Drug Design, Development and Therapy, Volume 13, Issue (2019)

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Drug Design, Development and Therapy, Volume 13, Issue (2019)

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Review

Review Article
Combination of rifaximin and lactulose improves clinical efficacy and mortality in patients with hepatic encephalopathy
Zhida Wang, Pei Chu & Wenjin Wang
Pages: 1-11
Published online: 17 Dec 2018
AbstractforCombination of rifaximin and lactulose improves clinical efficacy and mortality in patients with hepatic encephalopathy | Full Text | References | PDF (1.8 MB) | EPUB
  • 437 Views
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Open Access

Original Research

Article
Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study
Emine Turkmen Samdanci, Mustafa Huz, Onural Ozhan, Kevser Tanbek, Esra Pamukcu, Ayse Nur Akatli & Hakan Parlakpinar
Pages: 13-21
Published online: 29 Sep 2022
AbstractforCytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study | Full Text | References | PDF (1.7 MB) | EPUB
  • 195 Views
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Open Access
Article
Multimetal organic frameworks as drug carriers: aceclofenac as a drug candidate
Muder Al Haydar, Hussein Rasool Abid, Bruce Sunderland & Shaobin Wang
Pages: 23-35
Published online: 29 Sep 2022
AbstractforMultimetal organic frameworks as drug carriers: aceclofenac as a drug candidate | Full Text | References | PDF (2.3 MB) | EPUB
  • 168 Views
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Open Access

Clinical Trial Report

Ocular side effects of Levitra® (vardenafil) – results of a double-blind crossover study in healthy male subjects
Gernot Roessler, Michael Vobig, Peter Walter & Babac AE Mazinani
Pages: 37-43
Published online: 18 Dec 2018
AbstractforOcular side effects of Levitra® (vardenafil) – results of a double-blind crossover study in healthy male subjects | Full Text | References | PDF (234.4 KB) | EPUB
  • 171 Views
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Open Access

Original Research

Article
Osteogenic effect of bone marrow mesenchymal stem cell-derived exosomes on steroid-induced osteonecrosis of the femoral head
Shanhong Fang, Yongfeng Li & Peng Chen
Pages: 45-55
Published online: 18 Dec 2018
AbstractforOsteogenic effect of bone marrow mesenchymal stem cell-derived exosomes on steroid-induced osteonecrosis of the femoral head | Full Text | References | PDF (3.2 MB) | EPUB
  • 189 Views
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Open Access

Review

Review Article
Tocilizumab in the treatment of rheumatoid arthritis: an evidence-based review and patient selection
Martina Biggioggero, Chiara Crotti, Andrea Becciolini & Ennio Giulio Favalli
Pages: 57-70
Published online: 19 Dec 2018
AbstractforTocilizumab in the treatment of rheumatoid arthritis: an evidence-based review and patient selection | Full Text | References | PDF (286.2 KB) | EPUB
  • 373 Views
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Open Access

Original Research

Article
Protective effects of ethyl gallate and pentagalloylglucose, the active components of Qingwen Baidu Decoction, against lipopolysaccharide-induced acute lung injury in rats
Qi Zhang, Jing Nie, Su-Juan Chen & Qiang Li
Pages: 71-77
Published online: 19 Dec 2018
AbstractforProtective effects of ethyl gallate and pentagalloylglucose, the active components of Qingwen Baidu Decoction, against lipopolysaccharide-induced acute lung injury in rats | Full Text | References | PDF (1.5 MB) | EPUB
  • 111 Views
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Open Access
Article
Efficacy of neoadjuvant platinum-based chemotherapy during the second and third trimester of pregnancy in women with cervical cancer: an updated systematic review and meta-analysis
Yizuo Song, Yi Liu, Min Lin, Bo Sheng & Xueqiong Zhu
Pages: 79-102
Published online: 19 Dec 2018
AbstractforEfficacy of neoadjuvant platinum-based chemotherapy during the second and third trimester of pregnancy in women with cervical cancer: an updated systematic review and meta-analysis | Full Text | References | PDF (696.1 KB) | EPUB
  • 325 Views
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Open Access
Article
Potential therapeutic effects of Cordyceps cicadae and Paecilomyces cicadae on adenine-induced chronic renal failure in rats and their phytochemical analysis
Ling Li, Tong Zhang, Chunru Li, Lu Xie, Ning Li, Tianling Hou, Yuqin Wang & Bing Wang
Pages: 103-117
Published online: 19 Dec 2018
AbstractforPotential therapeutic effects of Cordyceps cicadae and Paecilomyces cicadae on adenine-induced chronic renal failure in rats and their phytochemical analysis | Full Text | References | PDF (5.1 MB) | EPUB
  • 233 Views
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Open Access
Article
Tetrandrine suppresses cervical cancer growth by inducing apoptosis in vitro and in vivo
Haiyan Zhang, Beibei Xie, Zhen Zhang, Xiugui Sheng & Shiqian Zhang
Pages: 119-127
Published online: 20 Dec 2018
AbstractforTetrandrine suppresses cervical cancer growth by inducing apoptosis in vitro and in vivo | Full Text | References | PDF (1.8 MB) | EPUB
  • 124 Views
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Open Access
Article
Pharmacokinetic interactions and tolerability of berberine chloride with simvastatin and fenofibrate: an open-label, randomized, parallel study in healthy Chinese subjects
Guofei Li, Mingming Zhao, Feng Qiu, Yaxin Sun & Limei Zhao
Pages: 129-139
Published online: 20 Dec 2018
AbstractforPharmacokinetic interactions and tolerability of berberine chloride with simvastatin and fenofibrate: an open-label, randomized, parallel study in healthy Chinese subjects | Full Text | References | PDF (525.2 KB) | EPUB
  • 178 Views
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Open Access
Article
Fenofibrate modified-release pellets with lag phase and high oral bioavailability
Fang Li, Xin Zheng, YongChu Bao, Ting Chen, Jia Zeng, XiaoLi Xu, Chao Yan & LingLin Feng
Pages: 141-151
Published online: 29 Sep 2022
AbstractforFenofibrate modified-release pellets with lag phase and high oral bioavailability | Full Text | References | PDF (2.8 MB) | EPUB
  • 205 Views
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Open Access
Article
Neuroprotective effects of dexmedetomidine against isoflurane-induced neuronal injury via glutamate regulation in neonatal rats
Xue Wang, Yangyang Shan, Zhiyin Tang, Linlin Gao & Hongtao Liu
Pages: 153-160
Published online: 21 Dec 2018
AbstractforNeuroprotective effects of dexmedetomidine against isoflurane-induced neuronal injury via glutamate regulation in neonatal rats | Full Text | References | PDF (1.3 MB) | EPUB
  • 133 Views
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Open Access
Article
Urapidil, compared to nitroglycerin, has better clinical safety in the treatment of hypertensive patients with acute heart failure: a meta-analysis
Jiaxiao Shi, Yulin Li, Cong Xing, Peng Peng, Hongyu Shi, Han Ding, Pengyuan Zheng, Guangzhi Ning & Shiqing Feng
Pages: 161-172
Published online: 27 Dec 2018
AbstractforUrapidil, compared to nitroglycerin, has better clinical safety in the treatment of hypertensive patients with acute heart failure: a meta-analysis | Full Text | References | PDF (1.2 MB) | EPUB
  • 170 Views
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Open Access
Article
Xyloketal derivative C53N protects against mild traumatic brain injury in mice
Fengyin Liang, Fengjuan Su, Xiaoxiao Wang, Simei Long, Yinglin Zheng, Xiaofei He, Jiyan Pang & Zhong Pei
Pages: 173-182
Published online: 27 Dec 2018
AbstractforXyloketal derivative C53N protects against mild traumatic brain injury in mice | Full Text | References | PDF (3 MB) | EPUB
  • 84 Views
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Open Access
Article
Efficacy and safety of sodium cantharidinate and vitamin B6 injection for the treatment of digestive system neoplasms: a meta-analysis of randomized controlled trials
Meirong Liu, Chunhong Xu & Yingying Sun
Pages: 183-203
Published online: 28 Dec 2018
AbstractforEfficacy and safety of sodium cantharidinate and vitamin B6 injection for the treatment of digestive system neoplasms: a meta-analysis of randomized controlled trials | Full Text | References | PDF (3.2 MB) | EPUB
  • 127 Views
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Open Access
Article
Formulation and clinical investigation of optimized vinpocetine lyoplant-tabs: new strategy in development of buccal solid dosage form
Tarek A Ahmed
Pages: 205-220
Published online: 28 Dec 2018
AbstractforFormulation and clinical investigation of optimized vinpocetine lyoplant-tabs: new strategy in development of buccal solid dosage form | Full Text | References | PDF (1.5 MB) | EPUB
  • 186 Views
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Open Access

Review

Review Article
Comparative effectiveness and safety of traditional Chinese medicine supporting Qi and enriching blood for cancer related anemia in patients not receiving chemoradiotherapy: a meta-analysis and systematic review
Zhibo Dang, Xiaoli Liu, Xinhui Wang, Mengge Li, Yuyong Jiang, Xianbo Wang & Zhiyun Yang
Pages: 221-230
Published online: 28 Dec 2018
AbstractforComparative effectiveness and safety of traditional Chinese medicine supporting Qi and enriching blood for cancer related anemia in patients not receiving chemoradiotherapy: a meta-analysis and systematic review | Full Text | References | PDF (746.8 KB) | EPUB
  • 211 Views
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Original Research

Article
A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model
Yejin Yang, Wooseong Kim, Dayoon Kim, Seongkeun Jeong, Jin-Wook Yoo & Yunjin Jung
Pages: 231-242
Published online: 28 Dec 2018
AbstractforA colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model | Full Text | References | PDF (1.4 MB) | EPUB
  • 121 Views
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Open Access
Article
Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway
Yuan Wang, Yali Shao, Yuqing Gao, Guoran Wan, Dong Wan, Huifeng Zhu, Yan Qiu & Xiyue Ye
Pages: 243-253
Published online: 31 Dec 2018
AbstractforCatalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway | Full Text | References | PDF (1.1 MB) | EPUB
  • 132 Views
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Open Access
Article
Bioequivalence of two quetiapine extended release tablets in Chinese healthy volunteers under fasting and fed conditions and effects of food on pharmacokinetic profiles
Xiaomei Huang, Suhua Zhang, Yanxia Ma, Heng Yang, Chuan He, Rufang Tian, Han Mei, Lipeng Liu & Bikui Zhang
Pages: 255-264
Published online: 31 Dec 2018
AbstractforBioequivalence of two quetiapine extended release tablets in Chinese healthy volunteers under fasting and fed conditions and effects of food on pharmacokinetic profiles | Full Text | References | PDF (390.9 KB) | EPUB
  • 193 Views
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Open Access
Article
Effect of progesterone administration on the prognosis of patients with severe traumatic brain injury: a meta-analysis of randomized clinical trials
Zhi-Yong Pan, Yu-Hang Zhao, Wen-Hong Huang, Zhi-Ze Xiao & Zhi-Qiang Li
Pages: 265-273
Published online: 11 Jan 2019
AbstractforEffect of progesterone administration on the prognosis of patients with severe traumatic brain injury: a meta-analysis of randomized clinical trials | Full Text | References | PDF (580.6 KB) | EPUB
  • 168 Views
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Open Access

Short Report

Brief Report
Antistaphylococcal evaluation of indole–naphthalene hybrid analogs
Kerolos Ashraf, Kaveh Yasrebi, Emmanuel Tola Adeniyi, Tobias Hertlein, Knut Ohlsen, Michael Lalk, Frank Erdmann & Andreas Hilgeroth
Pages: 275-283
Published online: 10 Jan 2019
AbstractforAntistaphylococcal evaluation of indole–naphthalene hybrid analogs | Full Text | References | PDF (299.6 KB) | EPUB
  • 93 Views
  • 1 CrossRef citations
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Open Access

