages: 763-775
Published online: 20 Oct 2008
AbstractforQSAR of aromatic substances: EGFR inhibitory activity of quinazoline analogues | Full Text | References | PDF (174.8 KB)
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Article
A comparison of the therapeutic and reactivating efficacy of newly developed bispyridinium compounds (K206, K269) with currently available oximes against tabun in rats and mice
Jiri Kassa, Jana Karasova, Jiri Bajgar, Kamil Kuca & Kamil Musilek
Pages: 776-780
Published online: 20 Oct 2008
AbstractforA comparison of the therapeutic and reactivating efficacy of newly developed bispyridinium compounds (K206, K269) with currently available oximes against tabun in rats and mice | Full Text | References | PDF (91.4 KB)
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Article
Photometric microplate assay for estimation of the efficacy of paraoxon-inhibited acetylcholinesterase reactivation
Miroslav Pohanka, Daniel Jun & Kamil Kuca
Pages: 781-784
Published online: 20 Oct 2008
AbstractforPhotometric microplate assay for estimation of the efficacy of paraoxon-inhibited acetylcholinesterase reactivation | Full Text | References | PDF (180.6 KB)
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Article
Copper (II) and zinc (ii) metal-based salicyl-, furanyl-, thienyl- and pyrrolyl-derived ONNO, NNNO, ONNS & NNNS donor asymmetrically mixed schiff-bases with antibacterial and antifungal potentials
Zahid H. Chohan, M. Arif & A. Rashid
Pages: 785-796
Published online: 20 Oct 2008
AbstractforCopper (II) and zinc (ii) metal-based salicyl-, furanyl-, thienyl- and pyrrolyl-derived ONNO, NNNO, ONNS & NNNS donor asymmetrically mixed schiff-bases with antibacterial and antifungal potentials | Full Text | References | PDF (180.3 KB)
  • 631 Views
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Article
Synthesis, physico-chemical characterization and antimicrobial activity of cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes with some acyldihydrazones
Vinod P. Singh & Parul Gupta
Pages: 797-805
Published online: 20 Oct 2008
AbstractforSynthesis, physico-chemical characterization and antimicrobial activity of cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes with some acyldihydrazones | Full Text | References | PDF (144.3 KB)
  • 670 Views
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Article
In vitro antileukemia, antibacterial and antifungal activities of some 3d metal complexes: Chemical synthesis and structure – activity relationships
Aurelian Gulea, Donald Poirier, Jenny Roy, Vitalie Stavila, Ion Bulimestru, Victor Tapcov, Maria Birca & Lilia Popovschi
Pages: 806-818
Published online: 20 Oct 2008
AbstractforIn vitro antileukemia, antibacterial and antifungal activities of some 3d metal complexes: Chemical synthesis and structure – activity relationships | Full Text | References | PDF (226.8 KB)
  • 1232 Views
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Article
Design, synthesis and pharmacological evaluation of novel tetrasubstituted thiophene analogues as anti-inflammatory agents
Khurshid I. Molvi, Vasudevan Sudarsanam, Madhubhai M. Patel & Navedul Haque
Pages: 819-828
Published online: 20 Oct 2008
AbstractforDesign, synthesis and pharmacological evaluation of novel tetrasubstituted thiophene analogues as anti-inflammatory agents | Full Text | References | PDF (207.7 KB)
  • 714 Views
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Article
Synthesis, anti-inflammatory, analgesic and antioxidant activities of some tetrasubstituted thiophenes
Khurshid I. Molvi, Mustakim Mansuri, Vasudevan Sudarsanam, Madhubhai M. Patel, Syed Muzaffar A. Andrabi & Navedul Haque
Pages: 829-838
Published online: 20 Oct 2008
AbstractforSynthesis, anti-inflammatory, analgesic and antioxidant activities of some tetrasubstituted thiophenes | Full Text | References | PDF (142.7 KB)
  • 1024 Views
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Article
Design and synthesis of 3-(4-Ethylphenyl)-2-substituted amino-3H-quinazolin-4-ones as a novel class of analgesic and anti-inflammatory agents
