Mitochondria and the reactive species interactome: shaping the future of mitoredox medicine

References

• Adav SS, Wang Y. 2021. Metabolomics signatures of aging: recent advances. Aging Dis. 12:646–38. doi: 10.14336/AD.2020.0909.
   PubMed Web of Science ®Google Scholar
• Aghagolzadeh P, Radpour R, Bachtler M, van Goor H, Smith ER, Lister A, Odermatt A, Feelisch M, Pasch A. 2017. Hydrogen sulfide attenuates calcification of vascular smooth muscle cells via KEAP1/NRF2/NQO1 activation. Atherosclerosis. 265:78–86. doi: 10.1016/j.atherosclerosis.2017.08.012.
   PubMed Web of Science ®Google Scholar
• Ahmed R, Nakahata Y, Shinohara K, Bessho Y. 2021. Cellular senescence triggers altered circadian clocks with a prolonged period and delayed phases. Front Neurosci. 15:638122. doi: 10.3389/fnins.2021.638122.
   PubMed Web of Science ®Google Scholar
• Ait-El-Mkadem S, Dayem-Quere M, Gusic M, Chaussenot A, Bannwarth S, François B, Genin EC, Fragaki K, Volker-Touw CLM, Vasnier C, et al. 2017. Mutations in MDH2, encoding a Krebs cycle enzyme, cause early-onset severe encephalopathy. Am J Hum Genet. 100:151–159. doi: 10.1016/j.ajhg.2016.11.014.
   PubMed Web of Science ®Google Scholar
• Al Amir Dache Z, Otandault A, Tanos R, Pastor B, Meddeb R, Sanchez C, Arena G, Lasorsa L, Bennett A, Grange T, et al. 2020. Blood contains circulating cell‐free respiratory competent mitochondria. FASEB J. 34:3616–3630. doi: 10.1096/fj.201901917RR.
   PubMed Web of Science ®Google Scholar
• Alam MM, Kishino A, Sung E, Sekine H, Abe T, Murakami S, Akaike T, Motohashi H. 2023. Contribution of NRF2 to sulfur metabolism and mitochondrial activity. Redox Biol. 60:102624. doi: 10.1016/j.redox.2023.102624.
   PubMed Web of Science ®Google Scholar
• Alevriadou BR, Patel A, Noble M, Ghosh S, Gohil VM, Stathopulos PB, Madesh M. 2021. Molecular nature and physiological role of the mitochondrial calcium uniporter channel. Am J Physiol Cell Physiol. 320:C465–C482. doi: 10.1152/ajpcell.00502.2020.
   PubMed Web of Science ®Google Scholar
• Alexandre J, Batteux F, Nicco C, Chéreau C, Laurent A, Guillevin L, Weill B, Goldwasser F. 2006. Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo. Int J Cancer. 119:41–48. doi: 10.1002/ijc.21685.
   PubMed Web of Science ®Google Scholar
• Alexeev EE, Dowdell AS, Henen MA, Lanis JM, Lee JS, Cartwright IM, Schaefer REM, Ornelas A, Onyiah JC, Vögeli B, et al. 2021. Microbial-derived indoles inhibit neutrophil myeloperoxidase to diminish bystander tissue damage. FASEB J Publ Fed Am Soc Exp Biol. 35:e21552. doi: 10.1096/fj.202100027R.
   PubMed Web of Science ®Google Scholar
• Alkan HF, Bogner-Strauss JG. 2019. Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells. Mol Cell Oncol. 6:e1536843. doi: 10.1080/23723556.2018.1536843.
   PubMed Web of Science ®Google Scholar
• Altman BJ, Hsieh AL, Sengupta A, Krishnanaiah SY, Stine ZE, Walton ZE, Gouw AM, Venkataraman A, Li B, Goraksha-Hicks P, et al. 2015. MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. Cell Metab. 22:1009–1019. doi: 10.1016/j.cmet.2015.09.003.
   PubMed Web of Science ®Google Scholar
• Altomare A, Baron G, Gianazza E, Banfi C, Carini M, Aldini G. 2021. Lipid peroxidation derived reactive carbonyl species in free and conjugated forms as an index of lipid peroxidation: limits and perspectives. Redox Biol. 101899. doi: 10.1016/j.redox.2021.101899.
   PubMed Web of Science ®Google Scholar
• Alupei MC, Maity P, Esser PR, Krikki I, Tuorto F, Parlato R, Penzo M, Schelling A, Laugel V, Montanaro L, et al. 2018. Loss of proteostasis is a pathomechanism in Cockayne syndrome. Cell Rep. 23:1612–1619. doi: 10.1016/j.celrep.2018.04.041.
   PubMed Web of Science ®Google Scholar
• Anea CB, Zhang M, Chen F, Ali MI, Hart CMM, Stepp DW, Kovalenkov YO, Merloiu A-M, Pati P, Fulton D, et al. 2013. Circadian clock control of Nox4 and reactive oxygen species in the vasculature. PLoS One. 8:e78626. doi: 10.1371/journal.pone.0078626.
   PubMed Web of Science ®Google Scholar
• Angelova PR, Vinogradova D, Neganova ME, Serkova TP, Sokolov VV, Bachurin SO, Shevtsova EF, Abramov AY. 2019. Pharmacological sequestration of mitochondrial calcium uptake protects neurons against glutamate excitotoxicity. Mol Neurobiol. 56:2244–2255. doi: 10.1007/s12035-018-1204-8.
   PubMed Web of Science ®Google Scholar
• Anzovino A, Lane DJR, Huang ML-H, Richardson DR. 2014. Fixing frataxin: ‘ironing out’ the metabolic defect in Friedreich’s ataxia. Br J Pharmacol. 171:2174–2190. doi: 10.1111/bph.12470.
   PubMed Web of Science ®Google Scholar
• Arena G, Cissé MY, Pyrdziak S, Chatre L, Riscal R, Fuentes M, Arnold JJ, Kastner M, Gayte L, Bertrand-Gaday C, et al. 2018. mitochondrial MDM2 regulates respiratory complex I activity independently of p53. Mol Cell. 69:594–609.e8. doi: 10.1016/j.molcel.2018.01.023.
   PubMed Web of Science ®Google Scholar
• Ast J, Stiebler AC, Freitag J, Bölker M. 2013. Dual targeting of peroxisomal proteins. Front Physiol. 4:297. doi: 10.3389/fphys.2013.00297.
   PubMed Web of Science ®Google Scholar
• Bai L, Yan F, Deng R, Gu R, Zhang X, Bai J. 2021. Thioredoxin-1 rescues MPP+/MPTP-induced ferroptosis by increasing glutathione peroxidase 4. Mol Neurobiol. 58:3187–3197. doi: 10.1007/s12035-021-02320-1.
   PubMed Web of Science ®Google Scholar
• Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, et al. 2019. Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab. 29:399–416.e10. doi: 10.1016/j.cmet.2018.10.014.
   PubMed Web of Science ®Google Scholar
• Baker ZN, Cobine PA, Leary SC. 2017. The mitochondrion: a central architect of copper homeostasis. Met Integr Biometal Sci. 9:1501–1512. doi: 10.1039/c7mt00221a.
   PubMed Web of Science ®Google Scholar
• Ballard JWO, Towarnicki SG. 2020. mitochondria, the gut microbiome and ROS. Cell Signal. 75:109737. doi: 10.1016/j.cellsig.2020.109737.
   PubMed Web of Science ®Google Scholar
• Bano D, Prehn JHM. 2018. Apoptosis-inducing factor (AIF) in physiology and disease: The tale of a repented natural born killer. EBioMedicine. 30:29–37. doi: 10.1016/j.ebiom.2018.03.016.
   PubMed Web of Science ®Google Scholar
• Barbier S, Chatre L, Bras M, Sancho P, Roué G, Virely C, Yuste VJ, Baudet S, Rubio M, Esquerda JE, et al. 2009. Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton. Haematologica. 94:507–517. doi: 10.3324/haematol.13690.
   PubMed Web of Science ®Google Scholar
• Baritaud M, Cabon L, Delavallée L, Galán-Malo P, Gilles M-E, Brunelle-Navas M-N, Susin SA. 2012. AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation. Cell Death Disease. 3:e390–e390. doi: 10.1038/cddis.2012.120.
   PubMed Web of Science ®Google Scholar
• Barshop BA. 2004. Metabolomic approaches to mitochondrial disease: correlation of urine organic acids. Mitochondrion. 4:521–527. doi: 10.1016/j.mito.2004.07.010.
   PubMed Web of Science ®Google Scholar
• Bartesaghi S, Radi R. 2018. Fundamentals on the biochemistry of peroxynitrite and protein tyrosine nitration. Redox Biol. 14:618–625. doi: 10.1016/j.redox.2017.09.009.
   PubMed Web of Science ®Google Scholar
• Bauer TM, Murphy E. 2020. Role of mitochondrial calcium and the permeability transition pore in regulating cell death. Circ Res. 126:280–293. doi: 10.1161/CIRCRESAHA.119.316306.
   PubMed Web of Science ®Google Scholar
• Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L, Goldberger O, Bogorad RL, et al. 2011. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature. 476:341–345. doi: 10.1038/nature10234.
   PubMed Web of Science ®Google Scholar
• Bender T, Martinou J-C. 2016. The mitochondrial pyruvate carrier in health and disease: To carry or not to carry? Biochim Biophys Acta BBA - Mol Cell Res. 1863:2436–2442. doi: 10.1016/j.bbamcr.2016.01.017.
   PubMed Web of Science ®Google Scholar
• Benkler C, O’Neil AL, Slepian S, Qian F, Weinreb PH, Rubin LL. 2018. Aggregated SOD1 causes selective death of cultured human motor neurons. Sci Rep. 8:16393. doi: 10.1038/s41598-018-34759-z.
   PubMed Web of Science ®Google Scholar
• Bernardi P, Gerle C, Halestrap AP, Jonas EA, Karch J, Mnatsakanyan N, Pavlov E, Sheu S-S, Soukas AA. 2023. Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions. Cell Death Differ. 30:1869–1885. doi: 10.1038/s41418-023-01187-0.
   PubMed Web of Science ®Google Scholar
• Bernardi P, Rasola A, Forte M, Lippe G. 2015. The mitochondrial permeability transition pore: channel formation by F-ATP synthase, integration in signal transduction, and role in pathophysiology. Physiol Rev. 95:1111–1155. doi: 10.1152/physrev.00001.2015.
   PubMed Web of Science ®Google Scholar
• Blachier F, Beaumont M, Kim E. 2019. Cysteine-derived hydrogen sulfide and gut health: a matter of endogenous or bacterial origin. Curr Opin Clin Nutr Metab Care. 22:68–75. doi: 10.1097/MCO.0000000000000526.
   PubMed Web of Science ®Google Scholar
• Bock FJ, Tait SWG. 2020. mitochondria as multifaceted regulators of cell death. Nat Rev Mol Cell Biol. 21:85–100. doi: 10.1038/s41580-019-0173-8.
   PubMed Web of Science ®Google Scholar
• Bohovych I, Chan SSL, Khalimonchuk O. 2015. Mitochondrial protein quality control: The mechanisms guarding mitochondrial health. Antioxid Redox Signal. 22:977–994. doi: 10.1089/ars.2014.6199.
   PubMed Web of Science ®Google Scholar
• Borchard S, Bork F, Rieder T, Eberhagen C, Popper B, Lichtmannegger J, Schmitt S, Adamski J, Klingenspor M, Weiss K, et al. 2018. The exceptional sensitivity of brain mitochondria to copper. Toxicol In Vitro. 51:11–22. doi: 10.1016/j.tiv.2018.04.012.
   PubMed Web of Science ®Google Scholar
• Bortolotti M, Polito L, Battelli MG, Bolognesi A. 2021. Xanthine oxidoreductase: one enzyme for multiple physiological tasks. Redox Biol. 41:101882. doi: 10.1016/j.redox.2021.101882.
   PubMed Web of Science ®Google Scholar
• Boujrad H, Gubkina O, Robert N, Krantic S, Susin SA. 2007. AIF-mediated programmed necrosis: a highly regulated way to die. Cell Cycle Georget Tex. 6:2612–2619. doi: 10.4161/cc.6.21.4842.
   PubMed Web of Science ®Google Scholar
• Bourgonje AR, Feelisch M, Faber KN, Pasch A, Dijkstra G, van Goor H. 2020. Oxidative stress and redox-modulating therapeutics in inflammatory bowel disease. Trends Mol Med. 26:1034–1046. S147149142030157X. doi: 10.1016/j.molmed.2020.06.006.
   PubMed Web of Science ®Google Scholar
• Brand MD. 2010. The sites and topology of mitochondrial superoxide production. Exp Gerontol. 45:466–472. doi: 10.1016/j.exger.2010.01.003.
   PubMed Web of Science ®Google Scholar
• Brentnall M, Rodriguez-Menocal L, De Guevara RL, Cepero E, Boise LH. 2013. Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis. BMC Cell Biol. 14:32. doi: 10.1186/1471-2121-14-32.
   PubMed Web of Science ®Google Scholar
• Broeks MH, Meijer NW, Westland D, Bosma M, Gerrits J, German HM, Ciapaite J, van Karnebeek CD, Wanders RJ, Zwartkruis FJ, et al. 2023. The malate-aspartate shuttle is important for de novo serine biosynthesis. Cell Rep. 42. doi: 10.1016/j.celrep.2023.113043.
   Web of Science ®Google Scholar
• Brown JA, Sammy MJ, Ballinger SW. 2020. An evolutionary, or “Mitocentric” perspective on cellular function and disease. Redox Biol. 36:101568. doi: 10.1016/j.redox.2020.101568.
   PubMed Web of Science ®Google Scholar
• Bruni F. 2021. Mitochondria: from physiology to pathology. Life. 11:991. doi: 10.3390/life11090991.
   PubMedGoogle Scholar
• Burner U, Furtmüller PG, Kettle AJ, Koppenol WH, Obinger C. 2000. Mechanism of reaction of myeloperoxidase with nitrite. J Biol Chem. 275:20597–20601. doi: 10.1074/jbc.M000181200.
   PubMed Web of Science ®Google Scholar
• Caito SW, Aschner M. 2015. Mitochondrial redox dysfunction and environmental exposures. Antioxid Redox Signal. 23:578–595. doi: 10.1089/ars.2015.6289.
   PubMed Web of Science ®Google Scholar
• Camara AKS, Zhou Y, Wen P-C, Tajkhorshid E, Kwok W-M. 2017. Mitochondrial VDAC1: a key gatekeeper as potential therapeutic target. Front Physiol. 8. doi: 10.3389/fphys.2017.00460.
   Web of Science ®Google Scholar
• Candé C, Cecconi F, Dessen P, Kroemer G. 2002. Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death? J Cell Sci. 115:4727–4734. doi: 10.1242/jcs.00210.
