Potential therapeutic effects of Cordyceps cicadae and Paecilomyces cicadae on adenine-induced chronic renal failure in rats and their phytochemical analysis

Abstract

Background

Natural Cordyceps cicadae (C. cicadae) has been utilized extensively in traditional Chinese medicine to treat chronic renal diseases, heart palpitations, infantile convulsions, and dizziness. However, given its slow growth and immoderate exploitation, C. cicadae resources have been severely depleted. By contrast, Paecilomyces cicadae (P. cicadae), as the anamorph stage of C. cicadae, is easy to cultivate, and this kind of cultivated P. cicadae has good and controllable quality.

Purpose

This study aimed to compare the therapeutic effects of C. cicadae and P. cicadae on adenine-induced chronic renal failure (CRF) rats. In accordance with the aforementioned studies, our work subsequently analyzed the intrinsic relationships between the efficacy and pharmacodynamic substances of C. cicadae and P. cicadae to conclude whether or not P. cicadae could be used as an alternative to C. cicadae in treating CRF.

Methods

Rats were administered with C. cicadae (1.0 g/kg) or P. cicadae (1.0 g/kg) by gavage for 4 weeks. Furthermore, we applied Fourier transform infrared spectroscopy, gas chromatography–mass spectrometry, liquid chromatography–tandem mass spectrometry, and ultraviolet spectrophotometry to comprehensively detect and analyze the chemical constituent differences from ten batches each of C. cicadae and P. cicadae.

Results

This study revealed that both C. cicadae and P. cicadae exerted obvious therapeutic effects on CRF and were more consistent with their chemical compositions.

Conclusion

P. cicadae can be used as an alternative to C. cicadae for treating CRF to cater to market demands.

Keywords:

• Cordyceps cicadae
• Paecilomyces cicadae
• chronic renal failure
• FTIR
• GC-MS
• LC-MS/MS
• identification

Acknowledgments

This research was funded by grants from Program of Shanghai Committee of Science and Technology (Grant No 17401902300) and Program of Shanghai Academic/Technology Research Leader (Grant No 18XD1403700).

Author contributions

BW and YW contributed to the conception of the paper; LL, CL, and NL contributed significantly to complete the experimental work; LL and LX prepared the manuscript; TH and TZ contributed to the constructive discussions. All authors contributed to data analysis, drafting and revising the article, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.

Disclosure

The authors report no conflicts of interest in this work.