Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 23, Issue 5 (2008)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 23, Issue 5 (2008)

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Research Article

Article
Proceedings of the 16th annual conference of the Groupement des Pharmacochimistes de l'Arc Atlantique (GP2A)
Jean Guillon, Guillaume Le Baut & Marc Le Borgne
Page: 587
Published online: 20 Oct 2008
CitationforProceedings of the 16th annual conference of the Groupement des Pharmacochimistes de l'Arc Atlantique (GP2A) | Full Text | PDF (28.6 KB)
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Article
A solid phase parallel synthesis of diverse amides as dopamine D3 receptor ligands
Mickaël Jean, Jacques Renault, Jean-Claude Camelin, Nicolas Levoin, Denis Danvy, Holger Stark, Marc Capet & Philippe Uriac
Pages: 588-592
Published online: 20 Oct 2008
AbstractforA solid phase parallel synthesis of diverse amides as dopamine D3 receptor ligands | Full Text | References | PDF (176.2 KB)
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Article
3D Pharmacophore, hierarchical methods, and 5-HT4 receptor binding data
Thibault Varin, Nicolas Saettel, Jonathan Villain, Aurelien Lesnard, François Dauphin, Ronan Bureau & Sylvain Rault
Pages: 593-603
Published online: 20 Oct 2008
Abstractfor3D Pharmacophore, hierarchical methods, and 5-HT4 receptor binding data | Full Text | References | PDF (401.5 KB)
  • 473 Views
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Article
Synthesis and preliminary evaluation of new ursolic and oleanolic acids derivatives as antileishmanial agents
Simone C. B. Gnoatto, Luciana Dalla Vechia, Claiton L. Lencina, Alexandra Dassonville-Klimpt, Sophie Da Nascimento, Djavad Mossalayi, Jean Guillon, Grace Gosmann & Pascal Sonnet
Pages: 604-610
Published online: 20 Oct 2008
AbstractforSynthesis and preliminary evaluation of new ursolic and oleanolic acids derivatives as antileishmanial agents | Full Text | References | PDF (121.4 KB)
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Article
Molecular modelling of phthalates – PPARs interactions
Nicolas Kambia, Nicolas Renault, Sebastien Dilly, Amaury Farce, Thierry Dine, Bernard Gressier, Michel Luyckx, Claude Brunet & Philippe Chavatte
Pages: 611-616
Published online: 20 Oct 2008
AbstractforMolecular modelling of phthalates – PPARs interactions | Full Text | References | PDF (409.8 KB)
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Article
Synthesis of new 1-[2-Azido-2-(2,4-dichlorophenyl)ethyl]-1H/-imidazoles and in vitro evaluation of their antifungal activity
Francis Chevreuil, Anne Landreau, Denis Seraphin, Gérald Larcher, Jean-Philippe Bouchara & Pascal Richomme
Pages: 617-622
Published online: 20 Oct 2008
AbstractforSynthesis of new 1-[2-Azido-2-(2,4-dichlorophenyl)ethyl]-1H/-imidazoles and in vitro evaluation of their antifungal activity | Full Text | References | PDF (130.3 KB)
  • 497 Views
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Article
PAMAM dendrimers for the delivery of the antibacterial Triclosan
Jonathan Gardiner, Sally Freeman, Matthew Leach, Alison Green, Jacqui Alcock & Antony D'Emanuele
Pages: 623-628
Published online: 20 Oct 2008
AbstractforPAMAM dendrimers for the delivery of the antibacterial Triclosan | Full Text | References | PDF (177.1 KB)
  • 950 Views
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Article
Design, synthesis and evaluation of new 6-substituted-5-benzyloxy-4-oxo-4H-pyran-2-carboxamides as potential Src inhibitors
Julien Farard, Gaëtan Lanceart, Cedric Logé, Marie-Renée Nourrisson, Francisco Cruzalegui, Bruno Pfeiffer & Muriel Duflos
Pages: 629-640
Published online: 20 Oct 2008
AbstractforDesign, synthesis and evaluation of new 6-substituted-5-benzyloxy-4-oxo-4H-pyran-2-carboxamides as potential Src inhibitors | Full Text | References | PDF (275.3 KB)
  • 843 Views
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Article
Synthesis and antitumour evaluation of novel 2-phenylbenzimidazoles
Hachemi Kadri, Charles S. Matthews, Tracey D. Bradshaw, Malcolm F. G. Stevens & Andrew D. Westwell
Pages: 641-647
Published online: 20 Oct 2008
AbstractforSynthesis and antitumour evaluation of novel 2-phenylbenzimidazoles | Full Text | References | PDF (160.8 KB)
  • 1220 Views