   PubMed Web of Science ®Google Scholar
• Cao X, Ding L, Xie Z, Yang Y, Whiteman M, Moore PK, Bian J-S. 2019. A review of hydrogen sulfide synthesis, metabolism, and measurement: is modulation of hydrogen sulfide a novel therapeutic for cancer? Antioxid Redox Signal. 31:1–38. doi: 10.1089/ars.2017.7058.
   PubMed Web of Science ®Google Scholar
• Cao SS, Kaufman RJ. 2014. Endoplasmic reticulum stress and oxidative stress in cell Fate decision and human disease. Antioxid Redox Signal. 21:396–413. doi: 10.1089/ars.2014.5851.
   PubMed Web of Science ®Google Scholar
• Carlström M, Moretti CH, Weitzberg E, Lundberg JO. 2020. Microbiota, diet and the generation of reactive nitrogen compounds. Free Radic Biol Med. 161:321–325. doi: 10.1016/j.freeradbiomed.2020.10.025.
   PubMed Web of Science ®Google Scholar
• Carraro M, Bernardi P. 2023. The mitochondrial permeability transition pore in Ca2+ homeostasis. Cell Calcium. 111:102719. doi: 10.1016/j.ceca.2023.102719.
   PubMed Web of Science ®Google Scholar
• Carvalho C, Cardoso S. 2021. Diabetes–Alzheimer’s disease link: targeting mitochondrial dysfunction and redox imbalance. Antioxid Redox Signal. 34:631–649. doi: 10.1089/ars.2020.8056.
   PubMed Web of Science ®Google Scholar
• Casey JR, Grinstein S, Orlowski J. 2010. Sensors and regulators of intracellular pH. Nat Rev Mol Cell Biol. 11:50–61. doi: 10.1038/nrm2820.
   PubMed Web of Science ®Google Scholar
• Castiglione N, Rinaldo S, Giardina G, Stelitano V, Cutruzzolà F. 2012. Nitrite and nitrite reductases: from molecular mechanisms to dignificance in human health and disease. Antioxid Redox Signal. 17:684–716. doi: 10.1089/ars.2011.4196.
   PubMed Web of Science ®Google Scholar
• Caterino M, Ruoppolo M, Mandola A, Costanzo M, Orrù S, Imperlini E. 2017. Protein–protein interaction networks as a new perspective to evaluate distinct functional roles of voltage-dependent anion channel isoforms. Mol Biosyst. 13:2466–2476. doi: 10.1039/C7MB00434F.
   PubMedGoogle Scholar
• Chatre L, Biard DSF, Sarasin A, Ricchetti M. 2015. Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne Syndrome. Proc Natl Acad Sci. 112:E2910–E2919. doi: 10.1073/pnas.1422264112.
   PubMed Web of Science ®Google Scholar
• Chatre L, Ducat A, Spradley FT, Palei AC, Chéreau C, Couderc B, Thomas KC, Wilson AR, Amaral LM, Gaillard I, et al. 2022. Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences. Redox Biol. 55:102406. doi: 10.1016/j.redox.2022.102406.
   PubMed Web of Science ®Google Scholar
• Chatre L, Ricchetti M. 2011. Nuclear mitochondrial DNA activates replication in Saccharomyces cerevisiae. PLoS One. 6:e17235. doi: 10.1371/journal.pone.0017235.
   PubMed Web of Science ®Google Scholar
• Chatre L, Ricchetti M. 2013. Prevalent coordination of mitochondrial DNA transcription and initiation of replication with the cell cycle. Nucleic Acids Res. 41:3068–3078. doi: 10.1093/nar/gkt015.
   PubMed Web of Science ®Google Scholar
• Cheema JY, He J, Wei W, Fu C. 2021. The Endoplasmic Reticulum-mitochondria encounter structure and its regulatory proteins. Contact. 4:251525642110644. doi: 10.1177/25152564211064491.
   Google Scholar
• Chen Y, Azad MB, Gibson SB. 2009. Superoxide is the major reactive oxygen species regulating autophagy. Cell Death Differ. 16:1040–1052. doi: 10.1038/cdd.2009.49.
   PubMed Web of Science ®Google Scholar
• Chen S, Chen L, Qi Y, Xu J, Ge Q, Fan Y, Chen D, Zhang Y, Wang L, Hou T, et al. 2021. Bifidobacterium adolescentis regulates catalase activity and host metabolism and improves healthspan and lifespan in multiple species. Nat Aging. 1:991–1001. doi: 10.1038/s43587-021-00129-0.
   PubMedGoogle Scholar
• Chevrollier A, Loiseau D, Reynier P, Stepien G. 2011. Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism. Biochim Biophys Acta BBA - Bioenerg. 1807:562–567. doi: 10.1016/j.bbabio.2010.10.008.
   PubMed Web of Science ®Google Scholar
• Choi ME, Price DR, Ryter SW, Choi AMK. 2019. Necroptosis: a crucial pathogenic mediator of human disease. JCI Insight. 4:e128834. doi: 10.1172/jci.insight.128834.
   PubMed Web of Science ®Google Scholar
• Chornyi S, IJlst L, van Roermund CWT, Wanders RJA, Waterham HR. 2021. Peroxisomal metabolite and cofactor transport in humans. Front Cell Dev Biol. 8. doi: 10.3389/fcell.2020.613892.
   PubMed Web of Science ®Google Scholar
• Chrétien D, Bénit P, Ha H-H, Keipert S, El-Khoury R, Chang Y-T, Jastroch M, Jacobs HT, Rustin P, Rak M. 2018. Mitochondria are physiologically maintained at close to 50 °C. PLoS Biol. 16:e2003992. doi: 10.1371/journal.pbio.2003992.
   PubMed Web of Science ®Google Scholar
• Cighetti G, Bortone L, Sala S, Allevi P. 2001. Mechanisms of action of malondialdehyde and 4-hydroxynonenal on xanthine oxidoreductase. Arch Biochem Biophys. 389:195–200. doi: 10.1006/abbi.2001.2328.
   PubMed Web of Science ®Google Scholar
• Clark A, Mach N. 2017. The Crosstalk between the gut microbiota and mitochondria during exercise. Front Physiol. 8. doi: 10.3389/fphys.2017.00319.
   Web of Science ®Google Scholar
• Colepicolo P, Camarero VC, Hastings JW. 1992. A circadian rhythm in the activity of superoxide dismutase in the photosynthetic alga gonyaulax polyedra. Chronobiol Int. 9:266–268. doi: 10.3109/07420529209064536.
   PubMed Web of Science ®Google Scholar
• Cortese-Krott MM, Koning A, Kuhnle GGC, Nagy P, Bianco CL, Pasch A, Wink DA, Fukuto JM, Jackson AA, van Goor H, et al. 2017. The reactive species interactome: evolutionary emergence, biological significance, and opportunities for redox metabolomics and personalized medicine. In: Mary AL, editor. Antioxid Redox Signal. p. 684–712. doi: 10.1089/ars.2017.7083.
   PubMed Web of Science ®Google Scholar
• Cortese-Krott MM, Santolini J, Wootton SA, Jackson AA, Feelisch M. 2020. The reactive species interactome. In: Oxidative stress. Elsevier; p. 51–64. doi: 10.1016/B978-0-12-818606-0.00004-3.
   Google Scholar
• Crochemore C, Fernández-Molina C, Montagne B, Salles A, Ricchetti M. 2019. CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence. Nat Commun. 10:5576. doi: 10.1038/s41467-019-13314-y.
   PubMed Web of Science ®Google Scholar
• Cryan JF, O’Riordan KJ, Sandhu K, Peterson V, Dinan TG. 2020. The gut microbiome in neurological disorders. Lancet Neurol. 19:79–194. doi: 10.1016/S1474-4422(19)30356-4.
   Web of Science ®Google Scholar
• Cui L, Gouw AM, LaGory EL, Guo S, Attarwala N, Tang Y, Qi J, Chen Y-S, Gao Z, Casey KM, et al. 2021. Mitochondrial copper depletion suppresses triple-negative breast cancer in mice. Nat Biotechnol. 39:357–367. doi: 10.1038/s41587-020-0707-9.
   PubMed Web of Science ®Google Scholar
• Cumpstey AF, Clark AD, Santolini J, Jackson AA, Feelisch M. 2021. COVID-19: a redox disease-what a stress pandemic can teach us about resilience and what we may learn from the reactive species interactome about its treatment. Antioxid Redox Signal. 35:1226–1268. doi: 10.1089/ars.2021.0017.
   PubMed Web of Science ®Google Scholar
• Cunningham CN, Rutter J. 2020. Picometers under the OMM: diving into the vastness of mitochondrial metabolite transport. EMBO Rep. 21:e50071. doi: 10.15252/embr.202050071.
   PubMed Web of Science ®Google Scholar
• Cvetko F, Caldwell ST, Higgins M, Suzuki T, Yamamoto M, Prag HA, Hartley RC, Dinkova-Kostova AT, Murphy MP. 2021. Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production. J Biol Chem. 296:100169. doi: 10.1074/jbc.RA120.016551.
   PubMed Web of Science ®Google Scholar
• Cӑtoi AF, Corina A, Katsiki N, Vodnar DC, Andreicuț AD, Stoian AP, Rizzo M, Pérez-Martínez P. 2020. Gut microbiota and aging-A focus on centenarians. Biochim Biophys Acta BBA - Mol Basis Dis. 1866:165765. doi: 10.1016/j.bbadis.2020.165765.
   PubMed Web of Science ®Google Scholar
• D’Acunzo P, Pérez-González R, Kim Y, Hargash T, Miller C, Alldred MJ, Erdjument-Bromage H, Penikalapati SC, Pawlik M, Saito M, et al. 2021. Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome. Sci Adv. 7:eabe5085. doi: 10.1126/sciadv.abe5085.
   PubMed Web of Science ®Google Scholar
• de Araujo TH, Okada SS, Ghosn EEB, Taniwaki NN, Rodrigues MR, de Almeida SR, Mortara RA, Russo M, Campa A, Albuquerque RC. 2013. Intracellular localization of myeloperoxidase in murine peritoneal B-lymphocytes and macrophages. Cell Immunol. 281:27–30. doi: 10.1016/j.cellimm.2013.01.002.
   PubMed Web of Science ®Google Scholar
• de Bari L, Scirè A, Minnelli C, Cianfruglia L, Kalapos MP, Armeni T. 2020. Interplay among oxidative stress, methylglyoxal pathway and S-Glutathionylation. Antioxidants. 10:19. doi: 10.3390/antiox10010019.
   Web of Science ®Google Scholar
• Deng F, Zhao B-C, Yang X, Lin Z-B, Sun Q-S, Wang Y-F, Yan Z-Z, Liu W-F, Li C, Hu J-J, et al. 2021. The gut microbiota metabolite capsiate promotes Gpx4 expression by activating TRPV1 to inhibit intestinal ischemia reperfusion-induced ferroptosis. Gut Microbes. 13:1–21. doi: 10.1080/19490976.2021.1902719.
   Web of Science ®Google Scholar
• Deng W, Zhu S, Zeng L, Liu J, Kang R, Yang M, Cao L, Wang H, Billiar TR, Jiang J, et al. 2018. The circadian clock controls immune checkpoint pathway in sepsis. Cell Rep. 24:366–378. doi: 10.1016/j.celrep.2018.06.026.
   PubMed Web of Science ®Google Scholar
• Deragon MA, McCaig WD, Patel PS, Haluska RJ, Hodges AL, Sosunov SA, Murphy MP, Ten VS, LaRocca TJ. 2020. Mitochondrial ROS prime the hyperglycemic shift from apoptosis to necroptosis. Cell Death Discov. 6:132. doi: 10.1038/s41420-020-00370-3.
   PubMed Web of Science ®Google Scholar
• De Stefani D, Raffaello A, Teardo E, Szabò I, Rizzuto R. 2011. A 40 kDa protein of the inner membrane is the mitochondrial calcium uniporter. Nature. 476:336–340. doi: 10.1038/nature10230.
   PubMed Web of Science ®Google Scholar
• Deus CM, Yambire KF, Oliveira PJ, Raimundo N. 2020. Mitochondria–lysosome crosstalk: from physiology to neurodegeneration. Trends Mol Med. 26:71–88. doi: 10.1016/j.molmed.2019.10.009.
   PubMed Web of Science ®Google Scholar
• Di Domenico F, Tramutola A, Butterfield DA. 2017. Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of Alzheimer disease and other selected age-related neurodegenerative disorders. Free Radic Biol Med. 111:253–261. doi: 10.1016/j.freeradbiomed.2016.10.490.
   PubMed Web of Science ®Google Scholar
• Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, et al. 2012. Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell. 149:1060–1072. doi: 10.1016/j.cell.2012.03.042.
   PubMed Web of Science ®Google Scholar
• Doridot L, Châtre L, Ducat A, Vilotte J-L, Lombès A, Méhats C, Barbaux S, Calicchio R, Ricchetti M, Vaiman D. 2014. Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia-associated gene. Antioxid Redox Signal. 21:819–834. doi: 10.1089/ars.2013.5661.
   PubMed Web of Science ®Google Scholar
• Doruk YU, Yarparvar D, Akyel YK, Gul S, Taskin AC, Yilmaz F, Baris I, Ozturk N, Türkay M, Ozturk N, et al. 2020. A clock-binding small molecule disrupts the interaction between clock and bmal1 and enhances circadian rhythm amplitude. J Biol Chem. 295:3518–3531. doi: 10.1074/jbc.RA119.011332.
   PubMed Web of Science ®Google Scholar
• Douma LG, Gumz ML. 2018. Circadian clock-mediated regulation of blood pressure. Free Radic Biol Med. 119:108–114. doi: 10.1016/j.freeradbiomed.2017.11.024.
   PubMed Web of Science ®Google Scholar
• Dubey AK, Godbole A, Mathew MK. 2016. Regulation of VDAC trafficking modulates cell death. Cell Death Discov. 2:1–10. doi: 10.1038/cddiscovery.2016.85.
   Web of Science ®Google Scholar
• Dumitrescu L, Popescu-Olaru I, Cozma L, Tulbă D, Hinescu ME, Ceafalan LC, Gherghiceanu M, Popescu BO. 2018. Oxidative Stress and the microbiota-gut-brain axis. Oxid Med Cell Longev. 2018:2406594. doi: 10.1155/2018/2406594.
   PubMed Web of Science ®Google Scholar
• Edeas M, Saleh J, Peyssonnaux C. 2020. Iron: innocent bystander or vicious culprit in covid-19 pathogenesis? Int J Infect Dis IJID Publ Int Soc Infect Dis. 97:303–305. doi: 10.1016/j.ijid.2020.05.110.
   PubMed Web of Science ®Google Scholar
• Edeas M, Weissig V. 2013. Targeting mitochondria: strategies, innovations and challenges: The future of medicine will come through mitochondria. Mitochondrion. 13:389–390. doi: 10.1016/j.mito.2013.03.009.
   PubMed Web of Science ®Google Scholar
• Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, et al. 2012. Peroxiredoxins are conserved markers of circadian rhythms. Nature. 485:459–464. doi: 10.1038/nature11088.