Original Research

Article
Endostatin attenuates PDGF-BB- or TGF-β1-induced HSCs activation via suppressing RhoA/ROCK1 signal pathways
Haitao Ren, Yuan Li, Yan Chen & Liang Wang
Pages: 285-290
Published online: 11 Jan 2019
AbstractforEndostatin attenuates PDGF-BB- or TGF-β1-induced HSCs activation via suppressing RhoA/ROCK1 signal pathways | Full Text | References | PDF (1.1 MB) | EPUB
  • 101 Views
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Open Access

Case Report

Case Report
Hyperprogression after anti-programmed cell death ligand-1 therapy in a patient with recurrent metastatic urothelial bladder carcinoma following first-line cisplatin-based chemotherapy: a case report
Shiyu Mao, Junfeng Zhang, Yadong Guo, Ziwei Zhang, Yuan Wu, Wentao Zhang, Longsheng Wang, Jiang Geng, Yang Yan & Xudong Yao
Pages: 291-300
Published online: 11 Jan 2019
AbstractforHyperprogression after anti-programmed cell death ligand-1 therapy in a patient with recurrent metastatic urothelial bladder carcinoma following first-line cisplatin-based chemotherapy: a case report | Full Text | References | PDF (2.4 MB) | EPUB
  • 121 Views
  • 9 CrossRef citations
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Open Access

Original Research

Article
Intravitreal corticosteroid implant vs intravitreal ranibizumab for the treatment of macular edema: a meta-analysis of randomized controlled trials
Qingquan Wei, Rui Chen, Qiyang Lou & Jing Yu
Pages: 301-307
Published online: 11 Jan 2019
AbstractforIntravitreal corticosteroid implant vs intravitreal ranibizumab for the treatment of macular edema: a meta-analysis of randomized controlled trials | Full Text | References | PDF (702 KB) | EPUB
  • 100 Views
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Open Access

Review

Review Article
A brief report of toxicity end points of HER2 vaccines for the treatment of patients with HER2+ breast cancer
Ricardo Costa, Saif Zaman, Susan Sharpe, Irene Helenowski, Colleen Shaw, Hyo Han, Hatem Soliman & Brian Czerniecki
Pages: 309-316
Published online: 14 Jan 2019
AbstractforA brief report of toxicity end points of HER2 vaccines for the treatment of patients with HER2+ breast cancer | Full Text | References | PDF (585.8 KB) | EPUB
  • 112 Views
  • 14 CrossRef citations
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Open Access

Original Research

Article
YB-1 modulates the drug resistance of glioma cells by activation of MDM2/p53 pathway
Hui Tong, Kai Zhao, Jingyu Zhang, Jinxin Zhu & Jianqi Xiao
Pages: 317-326
Published online: 29 Sep 2022
AbstractforYB-1 modulates the drug resistance of glioma cells by activation of MDM2/p53 pathway | Full Text | References | PDF (2.4 MB) | EPUB
  • 111 Views
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Open Access

Review

Review Article
Recent advances in the treatment of pathogenic infections using antibiotics and nano-drug delivery vehicles
Vo Van Giau, Seong Soo A An & John Hulme
Pages: 327-343
Published online: 18 Jan 2019
AbstractforRecent advances in the treatment of pathogenic infections using antibiotics and nano-drug delivery vehicles | Full Text | References | PDF (1.8 MB) | EPUB
  • 544 Views
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Open Access

Original Research

Article
Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation
Denise MS van Marion, Xu Hu, Deli Zhang, Femke Hoogstra-Berends, Jean-Paul G Seerden, Lizette Loen, Andre Heeres, Herman Steen, Robert H Henning & Bianca JJM Brundel
Pages: 345-364
Published online: 18 Jan 2019
AbstractforScreening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation | Full Text | References | PDF (6.4 MB) | EPUB
  • 107 Views
  • 14 CrossRef citations
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Open Access
Article
Different effects of oxycodone and remifentanil in patients undergoing ultrasound-guided percutaneous radiofrequency ablation of hepatic cancer: a randomized trial
Junbei Wu, Yunhong Lu & Xiaofei Cao
Pages: 365-372
Published online: 29 Sep 2022
AbstractforDifferent effects of oxycodone and remifentanil in patients undergoing ultrasound-guided percutaneous radiofrequency ablation of hepatic cancer: a randomized trial | Full Text | References | PDF (875.2 KB) | EPUB
  • 85 Views
  • 6 CrossRef citations
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Open Access
Article
Development of dual delivery antituberculotic system containing rifapentine microspheres and adipose stem cells seeded in hydroxyapatite/tricalcium phosphate
Qiuzhen Liang, Xinghua Song, Shengli She, Zhen Wang, Chong Wang & Dawei Jiang
Pages: 373-384
Published online: 29 Sep 2022
AbstractforDevelopment of dual delivery antituberculotic system containing rifapentine microspheres and adipose stem cells seeded in hydroxyapatite/tricalcium phosphate | Full Text | References | PDF (3.2 MB) | EPUB
  • 107 Views
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Open Access

Letter

Letter
Letter regarding the article, “A randomized, double- blind clinical trial of canrenone vs hydrochlorothiazide in addition to angiotensin II receptor blockers in hypertensive type 2 diabetic patients”
Ling-Yue Zhao, Yi-Jun Luo & Jing Zhu
Pages: 385-386
Published online: 21 Jan 2019
CitationforLetter regarding the article, “A randomized, double- blind clinical trial of canrenone vs hydrochlorothiazide in addition to angiotensin II receptor blockers in hypertensive type 2 diabetic patients” | Full Text | References | PDF (142.8 KB) | EPUB
  • 81 Views
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Original Research

Article
Melatonin receptor stimulation by agomelatine prevents Aβ-induced tau phosphorylation and oxidative damage in PC12 cells
Kai Yao, Yong-fei Zhao & Heng-bing Zu
Pages: 387-396
Published online: 21 Jan 2019
AbstractforMelatonin receptor stimulation by agomelatine prevents Aβ-induced tau phosphorylation and oxidative damage in PC12 cells | Full Text | References | PDF (2.2 MB) | EPUB
  • 169 Views
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Open Access
Article
A real-life experience of sorafenib treatment for patients with advanced hepatocellular carcinoma: a retrospective analysis at Cathay General Hospital, 2007–2015
Chi-Chun Huang, Hsin-Yi Chen, Ruei-Hsin Chang, Pen-An Liao, Heng-Hui Lien, Chih-Sheng Hung, Sien-Sing Yang & Jui-Ting Hu
Pages: 397-404
Published online: 29 Sep 2022
AbstractforA real-life experience of sorafenib treatment for patients with advanced hepatocellular carcinoma: a retrospective analysis at Cathay General Hospital, 2007–2015 | Full Text | References | PDF (602.8 KB) | EPUB
  • 98 Views
  • 5 CrossRef citations
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Open Access
Article
Statin use and prognosis of lung cancer: a systematic review and meta-analysis of observational studies and randomized controlled trials
Dao-Kui Xia, Zhi-Gang Hu, Yu-Feng Tian & Fan-Jun Zeng
Pages: 405-422
Published online: 23 Jan 2019
AbstractforStatin use and prognosis of lung cancer: a systematic review and meta-analysis of observational studies and randomized controlled trials | Full Text | References | PDF (1.1 MB) | EPUB
  • 185 Views
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Open Access
Article
Design, synthesis, and biologic evaluation of novel chrysin derivatives as cytotoxic agents and caspase-3/7 activators
Buthina Abdallah Al-Oudat, Mohammad Ali Alqudah, Suaad Abdallah Audat, Qosay Ali Al-Balas, Tamam El-Elimat, Mohammad Abdelhafeez Hassan, Islam Nawaf Frhat & Marwah Mohammad Azaizeh
Pages: 423-433
Published online: 22 Jan 2019
AbstractforDesign, synthesis, and biologic evaluation of novel chrysin derivatives as cytotoxic agents and caspase-3/7 activators | Full Text | References | PDF (591.9 KB) | EPUB
  • 234 Views
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Open Access
Article
MicroRNA-339 inhibits human hepatocellular carcinoma proliferation and invasion via targeting ZNF689
Hui Zeng, Jiaping Zheng, Song Wen, Jun Luo, Guoliang Shao & Yongjun Zhang
Pages: 435-445
Published online: 22 Jan 2019
AbstractforMicroRNA-339 inhibits human hepatocellular carcinoma proliferation and invasion via targeting ZNF689 | Full Text | References | PDF (2.6 MB) | EPUB
  • 96 Views
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Open Access
Article
Structure–activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities
Yuzhang Liu, Qiang Du, Chengbang Ma, Xinping Xi, Lei Wang, Mei Zhou, James F Burrows, Tianbao Chen & Hui Wang
Pages: 447-458
Published online: 29 Sep 2022
AbstractforStructure–activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities | Full Text | References | PDF (3.1 MB) | EPUB
  • 233 Views
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Open Access
Article
Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway
Shiyu Gao, Jianwei Lin, Tianqi Wang, Yan Shen, Yan Li, Wenyu Yang, Kailiang Zhou & Haiyan Hu
Pages: 459-475
Published online: 23 Jan 2019
AbstractforQingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway | Full Text | References | PDF (5.1 MB) | EPUB
  • 105 Views
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Open Access

Research Letter

Article
A nucleoside-sparing regimen of dolutegravir plus ritonavir-boosted atazanavir in HIV-1-infected patients with virological failure: the DOLATAV study
Vincenzo Spagnuolo, Laura Galli, Andrea Poli, Alba Bigoloni, Luca Fumagalli, Nicola Gianotti, Silvia Nozza, Davide Ferrari, Massimo Locatelli, Adriano Lazzarin & Antonella Castagna
Pages: 477-479
Published online: 24 Jan 2019
First Page PreviewforA nucleoside-sparing regimen of dolutegravir plus ritonavir-boosted atazanavir in HIV-1-infected patients with virological failure: the DOLATAV study | Full Text | References | PDF (160.9 KB) | EPUB
  • 92 Views
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Open Access

Original Research

Article
Model-dependent pharmacokinetic analysis of enalapril administered to healthy adult volunteers using orodispersible minitablets for use in pediatrics
Muhammad Faisal, Willi Cawello, Bjoern B Burckhardt, Stephanie Laer & On behalf of LENA Consortium
Pages: 481-490
Published online: 29 Sep 2022
AbstractforModel-dependent pharmacokinetic analysis of enalapril administered to healthy adult volunteers using orodispersible minitablets for use in pediatrics | Full Text | References | PDF (4.9 MB) | EPUB
  • 125 Views
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Open Access

Review

Review Article
Targeting the A3 adenosine receptor to treat cytokine release syndrome in cancer immunotherapy
Shira Cohen & Pnina Fishman
Pages: 491-497
Published online: 30 Jan 2019
AbstractforTargeting the A3 adenosine receptor to treat cytokine release syndrome in cancer immunotherapy | Full Text | References | PDF (207.6 KB) | EPUB
  • 148 Views
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Open Access

Erratum

Correction
Endostatin attenuates PDGF-BB- or TGF-β1-induced HSCs activation via suppressing RhoA/ROCK1 signal pathways [Erratum]
Pages: 499-500
Published online: 31 Jan 2019
CitationforEndostatin attenuates PDGF-BB- or TGF-β1-induced HSCs activation via suppressing RhoA/ROCK1 signal pathways [Erratum] | Full Text | PDF (270.1 KB) | EPUB
  • 78 Views
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Open Access

