Application of the Mannich reaction in the structural modification of natural products

Abstract

The Mannich reaction is commonly used to introduce N atoms into compound molecules and is thus widely applied in drug synthesis. The Mannich reaction accounts for a certain proportion of structural modifications of natural products. The introduction of Mannich bases can significantly improve the activity, hydrophilicity, and medicinal properties of compounds; therefore, the Mannich reaction is widely used for the structural modification of natural products. In this paper, the application of the Mannich reaction to the structural modification of natural products is reviewed, providing a method for the structural modification of natural products.

Keywords:

• Natural products
• Mannich reaction
• biological activity

Acknowledgement

We would like to thank Editage (www.editage.cn) for English language editing.

Disclosure statement

The authors report no conflicts of interest.

Additional information

Funding

This work was financially supported by the Higher Education Discipline Innovation Project [D18012], National Natural Science Foundation of China [No. 81960626, 82060628, 82204310], Key Projects of Jilin Province Science and Technology Development Plan [No. 20200404130YY], Jilin Scientific and Technological Development Program [No. YDZJ202301ZYTS440, YDZJ202301ZYTS143], Education Department Project of Jilin [JJKH20220559KJ, JJKH20220563KJ].