   PubMed Web of Science ®Google Scholar
• Esch T, Stefano GB, Ptacek R, Kream RM. 2020. Emerging Roles of blood-borne intact and respiring mitochondria as bidirectional mediators of pro- and anti-inflammatory processes. Med Sci Monit Int Med J Exp Clin Res. 26:e924337-1–e924337–3. doi: 10.12659/MSM.924337.
   Google Scholar
• Espinoza SE, Guo H, Fedarko N, DeZern A, Fried LP, Xue Q-L, Leng S, Beamer B, Walston JD. 2008. Glutathione peroxidase enzyme activity in aging. J Gerontol A Biol Sci Med Sci. 63:505–509. doi: 10.1093/gerona/63.5.505.
   PubMed Web of Science ®Google Scholar
• Esteras N, Abramov AY. 2022. Nrf2 as a regulator of mitochondrial function: energy metabolism and beyond. Free Radic Biol Med. 189:136–153. doi: 10.1016/j.freeradbiomed.2022.07.013.
   PubMed Web of Science ®Google Scholar
• Esterhuizen K, van der Westhuizen FH, Louw R. 2017. Metabolomics of mitochondrial disease. Mitochondrion. 35:97–110. doi: 10.1016/j.mito.2017.05.012.
   PubMed Web of Science ®Google Scholar
• Farah C, Michel LYM, Balligand J-L. 2018. Nitric oxide signalling in cardiovascular health and disease. Nat Rev Cardiol. 15:292–316. doi: 10.1038/nrcardio.2017.224.
   PubMed Web of Science ®Google Scholar
• Farhat F, Amérand A, Simon B, Guegueniat N, Moisan C. 2017. Gender-dependent differences of mitochondrial function and oxidative stress in rat skeletal muscle at rest and after exercise training. Redox Rep Commun Free Radic Res. 22:508–514. doi: 10.1080/13510002.2017.1296637.
   PubMed Web of Science ®Google Scholar
• Feelisch M. 2012. NO and hypoxia: taking nitrate to new heights. Nitric Oxide. 27:S4. doi: 10.1016/j.niox.2012.04.016.
   Web of Science ®Google Scholar
• Fiermonte G, Parisi G, Martinelli D, De Leonardis F, Torre G, Pierri CL, Saccari A, Lasorsa FM, Vozza A, Palmieri F, et al. 2011. A new caucasian case of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD): a clinical, molecular, and functional study. Mol Genet Metab. 104:501–506. doi: 10.1016/j.ymgme.2011.08.022.
   PubMed Web of Science ®Google Scholar
• Fiorese CJ, Schulz AM, Lin Y-F, Rosin N, Pellegrino MW, Haynes CM. 2016. The transcription factor ATF5 Mediates a mammalian mitochondrial UPR. Curr Biol CB. 26:2037–2043. doi: 10.1016/j.cub.2016.06.002.
   PubMed Web of Science ®Google Scholar
• Forstermann U, Sessa WC. 2012. Nitric oxide synthases: regulation and function. Eur Heart J. 33:829–837. doi: 10.1093/eurheartj/ehr304.
   PubMed Web of Science ®Google Scholar
• Friedman JR, Lackner LL, West M, DiBenedetto JR, Nunnari J, Voeltz GK. 2011. ER tubules mark sites of mitochondrial division. Sci. 334:358–362. doi: 10.1126/science.1207385.
   PubMed Web of Science ®Google Scholar
• Fukai T, Ushio-Fukai M. 2011. Superoxide Dismutases: role in redox signaling, vascular function, and diseases. Antioxid Redox Signal. 15:1583–1606. doi: 10.1089/ars.2011.3999.
   PubMed Web of Science ®Google Scholar
• Galijasevic S, Saed GM, Diamond MP, Abu-Soud HM. 2003. Myeloperoxidase up-regulates the catalytic activity of inducible nitric oxide synthase by preventing nitric oxide feedback inhibition. Proc Natl Acad Sci. 100:14766–14771. doi: 10.1073/pnas.2435008100.
   PubMed Web of Science ®Google Scholar
• Galimberti D, Mazzola G. 2021. Chapter 12 - chronobiology and chrononutrition: relevance for aging. In: Caruso C, Candore G, editors. Human aging. Cambridge: Academic Press; p. 219–254. doi: 10.1016/B978-0-12-822569-1.00006-8.
   Google Scholar
• Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, et al. 2018. Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. Cell Death Differ. 25:486–541. doi: 10.1038/s41418-017-0012-4.
   PubMed Web of Science ®Google Scholar
• Gan B. 2021. Mitochondrial regulation of ferroptosis. J Cell Biol. 220:e202105043. doi: 10.1083/jcb.202105043.
   PubMed Web of Science ®Google Scholar
• Ganini D, Santos JH, Bonini MG, Mason RP. 2018. Switch of mitochondrial superoxide dismutase into a prooxidant peroxidase in manganese-deficient cells and mice. Cell Chem Biol. 25:413–425.e6. doi: 10.1016/j.chembiol.2018.01.007.
   PubMed Web of Science ®Google Scholar
• Gao P, Yan Z, Zhu Z. 2020. Mitochondria-Associated endoplasmic reticulum membranes in cardiovascular diseases. Front Cell Dev Biol. 8:604240. doi: 10.3389/fcell.2020.604240.
   PubMed Web of Science ®Google Scholar
• Garai D, Ríos-González BB, Furtmüller PG, Fukuto JM, Xian M, López-Garriga J, Obinger C, Nagy P. 2017. Mechanisms of myeloperoxidase catalyzed oxidation of H2S by H2O2 or O2 to produce potent protein Cys-polysulfide-inducing species. Free Radic Biol Med. 113:551–563. doi: 10.1016/j.freeradbiomed.2017.10.384.
   PubMed Web of Science ®Google Scholar
• Garbincius JF, Elrod JW. 2022. Mitochondrial calcium exchange in physiology and disease. Physiol Rev. 102:893–992. doi: 10.1152/physrev.00041.2020.
   PubMed Web of Science ®Google Scholar
• Garcia-Bonilla L, Iadecola C. 2012. Peroxiredoxin sets the brain on fire after stroke. Nat Med. 18:858–859. doi: 10.1038/nm.2797.
   PubMed Web of Science ®Google Scholar
• Garza NM, Swaminathan AB, Maremanda KP, Zulkifli M, Gohil VM. 2023. Mitochondrial copper in human genetic disorders. Trends Endocrinol Metab. 34:21–33. doi: 10.1016/j.tem.2022.11.001.
   PubMed Web of Science ®Google Scholar
• Gaschler MM, Stockwell BR. 2017. Lipid peroxidation in cell death. Biochem Biophys Res Commun. 482:419–425. doi: 10.1016/j.bbrc.2016.10.086.
   PubMed Web of Science ®Google Scholar
• Geertsema S, Bourgonje AR, Fagundes RR, Gacesa R, Weersma RK, van Goor H, Mann GE, Dijkstra G, Faber KN. 2023. The NRF2/Keap1 pathway as a therapeutic target in inflammatory bowel disease. Trends Mol Med. 29:830–842. doi: 10.1016/j.molmed.2023.07.008.
   PubMed Web of Science ®Google Scholar
• Gekakis N, Staknis D, Nguyen HB, Davis FC, Wilsbacher LD, King DP, Takahashi JS, Weitz CJ. 1998. Role of the CLOCK protein in the mammalian circadian mechanism. Sci. 280:1564–1569. doi: 10.1126/science.280.5369.1564.
   PubMed Web of Science ®Google Scholar
• Ghafourifar P, Cadenas E. 2005. Mitochondrial nitric oxide synthase. Trends Pharmacol Sci. 26:190–195. doi: 10.1016/j.tips.2005.02.005.
   PubMed Web of Science ®Google Scholar
• Ghosh S, Dai C, Brown K, Rajendiran E, Makarenko S, Baker J, Ma C, Halder S, Montero M, Ionescu VA, et al. 2011. Colonic microbiota alters host susceptibility to infectious colitis by modulating inflammation, redox status, and ion transporter gene expression. Am J Physiol Gastrointest Liver Physiol. 301:G39–49. doi: 10.1152/ajpgi.00509.2010.
   PubMed Web of Science ®Google Scholar
• Ghosh A, Trivedi PP, Timbalia SA, Griffin AT, Rahn JJ, Chan SSL, Gohil VM. 2014. Copper supplementation restores cytochrome c oxidase assembly defect in a mitochondrial disease model of COA6 deficiency. Hum Mol Genet. 23:3596–3606. doi: 10.1093/hmg/ddu069.
   PubMed Web of Science ®Google Scholar
• Giacomello M, Pyakurel A, Glytsou C, Scorrano L. 2020. The cell biology of mitochondrial membrane dynamics. Nat Rev Mol Cell Biol. 21:204–224. doi: 10.1038/s41580-020-0210-7.
   PubMed Web of Science ®Google Scholar
• Giampietro R, Spinelli F, Contino M, Colabufo NA. 2018. The pivotal role of copper in neurodegeneration: a new strategy for the therapy of neurodegenerative disorders. Mol Pharm. 15:808–820. doi: 10.1021/acs.molpharmaceut.7b00841.
   PubMedGoogle Scholar
• Giorgi C, Marchi S, Pinton P. 2018. The machineries, regulation and cellular functions of mitochondrial calcium. Nat Rev Mol Cell Biol. 19:713–730. doi: 10.1038/s41580-018-0052-8.
   PubMed Web of Science ®Google Scholar
• Giorgio V, von Stockum S, Antoniel M, Fabbro A, Fogolari F, Forte M, Glick GD, Petronilli V, Zoratti M, Szabó I, et al. 2013. Dimers of mitochondrial ATP synthase form the permeability transition pore. Proc Natl Acad Sci U S A. 110:5887–5892. doi: 10.1073/pnas.1217823110.
   PubMed Web of Science ®Google Scholar
• Gladyshev VN. 2014. The free radical theory of aging is dead. Long live the damage theory! Antioxid. Redox Signal. 20:727–731. doi: 10.1089/ars.2013.5228.
   PubMed Web of Science ®Google Scholar
• Glorieux C, Calderon PB. 2017. Catalase, a remarkable enzyme: targeting the oldest antioxidant enzyme to find a new cancer treatment approach. Biol Chem. 398:1095–1108. doi: 10.1515/hsz-2017-0131.
   PubMed Web of Science ®Google Scholar
• Gonzalvez F, Schug ZT, Houtkooper RH, MacKenzie ED, Brooks DG, Wanders RJA, Petit PX, Vaz FM, Gottlieb E. 2008. Cardiolipin provides an essential activating platform for caspase-8 on mitochondria. J Cell Biol. 183:681–696. doi: 10.1083/jcb.200803129.
   PubMed Web of Science ®Google Scholar
• Gordaliza‐Alaguero I, Cantó C, Zorzano A. 2019. Metabolic implications of organelle–mitochondria communication. EMBO Rep. 20. doi: 10.15252/embr.201947928.
   PubMed Web of Science ®Google Scholar
• Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, et al. 2020. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Sci. 370:eabe9403. doi: 10.1126/science.abe9403.
   PubMed Web of Science ®Google Scholar
• Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O’Meara MJ, Rezelj VV, Guo JZ, Swaney DL, et al. 2020. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 583:459–468. doi: 10.1038/s41586-020-2286-9.
   PubMed Web of Science ®Google Scholar
• Gorman GS, Chinnery PF, DiMauro S, Hirano M, Koga Y, McFarland R, Suomalainen A, Thorburn DR, Zeviani M, Turnbull DM. 2016. Mitochondrial diseases. Nat Rev Dis Primer. 2:1–22. doi: 10.1038/nrdp.2016.80.
   Web of Science ®Google Scholar
• Go Y-M, Uppal K, Walker DI, Tran V, Dury L, Strobel FH, Baubichon-Cortay H, Pennell KD, Roede JR, Jones DP. 2014. Mitochondrial metabolomics using high-resolution fourier-transform mass spectrometry. In: Raftery D, editor. Mass spectrometry in metabolomics. New York: Springer; p. 43–73. 10.1007/978-1-4939-1258-2_4.
   Google Scholar
• Guaragnella N, Coyne LP, Chen XJ, Giannattasio S. 2018. Mitochondria–cytosol–nucleus crosstalk: learning from saccharomyces cerevisiae. FEMS Yeast Res. 18. doi: 10.1093/femsyr/foy088.
   PubMed Web of Science ®Google Scholar
• Guarnieri JW, Dybas JM, Fazelinia H, Kim MS, Frere J, Zhang Y, Soto Albrecht Y, Murdock DG, Angelin A, Singh LN, et al. 2023. Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts. Sci Transl Med. 15:eabq1533. doi: 10.1126/scitranslmed.abq1533.
   PubMed Web of Science ®Google Scholar
• Gucek M, Sack MN. 2021. Proteomic and metabolomic advances uncover biomarkers of mitochondrial disease pathophysiology and severity. J Clin Invest. 131. doi: 10.1172/JCI145158.
   PubMed Web of Science ®Google Scholar
• Gu L-F, Chen J-Q, Lin Q-Y, Yang Y-Z. 2021. Roles of mitochondrial unfolded protein response in mammalian stem cells. World J Stem Cells. 13:737–752. doi: 10.4252/wjsc.v13.i7.737.
   PubMed Web of Science ®Google Scholar
• Guillén-Samander A, Leonzino M, Hanna MG IV, Tang N, Shen H, De Camilli P. 2021. VPS13D bridges the ER to mitochondria and peroxisomes via Miro. J Cell Biol. 220:e202010004. doi: 10.1083/jcb.202010004.
   PubMed Web of Science ®Google Scholar
• Gumeni S, Papanagnou E-D, Manola MS, Trougakos IP. 2021. Nrf2 activation induces mitophagy and reverses Parkin/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes. Cell Death Disease. 12:1–12. doi: 10.1038/s41419-021-03952-w.
   PubMed Web of Science ®Google Scholar
• Guo D, He H, Meng Y, Luo S, Lu Z. 2023. Determiners of cell fates: the tricarboxylic acid cycle versus the citrate-malate shuttle. Protein Cell. 14:162–164. doi: 10.1093/procel/pwac026.
   PubMed Web of Science ®Google Scholar
• Guo J-H, Qu W-M, Chen S-G, Chen X-P, Lv K, Huang Z-L, Wu Y-L. 2014. Keeping the right time in space: importance of circadian clock and sleep for physiology and performance of astronauts. Mil Med Res. 1:23. doi: 10.1186/2054-9369-1-23.
   PubMedGoogle Scholar
• Gutierrez Lopez DE, Lashinger LM, Weinstock GM, Bray MS. 2021. Circadian rhythms and the gut microbiome synchronize the host’s metabolic response to diet. Cell Metab. 33:873–887. doi: 10.1016/j.cmet.2021.03.015.