V. Alagarsamy, V. Raja Solomon, M. Murugan, K. Dhanabal, P. Parthiban & G.V. Anjana
Pages: 839-847
Published online: 20 Oct 2008
AbstractforDesign and synthesis of 3-(4-Ethylphenyl)-2-substituted amino-3H-quinazolin-4-ones as a novel class of analgesic and anti-inflammatory agents | Full Text | References | PDF (150.8 KB)
  • 629 Views
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Article
In vitro cytotoxic, antibacterial, antifungal and urease inhibitory activities of some N4- substituted isatin-3-thiosemicarbazones
Humayun Pervez, Mohammad S. Iqbal, Muhammad Younas Tahir, Faiz-ul-Hassan Nasim, Muhammad Iqbal Choudhary & Khalid Mohammed Khan
Pages: 848-854
Published online: 20 Oct 2008
AbstractforIn vitro cytotoxic, antibacterial, antifungal and urease inhibitory activities of some N4- substituted isatin-3-thiosemicarbazones | Full Text | References | PDF (119.1 KB)
  • 1653 Views
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Article
Antimicrobial activities of Gloriosa superba Linn (Colchicaceae) extracts
Haroon Khan, Murad Ali Khan, Tahira Mahmood & Muhammad Iqbal Choudhary
Pages: 855-859
Published online: 20 Oct 2008
AbstractforAntimicrobial activities of Gloriosa superba Linn (Colchicaceae) extracts | Full Text | References | PDF (129.5 KB)
  • 2783 Views
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Article
Antimicrobial Activities of 3-Amino- and Polyaminosterol Analogues of Squalamine and Trodusquemine
Chanaz Salmi, Celine Loncle, Nicolas Vidal, Michèle Laget, Yves Letourneux & Jean Michel Brunel
Pages: 860-865
Published online: 20 Oct 2008
AbstractforAntimicrobial Activities of 3-Amino- and Polyaminosterol Analogues of Squalamine and Trodusquemine | Full Text | References | PDF (134.9 KB)
  • 1252 Views
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Article
Synthesis and anticandidal activity of some imidazopyridine derivatives
Zafer Asim Kaplancikli, Gülhan Turan-Zitouni, Ahmet Özdemr & Gilbert Revial
Pages: 866-870
Published online: 20 Oct 2008
AbstractforSynthesis and anticandidal activity of some imidazopyridine derivatives | Full Text | References | PDF (82.6 KB)
  • 878 Views
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Article
Measurement of antioxidant ability of melatonin and serotonin by the DMPD and CUPRAC methods as trolox equivalent
Ilhami Gülçin
Pages: 871-876
Published online: 20 Oct 2008
AbstractforMeasurement of antioxidant ability of melatonin and serotonin by the DMPD and CUPRAC methods as trolox equivalent | Full Text | References | PDF (146 KB)
  • 2640 Views
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Article
Lipoxygenase inhibition by novel fatty acid ester from Annona squamosa seeds
Nighat Sultana
Pages: 877-881
Published online: 20 Oct 2008
AbstractforLipoxygenase inhibition by novel fatty acid ester from Annona squamosa seeds | Full Text | References | PDF (145.2 KB)
  • 521 Views
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Article
Synthesis and characterization of biologically significant 5,5′-(1,4-phenylene)bis(1-N-alkoxyphthalimido-3-aryl-2-pyrazoline) derivatives
Jawahar Lal Jat, Swati Ojha, Dinesh Bhambi, Neelam Dhakar & G. L. Talesara
Pages: 882-887
Published online: 20 Oct 2008
AbstractforSynthesis and characterization of biologically significant 5,5′-(1,4-phenylene)bis(1-N-alkoxyphthalimido-3-aryl-2-pyrazoline) derivatives | Full Text | References | PDF (132.5 KB)
  • 584 Views
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Article
Benzo(a)pyrene-induced genotoxicity: Attenuation by farnesol in a mouse model
Tamanna Jahangir & Sarwat Sultana
Pages: 888-894
Published online: 20 Oct 2008
AbstractforBenzo(a)pyrene-induced genotoxicity: Attenuation by farnesol in a mouse model | Full Text | References | PDF (346.9 KB)
  • 618 Views
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Article
Amide derivatives with pyrazole carboxylic acids of 5-amino-1,3,4-thiadiazole 2-sulfonamide as new carbonic anhydrase inhibitors: Synthesis and investigation of inhibitory effects