Original Research

Article
Neuroprotective potential of ketamine prevents developing brain structure impairment and alteration of neurocognitive function induced via isoflurane through the PI3K/AKT/GSK-3β pathway
Ruiwei Wang, Zihao Zhang, Mukesh Kumar, Guangming Xu & Mengyuan Zhang
Pages: 501-512
Published online: 04 Feb 2019
AbstractforNeuroprotective potential of ketamine prevents developing brain structure impairment and alteration of neurocognitive function induced via isoflurane through the PI3K/AKT/GSK-3β pathway | Full Text | References | PDF (1.5 MB) | EPUB
  • 210 Views
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Open Access
Article
Bisperoxovanadium protects against spinal cord injury by regulating autophagy via activation of ERK1/2 signaling
Yu-jin Tang, Kai Li, Cheng-liang Yang, Ke Huang, Jing Zhou, Yu Shi, Ke-gong Xie & Jia Liu
Pages: 513-521
Published online: 01 Feb 2019
AbstractforBisperoxovanadium protects against spinal cord injury by regulating autophagy via activation of ERK1/2 signaling | Full Text | References | PDF (3.5 MB) | EPUB
  • 90 Views
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Open Access
Article
Safety and efficacy of atezolizumab in the treatment of cancers: a systematic review and pooled-analysis
Yan Tie, Hui Yang, Rui Zhao, Heng Zheng, Daoke Yang, Jingyi Zhao & Ming Liu
Pages: 523-538
Published online: 04 Feb 2019
AbstractforSafety and efficacy of atezolizumab in the treatment of cancers: a systematic review and pooled-analysis | Full Text | References | PDF (1.1 MB) | EPUB
  • 213 Views
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Open Access
Article
The benefit of taxane-based therapies over fluoropyrimidine plus platinum (FP) in the treatment of esophageal cancer: a meta-analysis of clinical studies
Tao Wang, Jie Yu, Min Liu, Yanliang Chen, Caiyun Zhu, Lin Lu, Mingzhu Wang, Lingfeng Min, Xinxin Liu, Xizhi Zhang, Johannes A Gubat & Yong Chen
Pages: 539-553
Published online: 05 Feb 2019
AbstractforThe benefit of taxane-based therapies over fluoropyrimidine plus platinum (FP) in the treatment of esophageal cancer: a meta-analysis of clinical studies | Full Text | References | PDF (846.3 KB) | EPUB
  • 121 Views
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Open Access
Article
Efficacy of a recombinant single-chain fragment variable region, VasSF, as a new drug for vasculitis
Yosuke Kameoka, Fukuko Kishi, Minako Koura, Yoshio Yamakawa, Rora Nagasawa, Fuyu Ito, Junichiro Matsuda, Osamu Suzuki, Toshinori Nakayama & Kazuo Suzuki
Pages: 555-568
Published online: 05 Feb 2019
AbstractforEfficacy of a recombinant single-chain fragment variable region, VasSF, as a new drug for vasculitis | Full Text | References | PDF (4.7 MB) | EPUB
  • 145 Views
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Open Access

Review

Review Article
Brigatinib for ALK-positive metastatic non-small-cell lung cancer: design, development and place in therapy
Robert Ali, Junaid Arshad, Sofia Palacio & Raja Mudad
Pages: 569-580
Published online: 08 Feb 2019
AbstractforBrigatinib for ALK-positive metastatic non-small-cell lung cancer: design, development and place in therapy | Full Text | References | PDF (234.6 KB) | EPUB
  • 208 Views
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Open Access

Original Research

Article
Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis
Jing Guo, Jie Tu, YingYing Hu, GuoXin Song & ZhiQiang Yin
Pages: 581-588
Published online: 08 Feb 2019
AbstractforCathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis | Full Text | References | PDF (1.7 MB) | EPUB
  • 176 Views
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Open Access
Article
The underlying mechanisms of Jie-Du-Hua-Yu granule for protecting rat liver failure
Hua Qiu, Dewen Mao, Nong Tang, Fuli Long, Rongzhen Zhang, Minggang Wang, Qinglan Shi, Jiahuan Li, Qin Jiang, Yueqiao Chen & Xiufeng Wang
Pages: 589-600
Published online: 11 Feb 2019
AbstractforThe underlying mechanisms of Jie-Du-Hua-Yu granule for protecting rat liver failure | Full Text | References | PDF (1.9 MB) | EPUB
  • 95 Views
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Open Access
Article
Emodin induces apoptosis and autophagy of fibroblasts obtained from patient with ankylosing spondylitis
Cong Ma, Bo Wen, Qin Zhang, Pei-Pei Shao, Wen Gu, Kun Qu, Yang Shi & Bei Wang
Pages: 601-609
Published online: 29 Sep 2022
AbstractforEmodin induces apoptosis and autophagy of fibroblasts obtained from patient with ankylosing spondylitis | Full Text | References | PDF (1.9 MB) | EPUB
  • 123 Views
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Review

Review Article
Epigallocatechin-3-gallate in the prevention and treatment of hepatocellular carcinoma: experimental findings and translational perspectives
Sabrina Bimonte, Vittorio Albino, Mauro Piccirillo, Aurelio Nasto, Carlo Molino, Raffaele Palaia & Marco Cascella
Pages: 611-621
Published online: 29 Sep 2022
AbstractforEpigallocatechin-3-gallate in the prevention and treatment of hepatocellular carcinoma: experimental findings and translational perspectives | Full Text | References | PDF (3.1 MB) | EPUB
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Original Research

Article
Amine derivatives of furocoumarin induce melanogenesis by activating Akt/GSK-3β/β-catenin signal pathway
Deng Zang, Chao Niu & Haji Akber Aisa
Pages: 623-632
Published online: 12 Feb 2019
AbstractforAmine derivatives of furocoumarin induce melanogenesis by activating Akt/GSK-3β/β-catenin signal pathway | Full Text | References | PDF (1.3 MB) | EPUB
  • 129 Views
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Article
Efficacy of a fixed dose combination of irbesartan and atorvastatin (Rovelito®) in Korean adults with hypertension and hypercholesterolemia
Sang-Hyun Ihm, Jinho Shin, Chang-Gyu Park & Cheol-Ho Kim
Pages: 633-645
Published online: 13 Feb 2019
AbstractforEfficacy of a fixed dose combination of irbesartan and atorvastatin (Rovelito®) in Korean adults with hypertension and hypercholesterolemia | Full Text | References | PDF (541.6 KB) | EPUB
  • 138 Views
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Article
Ginkgo biloba extract-761 protects myocardium by regulating Akt/Nrf2 signal pathway
Xiao-jie Chen, Shu-min Ren, Jian-zeng Dong, Chun-guang Qiu, Ying-wei Chen & Hai-long Tao
Pages: 647-655
Published online: 13 Feb 2019
AbstractforGinkgo biloba extract-761 protects myocardium by regulating Akt/Nrf2 signal pathway | Full Text | References | PDF (2.9 MB) | EPUB
  • 116 Views
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Article
Evaluation of pharmacokinetics and pharmaco­dynamics of sinomenine­hyaluronic acid conjugate after intra­articular administration for osteoarthritis treatment
Jie Liu, Huarong Shao, Shaoying Fang, Yanling Cheng, Peixue Ling & Jianying Chen
Pages: 657-665
Published online: 29 Sep 2022
AbstractforEvaluation of pharmacokinetics and pharmaco­dynamics of sinomenine­hyaluronic acid conjugate after intra­articular administration for osteoarthritis treatment | Full Text | References | PDF (808.2 KB) | EPUB
  • 177 Views
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Review

Review Article
Update in treatment of uveitic macular edema
Spyridon Koronis, Panagiotis Stavrakas, Miltiadis Balidis, Nikolaos Kozeis & Paris G Tranos
Pages: 667-680
Published online: 19 Feb 2019
AbstractforUpdate in treatment of uveitic macular edema | Full Text | References | PDF (1.3 MB) | EPUB
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Original Research

Article
Synthesis of budesonide conjugates and their anti-inflammatory effects: a preliminary study
Yan Yan, Pengchong Wang, Ruiying Li, Ying Sun, Rui Zhang, Chuanchuan Huo, Jianfeng Xing & Yalin Dong
Pages: 681-694
Published online: 19 Feb 2019
AbstractforSynthesis of budesonide conjugates and their anti-inflammatory effects: a preliminary study | Full Text | References | PDF (1.8 MB) | EPUB
  • 175 Views
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Article
Dexmedetomidine attenuates the neurotoxicity of propofol toward primary hippocampal neurons in vitro via Erk1/2/CREB/BDNF signaling pathways
Youbing Tu, Yubing Liang, Yong Xiao, Jing Lv, Ruicong Guan, Fei Xiao, Yubo Xie & Qiang Xiao
Pages: 695-706
Published online: 19 Feb 2019
AbstractforDexmedetomidine attenuates the neurotoxicity of propofol toward primary hippocampal neurons in vitro via Erk1/2/CREB/BDNF signaling pathways | Full Text | References | PDF (10.8 MB) | EPUB
  • 136 Views
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Article
Monosialoganglioside protects against bupivacaine-induced neurotoxicity caused by endoplasmic reticulum stress in rats
Benquan Liu, Jiemei Ji, Qing Feng, Xi Luo, Xiurong Yan, Yuxia Ni, Yajun He, Zhongxuan Mao & Jingchen Liu
Pages: 707-718
Published online: 19 Feb 2019
AbstractforMonosialoganglioside protects against bupivacaine-induced neurotoxicity caused by endoplasmic reticulum stress in rats | Full Text | References | PDF (5.2 MB) | EPUB
  • 104 Views
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Article
Comparisons between ticagrelor and clopidogrel following percutaneous coronary intervention in patients with acute coronary syndrome: a comprehensive meta-analysis
Zhong-Guo Fan, Wen-Ling Zhang, Bing Xu, Jun Ji, Nai-Liang Tian & Sheng-Hu He
Pages: 719-730
Published online: 20 Feb 2019
AbstractforComparisons between ticagrelor and clopidogrel following percutaneous coronary intervention in patients with acute coronary syndrome: a comprehensive meta-analysis | Full Text | References | PDF (1.2 MB) | EPUB
  • 232 Views
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Review

Review Article
Profile of semaglutide in the management of type 2 diabetes: design, development, and place in therapy
Fernando Gomez-Peralta & Cristina Abreu
Pages: 731-738
Published online: 29 Sep 2022
AbstractforProfile of semaglutide in the management of type 2 diabetes: design, development, and place in therapy | Full Text | References | PDF (676.1 KB) | EPUB
  • 348 Views
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Original Research

Article
Maresin 1 mitigates renal ischemia/reperfusion injury in mice via inhibition of the TLR4/MAPK/NF-κB pathways and activation of the Nrf2 pathway
Yun Qiu, Yichen Wu, Hongmei Zhao, Hong Sun & Sumin Gao
Pages: 739-745
Published online: 29 Sep 2022
AbstractforMaresin 1 mitigates renal ischemia/reperfusion injury in mice via inhibition of the TLR4/MAPK/NF-κB pathways and activation of the Nrf2 pathway | Full Text | References | PDF (1.4 MB) | EPUB
  • 151 Views
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Article
Resveratrol attenuates hydrogen peroxide-induced aging through upregulation of autophagy in human umbilical vein endothelial cells
Ligen Du, Enping Chen, Ting Wu, Yunjun Ruan & Saizhu Wu
Pages: 747-755
Published online: 29 Sep 2022
AbstractforResveratrol attenuates hydrogen peroxide-induced aging through upregulation of autophagy in human umbilical vein endothelial cells | Full Text | References | PDF (1.6 MB) | EPUB
  • 202 Views
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Article
siRNA-based breast cancer therapy by suppressing 17β-hydroxysteroid dehydrogenase type 1 in an optimized xenograft cell and molecular biology model in vivo
Fang Li, ZhiHan Zhu, Man Xue, WanHong He, Ting Zhang, LingLin Feng & ShengXiang Lin
Pages: 757-766
Published online: 22 Feb 2019
AbstractforsiRNA-based breast cancer therapy by suppressing 17β-hydroxysteroid dehydrogenase type 1 in an optimized xenograft cell and molecular biology model in vivo | Full Text | References | PDF (3.4 MB) | EPUB
  • 121 Views
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Article
RETRACTED ARTICLE: Ginkgolide B ameliorates myocardial ischemia reperfusion injury in rats via inhibiting endoplasmic reticulum stress
Changlei Guo, Junbiao Zhang, Peiyong Zhang, Aoyang Si, Zhenling Zhang, Liangping Zhao, Fenghua Lv & Guoan Zhao
Pages: 767-774
Published online: 26 Feb 2019
AbstractforRETRACTED ARTICLE: Ginkgolide B ameliorates myocardial ischemia reperfusion injury in rats via inhibiting endoplasmic reticulum stress | PDF (3.9 MB)
  • 27 Views
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Article
Synthesis, structure elucidation, and antifungal potential of certain new benzodioxole–imidazole molecular hybrids bearing ester functionalities
Reem I Al-Wabli, Alwah R Al-Ghamdi, Hazem A Ghabbour, Mohamed H Al-Agamy & Mohamed I Attia
Pages: 775-789
Published online: 26 Feb 2019
AbstractforSynthesis, structure elucidation, and antifungal potential of certain new benzodioxole–imidazole molecular hybrids bearing ester functionalities | Full Text | References | PDF (1.1 MB) | EPUB
  • 99 Views
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Clinical Trial Report