   PubMed Web of Science ®Google Scholar
• Hacker K, Medler KF. 2008. Mitochondrial calcium buffering contributes to the maintenance of basal calcium levels in mouse taste cells. J Neurophysiol. 100:2177–2191. doi: 10.1152/jn.90534.2008.
   PubMed Web of Science ®Google Scholar
• Hadian K, Stockwell BR. 2023. The therapeutic potential of targeting regulated non-apoptotic cell death. Nat Rev Drug Discov. 22:723–742. doi: 10.1038/s41573-023-00749-8.
   PubMed Web of Science ®Google Scholar
• Halestrap AP, McStay GP, Clarke SJ. 2002. The permeability transition pore complex: another view. Biochimie. 84:153–166. doi: 10.1016/S0300-9084(02)01375-5.
   PubMed Web of Science ®Google Scholar
• Hara Y, Kume S, Kataoka Y, Watanabe N. 2021. Changes in TCA cycle and TCA cycle-related metabolites in plasma upon citric acid administration in rats. Heliyon. 7:e08501. doi: 10.1016/j.heliyon.2021.e08501.
   PubMed Web of Science ®Google Scholar
• Harbauer AB, Zahedi RP, Sickmann A, Pfanner N, Meisinger C. 2014. The protein import machinery of mitochondria—a regulatory hub in metabolism, stress, and disease. Cell Metab. 19:357–372. doi: 10.1016/j.cmet.2014.01.010.
   PubMed Web of Science ®Google Scholar
• Hayyan M, Hashim MA, AlNashef IM. 2016. Superoxide Ion: Generation and chemical implications. Chem Rev. 116:3029–3085. doi: 10.1021/acs.chemrev.5b00407.
   PubMed Web of Science ®Google Scholar
• Hiemstra S, Fehling-Kaschek M, Kuijper IA, Bischoff LJM, Wijaya LS, Rosenblatt M, Esselink J, van Egmond A, Mos J, Beltman JB, et al. 2022. Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure. Sci Rep. 12:7336. doi: 10.1038/s41598-022-10857-x.
   PubMed Web of Science ®Google Scholar
• Hillen AEJ, Heine VM. 2020. Glutamate carrier involvement in mitochondrial dysfunctioning in the brain white matter. Front Mol Biosci. 7:151. doi: 10.3389/fmolb.2020.00151.
   PubMed Web of Science ®Google Scholar
• Hilton JB, Kysenius K, White AR, Crouch PJ. 2018. The accumulation of enzymatically inactive cuproenzymes is a CNS-specific phenomenon of the SOD1G37R mouse model of ALS and can be restored by overexpressing the human copper transporter hCTR1. Exp Neurol. 307:118–128. doi: 10.1016/j.expneurol.2018.06.006.
   PubMed Web of Science ®Google Scholar
• Holmström KM, Finkel T. 2014. Cellular mechanisms and physiological consequences of redox-dependent signalling. Nat Rev Mol Cell Biol. 15:411–421. doi: 10.1038/nrm3801.
   PubMed Web of Science ®Google Scholar
• Holmström KM, Kostov RV, Dinkova-Kostova AT. 2016. The multifaceted role of Nrf2 in mitochondrial function. Curr Opin Toxicol. 1:80–91. doi: 10.1016/j.cotox.2016.10.002.
   PubMedGoogle Scholar
• Hong P-P, Zhu X-X, Yuan W-J, Niu G-J, Wang J-X. 2021. Nitric Oxide synthase regulates gut microbiota homeostasis by erk-nf-κb pathway in shrimp. Front Immunol. 12:778098. doi: 10.3389/fimmu.2021.778098.
   PubMed Web of Science ®Google Scholar
• Hu Y, Bi Y, Yao D, Wang P, Li Y. 2019. Omi/HtrA2 protease associated cell apoptosis participates in blood-brain barrier dysfunction. Front Mol Neurosci. 12:48. doi: 10.3389/fnmol.2019.00048.
   PubMed Web of Science ®Google Scholar
• Ikeda T, Osaka H, Shimbo H, Tajika M, Yamazaki M, Ueda A, Murayama K, Yamagata T. 2018. Mitochondrial DNA 3243A>T mutation in a patient with MELAS syndrome. Hum Genome Var. 5:1–4. doi: 10.1038/s41439-018-0026-6.
   PubMedGoogle Scholar
• Janssen JJE, Grefte S, Keijer J, de Boer VCJ. 2019. Mito-Nuclear communication by mitochondrial metabolites and its regulation by b-vitamins. Front Physiol. 10:78. doi: 10.3389/fphys.2019.00078.
   PubMed Web of Science ®Google Scholar
• Jovaisaite V, Mouchiroud L, Auwerx J. 2014. The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease. J Exp Biol. 217:137–143. doi: 10.1242/jeb.090738.
   PubMed Web of Science ®Google Scholar
• Jung H, Kim SY, Canbakis Cecen FS, Cho Y, Kwon S-K. 2020. Dysfunction of mitochondriaL CA2+ regulatory Machineries in brain aging and neurodegenerative diseases. Front Cell Dev Biol. 8. doi: 10.3389/fcell.2020.599792.
   Web of Science ®Google Scholar
• Jung K-A, Lee S, Kwak M-K. 2017. NFE2L2/NRF2 activity is linked to MITOCHONDRIA and AMP-activated protein kinase signaling in cancers through miR-181c/mitochondria-encoded cytochrome c oxidase regulation. Antioxid Redox Signal. 27:945–961. doi: 10.1089/ars.2016.6797.
   PubMed Web of Science ®Google Scholar
• Kamer KJ, Mootha VK. 2015. The molecular era of the mitochondrial calcium uniporter. Nat Rev Mol Cell Biol. 16:545–553. doi: 10.1038/nrm4039.
   PubMed Web of Science ®Google Scholar
• Kanellopoulos AK, Mariano V, Spinazzi M, Woo YJ, McLean C, Pech U, Li KW, Armstrong JD, Giangrande A, Callaerts P, et al. 2020. Aralar Sequesters gaba into hyperactive mitochondria, causing social behavior deficits. Cell. 180:1178–1197.e20. doi: 10.1016/j.cell.2020.02.044.
   PubMed Web of Science ®Google Scholar
• Kanemitsu T, Tsurudome Y, Kusunose N, Oda M, Matsunaga N, Koyanagi S, Ohdo S. 2017. Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα. J Biol Chem. 292:21397–21406. doi: 10.1074/jbc.M117.791285.
   PubMed Web of Science ®Google Scholar
• Kao MPC, Ang DSC, Pall A, Struthers AD. 2010. Oxidative stress in renal dysfunction: mechanisms, clinical sequelae and therapeutic options. J Hum Hypertens. 24:1–8. doi: 10.1038/jhh.2009.70.
   PubMed Web of Science ®Google Scholar
• Karch J, Kanisicak O, Brody MJ, Sargent MA, Michael DM, Molkentin JD. 2015. Necroptosis interfaces with MOMP and the MPTP in mediating cell death. PLoS One. 10:e0130520. doi: 10.1371/journal.pone.0130520.
   PubMed Web of Science ®Google Scholar
• Khoshnam SE, Winlow W, Farzaneh M, Farbood Y, Moghaddam HF. 2017. Pathogenic mechanisms following ischemic stroke. Neurol Sci J Ital Neurol Soc Ital Soc Clin Neurophysiol. 38:1167–1186. doi: 10.1007/s10072-017-2938-1.
   Google Scholar
• Kinnally KW, Peixoto PM, Ryu S-Y, Dejean LM. 2011. Is mPTP the gatekeeper for necrosis, apoptosis, or both? Biochim Biophys Acta. 1813:616–622. doi: 10.1016/j.bbamcr.2010.09.013.
   PubMed Web of Science ®Google Scholar
• Kirches E. 2011. LHON: mitochondrial mutations and more. Curr Genomics. 12:44–54. doi: 10.2174/138920211794520150.
   PubMed Web of Science ®Google Scholar
• Kirichenko TV, Markina YV, Sukhorukov VN, Khotina VA, Wu W-K, Orekhov AN. 2020. A Novel insight at atherogenesis: the role of microbiome. Front Cell Dev Biol. 8. doi: 10.3389/fcell.2020.586189.
   PubMed Web of Science ®Google Scholar
• Kirichenko TV, Ryzhkova AI, Sinyov VV, Sazonova MD, Orekhova VA, Karagodin VP, Gerasimova EV, Voevoda MI, Orekhov AN, Ragino YI, et al. 2020. Impact of mitochondrial DNA mutations on carotid intima-media thickness in the novosibirsk region. Life Basel Switz. 10:E160. doi: 10.3390/life10090160.
   PubMed Web of Science ®Google Scholar
• Kitada M, Xu J, Ogura Y, Monno I, Koya D. 2020. Manganese Superoxide dismutase dysfunction and the pathogenesis of kidney disease. Front Physiol. 11. doi: 10.3389/fphys.2020.00755.
   PubMed Web of Science ®Google Scholar
• Klingenberg M. 2009. Cardiolipin and mitochondrial carriers. Biochim Biophys Acta. 1788:2048–2058. doi: 10.1016/j.bbamem.2009.06.007.
   PubMed Web of Science ®Google Scholar
• Koch CD, Gladwin MT, Freeman BA, Lundberg JO, Weitzberg E, Morris A. 2017. Enterosalivary nitrate metabolism and the microbiome: intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health. Free Radic Biol Med. 105:48–67. doi: 10.1016/j.freeradbiomed.2016.12.015.
   PubMed Web of Science ®Google Scholar
• Kolluru GK, Shen X, Bir SC, Kevil CG. 2013. Hydrogen sulfide chemical biology: pathophysiological roles and detection. Nitric Oxide. 35:5–20. doi: 10.1016/j.niox.2013.07.002.
   PubMed Web of Science ®Google Scholar
• Krueger K, Koch K, Jühling A, Tepel M, Scholze A. 2010. Low expression of thiosulfate sulfurtransferase (rhodanese) predicts mortality in hemodialysis patients. Clin Biochem. 43:95–101. doi: 10.1016/j.clinbiochem.2009.08.005.
   PubMed Web of Science ®Google Scholar
• Kunieda T, Minamino T, Miura K, Katsuno T, Tateno K, Miyauchi H, Kaneko S, Bradfield CA, FitzGerald GA, Komuro I. 2008. Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circ Res. 102:607–614. doi: 10.1161/CIRCRESAHA.107.162230.
   PubMed Web of Science ®Google Scholar
• Kyriazis ID, Vassi E, Alvanou M, Angelakis C, Skaperda Z, Tekos F, Garikipati VNS, Spandidos DA, Kouretas D. 2022. The impact of diet upon mitochondrial physiology (Review). Int J Mol Med. 50:1–26. doi: 10.3892/ijmm.2022.5191.
   Web of Science ®Google Scholar
• Lacza Z, Pankotai E, Busija DW. 2009. Mitochondrial nitric oxide synthase: current concepts and controversies. Front Biosci Landmark Ed. 14:4436–4443. doi: 10.2741/3539.
   PubMedGoogle Scholar
• Lambert AJ, Brand MD. 2009. Reactive oxygen species production by mitochondria. In: Stuart JA, editor. Mitochondrial DNA. Totowa, New Jersey: Humana Press; p. 165–181. doi: 10.1007/978-1-59745-521-3_11.
   Google Scholar
• Lananna BV, Musiek ES. 2020. The wrinkling of time: aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration. Neurobiol Dis. 139:104832. doi: 10.1016/j.nbd.2020.104832.
   PubMed Web of Science ®Google Scholar
• Lande-Diner L, Boyault C, Kim JY, Weitz CJ. 2013. A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery. Proc Natl Acad Sci U S A. 110:16021–16026. doi: 10.1073/pnas.1305980110.
   PubMed Web of Science ®Google Scholar
• Lee J, Choi J, Selen Alpergin ES, Zhao L, Hartung T, Scafidi S, Riddle RC, Wolfgang MJ. 2017. Loss of hepatic mitochondrial long-chain fatty acid oxidation confers resistance to diet-induced obesity and glucose intolerance. Cell Rep. 20:655–667. doi: 10.1016/j.celrep.2017.06.080.
   PubMed Web of Science ®Google Scholar
• Lei L, Zhang J, Decker EA, Zhang G. 2021. Roles of Lipid peroxidation-derived electrophiles in pathogenesis of colonic inflammation and colon cancer. Front Cell Dev Biol. 9:665591. doi: 10.3389/fcell.2021.665591.
   PubMed Web of Science ®Google Scholar
• Lemattre C, Imbert-Bouteille M, Gatinois V, Benit P, Sanchez E, Guignard T, Tran Mau-Them F, Haquet E, Rivier F, Carme E, et al. 2019. Report on three additional patients and genotype-phenotype correlation in SLC25A22-related disorders group. Eur J Hum Genet EJHG. 27:1692–1700. doi: 10.1038/s41431-019-0433-2.
   PubMed Web of Science ®Google Scholar
• Levine DC, Hong H, Weidemann BJ, Ramsey KM, Affinati AH, Schmidt MS, Cedernaes J, Omura C, Braun R, Lee C, et al. 2020. NAD+ controls circadian reprogramming through PER2 Nuclear translocation to counter aging. Mol Cell. 78:835–849.e7. doi: 10.1016/j.molcel.2020.04.010.
   PubMed Web of Science ®Google Scholar
• Lewis SC, Uchiyama LF, Nunnari J. 2016. ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells. Science. 353:aaf5549. doi: 10.1126/science.aaf5549.
   PubMed Web of Science ®Google Scholar
• Liang X, Bushman FD, FitzGerald GA. 2015. Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock. Proc Natl Acad Sci U S A. 112:10479–10484. doi: 10.1073/pnas.1501305112.
   PubMed Web of Science ®Google Scholar
• Liang Y, Cui L, Gao J, Zhu M, Zhang Y, Zhang H-L. 2021. Gut microbial metabolites in Parkinson’s disease: implications of mitochondrial dysfunction in the pathogenesis and treatment. Mol Neurobiol. 58:3745–3758. doi: 10.1007/s12035-021-02375-0.
   PubMed Web of Science ®Google Scholar
• Liang W, Sagar S, Ravindran R, Najor RH, Quiles JM, Chi L, Diao RY, Woodall BP, Leon LJ, Zumaya E, et al. 2023. Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired. Nat Commun. 14:5031. doi: 10.1038/s41467-023-40680-5.
   PubMed Web of Science ®Google Scholar
• Li J, Cao F, Yin H, Huang Z, Lin Z, Mao N, Sun B, Wang G. 2020. Ferroptosis: past, present and future. Cell Death Disease. 11:88. doi: 10.1038/s41419-020-2298-2.
   PubMed Web of Science ®Google Scholar
• Li Q, Hoppe T. 2023. Role of amino acid metabolism in mitochondrial homeostasis. Front Cell Dev Biol. 11:1127618. doi: 10.3389/fcell.2023.1127618.
