Screening and evaluation of antioxidant activity of some amido-carbonyl oxime derivatives and their radical scavenging activities

Abstract

The antioxidant activity of some amido-carbonyl oximes containing a C=O and –NH–R adjacent to the oxime group, [Phenyl-C(=O)-C(=N-OH)-N(-H)-Phenyl(-R)] where R= H, 4-chloro, 4-methyl, 4-methoxy, 3,4-dichloro, 3,4-dimethyl, 3-chloro-4-dimethyl, 3-chloro-4-methoxy, naphthyl and an amido-carbonyl dioxime were investigated in vitro by ferric thiocyanate, total reducing power by potassium ferricyanide reduction, 1,1-diphenyl-2- picryl-hydrazyl (DPPH^·) free radical scavenging, ferrous ions chelating, superoxide anion radical scavenging and hydrogen peroxide scavenging activity assays. The results indicated that the amido-carbonyl oximes have powerful antioxidant capacity.

Keywords::

• oxime
• amido-carbonyl oxime
• antioxidant activity
• radical scavenging activity

Acknowledgements

The authors are thankful to their graduates, Salih Çalık, Gül Dilaver and Ebru Gül Kutlu for their contributions.

Decleration of interest: The authors reports no conflicts of interest.