Article
Physicochemical characterization and phase I study of CMAB008, an infliximab biosimilar produced by a different expression system
Qing An, Yingxin Zheng, Yirong Zhao, Tao Liu, Huaizu Guo, Dapeng Zhang, Weizhu Qian, Hao Wang, Yajun Guo, Sheng Hou & Jing Li
Pages: 791-805
Published online: 12 Mar 2019
AbstractforPhysicochemical characterization and phase I study of CMAB008, an infliximab biosimilar produced by a different expression system | Full Text | References | PDF (1.7 MB) | EPUB
  • 201 Views
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Corrigendum

Correction
Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study [Corrigendum]
Page: 807
Published online: 28 Feb 2019
CitationforUtility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study [Corrigendum] | Full Text | PDF (106.5 KB) | EPUB
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Original Research

Article
Single-use suvorexant for treating insomnia during overnight polysomnography in patients with suspected obstructive sleep apnea: a single-center experience
Takuma Matsumura, Jiro Terada, Chikara Yoshimura, Ken Koshikawa, Taku Kinoshita, Misuzu Yahaba, Kengo Nagashima, Seiichiro Sakao & Koichiro Tatsumi
Pages: 809-816
Published online: 28 Feb 2019
AbstractforSingle-use suvorexant for treating insomnia during overnight polysomnography in patients with suspected obstructive sleep apnea: a single-center experience | Full Text | References | PDF (525.5 KB) | EPUB
  • 112 Views
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Review

Review Article
The journey from gene knockout to clinical medicine: telotristat and sotagliflozin
Marc S Rendell
Pages: 817-824
Published online: 06 Mar 2019
AbstractforThe journey from gene knockout to clinical medicine: telotristat and sotagliflozin | Full Text | References | PDF (215.9 KB) | EPUB
  • 219 Views
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Review Article
Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities
Sylwia Flis & Tomasz Chojnacki
Pages: 825-843
Published online: 08 Mar 2019
AbstractforChronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities | Full Text | References | PDF (3.7 MB) | EPUB
  • 442 Views
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Original Research

Article
Clinical efficacy and safety of rituximab in lupus nephritis
Zhiqing Zhong, Hongyan Li, Hongzhen Zhong & Tianbiao Zhou
Pages: 845-856
Published online: 11 Mar 2019
AbstractforClinical efficacy and safety of rituximab in lupus nephritis | Full Text | References | PDF (775.3 KB) | EPUB
  • 248 Views
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Article
Efficacy and safety of tacrolimus in induction therapy of patients with lupus nephritis
Tianbiao Zhou, Shujun Lin, Shen Yang & Wenshan Lin
Pages: 857-869
Published online: 12 Mar 2019
AbstractforEfficacy and safety of tacrolimus in induction therapy of patients with lupus nephritis | Full Text | References | PDF (725.7 KB) | EPUB
  • 152 Views
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Article
Intraoperative dexmedetomidine infusion is associated with reduced emergence agitation and improved recovery profiles after lung surgery: a retrospective cohort study
Xianhui Kang, Xiaodong Tang, Yang Yu, Fangping Bao, Shuyuan Gan, Wei Zheng, Jian Zhang & Shengmei Zhu
Pages: 871-879
Published online: 12 Mar 2019
AbstractforIntraoperative dexmedetomidine infusion is associated with reduced emergence agitation and improved recovery profiles after lung surgery: a retrospective cohort study | Full Text | References | PDF (310.2 KB) | EPUB
  • 160 Views
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Article
Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis
Hong Huang, Houhe Liu, Hua Zhou, Zhiling Liang, Dandan Song, Yun Zhang, Wanqiu Huang, Xiaotian Zhao, Bo Wu, Guodong Ye & Yugang Huang
Pages: 881-896
Published online: 12 Mar 2019
AbstractforDrug-release system of microchannel transport used in minimally invasive surgery for hemostasis | Full Text | References | PDF (8.1 MB) | EPUB
  • 130 Views
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Clinical Trial Report

Article
Dexmedetomidine for the prevention of emergence delirium and postoperative behavioral changes in pediatric patients with sevoflurane anesthesia: a double-blind, randomized trial
Mengzhu Shi, Shuai Miao, Tianchu Gu, Dongyue Wang, Hui Zhang & Jindong Liu
Pages: 897-905
Published online: 15 Mar 2019
AbstractforDexmedetomidine for the prevention of emergence delirium and postoperative behavioral changes in pediatric patients with sevoflurane anesthesia: a double-blind, randomized trial | Full Text | References | PDF (1.1 MB) | EPUB
  • 325 Views
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Retraction

Retraction
Protective role of quercetin against manganese-induced injury in the liver, kidney, and lung; and hematological parameters in acute and subchronic rat models [Retraction]
Pages: 897-908
Published online: 18 Mar 2019
CitationforProtective role of quercetin against manganese-induced injury in the liver, kidney, and lung; and hematological parameters in acute and subchronic rat models [Retraction] | Full Text | PDF (162.8 KB) | EPUB
  • 85 Views
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Review

Review Article
Mechanistic research holds promise for bacterial vaccines and phage therapies for Pseudomonas aeruginosa
Austin Hoggarth, Andrew Weaver, Qinqin Pu, Ting Huang, Jacob Schettler, Feng Chen, Xiefang Yuan & Min Wu
Pages: 909-924
Published online: 20 Mar 2019
AbstractforMechanistic research holds promise for bacterial vaccines and phage therapies for Pseudomonas aeruginosa | Full Text | References | PDF (705.8 KB) | EPUB
  • 409 Views
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Original Research

Article
Hexyl alginate derivative, an amphiphilic innovative buccal film-forming material of promising mechanical and release characteristics for the improvement of repaglinide bioavailability
Ahmed Khames
Pages: 925-940
Published online: 21 Mar 2019
AbstractforHexyl alginate derivative, an amphiphilic innovative buccal film-forming material of promising mechanical and release characteristics for the improvement of repaglinide bioavailability | Full Text | References | PDF (3.6 MB) | EPUB
  • 143 Views
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Article
Increased branching and sialylation of N-linked glycans correlate with an improved pharmacokinetic profile for BAY 81–8973 compared with other full-length rFVIII products
John M Teare, David S Kates, Anita Shah & Stephen Garger
Pages: 941-948
Published online: 22 Mar 2019
AbstractforIncreased branching and sialylation of N-linked glycans correlate with an improved pharmacokinetic profile for BAY 81–8973 compared with other full-length rFVIII products | Full Text | References | PDF (2.3 MB) | EPUB
  • 122 Views
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Article
Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects
Patricia N Sidharta, Meggane Melchior, Martin K Kankam & Jasper Dingemanse
Pages: 949-964
Published online: 22 Mar 2019
AbstractforSingle- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects | Full Text | References | PDF (1,009.6 KB) | EPUB
  • 248 Views
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Article
Effectiveness and safety of intravenous application of dexmedetomidine for cesarean section under general anesthesia: a meta-analysis of randomized trials
Li Ao, Jinlin Shi, Yaowu Bai, Yujuan Zheng & Jianhui Gan
Pages: 965-974
Published online: 25 Mar 2019
AbstractforEffectiveness and safety of intravenous application of dexmedetomidine for cesarean section under general anesthesia: a meta-analysis of randomized trials | Full Text | References | PDF (904.9 KB)
  • 154 Views
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Article
Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes
Bozhi Ye, Xudong Chen, Shanshan Dai, Jibo Han, Xiaohe Liang, Shuang Lin, Xueli Cai, Zhouqing Huang & Weijian Huang
Pages: 975-990
Published online: 25 Mar 2019
AbstractforEmodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes | Full Text | References | PDF (4 MB) | EPUB
  • 158 Views
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Article
Pharmacokinetic comparison of a fixed-dose combination versus concomitant administration of amlodipine, olmesartan, and rosuvastatin in healthy adult subjects
Minkyung Oh, Jae-Gook Shin, Sangzin Ahn, Bo Hoon Kim, Ji Yeon Kim, Hyun Ju Shin, Hyun Ju Shin & Jong-Lyul Ghim
Pages: 991-997
Published online: 03 Apr 2019
AbstractforPharmacokinetic comparison of a fixed-dose combination versus concomitant administration of amlodipine, olmesartan, and rosuvastatin in healthy adult subjects | Full Text | References | PDF (388.6 KB) | EPUB
  • 148 Views
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Article
Efficacy and safety of paricalcitol in patients undergoing hemodialysis: a meta-analysis
Yang Liu, Ling-Yun Liu, Ye Jia, Mei-Yan Wu, Yan-Yan Sun & Fu-Zhe Ma
Pages: 999-1009
Published online: 28 Mar 2019
AbstractforEfficacy and safety of paricalcitol in patients undergoing hemodialysis: a meta-analysis | Full Text | References | PDF (668.1 KB) | EPUB
  • 119 Views
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Article
A first-in-human study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of KM-819 (FAS-associated factor 1 inhibitor), a drug for Parkinson’s disease, in healthy volunteers
Wonsuk Shin, Kyoung Soo Lim, Min-Kyoung Kim, Hyun Sook Kim, Jihwa Hong, Stanford Jhee, Joseph Kim, Sungeun Yoo, Yeon-Tae Chung, Jae Moon Lee & Doo-Yeoun Cho
Pages: 1011-1022
Published online: 29 Mar 2019
AbstractforA first-in-human study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of KM-819 (FAS-associated factor 1 inhibitor), a drug for Parkinson’s disease, in healthy volunteers | Full Text | References | PDF (651.4 KB) | EPUB
  • 280 Views
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Article
Jinlong capsule inhibits migration and invasion in human glioblastoma cells via the modulation of mTOR/S6 signaling pathway
Jingren Shi, Wenli Zhang, Lu He, Fanhong Kong, Meichen Pan, Jingjing Guo, Xinmin Xu, Jie Guo, Huizhu Wang & Yajie Wang
Pages: 1023-1032
Published online: 01 Apr 2019
AbstractforJinlong capsule inhibits migration and invasion in human glioblastoma cells via the modulation of mTOR/S6 signaling pathway | Full Text | References | PDF (795.2 KB) | EPUB
  • 94 Views
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Article
Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system
Nora Freyer, Fanny Knöspel, Georg Damm, Selina Greuel, Christin Schneider, Daniel Seehofer, Thomas Stöhr, Karl-Uwe Petersen & Katrin Zeilinger
Pages: 1033-1047
Published online: 02 Apr 2019
AbstractforMetabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system | Full Text | References | PDF (2.9 MB) | EPUB
  • 169 Views
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Article
Formulation and bioequivalence studies of choline alfoscerate tablet comparing with soft gelatin capsule in healthy male volunteers
Mi-Hong Min, Jin-Hyong Park, Jong-Hyun Hur, Ho-Chul Shin, YoungJoo Cho & Dae-Duk Kim
Pages: 1049-1058
Published online: 05 Apr 2019
AbstractforFormulation and bioequivalence studies of choline alfoscerate tablet comparing with soft gelatin capsule in healthy male volunteers | Full Text | References | PDF (570.6 KB) | EPUB
  • 436 Views
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Article
Transportan-derived cell-penetrating peptide delivers siRNA to inhibit replication of influenza virus in vivo
Cuiling Zhang, Weigang Ren, Qingxin Liu, Zhikai Tan, Junwei Li & Chunyi Tong
Pages: 1059-1068
Published online: 04 Apr 2019
AbstractforTransportan-derived cell-penetrating peptide delivers siRNA to inhibit replication of influenza virus in vivo | Full Text | References | PDF (1.3 MB) | EPUB
  • 144 Views
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Article
Systematic elucidation of the mechanism of geraniol via network pharmacology
Yun-Fei Zhang, Yue Huang, Yi-Hua Ni & Zheng-Min Xu
Pages: 1069-1075
Published online: 04 Apr 2019
AbstractforSystematic elucidation of the mechanism of geraniol via network pharmacology | Full Text | References | PDF (1.5 MB) | EPUB
  • 321 Views
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Article
A novel hybrid compound LLP2A-alendronate accelerates open fracture healing in a rabbit model
Zheng Wang, Yong Zhao, Dong Zhang, Baiwen Qi, Weidong Xiao, Xiang Hu & Aixi Yu
Pages: 1077-1086
Published online: 05 Apr 2019
AbstractforA novel hybrid compound LLP2A-alendronate accelerates open fracture healing in a rabbit model | Full Text | References | PDF (5.6 MB) | EPUB
  • 124 Views
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Article
Lung cancer combination therapy: doxorubicin and β-elemene co-loaded, pH-sensitive nanostructured lipid carriers
Chengsong Cao, Qun Wang & Yong Liu
Pages: 1087-1098
Published online: 05 Apr 2019
AbstractforLung cancer combination therapy: doxorubicin and β-elemene co-loaded, pH-sensitive nanostructured lipid carriers | Full Text | References | PDF (759.8 KB) | EPUB
  • 223 Views
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Article
Can a cyclooxygenase inhibitor be an option for treatment of ovarian hyperstimulation syndrome?
Hasan Çilgin
Pages: 1099-1105
Published online: 05 Apr 2019
AbstractforCan a cyclooxygenase inhibitor be an option for treatment of ovarian hyperstimulation syndrome? | Full Text | References | PDF (426.5 KB) | EPUB
  • 118 Views
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Article
Applications of daunorubicin-loaded PLGA-PLL-PEG-Tf nanoparticles in hematologic malignancies: an in vitro and in vivo evaluation
Wen Bao, Ran Liu, Guohua Xia, Fei Wang & Baoan Chen
Pages: 1107-1115
Published online: 08 Apr 2019
AbstractforApplications of daunorubicin-loaded PLGA-PLL-PEG-Tf nanoparticles in hematologic malignancies: an in vitro and in vivo evaluation | Full Text | References | PDF (2 MB) | EPUB
  • 105 Views
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Review