   PubMed Web of Science ®Google Scholar
• Li X, Liu X, Meng Q, Wu X, Bing X, Guo N, Zhao X, Hou X, Wang B, Xia M, et al. 2022. Circadian clock disruptions link oxidative stress and systemic inflammation to metabolic syndrome in obstructive sleep apnea patients. Front Physiol. 13. doi:10.3389/fphys.2022.932596.
   Web of Science ®Google Scholar
• Li X-X, Tsoi B, Li Y-F, Kurihara H, He R-R. 2015. Cardiolipin and its different properties in mitophagy and apoptosis. J Histochem Cytochem. 63:301–311. doi: 10.1369/0022155415574818.
   PubMed Web of Science ®Google Scholar
• Liu S, Gao J, Zhu M, Liu K, Zhang H-L. 2020. Gut microbiota and dysbiosis in alzheimer’s disease: implications for pathogenesis and treatment. Mol Neurobiol. 57:5026–5043. doi: 10.1007/s12035-020-02073-3.
   PubMed Web of Science ®Google Scholar
• Liu TF, Vachharajani VT, Yoza BK, McCall CE. 2012. Nad±dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response. J Biol Chem. 287:25758–25769. doi: 10.1074/jbc.M112.362343.
   PubMed Web of Science ®Google Scholar
• Li Q, Vande Velde C, Israelson A, Xie J, Bailey AO, Dong M-Q, Chun S-J, Roy T, Winer L, Yates JR, et al. 2010. ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import. Proc Natl Acad Sci. 107:21146–21151. doi: 10.1073/pnas.1014862107.
   PubMed Web of Science ®Google Scholar
• Li L, Wang C, Yang H, Liu S, Lu Y, Fu P, Liu J. 2017. Metabolomics reveal mitochondrial and fatty acid metabolism disorders that contribute to the development of DKD in T2DM patients. Mol Biosyst. 13:2392–2400. doi: 10.1039/C7MB00167C.
   PubMedGoogle Scholar
• Li R, Yan G, Li Q, Sun H, Hu Y, Sun J, Xu B. 2012. MicroRNA-145 protects cardiomyocytes against hydrogen peroxide (h2o2)-induced apoptosis through targeting the mitochondria apoptotic pathway. PLoS One. 7:e44907. doi: 10.1371/journal.pone.0044907.
   PubMed Web of Science ®Google Scholar
• Lopes AFC. 2020. Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes. Clin Epigenetics. 12:182. doi: 10.1186/s13148-020-00976-5.
   PubMed Web of Science ®Google Scholar
• Lopez J, Tait SWG. 2015. Mitochondrial apoptosis: killing cancer using the enemy within. Br J Cancer. 112:957–962. doi: 10.1038/bjc.2015.85.
   PubMed Web of Science ®Google Scholar
• Lorenzo HK, Susin SA, Penninger J, Kroemer G. 1999. Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death. Cell Death Differ. 6:516–524. doi: 10.1038/sj.cdd.4400527.
   PubMed Web of Science ®Google Scholar
• Lozoya OA, Wang T, Grenet D, Wolfgang TC, Sobhany M, Ganini da Silva D, Riadi G, Chandel N, Woychik RP, Santos JH. 2019. Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression. Life Sci Alli. 2:e201800228. doi: 10.26508/lsa.201800228.
   PubMed Web of Science ®Google Scholar
• Lu B, Gong X, Wang Z, Ding Y, Wang C, Luo T, Piao M, Meng F, Chi G, Luo Y, et al. 2017. Shikonin induces glioma cell necroptosis in vitro by ROS overproduction and promoting RIP1/RIP3 necrosome formation. Acta Pharmacol Sin. 38:1543–1553. doi: 10.1038/aps.2017.112.
   PubMed Web of Science ®Google Scholar
• Lu Q, Haragopal H, Slepchenko KG, Stork C, Li YV. 2016. Intracellular zinc distribution in mitochondria, ER and the Golgi apparatus. Int J Physiol Pathophysiol Pharmacol. 8:35–43.
   PubMedGoogle Scholar
• Luo Y, Chatre L, Melhem S, Al-Dahmani ZM, Homer NZM, Miedema A, Deelman LE, Groves MR, Feelisch M, Morton NM, et al. 2023. Thiosulfate sulfurtransferase deficiency promotes oxidative distress and aberrant NRF2 function in the brain. Redox Biol. 68:102965. doi: 10.1016/j.redox.2023.102965.
   PubMed Web of Science ®Google Scholar
• Lynch DR, Farmer G. 2021. Mitochondrial and metabolic dysfunction in Friedreich ataxia: update on pathophysiological relevance and clinical interventions. Neuronal Signal. 5:NS20200093. doi: 10.1042/NS20200093.
   PubMedGoogle Scholar
• Mailloux RJ, McBride SL, Harper M-E. 2013. Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics. Trends Biochem Sci. 38:592–602. doi: 10.1016/j.tibs.2013.09.001.
   PubMed Web of Science ®Google Scholar
• Malard E, Valable S, Bernaudin M, Pérès E, Chatre L. 2021. The Reactive species interactome in the brain. Antioxid Redox Signal Ars. 35:1176–1206. doi: 10.1089/ars.2020.8238.
   Google Scholar
• Mani S, Swargiary G, Ralph SJ. 2022. Targeting the redox imbalance in mitochondria: a novel mode for cancer therapy. Mitochondrion. 62:50–73. doi: 10.1016/j.mito.2021.11.002.
   PubMed Web of Science ®Google Scholar
• Marshall KD, Baines CP. 2014. Necroptosis: is there a role for mitochondria? Front Physiol. 5. doi: 10.3389/fphys.2014.00323.
   Web of Science ®Google Scholar
• Martínez-Reyes I, Chandel NS. 2020. Mitochondrial TCA cycle metabolites control physiology and disease. Nat Commun. 11:102. doi: 10.1038/s41467-019-13668-3.
   PubMed Web of Science ®Google Scholar
• Martín-Jiménez R, Lurette O, Hebert-Chatelain E. 2020. Damage in mitochondriaL DNA associated with Parkinson’s disease. DNA Cell Biol. 39:1421–1430. doi: 10.1089/dna.2020.5398.
   PubMed Web of Science ®Google Scholar
• Maurya SR, Mahalakshmi R. 2016. VDAC-2: mitochondrial outer membrane regulator masquerading as a channel? FEBS J. 283:1831–1836. doi: 10.1111/febs.13637.
   PubMed Web of Science ®Google Scholar
• McCommis KS, Finck BN. 2015. Mitochondrial pyruvate transport: a historical perspective and future research directions. Biochem J. 466:443–454. doi: 10.1042/BJ20141171.
   PubMed Web of Science ®Google Scholar
• Meijer AJ, Lorin S, Blommaart EF, Codogno P. 2015. Regulation of autophagy by amino acids and MTOR-dependent signal transduction. Amino Acids. 47:2037–2063. doi: 10.1007/s00726-014-1765-4.
   PubMed Web of Science ®Google Scholar
• Mellis A-T, Misko AL, Arjune S, Liang Y, Erdélyi K, Ditrói T, Kaczmarek AT, Nagy P, Schwarz G. 2021. The role of glutamate oxaloacetate transaminases in sulfite biosynthesis and H2S metabolism. Redox Biol. 38:101800. doi: 10.1016/j.redox.2020.101800.
   PubMed Web of Science ®Google Scholar
• Meng J, Lv Z, Zhang Y, Wang Y, Qiao X, Sun C, Chen Y, Guo M, Han W, Ye A, et al. 2021. Precision redox: the key for antioxidant pharmacology. Antioxid Redox Signal. 34:1069–1082. doi: 10.1089/ars.2020.8212.
   PubMed Web of Science ®Google Scholar
• Mezhnina V, Ebeigbe OP, Poe A, Kondratov RV. 2022. Circadian control of mitochondria in reactive oxygen species homeostasis. Antioxid Redox Signal. 37:647–663. doi: 10.1089/ars.2021.0274.
   PubMed Web of Science ®Google Scholar
• Mitter SK, Rao HV, Cai J, Thampi P, Qi X, Dunn WA, Grant MB, Boulton ME. 2010. Nitric oxide affects the circadian rhythmicity of autophagy in retinal microvascular endothelial cells. Invest Ophthalmol Visual Sci. 51:5624.
   Web of Science ®Google Scholar
• Miyamoto R, Otsuguro K, Yamaguchi S, Ito S. 2014. Contribution of cysteine aminotransferase and mercaptopyruvate sulfurtransferase to hydrogen sulfide production in peripheral neurons. J Neurochem. 130:29–40. doi: 10.1111/jnc.12698.
   PubMed Web of Science ®Google Scholar
• Morin AL, Win PW, Lin AZ, Castellani CA. 2022. Mitochondrial genomic integrity and the nuclear epigenome in health and disease. Front Endocrinol. 13:1059085. doi: 10.3389/fendo.2022.1059085.
   PubMed Web of Science ®Google Scholar
• Morioka E, Kasuga Y, Kanda Y, Moritama S, Koizumi H, Yoshikawa T, Miura N, Ikeda M, Higashida H, Holmes TC, et al. 2022. Mitochondrial LETM1 drives ionic and molecular clock rhythms in circadian pacemaker neurons. Cell Rep. 39:110787. doi: 10.1016/j.celrep.2022.110787.
   PubMed Web of Science ®Google Scholar
• Mossad O, Batut B, Yilmaz B, Dokalis N, Mezö C, Nent E, Nabavi LS, Mayer M, Maron FJM, Buescher JM, et al. 2022. Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine. Nat Neurosci. 25:295–305. doi: 10.1038/s41593-022-01027-3.
   PubMed Web of Science ®Google Scholar
• Mottawea W, Chiang C-K, Mühlbauer M, Starr AE, Butcher J, Abujamel T, Deeke SA, Brandel A, Zhou H, Shokralla S, et al. 2016. Altered intestinal microbiota–host mitochondria crosstalk in new onset Crohn’s disease. Nat Commun. 7:13419. doi: 10.1038/ncomms13419.
   PubMed Web of Science ®Google Scholar
• Müller S, Versini A, Sindikubwabo F, Belthier G, Niyomchon S, Pannequin J, Grimaud L, Cañeque T, Rodriguez R. 2018. Metformin reveals a mitochondrial copper addiction of mesenchymal cancer cells. PLoS One. 13:e0206764. doi: 10.1371/journal.pone.0206764.
   PubMed Web of Science ®Google Scholar
• Murphy MP. 2009. How mitochondria produce reactive oxygen species. Biochem J. 417:1–13. doi: 10.1042/BJ20081386.
   PubMed Web of Science ®Google Scholar
• Murros KE. 2022. hydrogen sulfide produced by gut bacteria may induce Parkinson’s disease. Cells. 11:978. doi: 10.3390/cells11060978.
   PubMed Web of Science ®Google Scholar
• Najbauer EE, Becker S, Giller K, Zweckstetter M, Lange A, Steinem C, de Groot BL, Griesinger C, Andreas LB. 2021. Structure, gating and interactions of the voltage-dependent anion channel. Eur Biophys J. 50:159–172. doi: 10.1007/s00249-021-01515-7.
   PubMed Web of Science ®Google Scholar
• Nakao N, Kurokawa T, Nonami T, Tumurkhuu G, Koide N, Yokochi T. 2008. Hydrogen peroxide induces the production of tumor necrosis factor-α in RAW 264.7 macrophage cells via activation of p38 and stress-activated protein kinase. Innate Immun. 14:190–196. doi: 10.1177/1753425908093932.
   PubMed Web of Science ®Google Scholar
• Nardo T, Oneda R, Spivak G, Vaz B, Mortier L, Thomas P, Orioli D, Laugel V, Stary A, Hanawalt PC, et al. 2009. A UV-sensitive syndrome patient with a specific CSA mutation reveals separable roles for CSA in response to UV and oxidative DNA damage. Proc Natl Acad Sci. 106:6209–6214. doi: 10.1073/pnas.0902113106.
   PubMed Web of Science ®Google Scholar
• Navigatore-Fonzo LS, Delgado SM, Gimenez MS, Anzulovich AC. 2014. Daily rhythms of catalase and glutathione peroxidase expression and activity are endogenously driven in the hippocampus and are modified by a vitamin A-free diet. Nutr Neurosci. 17:21–30. doi: 10.1179/1476830513Y.0000000062.
   PubMed Web of Science ®Google Scholar
• Neufeld-Cohen A, Robles MS, Aviram R, Manella G, Adamovich Y, Ladeuix B, Nir D, Rousso-Noori L, Kuperman Y, Golik M, et al. 2016. Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins. Proc Natl Acad Sci. 113:E1673–E1682. doi: 10.1073/pnas.1519650113.
   PubMed Web of Science ®Google Scholar
• Nicolli A, Petronilli V, Bernardi P. 1993. Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by matrix pH. Evidence that the pore open-closed probability is regulated by reversible histidine protonation. Biochemistry. 32:4461–4465. doi: 10.1021/bi00067a039.
   PubMed Web of Science ®Google Scholar
• Ni C, Li X, Wang L, Li X, Zhao J, Zhang H, Wang G, Chen W. 2021. Lactic acid bacteria strains relieve hyperuricaemia by suppressing xanthine oxidase activity via a short-chain fatty acid-dependent mechanism. Food Funct. 12:7054–7067. doi: 10.1039/D1FO00198A.
   PubMed Web of Science ®Google Scholar
• Nomiyama T, Setoyama D, Yasukawa T, Kang D. 2022. Mitochondria metabolomics reveals a role of β-nicotinamide mononucleotide metabolism in mitochondrial DNA replication. J Biochem (Tokyo). 171:325–338. doi: 10.1093/jb/mvab136.
   PubMed Web of Science ®Google Scholar
• Norambuena A, Sun X, Wallrabe H, Cao R, Sun N, Pardo E, Shivange N, Wang DB, Post LA, Ferris HA, et al. 2022. SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers. Neurobiol Dis. 169:105737. doi: 10.1016/j.nbd.2022.105737.
   PubMed Web of Science ®Google Scholar
• Nørgård MØ, Lund PM, Kalisi N, Andresen TL, Larsen JB, Vogel S, Svenningsen P. 2023. Mitochondrial reactive oxygen species modify extracellular vesicles secretion rate. FASEB BioAdvances. 5:355–366. doi: 10.1096/fba.2023-00053.
   PubMedGoogle Scholar
• Novotny BC, Fernandez MV, Wang C, Budde JP, Bergmann K, Eteleeb AM, Bradley J, Webster C, Ebl C, Norton J, et al. 2023. Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer’s disease brains. Alzheimers Dement J Alzheimers Assoc. 19:1785–1799. doi: 10.1002/alz.12800.
   PubMed Web of Science ®Google Scholar
• Ogino K, Kodama N, Nakajima M, Yamada A, Nakamura H, Nagase H, Sadamitsu D, Maekawa T. 2001. Catalase catalyzes nitrotyrosine formation from sodium azide and hydrogen peroxide. Free Radic Res. 35:735–747. doi: 10.1080/10715760100301241.
