N-Pyridinyl(methyl)-indole-1- or 3-propanamides and propenamides acting as topical and systemic inflammation inhibitors

Abstract

In this study, the synthetic way to new N-pyridinyl(methyl)indolylpropanamides acting as non acidic NSAIDs has been described. Pharmacomodulation was carried out at N¹ and C⁵ of the indole ring and at the level of the propanamide chain. N³-pyridinylmethyl-[1(4-chlorobenzyl-5-chloroindol-3-yl)propanamide represents one of the most potent compounds in the TPA-induced mouse ear swelling assay, with a level of activity higher than that of ibuprofen and comparable to that of dexamethasone.

• N-pyridinyl and N-pyridinylmethyl-indole-1-or-3-propanamides and propenamides
• topical and systemic inflammation inhibitors

Acknowledgements

The authors deeply appreciate the helpful technical assistance of Catherine Chauvet for the pharmacological assays.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.