Design, synthesis and evaluation of new 6-substituted-5-benzyloxy-4-oxo-4H-pyran-2-carboxamides as potential Src inhibitors

Abstract

Src family kinases (SFKs) are nonreceptor tyrosine kinases that are reported to be critical for cancer progression. Inhibiting the catalytic activity of these proteins has become one of the major therapeutic concepts in contemporary drug discovery. We report here the design and the synthesis of novel 6-substituted-5-benzyloxy-4-oxo-4H-pyran-2-carboxamides as potential inhibitors of Src kinase. The synthesis of these derivatives and the preliminary results of biological activity will be discussed.

• Src
• cancer
• drug design
• pyran-4-one
• amide bond formation

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Acknowledgements

We wish to thank Les Laboratoires Servier for their financial support and biological evalutations.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.