Review Article
Quizartinib (AC220): a promising option for acute myeloid leukemia
Fang Zhou, Zheng Ge & Baoan Chen
Pages: 1117-1125
Published online: 08 Apr 2019
AbstractforQuizartinib (AC220): a promising option for acute myeloid leukemia | Full Text | References | PDF (341.7 KB) | EPUB
  • 320 Views
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Case Series

Low-dose adefovir dipivoxil–induced hypophosphatemia osteomalacia in five chronic hepatitis B virus–infected patients. Is low-dose adefovir dipivoxil–induced nephrotoxicity completely reversible?
Yan-Ying Qian, Zhi-Juan Dai, Lu-Ya Ruan, You-Jin Pan, Jian Jin, Meng-Te Shi, Yao-Xin Zhu & Chao-Ming Wu
Pages: 1127-1133
Published online: 10 Apr 2019
AbstractforLow-dose adefovir dipivoxil–induced hypophosphatemia osteomalacia in five chronic hepatitis B virus–infected patients. Is low-dose adefovir dipivoxil–induced nephrotoxicity completely reversible? | Full Text | References | PDF (224.6 KB) | EPUB
  • 83 Views
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Original Research

Article
The neuroprotective effects of curcumin are associated with the regulation of the reciprocal function between autophagy and HIF-1α in cerebral ischemia-reperfusion injury
Yang Hou, Jue Wang & Juan Feng
Pages: 1135-1144
Published online: 09 Apr 2019
AbstractforThe neuroprotective effects of curcumin are associated with the regulation of the reciprocal function between autophagy and HIF-1α in cerebral ischemia-reperfusion injury | Full Text | References | PDF (2.1 MB) | EPUB
  • 127 Views
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Article
Emodin enhances antitumor effect of paclitaxel on human non-small-cell lung cancer cells in vitro and in vivo
Shuifang Chen, Zeying Zhang & Jianli Zhang
Pages: 1145-1153
Published online: 10 Apr 2019
AbstractforEmodin enhances antitumor effect of paclitaxel on human non-small-cell lung cancer cells in vitro and in vivo | Full Text | References | PDF (604.2 KB) | EPUB
  • 173 Views
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Article
Neuroprotective effect of N-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation
Wessam M Abdel-Wahab & Farouzia I Moussa
Pages: 1155-1162
Published online: 11 Apr 2019
AbstractforNeuroprotective effect of N-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation | Full Text | References | PDF (387.1 KB) | EPUB
  • 401 Views
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Article
Effect of umbelliferone on adjuvant-induced arthritis in rats by MAPK/NF-κB pathway
Liu Ouyang, Yang Dan, Zengwu Shao, Shuhua Yang, Cao Yang, Guohui Liu, Wu Zhou & Deyu Duan
Pages: 1163-1170
Published online: 11 Apr 2019
AbstractforEffect of umbelliferone on adjuvant-induced arthritis in rats by MAPK/NF-κB pathway | Full Text | References | PDF (1.9 MB) | EPUB
  • 144 Views
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Clinical Trial Report

Article
Comparison of dexmedetomidine and sufentanil as adjuvants to local anesthetic for epidural labor analgesia: a randomized controlled trial
Tao Zhang, Yulong Yu, Wang Zhang & Jin Zhu
Pages: 1171-1175
Published online: 11 Apr 2019
AbstractforComparison of dexmedetomidine and sufentanil as adjuvants to local anesthetic for epidural labor analgesia: a randomized controlled trial | Full Text | References | PDF (325.4 KB) | EPUB
  • 304 Views
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Letter

Letter
Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study [Letter]
Leticia Orsatti, Josep Fortea & Manuel Quaresma
Pages: 1177-1178
Published online: 12 Apr 2019
CitationforUtility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study [Letter] | Full Text | References | PDF (154.1 KB) | EPUB
  • 90 Views
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Original Research

Article
Antileishmanial and antitrypanosomal activity of symmetrical dibenzyl-substituted α,β-unsaturated carbonyl-based compounds
Abdulsalam AM Alkhaldi, Harry P de Koning & Syed Nasir Abbas Bukhari
Pages: 1179-1185
Published online: 24 Apr 2019
AbstractforAntileishmanial and antitrypanosomal activity of symmetrical dibenzyl-substituted α,β-unsaturated carbonyl-based compounds | Full Text | References | PDF (945.1 KB) | EPUB
  • 112 Views
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Article
Tetramethylpyrazine attenuated bupivacaine-induced neurotoxicity in SH-SY5Y cells through regulating apoptosis, autophagy and oxidative damage
Shouliang Wang, Bin Xia, Zonglei Qiao, Lian Duan, Gongming Wang, Wenjun Meng, Zhifei Liu, Yu Wang & Mengyuan Zhang
Pages: 1187-1196
Published online: 29 Sep 2022
AbstractforTetramethylpyrazine attenuated bupivacaine-induced neurotoxicity in SH-SY5Y cells through regulating apoptosis, autophagy and oxidative damage | Full Text | References | PDF (1.6 MB) | EPUB
  • 144 Views
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Article
Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer’s disease
Mitra Esfandiarei, Brikena Hoxha, Nicholas A Talley, Miranda R Anderson, Mustafa F Alkhouli, Michaela A Squire, Delrae M Eckman, Jeganathan Ramesh Babu, Gary D Lopaschuk & Tom L Broderick
Pages: 1197-1211
Published online: 17 Apr 2019
AbstractforBeneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer’s disease | Full Text | References | PDF (1.4 MB) | EPUB
  • 179 Views
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Article
Effect of butorphanol on etomidate-induced myoclonus: a systematic review and meta-analysis
Jun Hua, Shuai Miao, Mengzhu Shi, Qing Tu, Xiuli Wang, Su Liu, Guanglei Wang & Jianhui Gan
Pages: 1213-1220
Published online: 16 Apr 2019
AbstractforEffect of butorphanol on etomidate-induced myoclonus: a systematic review and meta-analysis | Full Text | References | PDF (1.7 MB) | EPUB
  • 115 Views
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Article
The molecular mechanisms of Aloin induce gastric cancer cells apoptosis by targeting High Mobility Group Box 1
Hong Tao, Tuo Tang, Shengnan Wang, Ziqian Wang, Yunfei Ma, Tianyu Cai, Xiuliang Cheng, Shimei Qi, Yao Zhang & Zhilin Qi
Pages: 1221-1231
Published online: 17 Apr 2019
AbstractforThe molecular mechanisms of Aloin induce gastric cancer cells apoptosis by targeting High Mobility Group Box 1 | Full Text | References | PDF (4.4 MB) | EPUB
  • 138 Views
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Article
Effect of loading dose of atorvastatin therapy prior to percutaneous coronary intervention in patients with acute coronary syndrome: a meta-analysis of six randomized controlled trials
Mingfeng Ma, Lixia Bu, Li Shi, Renwei Guo, Bin Yang, Huili Cao, Liangping Luo & Ligong Lu
Pages: 1233-1240
Published online: 16 Apr 2019
AbstractforEffect of loading dose of atorvastatin therapy prior to percutaneous coronary intervention in patients with acute coronary syndrome: a meta-analysis of six randomized controlled trials | Full Text | References | PDF (878.5 KB) | EPUB
  • 145 Views
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Article
In vitro comparative quality assessment of different brands of norfloxacin tablets available in Jimma, Southwest Ethiopia
Solomon Hambisa, Sileshi Belew & Sultan Suleman
Pages: 1241-1249
Published online: 17 Apr 2019
AbstractforIn vitro comparative quality assessment of different brands of norfloxacin tablets available in Jimma, Southwest Ethiopia | Full Text | References | PDF (716.2 KB) | EPUB
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Review

Review Article
Caplacizumab as an emerging treatment option for acquired thrombotic thrombocytopenic purpura
Tugrul Elverdi & Ahmet Emre Eskazan
Pages: 1251-1258
Published online: 29 Sep 2022
AbstractforCaplacizumab as an emerging treatment option for acquired thrombotic thrombocytopenic purpura | Full Text | References | PDF (565.1 KB) | EPUB
  • 227 Views
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Original Research

