ABSTRACT
Redox medicine improvement could come from integrating insights from both the mitochondria and redox fields. One-step further is finding new clues with a comprehensive discussion of the two fields, and their relationship, including through the reactive species interactome (RSI). Here, the review provides a platform for future studies focusing on both mitochondria and the RSI. Mitochondria are discussed at length with focus on the mitochondrial permeability transition pore, the regulation of cell death types, the protein quality control system, calcium homoeostasis, ionome, metabolome, mitochondrial carriers, and organelle interaction. Then, the RSI is discussed focusing on its relationship with mitochondria. Finally, the mitochondria-RSI axis is proposed as a brand-new perspective, including with the involvement of the circadian clock and bacterial microbiota, as the first stone of the concept of MitoRedox Medicine.
Acknowledgments
The author acknowledges the use of Servier Medical Art image bank. The figures were partly generated using Servier Medical Art, licensed under a Creative Commons Attribution 3.0 unported license.
Disclosure statement
No potential conflict of interest was reported by the author.