   PubMed Web of Science ®Google Scholar
• Olson KR. 2018. H2S and polysulfide metabolism: conventional and unconventional pathways. Biochem Pharmacol. 149:77–90. doi: 10.1016/j.bcp.2017.12.010.
   PubMed Web of Science ®Google Scholar
• Olson KR. 2020. Are reactive sulfur species the new reactive oxygen species? antioxid. Redox Signal Ars. 33:1125–1142. 2020.8132. doi: 10.1089/ars.2020.8132.
   PubMed Web of Science ®Google Scholar
• Olson KR, Gao Y, Arif F, Arora K, Patel S, DeLeon ER, Sutton TR, Feelisch M, Cortese-Krott MM, Straub KD. 2018. Metabolism of hydrogen sulfide (H2S) and Production of reactive sulfur species (RSS) by superoxide dismutase. Redox Biol. 15:74–85. doi: 10.1016/j.redox.2017.11.009.
   PubMed Web of Science ®Google Scholar
• Olson KR, Gao Y, DeLeon ER, Arif M, Arif F, Arora N, Straub KD. 2017. Catalase as a sulfide-sulfur oxido-reductase: an ancient (and modern?) regulator of reactive sulfur species (RSS). Redox Biol. 12:325–339. doi: 10.1016/j.redox.2017.02.021.
   PubMed Web of Science ®Google Scholar
• Özdemir BC, Gerard CL, Espinosa da Silva C. 2022. Sex and gender differences in anticancer treatment toxicity: a call for revisiting drug dosing in oncology. Endocrinology. 163:bqac058. doi: 10.1210/endocr/bqac058.
   PubMed Web of Science ®Google Scholar
• Padmanabhan K, Billaud M. 2017. Desynchronization of Circadian clocks in cancer: a metabolic and epigenetic connection. Front Endocrinol. 8. doi: 10.3389/fendo.2017.00136.
   PubMed Web of Science ®Google Scholar
• Pálinkás Z, Furtmüller PG, Nagy A, Jakopitsch C, Pirker KF, Magierowski M, Jasnos K, Wallace JL, Obinger C, Nagy P. 2015. Interactions of hydrogen sulfide with myeloperoxidase: sulfide is a substrate and inhibitor of myeloperoxidase. Br J Pharmacol. 172:1516–1532. doi: 10.1111/bph.12769.
   PubMed Web of Science ®Google Scholar
• Palma FR, He C, Danes JM, Paviani V, Coelho DR, Gantner BN, Bonini MG. 2020. Mitochondrial superoxide dismutase: what the established, the intriguing, and the novel reveal about a key cellular redox switch. Antioxid Redox Signal. 32:701–714. doi: 10.1089/ars.2019.7962.
   PubMed Web of Science ®Google Scholar
• Palmieri F. 2013. The mitochondrial transporter family SLC25: identification, properties and physiopathology. Mol Aspects Med. 34:465–484. doi: 10.1016/j.mam.2012.05.005.
   PubMed Web of Science ®Google Scholar
• Palmieri F, Monné M. 2016. Discoveries, metabolic roles and diseases of mitochondrial carriers: a review. Biochim Biophys Acta BBA - Mol Cell Res. 1863:2362–2378. doi: 10.1016/j.bbamcr.2016.03.007.
   PubMed Web of Science ®Google Scholar
• Pandey R, Caflisch L, Lodi A, Brenner AJ, Tiziani S. 2017. Metabolomic signature of brain cancer. Mol Carcinog. 56:2355–2371. doi: 10.1002/mc.22694.
   PubMed Web of Science ®Google Scholar
• Pardo B, Contreras L, Satrústegui J. 2013. De novo synthesis of glial glutamate and glutamine in young mice requires aspartate provided by the neuronal mitochondrial aspartate-glutamate carrier aralar/AGC1. Front Endocrinol. 4. doi: 10.3389/fendo.2013.00149.
   PubMedGoogle Scholar
• Paré B, Lehmann M, Beaudin M, Nordström U, Saikali S, Julien J-P, Gilthorpe JD, Marklund SL, Cashman NR, Andersen PM, et al. 2018. Misfolded SOD1 pathology in sporadic amyotrophic lateral sclerosis. Sci Rep. 8:14223. doi: 10.1038/s41598-018-31773-z.
   PubMed Web of Science ®Google Scholar
• Park MH, Jo M, Kim YR, Lee C-K, Hong JT. 2016. Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases. Pharmacol Ther. 163:1–23. doi: 10.1016/j.pharmthera.2016.03.018.
   PubMed Web of Science ®Google Scholar
• Park YS, Koh YH, Takahashi M, Miyamoto Y, Suzuki K, Dohmae N, Takio K, Honke K, Taniguchi N. 2003. Identification of the Binding site of methylglyoxal on glutathione peroxidase: methylglyoxal inhibits glutathione peroxidase activity via binding to glutathione binding sites arg 184 and 185. Free Radic Res. 37:205–211. doi: 10.1080/1071576021000041005.
   PubMed Web of Science ®Google Scholar
• Parsanathan R, Jain SK. 2019. Hydrogen sulfide regulates circadian-clock genes in C2C12 myotubes and the muscle of high-fat-diet-fed mice. Arch Biochem Biophys. 672:108054. doi: 10.1016/j.abb.2019.07.019.
   PubMed Web of Science ®Google Scholar
• Paul BD, Snyder SH, Kashfi K. 2020. Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics. Redox Biol. 38:101772. doi: 10.1016/j.redox.2020.101772.
   PubMed Web of Science ®Google Scholar
• Peek CB, Affinati AH, Ramsey KM, Kuo H-Y, Yu W, Sena LA, Ilkayeva O, Marcheva B, Kobayashi Y, Omura C, et al. 2013. Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Sci. 342:1243417. doi: 10.1126/science.1243417.
   PubMed Web of Science ®Google Scholar
• Peeters A, Shinde AB, Dirkx R, Smet J, De Bock K, Espeel M, Vanhorebeek I, Vanlander A, Van Coster R, Carmeliet P, et al. 2015. Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1α independent proliferation. Biochim Biophys Acta BBA - Mol Cell Res. 1853:285–298. doi: 10.1016/j.bbamcr.2014.11.017.
   PubMed Web of Science ®Google Scholar
• Petrova VY, Drescher D, Kujumdzieva AV, Schmitt MJ. 2004. Dual targeting of yeast catalase a to peroxisomes and mitochondria. Biochem J. 380:393–400. doi: 10.1042/BJ20040042.
   PubMed Web of Science ®Google Scholar
• Pfanner N, Warscheid B, Wiedemann N. 2019. Mitochondrial proteins: from biogenesis to functional networks. Nat Rev Mol Cell Biol. 20:267–284. doi: 10.1038/s41580-018-0092-0.
   PubMed Web of Science ®Google Scholar
• Pilchova I, Klacanova K, Tatarkova Z, Kaplan P, Racay P. 2017. The Involvement of Mg2+ in Regulation of cellular and mitochondrial functions. Oxid Med Cell Longev. 2017:6797460. doi: 10.1155/2017/6797460.
   PubMed Web of Science ®Google Scholar
• Pileggi CA, Blondin DP, Hooks BG, Parmar G, Alecu I, Patten DA, Cuillerier A, O’Dwyer C, Thrush AB, Fullerton MD, et al. 2022. Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity. EBioMedicine. 83:104192. doi: 10.1016/j.ebiom.2022.104192.
   PubMed Web of Science ®Google Scholar
• Pittalà MGG, Conti Nibali S, Reina S, Cunsolo V, Di Francesco A, De Pinto V, Messina A, Foti S, Saletti R. 2021. Vdacs post-translational modifications discovery by mass spectrometry: impact on their hub function. Int J Mol Sci. 22:12833. doi: 10.3390/ijms222312833.
   PubMed Web of Science ®Google Scholar
• Podlesniy P, Puigròs M, Serra N, Fernández-Santiago R, Ezquerra M, Tolosa E, Trullas R. 2019. Accumulation of mitochondrial 7S DNA in idiopathic and LRRK2 associated Parkinson’s disease. EBioMedicine. 48:554–567. doi: 10.1016/j.ebiom.2019.09.015.
   PubMed Web of Science ®Google Scholar
• Pollicino F, Veronese N, Dominguez LJ, Barbagallo M. 2023. Mediterranean diet and mitochondria: new findings. Exp Gerontol. 176:112165. doi: 10.1016/j.exger.2023.112165.
   PubMed Web of Science ®Google Scholar
• Qin J, Guo Y, Xue B, Shi P, Chen Y, Su QP, Hao H, Zhao S, Wu C, Yu L, et al. 2020. ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation. Nat Commun. 11:4471. doi: 10.1038/s41467-020-18202-4.
   PubMed Web of Science ®Google Scholar
• Ravi A, Palamiuc L, Loughran RM, Triscott J, Arora GK, Kumar A, Tieu V, Pauli C, Reist M, Lew RJ, et al. 2021. PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay. Dev Cell. 56:1661–1676.e10. doi: 10.1016/j.devcel.2021.04.019.
   PubMed Web of Science ®Google Scholar
• Ray RS, Katyal A. 2016. Myeloperoxidase: Bridging the gap in neurodegeneration. Neurosci Biobehav Rev. 68:611–620. doi: 10.1016/j.neubiorev.2016.06.031.
   PubMed Web of Science ®Google Scholar
• Reddam A, McLarnan S, Kupsco A. 2022. Environmental chemical exposures and mitochondrial dysfunction: a review of recent literature. Curr Environ Health Rep. 9:631–649. doi: 10.1007/s40572-022-00371-7.
   PubMedGoogle Scholar
• Reelfs O, Abbate V, Cilibrizzi A, Pook MA, Hider RC, Pourzand C. 2019. The role of mitochondrial labile iron in Friedreich’s ataxia skin fibroblasts sensitivity to ultraviolet A. Metallomics. 11:656–665. doi: 10.1039/C8MT00257F.
   PubMed Web of Science ®Google Scholar
• Ricchetti M. 2018. Replication stress in mitochondria. Mutat Res Mol Mech Mutagen. 808:93–102. doi: 10.1016/j.mrfmmm.2018.01.005.
   PubMed Web of Science ®Google Scholar
• Ricchetti M, Tekaia F, Dujon B. 2004. Continued colonization of the human genome by mitochondrial DNA. PLoS Biol. 2:e273. doi: 10.1371/journal.pbio.0020273.
   PubMed Web of Science ®Google Scholar
• Richards BJ, Slavin M, Oliveira AN, Sanfrancesco VC, Hood DA. 2022. Mitochondrial protein import and UPRmt in skeletal muscle remodeling and adaptation. Semin Cell Dev Biol. S1084-9521(22)00004-0. doi: 10.1016/j.semcdb.2022.01.002.
   Web of Science ®Google Scholar
• Rodríguez LR, Lapeña-Luzón T, Benetó N, Beltran-Beltran V, Pallardó FV, Gonzalez-Cabo P, Navarro JA. 2022. Therapeutic Strategies targeting mitochondrial calcium signaling: a new hope for neurological diseases? Antioxidants. 11(1):165. doi: 10.3390/antiox11010165.
   Web of Science ®Google Scholar
• Rodriguez J, Li T, Xu Y, Sun Y, Zhu C. 2021. Role of apoptosis-inducing factor in perinatal hypoxic-ischemic brain injury. Neural Regen Res. 16:205–213. doi: 10.4103/1673-5374.290875.
   PubMed Web of Science ®Google Scholar
• Roe ND, Ren J. 2012. Nitric oxide synthase uncoupling: A therapeutic target in cardiovascular diseases. Vascul Pharmacol. 57:168–172. doi: 10.1016/j.vph.2012.02.004.
   PubMed Web of Science ®Google Scholar
• Rostovtseva TK, Bezrukov SM, Hoogerheide DP. 2021. Regulation of mitochondriaL Respiration by VDAC is enhanced by membrane-bound inhibitors with disordered polyanionic c-terminal domains. Int J Mol Sci. 22:7358. doi: 10.3390/ijms22147358.
   PubMed Web of Science ®Google Scholar
• Rouault TA. 2016. Mitochondrial iron overload: causes and consequences. Curr Opin Genet Dev. 38:31–37. doi: 10.1016/j.gde.2016.02.004.
   PubMed Web of Science ®Google Scholar
• Rubin JB. 2022. The spectrum of sex differences in cancer. Trends Cancer. 8:303–315. doi: 10.1016/j.trecan.2022.01.013.
   PubMed Web of Science ®Google Scholar
• Rueda CB, Llorente-Folch I, Traba J, Amigo I, Gonzalez-Sanchez P, Contreras L, Juaristi I, Martinez-Valero P, Pardo B, Del Arco A, et al. 2016. Glutamate excitotoxicity and Ca 2+ -regulation of respiration: Role of the Ca 2+ activated mitochondrial transporters (CaMCs). Biochim Biophys Acta BBA - Bioenerg. 1857:1158–1166. doi: 10.1016/j.bbabio.2016.04.003.
   PubMed Web of Science ®Google Scholar
• Ruiz LM, Libedinsky A, Elorza AA. 2021. Role of copper on mitochondrial function and metabolism. Front Mol Biosci. 8. doi: 10.3389/fmolb.2021.711227.
   PubMed Web of Science ®Google Scholar
• Ruprecht JJ, Kunji ERS. 2020. The SLC25 mitochondrial carrier family: structure and mechanism. Trends Biochem Sci. 45:244–258. doi: 10.1016/j.tibs.2019.11.001.
   PubMed Web of Science ®Google Scholar
• Ryan DG, Yang M, Prag HA, Blanco GR, Nikitopoulou E, Segarra-Mondejar M, Powell CA, Young T, Burger N, Miljkovic JL, et al. 2021. Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism. eLife. 10:e72593.doi:10.7554/eLife.72593.
   Google Scholar
• Sabharwal SS, Schumacker PT. 2014. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles’ heel? Nat Rev Cancer. 14:709–721. doi: 10.1038/nrc3803.
   PubMed Web of Science ®Google Scholar
• Saeedi BJ, Liu KH, Owens JA, Hunter-Chang S, Camacho MC, Eboka RU, Chandrasekharan B, Baker NF, Darby TM, Robinson BS, et al. 2020. Gut-resident lactobacilli activate hepatic Nrf2 and protect against oxidative liver injury. Cell Metab. 31:956–968.e5. doi: 10.1016/j.cmet.2020.03.006.
   PubMed Web of Science ®Google Scholar
• Saint-Georges-Chaumet Y, Edeas M. 2016. Microbiota-mitochondria inter-talk: consequence for microbiota-host interaction. Pathog Dis. 74:ftv096. doi: 10.1093/femspd/ftv096.
   PubMed Web of Science ®Google Scholar
• Saito Y, Nishio K, Ogawa Y, Kimata J, Kinumi T, Yoshida Y, Noguchi N, Niki E. 2006. Turning point in apoptosis/necrosis induced by hydrogen peroxide. Free Radic Res. 40:619–630. doi: 10.1080/10715760600632552.