Article
Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates
Scott A Reisman, Sarabjit S Gahir, Chun-Yue I Lee, Joel W Proksch, Mitsumasa Sakamoto & Keith W Ward
Pages: 1259-1270
Published online: 17 Apr 2019
AbstractforPharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates | Full Text | References | PDF (1.4 MB) | EPUB
  • 511 Views
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Article
Anti-tumor efficacy of folate modified PLGA-based nanoparticles for the co-delivery of drugs in ovarian cancer
Shu Li, Xiaofeng Li, Jianyi Ding, Lingfei Han & Xiaoqing Guo
Pages: 1271-1280
Published online: 18 Apr 2019
AbstractforAnti-tumor efficacy of folate modified PLGA-based nanoparticles for the co-delivery of drugs in ovarian cancer | Full Text | References | PDF (3 MB) | EPUB
  • 228 Views
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Article
Effects of dezocine for the prevention of postoperative catheter-related bladder discomfort: a prospective randomized trial
Guang-Fen Zhang, Jie Guo, Li-Li Qiu, Shu-Ming Li, Man Zheng, Jiang-Yan Xia & Jian-Jun Yang
Pages: 1281-1288
Published online: 23 Apr 2019
AbstractforEffects of dezocine for the prevention of postoperative catheter-related bladder discomfort: a prospective randomized trial | Full Text | References | PDF (258.7 KB) | EPUB
  • 107 Views
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Article
Plumbagin inhibits proliferation and induces apoptosis of hepatocellular carcinoma by downregulating the expression of SIVA
Tingting Li, Mengjiao Lv, Xiaohua Chen, Yongsheng Yu, Guoqing Zang & Zhenghao Tang
Pages: 1289-1300
Published online: 29 Sep 2022
AbstractforPlumbagin inhibits proliferation and induces apoptosis of hepatocellular carcinoma by downregulating the expression of SIVA | Full Text | References | PDF (4.5 MB) | EPUB
  • 122 Views
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Article
Safety and sedative effect of intranasal dexmedetomidine in mandibular third molar surgery: a systematic review and meta-analysis
Shaopeng Liu, Ye Wang, Yong Zhu, Tingting Yu & Huaqiang Zhao
Pages: 1301-1310
Published online: 23 Apr 2019
AbstractforSafety and sedative effect of intranasal dexmedetomidine in mandibular third molar surgery: a systematic review and meta-analysis | Full Text | References | PDF (396.9 KB) | EPUB
  • 182 Views
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Article
Epigallocatechin-3-gallate enhances the osteoblastogenic differentiation of human adipose-derived stem cells
Jing Zhang, Kai Wu, Ting Xu, Jiajun Wu, Pengfei Li, Hong Wang, Huiling Wu & Gang Wu
Pages: 1311-1321
Published online: 23 Apr 2019
AbstractforEpigallocatechin-3-gallate enhances the osteoblastogenic differentiation of human adipose-derived stem cells | Full Text | References | PDF (3.2 MB) | EPUB
  • 115 Views
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Article
Ocular surface squamous neoplasia: angiographic characteristics and response to subconjunctival/perilesional 5-fluorouracil injections
Yuzhao Sun & Rui Hua
Pages: 1323-1334
Published online: 29 Apr 2019
AbstractforOcular surface squamous neoplasia: angiographic characteristics and response to subconjunctival/perilesional 5-fluorouracil injections | Full Text | References | PDF (3.2 MB) | EPUB
  • 133 Views
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Article
Caffeic acid phenethyl ester suppressed growth and metastasis of nasopharyngeal carcinoma cells by inactivating the NF-κB pathway
Yushan Liang, Guofei Feng, Liang Wu, Suhua Zhong, Xiaoyu Gao, Yan Tong, Wanmeng Cui, Yongying Qin, WenQing Xu, Xue Xiao, Zhe Zhang, Guangwu Huang & Xiaoying Zhou
Pages: 1335-1345
Published online: 26 Apr 2019
AbstractforCaffeic acid phenethyl ester suppressed growth and metastasis of nasopharyngeal carcinoma cells by inactivating the NF-κB pathway | Full Text | References | PDF (2.4 MB) | EPUB
  • 171 Views
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Article
Clinical efficacy of 60-mg dexlansoprazole and 40-mg esomeprazole after 24 weeks for the on-demand treatment of gastroesophageal reflux disease grades A and B: a prospective randomized trial
Hung-Hsien Chiang, Deng-Chyang Wu, Pin-I Hsu, Chao-Hung Kuo, Wei-Chen Tai, Shih-Cheng Yang, Keng-Liang Wu, Chih-Chien Yao, Cheng-En Tsai, Chih-Ming Liang, Yao-Kuang Wang, Jiunn-Wei Wang, Chih-Fang Huang, Seng-Kee Chuah & on behalf of the Taiwan Acid-Related Disease Study Group
Pages: 1347-1356
Published online: 29 Sep 2022
AbstractforClinical efficacy of 60-mg dexlansoprazole and 40-mg esomeprazole after 24 weeks for the on-demand treatment of gastroesophageal reflux disease grades A and B: a prospective randomized trial | Full Text | References | PDF (327.7 KB) | EPUB
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Article
Codelivery of GRP78 siRNA and docetaxel via RGD-PEG-DSPE/DOPA/CaP nanoparticles for the treatment of castration-resistant prostate cancer
Xiangyu Zhang, Zelai He, Longquan Xiang, Liang Li, Haiyan Zhang, Fanzhong Lin & Hongying Cao
Pages: 1357-1372
Published online: 29 Apr 2019
AbstractforCodelivery of GRP78 siRNA and docetaxel via RGD-PEG-DSPE/DOPA/CaP nanoparticles for the treatment of castration-resistant prostate cancer | Full Text | References | PDF (3.8 MB) | EPUB
  • 197 Views
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Article
The TwistDock workflow for evaluation of bivalent Smac mimetics targeting XIAP
Qingsheng Huang, Yin Peng, Yuefeng Peng, Dan Wei, Yanjie Wei & Shengzhong Feng
Pages: 1373-1388
Published online: 26 Apr 2019
AbstractforThe TwistDock workflow for evaluation of bivalent Smac mimetics targeting XIAP | Full Text | References | PDF (4.2 MB) | EPUB
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Review

Review Article
Nicorandil prior to primary percutaneous coronary intervention improves clinical outcomes in patients with acute myocardial infarction: a meta-analysis of randomized controlled trials
Li Xu, Lefeng Wang, Kuibao Li, Zhiyong Zhang, Hao Sun & Xinchun Yang
Pages: 1389-1400
Published online: 29 Apr 2019
AbstractforNicorandil prior to primary percutaneous coronary intervention improves clinical outcomes in patients with acute myocardial infarction: a meta-analysis of randomized controlled trials | Full Text | References | PDF (1.4 MB) | EPUB
  • 129 Views
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Review Article
Combination of drugs and carriers in drug delivery technology and its development
Ying Du & Baoan Chen
Pages: 1401-1408
Published online: 30 Apr 2019
AbstractforCombination of drugs and carriers in drug delivery technology and its development | Full Text | References | PDF (425.8 KB) | EPUB
  • 311 Views
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Original Research

Article
Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization
Ahmed M Naglah, Moamen S Refat, Mohamed A Al-Omar, Mashooq A Bhat, Hamad M AlKahtani & Asma S Al-Wasidi
Pages: 1409-1420
Published online: 30 Apr 2019
AbstractforSynthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization | Full Text | References | PDF (2 MB) | EPUB
  • 115 Views
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Article
Enhanced immunosuppressive effects of 3,5-bis[4(diethoxymethyl)benzylidene]-1-methyl-piperidin-4-one, an α, β-unsaturated carbonyl-based compound as PLGA-b-PEG nanoparticles
Laiba Arshad, Ibrahim Jantan & Syed Nasir Abbas Bukhari
Pages: 1421-1436
Published online: 30 Apr 2019
AbstractforEnhanced immunosuppressive effects of 3,5-bis[4(diethoxymethyl)benzylidene]-1-methyl-piperidin-4-one, an α, β-unsaturated carbonyl-based compound as PLGA-b-PEG nanoparticles | Full Text | References | PDF (2.4 MB) | EPUB
  • 99 Views
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Article
Tetramethylpyrazine improved the survival of multiterritory perforator flaps by inducing angiogenesis and suppressing apoptosis via the Akt/Nrf2 pathway
LiMing Qing, PanFeng Wu, ZhengBing Zhou, Fang Yu & JuYu Tang
Pages: 1437-1447
Published online: 01 May 2019
AbstractforTetramethylpyrazine improved the survival of multiterritory perforator flaps by inducing angiogenesis and suppressing apoptosis via the Akt/Nrf2 pathway | Full Text | References | PDF (3 MB) | EPUB
  • 95 Views
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Article
Isobavachalcone isolated from Psoralea corylifolia inhibits cell proliferation and induces apoptosis via inhibiting the AKT/GSK-3β/β-catenin pathway in colorectal cancer cells
Yanxi Li, Xiaoxue Qin, Penglei Li, Hao Zhang, Tao Lin, Ziwei Miao & Siping Ma
Pages: 1449-1460
Published online: 01 May 2019
AbstractforIsobavachalcone isolated from Psoralea corylifolia inhibits cell proliferation and induces apoptosis via inhibiting the AKT/GSK-3β/β-catenin pathway in colorectal cancer cells | Full Text | References | PDF (4.4 MB) | EPUB
  • 189 Views
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Article
Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress
Jinti Lin, Chang Jia, Yongli Wang, Shanghong Jiang, Zhenyu Jia, Nan Chen, Shimin Sheng, Shihen Li, Liangfu Jiang, Huazi Xu, Kailiang Zhou & Yijie Chen
Pages: 1461-1472
Published online: 01 May 2019
AbstractforTherapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress | Full Text | References | PDF (4.3 MB) | EPUB
  • 99 Views
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Article
Resveratrol reduces liver endoplasmic reticulum stress and improves insulin sensitivity in vivo and in vitro
Hang Zhao, Yunjia Zhang, Linyi Shu, Guangyao Song & Huijuan Ma
Pages: 1473-1485
Published online: 02 May 2019
AbstractforResveratrol reduces liver endoplasmic reticulum stress and improves insulin sensitivity in vivo and in vitro | Full Text | References | PDF (6.4 MB) | EPUB
  • 214 Views
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Review

Review Article
Safety evaluation and cardiovascular effect of additional use of spironolactone in hemodialysis patients: a meta-analysis
Qing Zeng, XiaoDuo Zhou & Ge Xu
Pages: 1487-1499
Published online: 03 May 2019
AbstractforSafety evaluation and cardiovascular effect of additional use of spironolactone in hemodialysis patients: a meta-analysis | Full Text | References | PDF (3.7 MB) | EPUB
  • 159 Views
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Original Research

Article
In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model
Arif Malik, Uzma Jamil, Tariq Tahir Butt, Sulayman Waquar, Siew Hua Gan, Hassan Shafique & Tassadaq Hussain Jafar
Pages: 1501-1513
Published online: 06 May 2019
AbstractforIn silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model | Full Text | References | PDF (3.4 MB) | EPUB
  • 390 Views
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Review

Review Article
Inotersen: new promise for the treatment of hereditary transthyretin amyloidosis
Veena Mathew & Annabel K Wang
Pages: 1515-1525
Published online: 06 May 2019
AbstractforInotersen: new promise for the treatment of hereditary transthyretin amyloidosis | Full Text | References | PDF (1.7 MB) | EPUB
  • 316 Views
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Review Article
Dabigatran must be used carefully: literature review and recommendations for management of adverse events
Shan Lin, Yan Wang, Lei Zhang & Wei Guan
Pages: 1527-1533
Published online: 06 May 2019
AbstractforDabigatran must be used carefully: literature review and recommendations for management of adverse events | Full Text | References | PDF (290.8 KB) | EPUB
  • 510 Views
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Review Article
Spotlight on anifrolumab and its potential for the treatment of moderate-to-severe systemic lupus erythematosus: evidence to date
Renaud Felten, Florence Scher, Flora Sagez, François Chasset & Laurent Arnaud
Pages: 1535-1543
Published online: 08 May 2019
AbstractforSpotlight on anifrolumab and its potential for the treatment of moderate-to-severe systemic lupus erythematosus: evidence to date | Full Text | References | PDF (598.4 KB) | EPUB
  • 425 Views
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Original Research