Metiˇn Bülbül, Rahmiˇ Kasimoğullari & Ö. Iˇrfan Küfreviˇoğlu
Pages: 895-900
Published online: 20 Oct 2008
AbstractforAmide derivatives with pyrazole carboxylic acids of 5-amino-1,3,4-thiadiazole 2-sulfonamide as new carbonic anhydrase inhibitors: Synthesis and investigation of inhibitory effects | Full Text | References | PDF (157 KB)
  • 1251 Views
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Article
Chlorpromazine oligomer is a potentially active substance that inhibits human D-amino acid oxidase, product of a susceptibility gene for schizophrenia
Sanae Iwana, Tomoya Kawazoe, Hwan KI. Park, Koichiro Tsuchiya, Koji Ono, Kazuko Yorita, Takashi Sakai, Takenori Kusumi & Kiyoshi Fukui
Pages: 901-911
Published online: 20 Oct 2008
AbstractforChlorpromazine oligomer is a potentially active substance that inhibits human D-amino acid oxidase, product of a susceptibility gene for schizophrenia | Full Text | References | PDF (188.2 KB)
  • 806 Views
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Article
Comparative study of the inhibitory effect of antidepressants on cholinesterase activity in Bungarus sindanus (krait) venom, human serum and rat striatum
Mushtaq Ahmed, João Batista T. Rocha, Cinthia M. Mazzanti, Waseem Hassan, Vera M. Morsch, Vânia Lúcia Loro, Gustavo Thomé & Maria R.C. Schetinger
Pages: 912-917
Published online: 20 Oct 2008
AbstractforComparative study of the inhibitory effect of antidepressants on cholinesterase activity in Bungarus sindanus (krait) venom, human serum and rat striatum | Full Text | References | PDF (399.2 KB)
  • 1293 Views
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Article
Urease and Serine Protease inhibitory alkaloids from Isatis tinctoria
Ijaz Ahmad, Itrat Fatima, Nighat Afza, Abdul Malik, Muhammad Arif Lodhi & Muhammad Iqbal Choudhary
Pages: 918-921
Published online: 20 Oct 2008
AbstractforUrease and Serine Protease inhibitory alkaloids from Isatis tinctoria | Full Text | References | PDF (95.8 KB)
  • 861 Views
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Article
Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz
Y. B. Ryu, T. J. Ha, M. J. Curtis-Long, H. W. Ryu, S. W. Gal & K. H. Park
Pages: 922-930
Published online: 20 Oct 2008
AbstractforInhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz | Full Text | References | PDF (262 KB)
  • 1452 Views
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Article
A high density assay format for the detection of novel cytotoxic agents in large chemical libraries
David Shum, Constantin Radu, Earl Kim, Muriel Cajuste, Yufang Shao, Venkatraman E. Seshan & Hakim Djaballah
Pages: 931-945
Published online: 20 Oct 2008
AbstractforA high density assay format for the detection of novel cytotoxic agents in large chemical libraries | Full Text | References | PDF (1.3 MB)
  • 1292 Views
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Article
Design and synthesis of 3-pyrrol-3-yl-3H-isobenzofuran-1-ones as inhibitors of human cytosolic phospholipase A2α
Mark Hess, Alwine Schulze Elfringhoff & Matthias Lehr
Pages: 946-957
Published online: 20 Oct 2008
AbstractforDesign and synthesis of 3-pyrrol-3-yl-3H-isobenzofuran-1-ones as inhibitors of human cytosolic phospholipase A2α | Full Text | References | PDF (216.1 KB)
  • 500 Views
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Article
Enzyme kinetic and molecular modelling studies of sulphur-containing substrates of phenylalanine 4-monooxygenase
N. G. Patel, C. Iliadou, B. Boonyapiwat, D. J. Barlow, B. Forbes, S. C. Mitchell & G. B. Steventon
Pages: 958-963
Published online: 20 Oct 2008
AbstractforEnzyme kinetic and molecular modelling studies of sulphur-containing substrates of phenylalanine 4-monooxygenase | Full Text | References | PDF (204.1 KB)
  • 409 Views
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Article
Structure-activity relationships for a class of selective inhibitors of the major cysteine protease from Trypanosoma cruzi