   PubMed Web of Science ®Google Scholar
• Saleh J, Peyssonnaux C, Singh KK, Edeas M. 2020. Mitochondria and microbiota dysfunction in COVID-19 pathogenesis. Mitochondrion. 54:1–7. doi: 10.1016/j.mito.2020.06.008.
   PubMed Web of Science ®Google Scholar
• Sánchez-Caballero L, Ruzzenente B, Bianchi L, Assouline Z, Barcia G, Metodiev MD, Rio M, Funalot B, van den Brand MAM, Guerrero-Castillo S, et al. 2016. Mutations in complex i assembly factor tmem126b result in muscle weakness and isolated complex i deficiency. Am J Hum Genet. 99:208–216. doi: 10.1016/j.ajhg.2016.05.022.
   PubMed Web of Science ®Google Scholar
• Sander P, Gudermann T, Schredelseker J. 2021. A calcium guard in the outer membrane: is vdac a regulated gatekeeper of mitochondrial calcium uptake? Int J Mol Sci. 22:946. doi: 10.3390/ijms22020946.
   PubMed Web of Science ®Google Scholar
• Santolini J, Wootton SA, Jackson AA, Feelisch M. 2019. The redox architecture of physiological function. Curr Opin Physiol. 9:34–47. doi: 10.1016/j.cophys.2019.04.009.
   PubMed Web of Science ®Google Scholar
• Santos JH. 2021. Mitochondria signaling to the epigenome: a novel role for an old organelle. Free Radic Biol Med. 170:59–69. doi: 10.1016/j.freeradbiomed.2020.11.016.
   PubMed Web of Science ®Google Scholar
• Scammahorn JJ, Nguyen ITN, Bos EM, Van Goor H, Joles JA. 2021. Fighting oxidative stress with sulfur: hydrogen sulfide in the renal and cardiovascular systems. Antioxid Basel Switz. 10:373. doi: 10.3390/antiox10030373.
   PubMed Web of Science ®Google Scholar
• Schalkwijk CG, Stehouwer CDA. 2020. Methylglyoxal, a Highly reactive dicarbonyl compound, in diabetes, its vascular complications, and other age-related diseases. Physiol Rev. 100:407–461. doi: 10.1152/physrev.00001.2019.
   PubMed Web of Science ®Google Scholar
• Schmidt O, Pfanner N, Meisinger C. 2010. Mitochondrial protein import: from proteomics to functional mechanisms. Nat Rev Mol Cell Biol. 11:655–667. doi: 10.1038/nrm2959.
   PubMed Web of Science ®Google Scholar
• Schmitt K, Grimm A, Dallmann R, Oettinghaus B, Restelli LM, Witzig M, Ishihara N, Mihara K, Ripperger JA, Albrecht U, et al. 2018. Circadian control of DRP1 activity regulates mitochondrial dynamics and bioenergetics. Cell Metab. 27:657–666.e5. doi: 10.1016/j.cmet.2018.01.011.
   PubMed Web of Science ®Google Scholar
• Schuler M-H, English AM, Xiao T, Campbell TJ, Shaw JM, Hughes AL. 2021. Mitochondrial-derived compartments facilitate cellular adaptation to amino acid stress. Mol Cell. 81:3786–3802.e13. doi: 10.1016/j.molcel.2021.08.021.
   PubMed Web of Science ®Google Scholar
• Scrima R, Cela O, Agriesti F, Piccoli C, Tataranni T, Pacelli C, Mazzoccoli G, Capitanio N. 2020. Mitochondrial calcium drives clock gene-dependent activation of pyruvate dehydrogenase and of oxidative phosphorylation. Biochim Biophys Acta BBA - Mol Cell Res. 1867:118815. doi: 10.1016/j.bbamcr.2020.118815.
   PubMed Web of Science ®Google Scholar
• Scrima R, Cela O, Merla G, Augello B, Rubino R, Quarato G, Fugetto S, Menga M, Fuhr L, Relógio A, et al. 2016. Clock-genes and mitochondrial respiratory activity: evidence of a reciprocal interplay. Biochim Biophys Acta BBA - Bioenerg. 1857:1344–1351. doi: 10.1016/j.bbabio.2016.03.035.
   PubMed Web of Science ®Google Scholar
• Sena LA, Chandel NS. 2012. Physiological roles of mitochondrial reactive oxygen species. Mol Cell. 48:158–167. doi: 10.1016/j.molcel.2012.09.025.
   PubMed Web of Science ®Google Scholar
• Shai N, Schuldiner M, Zalckvar E. 2016. No peroxisome is an island — peroxisome contact sites. Biochim Biophys Acta BBA - Mol Cell Res. 1863:1061–1069. doi: 10.1016/j.bbamcr.2015.09.016.
   PubMed Web of Science ®Google Scholar
• Shan Y, Cortopassi G. 2016. Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly. Mitochondrion. 26:94–103. doi: 10.1016/j.mito.2015.12.005.
   PubMed Web of Science ®Google Scholar
• Shandilya S, Kumar S, Kumar Jha N, Kumar Kesari K, Ruokolainen J. 2022. Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection. J Adv Res. 38:223–244. doi: 10.1016/j.jare.2021.09.005.
   PubMed Web of Science ®Google Scholar
• Shang H, Huang C, Xiao Z, Yang P, Zhang S, Hou X, Zhang L. 2023. Gut microbiota-derived tryptophan metabolites alleviate liver injury via AhR/Nrf2 activation in pyrrolizidine alkaloids-induced sinusoidal obstruction syndrome. Cell Biosci. 13:127. doi: 10.1186/s13578-023-01078-4.
   PubMed Web of Science ®Google Scholar
• Shanmugasundaram K, Nayak BK, Friedrichs WE, Kaushik D, Rodriguez R, Block K. 2017. NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance. Nat Commun. 8:997. doi: 10.1038/s41467-017-01106-1.
   PubMed Web of Science ®Google Scholar
• Shin WH, Chung KC. 2020. Human telomerase reverse transcriptase positively regulates mitophagy by inhibiting the processing and cytoplasmic release of mitochondrial PINK1. Cell Death Disease. 11:425. doi: 10.1038/s41419-020-2641-7.
   PubMed Web of Science ®Google Scholar
• Siddiqui R, Akbar N, Khan NA. 2021. Gut microbiome and human health under the space environment. J Appl Microbiol. 130:14–24. doi: 10.1111/jam.14789.
   PubMed Web of Science ®Google Scholar
• Sies H. 2015. Oxidative stress: a concept in redox biology and medicine. Redox Biol. 4:180–183. doi: 10.1016/j.redox.2015.01.002.
   PubMed Web of Science ®Google Scholar
• Sies H. 2017. Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. Redox Biol. 11:613–619. doi: 10.1016/j.redox.2016.12.035.
   PubMed Web of Science ®Google Scholar
• Sies H. 2020. Findings in redox biology: from H2O2 to oxidative stress. J Biol Chem. 295:13458–13473. doi: 10.1074/jbc.X120.015651.
   PubMed Web of Science ®Google Scholar
• Sies H, Jones DP. 2020. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol. 21:363–383. doi: 10.1038/s41580-020-0230-3.
   PubMed Web of Science ®Google Scholar
• Singhapol C, Pal D, Czapiewski R, Porika M, Nelson G, Saretzki GC. 2013. Mitochondrial telomerase protects cancer cells from nuclear dna damage and apoptosis. PLoS One. 8:e52989. doi: 10.1371/journal.pone.0052989.
   PubMed Web of Science ®Google Scholar
• Singh R, Chandrashekharappa S, Bodduluri SR, Baby BV, Hegde B, Kotla NG, Hiwale AA, Saiyed T, Patel P, Vijay-Kumar M, et al. 2019. Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway. Nat Commun. 10:89. doi: 10.1038/s41467-018-07859-7.
   PubMed Web of Science ®Google Scholar
• Singh R, Singh RK, Mahdi AA, Singh RK, Kumar A, Tripathi AK, Rai R, Singh U, Cornélissen G, Schwartzkopff O, et al. 2003. Circadian periodicity of plasma lipid peroxides and other anti-oxidants as putative markers in gynecological malignancies. Vivo Athens Greece. 17:593–600.
   PubMed Web of Science ®Google Scholar
• Singh V, Yeoh BS, Xiao X, Kumar M, Bachman M, Borregaard N, Joe B, Vijay-Kumar M. 2015. Interplay between enterobactin, myeloperoxidase and lipocalin 2 regulates E. coli survival in the inflamed gut. Nat Commun. 6:7113. doi: 10.1038/ncomms8113.
   PubMed Web of Science ®Google Scholar
• Snezhkina AV, Kudryavtseva AV, Kardymon OL, Savvateeva MV, Melnikova NV, Krasnov GS, Dmitriev AA. 2019. ROS generation and antioxidant defense systems in normal and malignant cells. Oxid Med Cell Longev. 2019:1–17. doi: 10.1155/2019/6175804.
   Web of Science ®Google Scholar
• Solier S, Müller S, Cañeque T, Versini A, Mansart A, Sindikubwabo F, Baron L, Emam L, Gestraud P, Pantoș GD, et al. 2023. A druggable copper-signalling pathway that drives inflammation. Nature. 617:386–394. doi: 10.1038/s41586-023-06017-4.
   PubMed Web of Science ®Google Scholar
• Song J, Herrmann JM, Becker T. 2021. Quality control of the mitochondrial proteome. Nat Rev Mol Cell Biol. 22:54–70. doi: 10.1038/s41580-020-00300-2.
   PubMed Web of Science ®Google Scholar
• Song X, Long D. 2020. Nrf2 and ferroptosis: a new research direction for neurodegenerative diseases. Front Neurosci. 14. doi: 10.3389/fnins.2020.00267.
   Web of Science ®Google Scholar
• Šrejber M, Navrátilová V, Paloncýová M, Bazgier V, Berka K, Anzenbacher P, Otyepka M. 2018. Membrane-attached mammalian cytochromes P450: An overview of the membrane’s effects on structure, drug binding, and interactions with redox partners. J Inorg Biochem. 183:117–136. doi: 10.1016/j.jinorgbio.2018.03.002.
   PubMed Web of Science ®Google Scholar
• Stangherlin A, Reddy AB. 2013. Regulation of Circadian clocks by redox homeostasis*. J Biol Chem. 288:26505–26511. doi: 10.1074/jbc.R113.457564.
   PubMed Web of Science ®Google Scholar
• Stier A. 2021. Human blood contains circulating cell-free mitochondria, but are they really functional? Am J Physiol -Endocrinol Metab. 320:E859–E863. doi: 10.1152/ajpendo.00054.2021.
   PubMed Web of Science ®Google Scholar
• Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, et al. 2017. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 171:273–285. doi: 10.1016/j.cell.2017.09.021.
   PubMed Web of Science ®Google Scholar
• Strasser B, Wolters M, Weyh C, Krüger K, Ticinesi A. 2021. The Effects of lifestyle and diet on gut microbiota composition, inflammation and muscle performance in our aging society. Nutrients. 13:2045. doi: 10.3390/nu13062045.
   PubMed Web of Science ®Google Scholar
• Stukalov A, Girault V, Grass V, Karayel O, Bergant V, Urban C, Haas DA, Huang Y, Oubraham L, Wang A, et al. 2021. Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature. 594:246–252. doi: 10.1038/s41586-021-03493-4.
   PubMed Web of Science ®Google Scholar
• Sullivan LB, Gui DY, Hosios AM, Bush LN, Freinkman E, Vander Heiden MG. 2015. Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells. Cell. 162:552–563. doi: 10.1016/j.cell.2015.07.017.
   PubMed Web of Science ®Google Scholar
• Sun Q, Zeng C, Du L, Dong C. 2021. Mechanism of circadian regulation of the NRF2/ARE pathway in renal ischemia‑reperfusion. Exp Ther Med. 21:1. doi: 10.3892/etm.2021.9622.
   PubMed Web of Science ®Google Scholar
• Suomalainen A, Battersby BJ. 2018. Mitochondrial diseases: the contribution of organelle stress responses to pathology. Nat Rev Mol Cell Biol. 19:77–92. doi: 10.1038/nrm.2017.66.
   PubMed Web of Science ®Google Scholar
• Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, et al. 1999. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 397:441–446. doi: 10.1038/17135.
   PubMed Web of Science ®Google Scholar
• Susin SA, Zamzami N, Kroemer G. 1998. Mitochondria as regulators of apoptosis: doubt no more. Biochim Biophys Acta BBA - Bioenerg. 1366:151–165. doi: 10.1016/S0005-2728(98)00110-8.
   PubMed Web of Science ®Google Scholar
• Szczepanowska K, Trifunovic A. 2021. Mitochondrial matrix proteases: quality control and beyond. FEBS J. 289:7128–7146. doi: 10.1111/febs.15964.
   PubMed Web of Science ®Google Scholar
• Tadokoro T, Ikeda M, Ide T, Deguchi H, Ikeda S, Okabe K, Ishikita A, Matsushima S, Koumura T, Yamada K, et al. 2020. Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity. JCI Insight. 5. doi:10.1172/jci.insight.132747.
   PubMed Web of Science ®Google Scholar
• Tafuri F, Ronchi D, Magri F, Comi GP, Corti S. 2015. SOD1 misplacing and mitochondrial dysfunction in amyotrophic lateral sclerosis pathogenesis. Front Cell Neurosci. 9:336. doi: 10.3389/fncel.2015.00336.
   PubMed Web of Science ®Google Scholar
• Tamaru T, Hattori M, Ninomiya Y, Kawamura G, Varès G, Honda K, Mishra DP, Wang B, Benjamin I, Sassone-Corsi P, et al. 2013. ROS stress resets circadian clocks to coordinate pro-survival signals. PLoS One. 8:e82006. doi: 10.1371/journal.pone.0082006.
   PubMed Web of Science ®Google Scholar
• Tanaka H, Okazaki T, Aoyama S, Yokota M, Koike M, Okada Y, Fujiki Y, Gotoh Y. 2019. Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent pathway of apoptosis. J Cell Sci Jcs. 224766. doi: 10.1242/jcs.224766.
   Web of Science ®Google Scholar
• Tang X, Yan Z, Miao Y, Ha W, Li Z, Yang L, Mi D. 2023. Copper in cancer: from limiting nutrient to therapeutic target. Front Oncol. 13. doi: 10.3389/fonc.2023.1209156.
   Web of Science ®Google Scholar
• Tartour K, Andriani F, Folco EG, Letkova D, Schneider R, Saidi I, Sato T, Welz P-S, Benitah SA, Allier C, et al. 2022. Mammalian PERIOD2 regulates H2A.Z incorporation in chromatin to orchestrate circadian negative feedback. Nature Structural & Molecular Biology. 29:549–562. doi: 10.1038/s41594-022-00777-9.
   PubMed Web of Science ®Google Scholar
• Taylor RW, Turnbull DM. 2005. Mitochondrial DNA mutations in human disease. Nat Rev Genet. 6:389–402. doi: 10.1038/nrg1606.