Article
Glibenclamide alleviates inflammation in oleic acid model of acute lung injury through NLRP3 inflammasome signaling pathway
Hong Chen, Yongjie Ding, Wei Chen, Yun Feng & Guochao Shi
Pages: 1545-1554
Published online: 07 May 2019
AbstractforGlibenclamide alleviates inflammation in oleic acid model of acute lung injury through NLRP3 inflammasome signaling pathway | Full Text | References | PDF (1.9 MB) | EPUB
  • 116 Views
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Article
Protective effects of five compounds from Livistona chinensis R. Brown leaves against hypoxia/reoxygenation, H2O2, or adriamycin-induced injury in H9c2 cells
Shaoguang Li, Shaohong Luo, Hao Chen, Yanjie Zheng, Liqing Lin, Hong Yao & Xinhua Lin
Pages: 1555-1566
Published online: 08 May 2019
AbstractforProtective effects of five compounds from Livistona chinensis R. Brown leaves against hypoxia/reoxygenation, H2O2, or adriamycin-induced injury in H9c2 cells | Full Text | References | PDF (2.7 MB) | EPUB
  • 165 Views
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Article
Formulation and evaluation of simvastatin polymeric nanoparticles loaded in hydrogel for optimum wound healing purpose
Usama Farghaly Aly, Heba A Abou-Taleb, Ahmed AH Abdellatif & Nahla Sameh Tolba
Pages: 1567-1580
Published online: 10 May 2019
AbstractforFormulation and evaluation of simvastatin polymeric nanoparticles loaded in hydrogel for optimum wound healing purpose | Full Text | References | PDF (4.2 MB) | EPUB
  • 947 Views
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Article
Extending the application of a magnetic PEG three-part drug release device on a graphene substrate for the removal of Gram-positive and Gram-negative bacteria and cancerous and pathologic cells
M Ramezani Farani, P Khadive Parsi, Gh Riazi, M Shafiee Ardestani & H Saligeh Rad
Pages: 1581-1591
Published online: 10 May 2019
AbstractforExtending the application of a magnetic PEG three-part drug release device on a graphene substrate for the removal of Gram-positive and Gram-negative bacteria and cancerous and pathologic cells | Full Text | References | PDF (1.7 MB) | EPUB
  • 136 Views
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Article
Comparison of the efficacy and safety of remifentanil versus different pharmacological approaches on prevention of etomidate-induced myoclonus: a meta-analysis of randomized controlled trials
Bingchen Lang, Lingli Zhang, Fengshan Li, Yunzhu Lin, Wensheng Zhang & Chunsong Yang
Pages: 1593-1607
Published online: 09 May 2019
AbstractforComparison of the efficacy and safety of remifentanil versus different pharmacological approaches on prevention of etomidate-induced myoclonus: a meta-analysis of randomized controlled trials | Full Text | References | PDF (9.1 MB) | EPUB
  • 101 Views
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Article
6,7-Dihydroxy-2-(4′-hydroxyphenyl)naphthalene induces HCT116 cell apoptosis through activation of endoplasmic reticulum stress and the extrinsic apoptotic pathway
Ching-Feng Chiu, Guan-Ying Lai, Chung-Hwan Chen, Chien-Chao Chiu, Shao-Wen Hung & Chi-Fen Chang
Pages: 1609-1621
Published online: 09 May 2019
Abstractfor6,7-Dihydroxy-2-(4′-hydroxyphenyl)naphthalene induces HCT116 cell apoptosis through activation of endoplasmic reticulum stress and the extrinsic apoptotic pathway | Full Text | References | PDF (2.5 MB) | EPUB
  • 94 Views
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Article
Pharmacokinetics of fixed-dose combination of atorvastatin and metformin compared with individual tablets
Jong-Lyul Ghim, Nguyen Thi Thu Phuong, Min Jung Kim, Eun-Ji Kim, Geun Seog Song, Sangzin Ahn, Jae-Gook Shin & Eun-Young Kim
Pages: 1623-1632
Published online: 13 May 2019
AbstractforPharmacokinetics of fixed-dose combination of atorvastatin and metformin compared with individual tablets | Full Text | References | PDF (730.1 KB) | EPUB
  • 219 Views
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Review

Review Article
Effect of pravastatin treatment on circulating adiponectin: a meta-analysis of randomized controlled trials
Xiangrong Shu & Liqun Chi
Pages: 1633-1641
Published online: 13 May 2019
AbstractforEffect of pravastatin treatment on circulating adiponectin: a meta-analysis of randomized controlled trials | Full Text | References | PDF (783.4 KB) | EPUB
  • 110 Views
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Original Research

Article
Dexibuprofen amide derivatives as potential anticancer agents: synthesis, in silico docking, bioevaluation, and molecular dynamic simulation
Zaman Ashraf, Tariq Mahmood, Mubashir Hassan, Samina Afzal, Hummera Rafique, Khurram Afzal & Jalifah Latip
Pages: 1643-1657
Published online: 29 Sep 2022
AbstractforDexibuprofen amide derivatives as potential anticancer agents: synthesis, in silico docking, bioevaluation, and molecular dynamic simulation | Full Text | References | PDF (2.1 MB) | EPUB
  • 283 Views
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Article
Andrographolide attenuates bupivacaine-induced cytotoxicity in SH-SY5Y cells through preserving Akt/mTOR activity
Huiyuan Zhang, Weiwei Wang & Qian Du
Pages: 1659-1666
Published online: 16 May 2019
AbstractforAndrographolide attenuates bupivacaine-induced cytotoxicity in SH-SY5Y cells through preserving Akt/mTOR activity | Full Text | References | PDF (1.7 MB) | EPUB
  • 119 Views
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Article
Cardiovascular adverse events during treatment with darunavir-based regimens in an Italian observational study
A Antinori, S Rusconi, N Gianotti, T Bini, D Mancusi & R Termini
Pages: 1667-1685
Published online: 14 May 2019
AbstractforCardiovascular adverse events during treatment with darunavir-based regimens in an Italian observational study | Full Text | References | PDF (380.4 KB) | EPUB
  • 100 Views
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Response to Letter

Reply
Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study [Response to letter]
Mitsuhiro Abe, Kenji Tsushima & Koichiro Tatsumi
Pages: 1687-1688
Published online: 29 Sep 2022
CitationforUtility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study [Response to letter] | Full Text | References | PDF (159.3 KB) | EPUB
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Corrigendum

Correction
Efficacy of a recombinant single-chain fragment variable region, VasSF, as a new drug for vasculitis [Corrigendum]
Page: 1689
Published online: 22 May 2019
CitationforEfficacy of a recombinant single-chain fragment variable region, VasSF, as a new drug for vasculitis [Corrigendum] | Full Text | PDF (148.5 KB) | EPUB
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Original Research

Article
Sevoflurane post-conditioning alleviates neonatal rat hypoxic-ischemic cerebral injury via Ezh2-regulated autophagy
Hang Xue, Ying Xu, Shuo Wang, Zi-Yi Wu, Xing-Yue Li, Ya-Han Zhang, Jia-Yuan Niu, Qiu-Shi Gao & Ping Zhao
Pages: 1691-1706
Published online: 15 May 2019
AbstractforSevoflurane post-conditioning alleviates neonatal rat hypoxic-ischemic cerebral injury via Ezh2-regulated autophagy | Full Text | References | PDF (6.2 MB) | EPUB
  • 107 Views
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Article
Subcutaneous bortezomib might be standard of care for patients with multiple myeloma: a systematic review and meta-analysis
Ziqi Ye, Jie Chen, Zixue Xuan, Wenchao Yang & Jing Chen
Pages: 1707-1716
Published online: 16 May 2019
AbstractforSubcutaneous bortezomib might be standard of care for patients with multiple myeloma: a systematic review and meta-analysis | Full Text | References | PDF (1.3 MB) | EPUB
  • 132 Views
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Article
Genetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy
Jeong Yee, Woorim Kim, Byung Chul Chang, Jee Eun Chung, Kyung Eun Lee & Hye Sun Gwak
Pages: 1717-1727
Published online: 17 May 2019
AbstractforGenetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy | Full Text | References | PDF (1.7 MB) | EPUB
  • 86 Views
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Article
The effect of midazolam administration for the prevention of emergence agitation in pediatric patients with extreme fear and non-cooperation undergoing dental treatment under sevoflurane anesthesia, a double-blind, randomized study
Mari Kawai, Shinji Kurata, Takuro Sanuki, Gaku Mishima, Kensuke Kiriishi, Toshihiro Watanabe, Yu Ozaki-Honda, Mizuki Yoshida, Ichiro Okayasu, Terumi Ayuse, Naomi Tanoue & Takao Ayuse
Pages: 1729-1737
Published online: 17 May 2019
AbstractforThe effect of midazolam administration for the prevention of emergence agitation in pediatric patients with extreme fear and non-cooperation undergoing dental treatment under sevoflurane anesthesia, a double-blind, randomized study | Full Text | References | PDF (231.9 KB) | EPUB
  • 351 Views
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Article
Bioequivalence of paclitaxel protein-bound particles in patients with breast cancer: determining total and unbound paclitaxel in plasma by rapid equilibrium dialysis and liquid chromatography–tandem mass spectrometry
Junling Li, Wei Li, Xiaojian Dai, Dafang Zhong, Yaping Ding & Xiaoyan Chen
Pages: 1739-1749
Published online: 20 May 2019
AbstractforBioequivalence of paclitaxel protein-bound particles in patients with breast cancer: determining total and unbound paclitaxel in plasma by rapid equilibrium dialysis and liquid chromatography–tandem mass spectrometry | Full Text | References | PDF (639.1 KB) | EPUB
  • 290 Views
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Article
Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6
Joomi Lee, Hee-Doo Yoo, Jung-Woo Bae, Sooyeun Lee & Kwang-Hee Shin
Pages: 1751-1761
Published online: 23 May 2019
AbstractforPopulation pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6 | Full Text | References | PDF (739.1 KB) | EPUB
  • 307 Views
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Article
SU5416 attenuated lipopolysaccharide-induced acute lung injury in mice by modulating properties of vascular endothelial cells
Xuqing Huang, Junqi Zhu, Yuyue Jiang, Changqing Xu, Qun Lv, Dongwei Yu, Kai Shi, Zhaoyang Ruan & Yan Wang
Pages: 1763-1772
Published online: 23 May 2019
AbstractforSU5416 attenuated lipopolysaccharide-induced acute lung injury in mice by modulating properties of vascular endothelial cells | Full Text | References | PDF (2 MB) | EPUB
  • 103 Views
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Article
Synthesis, comparative docking, and pharmacological activity of naproxen amino acid derivatives as possible anti-inflammatory and analgesic agents
Ahmed A Elhenawy, LM Al-Harbi, Gaber O Moustafa, MA El-Gazzar, Rehab F Abdel-Rahman & Abd Elhamid Salim
Pages: 1773-1790
Published online: 24 May 2019
AbstractforSynthesis, comparative docking, and pharmacological activity of naproxen amino acid derivatives as possible anti-inflammatory and analgesic agents | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Low-dose doxycycline inhibits hydrogen peroxide-induced oxidative stress, MMP-2 up-regulation and contractile dysfunction in human saphenous vein grafts
Mazen Saeed, Mehmet Zuhuri Arun, Mehmet Guzeloglu, Ceylan Onursal, Goksel Gokce, Ceren Gonen Korkmaz & Buket Reel
Pages: 1791-1801
Published online: 23 May 2019
AbstractforLow-dose doxycycline inhibits hydrogen peroxide-induced oxidative stress, MMP-2 up-regulation and contractile dysfunction in human saphenous vein grafts | Full Text | References | PDF (1.7 MB) | EPUB
  • 117 Views
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Article
Effect of dexmedetomidine on etomidate-induced myoclonus: a randomized, double-blind controlled trial
Shuai Miao, Lan Zou, Guanglei Wang, Xiuli Wang, Su Liu & Mengzhu Shi
Pages: 1803-1808
Published online: 27 May 2019
AbstractforEffect of dexmedetomidine on etomidate-induced myoclonus: a randomized, double-blind controlled trial | Full Text | References | PDF (260.6 KB) | EPUB
  • 145 Views
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Article
Frequency, clinical features and differential response to therapy of concurrent ALK/EGFR alterations in Chinese lung cancer patients
Jixian Liu, Zhimin Mu, Li Liu, Kang Li, Richeng Jiang, Peng Chen, Qiang Zhou, Meiling Jin, Yuxiang Ma, Yuancai Xie, Jianxing Xiang, Bing Li, Yafeng Ma, Xinru Mao, Lu Zhang, Tengfei Zhang & Da Wu
Pages: 1809-1817
Published online: 23 May 2019
AbstractforFrequency, clinical features and differential response to therapy of concurrent ALK/EGFR alterations in Chinese lung cancer patients | Full Text | References | PDF (1.5 MB) | EPUB
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Corrigendum