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Article
Synthesis of New Pyrrolo[1,2-a]quinoxaline Derivatives as Potential Inhibitors of Akt Kinase
Vanessa Desplat, Ambre Geneste, Marc-Antoine Begorre, Solene Belisle Fabre, Stephane Brajot, Stephane Massip, Denis Thiolat, Djavad Mossalayi, Christian Jarry & Jean Guillon
Pages: 648-658
Published online: 20 Oct 2008
AbstractforSynthesis of New Pyrrolo[1,2-a]quinoxaline Derivatives as Potential Inhibitors of Akt Kinase | Full Text | References | PDF (204.9 KB)
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Article
Synthesis and immunosuppressive activity evaluation of substituted N-imidazolidin-2-ones and N-tetrahydropyrimidin-2(1H)-ones
Caroline Sabourin & Jean-Michel Robert
Pages: 659-667
Published online: 20 Oct 2008
AbstractforSynthesis and immunosuppressive activity evaluation of substituted N-imidazolidin-2-ones and N-tetrahydropyrimidin-2(1H)-ones | Full Text | References | PDF (174 KB)
  • 511 Views
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Article
β-Lactam type molecular scaffolds for antiproliferative activity: Synthesis and cytotoxic effects in breast cancer cells
Mary J. Meegan, Miriam Carr, Andrew J. S. Knox, Daniela M. Zisterer & David G. Lloyd
Pages: 668-685
Published online: 20 Oct 2008
Abstractforβ-Lactam type molecular scaffolds for antiproliferative activity: Synthesis and cytotoxic effects in breast cancer cells | Full Text | References | PDF (356.4 KB)
  • 719 Views
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Article
Side chain modifications of (indol-3-yl)glyoxamides as antitumor agents
Maud Antoine, Pascal Marchand, Guillaume Le Baut, Michael Czech, Silke Baasner & Eckhard Gunther
Pages: 686-695
Published online: 20 Oct 2008
AbstractforSide chain modifications of (indol-3-yl)glyoxamides as antitumor agents | Full Text | References | PDF (223 KB)
  • 1041 Views
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Article
Synthesis and biological evaluation of new Donepezil-like Thiaindanones as AChE inhibitors
Ziad Omran, Silvia Stiebing, Anne-Marie Godard, Jana Sopkova-De Oliveira-Santos & Patrick Dallemagne
Pages: 696-703
Published online: 20 Oct 2008
AbstractforSynthesis and biological evaluation of new Donepezil-like Thiaindanones as AChE inhibitors | Full Text | References | PDF (157.7 KB)
  • 402 Views
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Article
Cytotoxic evaluation of sarcodifurines A and B, two novel dihydrofuroquinolines from Sarcomelicope follicularis (Rutaceae)
Elizabeth Chosson, Christiane Guguen-Guillouzo, Denise Glaise, Laurent Picot, Elisabeth Seguin & Thierry Besson
Pages: 704-707
Published online: 20 Oct 2008
AbstractforCytotoxic evaluation of sarcodifurines A and B, two novel dihydrofuroquinolines from Sarcomelicope follicularis (Rutaceae) | Full Text | References | PDF (111 KB)
  • 389 Views
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Article
Development of new antileishmanial drugs – current knowledge and future prospects
Patrice Le Pape
Pages: 708-718
Published online: 20 Oct 2008
AbstractforDevelopment of new antileishmanial drugs – current knowledge and future prospects | Full Text | References | PDF (361.3 KB)
  • 1606 Views
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Article
Indole carboxamides inhibit bovine testes hyaluronidase at pH 7.0 and indole acetamides activate the enzyme at pH 3.5 by different mechanisms
Andre Kaessler, Marie-Renee Nourrisson, Muriel Duflos & Joachim Jose
Pages: 719-727
Published online: 20 Oct 2008
AbstractforIndole carboxamides inhibit bovine testes hyaluronidase at pH 7.0 and indole acetamides activate the enzyme at pH 3.5 by different mechanisms | Full Text | References | PDF (188.3 KB)
  • 893 Views
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Article
N-Pyridinyl(methyl)-indole-1- or 3-propanamides and propenamides acting as topical and systemic inflammation inhibitors
Alexandra Dassonville, Morgane Lardic, Anne Breteche, Marie Renee Nourrisson, Guillaume Le Baut, Nicole Grimaud, Jean-Yves Petit & Muriel Duflos
Pages: 728-738
Published online: 20 Oct 2008
AbstractforN-Pyridinyl(methyl)-indole-1- or 3-propanamides and propenamides acting as topical and systemic inflammation inhibitors | Full Text | References | PDF (204.2 KB)
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