   PubMed Web of Science ®Google Scholar
• Tedesco L, Rossi F, Ragni M, Ruocco C, Brunetti D, Carruba MO, Torrente Y, Valerio A, Nisoli E. 2020. A Special amino-acid formula tailored to boosting cell respiration prevents mitochondrial dysfunction and oxidative stress caused by doxorubicin in mouse cardiomyocytes. Nutrients. 12:282. doi: 10.3390/nu12020282.
   PubMed Web of Science ®Google Scholar
• Teramoto S, Tomita T, Matsui H, Ohga E, Matsuse T, Ouchi Y. 1999. Hydrogen peroxide-induced apoptosis and necrosis in human lung fibroblasts: protective roles of glutathione. Jpn J Pharmacol. 79:33–40. doi: 10.1254/jjp.79.33.
   PubMedGoogle Scholar
• Tirichen H, Yaigoub H, Xu W, Wu C, Li R, Li Y. 2021. Mitochondrial reactive oxygen species and their contribution in chronic kidney disease progression through oxidative stress. Front Physiol. 12:627837. doi: 10.3389/fphys.2021.627837.
   PubMed Web of Science ®Google Scholar
• Todkar K, Ilamathi HS, Germain M. 2017. Mitochondria and Lysosomes: discovering bonds. Front Cell Dev Biol. 5:106. doi: 10.3389/fcell.2017.00106.
   PubMed Web of Science ®Google Scholar
• Tonazzi A, Giangregorio N, Console L, Palmieri F, Indiveri C. 2021. The mitochondrial Carnitine acyl-carnitine carrier (SLC25A20): molecular mechanisms of transport, role in redox sensing and interaction with drugs. Biomolecules. 11:521. doi: 10.3390/biom11040521.
   PubMed Web of Science ®Google Scholar
• Tonelli C, Chio IIC, Tuveson DA. 2018. Transcriptional regulation by Nrf2. Antioxid Redox Signal. 29:1727–1745. doi: 10.1089/ars.2017.7342.
   PubMed Web of Science ®Google Scholar
• Torrens-Mas M, Pons D-G, Sastre-Serra J, Oliver J, Roca P. 2020. Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological Implications Redox Biol. 31:101505. doi: 10.1016/j.redox.2020.101505.
   PubMed Web of Science ®Google Scholar
• Trisolini L, Laera L, Favia M, Muscella A, Castegna A, Pesce V, Guerra L, De Grassi A, Volpicella M, Pierri CL. 2021. Differential expression of ADP/ATP carriers as a biomarker of metabolic remodeling and survival in kidney cancers. Biomolecules. 11:38. doi: 10.3390/biom11010038.
   Web of Science ®Google Scholar
• Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, et al. 2022. Copper induces cell death by targeting lipoylated TCA cycle proteins. Sci. 375:1254–1261. doi: 10.1126/science.abf0529.
   PubMed Web of Science ®Google Scholar
• Tyagi S, Tyagi S, Sathnur S, Sen U, Akinterinwa O, Zheng Y, Mokshagundam S, Singh M. 2023. Role of the circadian clock system in trans-sulfuration pathway and tissue remodeling. Physiology. 38:5732949. doi: 10.1152/physiol.2023.38.S1.5732949.
   Web of Science ®Google Scholar
• Vergeade A, Mulder P, Vendeville C, Ventura-Clapier R, Thuillez C, Monteil C. 2012. Xanthine oxidase contributes to mitochondrial ROS generation in an experimental model of cocaine-induced diastolic dysfunction. J Cardiovasc Pharmacol. 60:538–543. doi: 10.1097/FJC.0b013e318271223c.
   PubMed Web of Science ®Google Scholar
• Verma M, Lizama BN, Chu CT. 2022. Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration. Transl Neurodegener. 11:3. doi: 10.1186/s40035-021-00278-7.
   PubMed Web of Science ®Google Scholar
• Vezza T, Abad-Jiménez Z, Marti-Cabrera M, Rocha M, Víctor VM. 2020. Microbiota-mitochondria inter-talk: a potential therapeutic strategy in obesity and type 2 diabetes. Antioxidants. 9:848. doi: 10.3390/antiox9090848.
   Web of Science ®Google Scholar
• Voigt RM, Summa KC, Forsyth CB, Green SJ, Engen P, Naqib A, Vitaterna MH, Turek FW, Keshavarzian A. 2016. The Circadian Clock mutation promotes intestinal dysbiosis. Alcohol Clin Exp Res. 40:335–347. doi: 10.1111/acer.12943.
   PubMed Web of Science ®Google Scholar
• Voorhies AA, Mark Ott C, Mehta S, Pierson DL, Crucian BE, Feiveson A, Oubre CM, Torralba M, Moncera K, Zhang Y, et al. 2019. Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome. Sci Rep. 9:9911. doi: 10.1038/s41598-019-46303-8.
   PubMed Web of Science ®Google Scholar
• Wallace DC. 2005. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet. 39:359. doi: 10.1146/annurev.genet.39.110304.095751.
   PubMed Web of Science ®Google Scholar
• Wallace DC. 2013. A mitochondrial bioenergetic etiology of disease. J Clin Invest. 123:1405–1412. doi: 10.1172/JCI61398.
   PubMed Web of Science ®Google Scholar
• Wallace DC, Singh G, Lott MT, Hodge JA, Schurr TG, Lezza AMS, Elsas LJ, Nikoskelainen EK. 1988. Mitochondrial DNA mutation associated with leber’s hereditary optic Neuropathy. Science. 242:1427–1430. doi: 10.1126/science.3201231.
   PubMed Web of Science ®Google Scholar
• Wang G, Fan Y, Cao P, Tan K. 2022. Insight into the mitochondrial unfolded protein response and cancer: opportunities and challenges. Cell Biosci. 12:18. doi: 10.1186/s13578-022-00747-0.
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhang X, Yao H, Chen X, Shang L, Li P, Cui X, Zeng J. 2022. Peroxisome-generated succinate induces lipid accumulation and oxidative stress in the kidneys of diabetic mice. J Biol Chem. 298:101660. doi: 10.1016/j.jbc.2022.101660.
   PubMed Web of Science ®Google Scholar
• Wible RS, Ramanathan C, Sutter CH, Olesen KM, Kensler TW, Liu AC, Sutter TR. 2018. NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus. eLife. 7:e31656. doi: 10.7554/eLife.31656.
   PubMed Web of Science ®Google Scholar
• Wibom R, Lasorsa FM, Töhönen V, Barbaro M, Sterky FH, Kucinski T, Naess K, Jonsson M, Pierri CL, Palmieri F, et al. 2009. AGC1 deficiency associated with global cerebral hypomyelination. N Engl J Med. 361:489–495. doi: 10.1056/NEJMoa0900591.
   PubMed Web of Science ®Google Scholar
• Wiehe RS, Gole B, Chatre L, Walther P, Calzia E, Ricchetti M, Wiesmüller L. 2018. Endonuclease G promotes mitochondrial genome cleavage and replication. Oncotarget. 9:18309–18326. doi: 10.18632/oncotarget.24822.
   PubMedGoogle Scholar
• Wu D, Hu Q, Zhu D. 2018. An update on hydrogen sulfide and nitric oxide interactions in the cardiovascular system. Oxid Med Cell Longev. 2018:1–16. doi: 10.1155/2018/4579140.
   Web of Science ®Google Scholar
• Wu R, Li S, Hudlikar R, Wang L, Shannar A, Peter R, Chou PJ, Kuo H-CD, Liu Z, Kong A-N. 2022. Redox signaling, mitochondrial metabolism, epigenetics and redox active phytochemicals. Free Radic Biol Med. 179:328–336. doi: 10.1016/j.freeradbiomed.2020.12.007.
   PubMed Web of Science ®Google Scholar
• Wu S, Lu H, Bai Y. 2019. Nrf2 in cancers: a double-edged sword. Cancer Med. 8:2252–2267. doi: 10.1002/cam4.2101.
   PubMed Web of Science ®Google Scholar
• Wu P, Zhang X, Duan D, Zhao L. 2023. Organelle-specific mechanisms in crosstalk between apoptosis and ferroptosis. Oxid Med Cell Longev. 2023:3400147. doi: 10.1155/2023/3400147.
   PubMed Web of Science ®Google Scholar
• Wu B, Zhao TV, Jin K, Hu Z, Abdel MP, Warrington KJ, Goronzy JJ, Weyand CM. 2021. Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation. Nat Immunol. 22:1551–1562. doi: 10.1038/s41590-021-01065-2.
   PubMed Web of Science ®Google Scholar
• Xia M, Zhang Y, Jin K, Lu Z, Zeng Z, Xiong W. 2019. Communication between mitochondria and other organelles: a brand-new perspective on mitochondria in cancer. Cell Biosci. 9:27. doi: 10.1186/s13578-019-0289-8.
   PubMed Web of Science ®Google Scholar
• Yan B, Ai Y, Sun Q, Ma Y, Cao Y, Wang J, Zhang Z, Wang X. 2021. Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1. Mol Cell. 81:355–369.e10. doi: 10.1016/j.molcel.2020.11.024.
   PubMed Web of Science ®Google Scholar
• Yang X, Wang H, Huang C, He X, Xu W, Luo Y, Huang K. 2017. Zinc enhances the cellular energy supply to improve cell motility and restore impaired energetic metabolism in a toxic environment induced by OTA. Sci Rep. 7:14669. doi: 10.1038/s41598-017-14868-x.
   PubMed Web of Science ®Google Scholar
• Ye R, Selby CP, Chiou Y-Y, Ozkan-Dagliyan I, Gaddameedhi S, Sancar A. 2014. Dual modes of CLOCK: BMAL1 inhibition mediated by cryptochrome and Period proteins in the mammalian circadian clock. Genes Dev. 28:1989–1998. doi: 10.1101/gad.249417.114.
   PubMed Web of Science ®Google Scholar
• Yin W, Wang C, Peng Y, Yuan W, Zhang Z, Liu H, Xia Z, Ren C, Qian J. 2020. Dexmedetomidine alleviates H2O2-induced oxidative stress and cell necroptosis through activating of α2-adrenoceptor in H9C2 cells. Mol Biol Rep. 47:3629–3639. doi: 10.1007/s11033-020-05456-w.
   PubMed Web of Science ®Google Scholar
• Yoo HC, Yu YC, Sung Y, Han JM. 2020. Glutamine reliance in cell metabolism. Exp. Mol. Med. 52:1496–1516. doi: 10.1038/s12276-020-00504-8.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Li Y, Barber AF, Noya SB, Williams JA, Li F, Daniel SG, Bittinger K, Fang J, Sehgal A. 2023. The microbiome stabilizes circadian rhythms in the gut. Proc Natl Acad Sci. 120:e2217532120. doi: 10.1073/pnas.2217532120.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Peng L, Song W. 2020. Mitochondria hyperactivity contributes to social behavioral impairments. Signal Transduct Target Ther. 5:126. doi: 10.1038/s41392-020-00239-y.
   PubMed Web of Science ®Google Scholar
• Zhang G, Sheng M, Wang J, Teng T, Sun Y, Yang Q, Xu Z. 2018. Zinc improves mitochondrial respiratory function and prevents mitochondrial ROS generation at reperfusion by phosphorylating STAT3 at Ser727. J Mol Cell Cardiol. 118:169–182. doi: 10.1016/j.yjmcc.2018.03.019.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wong HS. 2021. Are mitochondria the main contributor of reactive oxygen species in cells? J Exp Biol. 224:jeb221606. doi: 10.1242/jeb.221606.
   PubMed Web of Science ®Google Scholar
• Zhang S, Xin W, Anderson GJ, Li R, Gao L, Chen S, Zhao J, Liu S. 2022. Double-edge sword roles of iron in driving energy production versus instigating ferroptosis. Cell Death Disease. 13:1–13. doi: 10.1038/s41419-021-04490-1.
   Web of Science ®Google Scholar
• Zhang S, Zhao Y, Ohland C, Jobin C, Sang S. 2019. Microbiota facilitates the formation of the aminated metabolite of green tea polyphenol (-)-epigallocatechin-3-gallate which trap deleterious reactive endogenous metabolites. Free Radic Biol Med. 131:332–344. doi: 10.1016/j.freeradbiomed.2018.12.023.
   PubMed Web of Science ®Google Scholar
• Zhao T-X, Wei Y-X, Wang J-K, Han L-D, Sun M, Wu Y-H, Shen L-J, Long C-L, Wu S-D, Wei G-H. 2020. The gut-microbiota-testis axis mediated by the activation of the Nrf2 antioxidant pathway is related to prepuberal steroidogenesis disorders induced by di-(2-ethylhexyl) phthalate. Environ Sci Pollut Res. 27:35261–35271. doi: 10.1007/s11356-020-09854-2.
   PubMed Web of Science ®Google Scholar
• Zhao F, Zou M-H. 2021. Role of the mitochondrial protein import machinery and protein processing in heart disease. Front Cardiovasc Med. 8. doi: 10.3389/fcvm.2021.749756.
   Web of Science ®Google Scholar
• Zheng J, Chen X, Liu Q, Zhong G, Zhuang M. 2021. Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy. J Cell Biol. 221:e202103156. doi: 10.1083/jcb.202103156.
   PubMed Web of Science ®Google Scholar
• Zheng F, Gonçalves FM, Abiko Y, Li H, Kumagai Y, Aschner M. 2020. Redox toxicology of environmental chemicals causing oxidative stress. Redox Biol. 34:101475. doi: 10.1016/j.redox.2020.101475.
   PubMed Web of Science ®Google Scholar
• Zheng Q, Huang J, Wang G. 2019. Mitochondria, telomeres and telomerase subunits. Front Cell Dev Biol. 7:274. doi: 10.3389/fcell.2019.00274.
   PubMed Web of Science ®Google Scholar
• Zhu D, Wu X, Zhou J, Li X, Huang X, Li J, Wu J, Bian Q, Wang Y, Tian Y. 2020. NuRD mediates mitochondrial stress–induced longevity via chromatin remodeling in response to acetyl-CoA level. Sci Adv. 6:eabb2529. doi: 10.1126/sciadv.abb2529.
   PubMed Web of Science ®Google Scholar
• Zhu L, Zhou Q, He L, Chen L. 2021. Mitochondrial unfolded protein response: an emerging pathway in human diseases. Free Radic Biol Med. 163:125–134. doi: 10.1016/j.freeradbiomed.2020.12.013.
   PubMed Web of Science ®Google Scholar
• Zinghirino F, Pappalardo XG, Messina A, Nicosia G, De Pinto V, Guarino F. 2021. VDAC genes expression and regulation in mammals. Front Physiol. 12:708695. doi: 10.3389/fphys.2021.708695.
   PubMed Web of Science ®Google Scholar
• Zischka H, Einer C. 2018. Mitochondrial copper homeostasis and its derailment in Wilson disease. Int J Biochem Cell Biol. 102:71–75. doi: 10.1016/j.biocel.2018.07.001.
   PubMed Web of Science ®Google Scholar