Rafael V. C. Guido, Gustavo H. G. Trossini, Marcelo S. Castilho, Glaucius Oliva, Elizabeth I. Ferreira & Adriano D. Andricopulo
Pages: 964-973
Published online: 20 Oct 2008
AbstractforStructure-activity relationships for a class of selective inhibitors of the major cysteine protease from Trypanosoma cruzi | Full Text | References | PDF (313.7 KB)
  • 703 Views
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Article
Synthesis, spectral analysis, antibacterial and antifungal activities of some 4,6-diaryl-4,5-dihydro-3-hydroxy-2[H]-indazole—a novel fused indazole derivative
M. Gopalakrishnan, P. Sureshkumar, J. Thanusu & V. Kanagarajan
Pages: 974-979
Published online: 20 Oct 2008
AbstractforSynthesis, spectral analysis, antibacterial and antifungal activities of some 4,6-diaryl-4,5-dihydro-3-hydroxy-2[H]-indazole—a novel fused indazole derivative | Full Text | References | PDF (115.8 KB)
  • 542 Views
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Article
Development of linear and nonlinear predictive QSAR models and their external validation using molecular similarity principle for anti-HIV indolyl aryl sulfones
Kunal Roy & Asim Sattwa Mandal
Pages: 980-995
Published online: 20 Oct 2008
AbstractforDevelopment of linear and nonlinear predictive QSAR models and their external validation using molecular similarity principle for anti-HIV indolyl aryl sulfones | Full Text | References | PDF (196.2 KB)
  • 2598 Views
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Article
Synthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Aβ-peptide production inhibitors
Y. Laras, N. Pietrancosta, T. Tomita, T. Iwatsubo & J. L. Kraus
Pages: 996-1001
Published online: 20 Oct 2008
AbstractforSynthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Aβ-peptide production inhibitors | Full Text | References | PDF (119.6 KB)
  • 660 Views
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Article
The influence of Al3+ ion on porcine pepsin activity in vitro
Vesna M. Pavelkic, Kristina R. Gopcevic, Danijela Z. Krstic & Marija A. Ilic
Pages: 1002-1010
Published online: 20 Oct 2008
AbstractforThe influence of Al3+ ion on porcine pepsin activity in vitro | Full Text | References | PDF (158.4 KB)
  • 735 Views
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Article
Evaluation of anti-inflammatory and antioxidant activities of Copper (II) Schiff mono-base and Copper(II) Schiff base coordination compounds of dien with heterocyclic aldehydes and 2-amino-5-methyl-thiazole
E. Pontiki, D. Hadjipavlou-Litina & A. T. Chaviara
Pages: 1011-1017
Published online: 20 Oct 2008
AbstractforEvaluation of anti-inflammatory and antioxidant activities of Copper (II) Schiff mono-base and Copper(II) Schiff base coordination compounds of dien with heterocyclic aldehydes and 2-amino-5-methyl-thiazole | Full Text | References | PDF (156.4 KB)
  • 1937 Views
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Short Communication

Article
Norditerpenoid alkaloids from the roots of Aconitum heterophyllum Wall with antibacterial activity
Manzoor Ahmad, Waqar Ahmad, Mansoor Ahmad, Muhammad Zeeshan, Obaidullah & Farzana Shaheen
Pages: 1018-1022
Published online: 20 Oct 2008
AbstractforNorditerpenoid alkaloids from the roots of Aconitum heterophyllum Wall with antibacterial activity | Full Text | References | PDF (162 KB)
  • 1578 Views
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Article
New antibacterial pentacyclic triterpenes from Myricaria elegans Royle. (tamariscineae)
Manzoor Ahmad, Waqar Ahmad, Salimullah Khan, Muhammad Zeeshan, Obaidullah, Muhammad Nisar, Farzana Shaheen & Mansoor Ahmad
Pages: 1023-1027
Published online: 20 Oct 2008
AbstractforNew antibacterial pentacyclic triterpenes from Myricaria elegans Royle. (tamariscineae) | Full Text | References | PDF (150 KB)
  • 637 Views
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Research Article

Article
Erratum
Page: 1028
Published online: 02 Dec 2008
CitationforErratum | Full Text | PDF (78.2 KB)
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