Multifunctional nanoparticles for prostate cancer therapy

Carolina Salvador-Morales Laboratory of Nanomedicine and Biomaterials, Department of Anaesthesia, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA and Harvard-MIT Center of Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA

Weiwei Gao Laboratory of Nanomedicine and Biomaterials, Department of Anaesthesia, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA and Harvard-MIT Center of Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA

Pooja Ghatalia Laboratory of Nanomedicine and Biomaterials, Department of Anesthesia Brigham and Women’s Hospital-Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA

Farhan Murshed Laboratory of Nanomedicine and Biomaterials, Department of Anaesthesia, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA

Wataru Aizu Laboratory of Nanomedicine and Biomaterials, Department of Anaesthesia, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA and Harvard-MIT Center of Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA

Robert Langer Institute Professor, Harvard-MIT Center of Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA and Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA

Omid C Farokhzad Harvard-MIT Center of Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA and Laboratory of Nanomedicine and Biomaterials, Department of Anaesthesia, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. [email protected]

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Abstract

Multifunctional nanoparticles promise significantly better treatment for prostate cancer. This review begins with a molecular and physiological overview of prostate cancer, including current treatments in various stages of disease development. Emerging nanoparticle technology in chemotherapy, hyperthermia therapy and gene therapy will be discussed. We highlight novel advances in nanoparticle technology for prostate cancer and indicate future challenges in the rational design of multifunctional nanoparticles, such as understanding tumor characteristics and the activation of the complement system.

Keywords::

Financial & competing interests disclosure

This work was supported by NIH Grants CA119349 and EB003647 and David Koch-Prostate Cancer Foundation Award in Nanotherapeutics. OC Farokhzad and R Langer have financial interest in BIND Biosciences. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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Multifunctional nanoparticles for prostate cancer therapy

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Multifunctional nanoparticles for prostate cancer therapy

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