Correction
Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway [Corrigendum]
Page: 1819
Published online: 24 May 2019
CitationforFerulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway [Corrigendum] | Full Text | PDF (466.1 KB) | EPUB
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Original Research

Article
A novel non-invasive monitoring assay of 5-azacitidine efficacy using global DNA methylation of peripheral blood in myelodysplastic syndrome
Michiyo Asano, Junko H Ohyashiki, Chiaki Kobayashi-Kawana, Tomohiro Umezu, Satoshi Imanishi, Kenko Azuma, Daigo Akahane, Hiroaki Fujimoto, Yoshikazu Ito & Kazuma Ohyashiki
Pages: 1821-1833
Published online: 30 May 2019
AbstractforA novel non-invasive monitoring assay of 5-azacitidine efficacy using global DNA methylation of peripheral blood in myelodysplastic syndrome | Full Text | References | PDF (369.1 KB) | EPUB
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Clinical Trial Report

Article
Use of lidocaine to prevent postoperative coughing after partial laryngectomy: comparison of three delivery methods
Yuezhi Wang, Wei S Lu, Hui Qiao, Jian Zhao & Qing Fan
Pages: 1835-1841
Published online: 27 May 2019
AbstractforUse of lidocaine to prevent postoperative coughing after partial laryngectomy: comparison of three delivery methods | Full Text | References | PDF (622.1 KB) | EPUB
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Original Research

Article
Resveratrol downregulates TNF-α-induced monocyte chemoattractant protein-1 in primary rat pulmonary artery endothelial cells by P38 mitogen-activated protein kinase signaling
Jian-Wei Lin, Le-He Yang, Zhuo-Chao Ren, De-Guang Mu, Ya-Qing Li, Jian-Ping Yan, Liang-Xing Wang & Chun Chen
Pages: 1843-1853
Published online: 27 May 2019
AbstractforResveratrol downregulates TNF-α-induced monocyte chemoattractant protein-1 in primary rat pulmonary artery endothelial cells by P38 mitogen-activated protein kinase signaling | Full Text | References | PDF (3 MB) | EPUB
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Article
Comparative proteomics reveal negative effects of gonadotropin-releasing hormone agonist and antagonist on human endometrium
Qian Chen, Feng Yu, Yan Li, Ai-Jun Zhang & Xiao-Bin Zhu
Pages: 1855-1863
Published online: 30 May 2019
AbstractforComparative proteomics reveal negative effects of gonadotropin-releasing hormone agonist and antagonist on human endometrium | Full Text | References | PDF (1.4 MB) | EPUB
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Corrigendum

Correction
Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress [Corrigendum]
Page: 1865
Published online: 29 May 2019
CitationforTherapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress [Corrigendum] | Full Text | PDF (146.9 KB) | EPUB
  • 79 Views
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Original Research

Article
Efficacy and toxicity of cladribine for the treatment of refractory acute myeloid leukemia: a meta-analysis
Anqi Zhou, Qi Han, Huihui Song, Jie Zi, Jinlong Ma & Zheng Ge
Pages: 1867-1878
Published online: 29 May 2019
AbstractforEfficacy and toxicity of cladribine for the treatment of refractory acute myeloid leukemia: a meta-analysis | Full Text | References | PDF (2.7 MB) | EPUB
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Review

Review Article
15-Deoxy-Δ12,14-prostaglandin J2 as a potential regulator of bone metabolism via PPARγ-dependent and independent pathways: a review
Zhencheng Xiong, Pan Luo, Jun Zhou & Mingsheng Tan
Pages: 1879-1888
Published online: 30 May 2019
Abstractfor15-Deoxy-Δ12,14-prostaglandin J2 as a potential regulator of bone metabolism via PPARγ-dependent and independent pathways: a review | Full Text | References | PDF (439.3 KB) | EPUB
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Original Research

Article
Salvianolic acid A attenuates CCl4-induced liver fibrosis by regulating the PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways
Rong Wang, Fuxing Song, Shengnan Li, Bin Wu, Yanqiu Gu & Yongfang Yuan
Pages: 1889-1900
Published online: 31 May 2019
AbstractforSalvianolic acid A attenuates CCl4-induced liver fibrosis by regulating the PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways | Full Text | References | PDF (2.8 MB) | EPUB
  • 381 Views
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Article
Effects of Qi Teng Xiao Zhuo granules on circRNA expression profiles in rats with chronic glomerulonephritis
Jia-Rong Gao, Nan-Nan Jiang, Hui Jiang, Liang-Bing Wei, Ya-Chen Gao, Xiu-Juan Qin, Meng-Qing Zhu & Jing Wang
Pages: 1901-1913
Published online: 04 Jun 2019
AbstractforEffects of Qi Teng Xiao Zhuo granules on circRNA expression profiles in rats with chronic glomerulonephritis | Full Text | References | PDF (15.7 MB) | EPUB
  • 119 Views
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Article
Decreased sEng plasma levels in hypertensive patients with endothelial dysfunction under chronic treatment with Perindopril
Valentina Buda, Minodora Andor, Dana Emilia Baibata, Ramona Cozlac, Gabriela Radu, Dorina Coricovac, Corina Danciu, Ionut Ledeti, Adelina Cheveresan, Cristian Nica, Paul Tuduce & Mirela Cleopatra Tomescu
Pages: 1915-1925
Published online: 04 Jun 2019
AbstractforDecreased sEng plasma levels in hypertensive patients with endothelial dysfunction under chronic treatment with Perindopril | Full Text | References | PDF (2 MB) | EPUB
  • 100 Views
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Article
Notopterol-induced apoptosis and differentiation in human acute myeloid leukemia HL-60 cells
Qinwan Huang, Lin Wang, Qian Ran, Jin Wang, Chengqiang Wang, Hui He, Li Li & Hongyi Qi
Pages: 1927-1940
Published online: 06 Jun 2019
AbstractforNotopterol-induced apoptosis and differentiation in human acute myeloid leukemia HL-60 cells | Full Text | References | PDF (4.4 MB) | EPUB
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Clinical Trial Report

The effect of etomidate or propofol on brainstem function during anesthesia induction: a bispectral index-guided study
Huibao Zheng, Yuexin Zhu, Kaizheng Chen & Xia Shen
Pages: 1941-1946
Published online: 05 Jun 2019
AbstractforThe effect of etomidate or propofol on brainstem function during anesthesia induction: a bispectral index-guided study | Full Text | References | PDF (831.5 KB) | EPUB
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Original Research

Article
Solutol®HS15+pluronicF127 and Solutol®HS15+pluronicL61 mixed micelle systems for oral delivery of genistein
Pinggang Ding, Yuxuan Chen, Guangshang Cao, Hongxue Shen, Jianming Ju & Weiguang Li
Pages: 1947-1956
Published online: 07 Jun 2019
AbstractforSolutol®HS15+pluronicF127 and Solutol®HS15+pluronicL61 mixed micelle systems for oral delivery of genistein | Full Text | References | PDF (3.2 MB) | EPUB
  • 139 Views
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Article
The neuroprotective effect of bisperoxovandium (pyridin-2-squaramide) in intracerebral hemorrhage
Xin-Yu Liao, Yang Lei, Song-Feng Chen, Jing Cheng, Dan Zhao, Zhi-Feng Zhang, Xin Han, Ya Zhang, Hua-Bao Liao, Yang Zhuang, Juan Chen, Hai-Bing Zhou, Qi Wan & Ying-Ying Zou
Pages: 1957-1967
Published online: 13 Jun 2019
AbstractforThe neuroprotective effect of bisperoxovandium (pyridin-2-squaramide) in intracerebral hemorrhage | Full Text | References | PDF (2.2 MB) | EPUB
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Review

Review Article
Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis: a meta-analysis
Yao Huang, Hui Wang, Zhe Chen, Yu Wang, Kai Qin, Ying Huang, Xin Ba, Weiji Lin & Shenghao Tu
Pages: 1969-1984
Published online: 17 Jun 2019
AbstractforEfficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis: a meta-analysis | Full Text | References | PDF (6.4 MB) | EPUB
  • 117 Views
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Clinical Trial Report

Article
A comparative double-blind randomized study on the effectiveness of Duloxetine and Gabapentin on painful diabetic peripheral polyneuropathy
Nastaran Majdinasab, Hossein Kaveyani & Mojgan Azizi
Pages: 1985-1992
Published online: 17 Jun 2019
AbstractforA comparative double-blind randomized study on the effectiveness of Duloxetine and Gabapentin on painful diabetic peripheral polyneuropathy | Full Text | References | PDF (656.4 KB) | EPUB
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Review

Review Article
Evaluating guselkumab: an anti-IL-23 antibody for the treatment of plaque psoriasis
Eric J Yang, Mary Patricia Smith, Karen Ly & Tina Bhutani
Pages: 1993-2000
Published online: 18 Jun 2019
AbstractforEvaluating guselkumab: an anti-IL-23 antibody for the treatment of plaque psoriasis | Full Text | References | PDF (260.8 KB) | EPUB
  • 163 Views
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Case Series

Case Report
A study of refractory cases of persistent epithelial defects associated with dry eye syndrome and recurrent corneal erosions successfully treated with cyclosporine A 0.05% eye drops
Pietro Emanuele Napoli, Mirco Braghiroli, Claudio Iovino, Giuseppe Demarinis & Maurizio Fossarello
Pages: 2001-2008
Published online: 19 Jun 2019
AbstractforA study of refractory cases of persistent epithelial defects associated with dry eye syndrome and recurrent corneal erosions successfully treated with cyclosporine A 0.05% eye drops | Full Text | References | PDF (837.6 KB) | EPUB
  • 151 Views
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Original Research

Article
RETRACTED ARTICLE: TMF inhibits miR-29a/Wnt/β-catenin signaling through upregulating Foxo3a activity in osteoarthritis chondrocytes
Xianhua Huang, Zhixi Chen, Weimei Shi, Rui Zhang, Linfu Li, Hai Liu & Longhuo Wu
Pages: 2009-2019
Published online: 19 Jun 2019
AbstractforRETRACTED ARTICLE: TMF inhibits miR-29a/Wnt/β-catenin signaling through upregulating Foxo3a activity in osteoarthritis chondrocytes | PDF (3.4 MB)
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Article
A novel mutation panel for predicting etoposide resistance in small-cell lung cancer
Zhengang Qiu, Anqi Lin, Kun Li, Weiyin Lin, Qiongyao Wang, Ting Wei, Weiliang Zhu, Peng Luo & Jian Zhang
Pages: 2021-2041
Published online: 29 Sep 2022
AbstractforA novel mutation panel for predicting etoposide resistance in small-cell lung cancer | Full Text | References | PDF (2.5 MB) | EPUB
  • 239 Views
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Article
In vitro and in vivo effect of hyaluronic acid modified, doxorubicin and gallic acid co-delivered lipid-polymeric hybrid nano-system for leukemia therapy
Yanping Shao, Wenda Luo, Qunyi Guo, Xiaohong Li, Qianqian Zhang & Jing Li
Pages: 2043-2055
Published online: 28 Jun 2019
AbstractforIn vitro and in vivo effect of hyaluronic acid modified, doxorubicin and gallic acid co-delivered lipid-polymeric hybrid nano-system for leukemia therapy | Full Text | References | PDF (2.8 MB) | EPUB
  • 266 Views
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Article
Ginsenoside Rg3 protects mouse leydig cells against triptolide by downregulation of miR-26a
Haiyan Liang, Suwei Zhang & Zhiling Li
Pages: 2057-2066
Published online: 24 Jun 2019
AbstractforGinsenoside Rg3 protects mouse leydig cells against triptolide by downregulation of miR-26a | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Dexmedetomidine protects PC12 cells from lidocaine-induced cytotoxicity via downregulation of Stathmin 1
Yonghong Tan, Xiaobao Bi, Qiong Wang, Yu Li, Na Zhang, Jianxin Lao & Xiaoping Liu
Pages: 2067-2079
Published online: 03 Jul 2019
AbstractforDexmedetomidine protects PC12 cells from lidocaine-induced cytotoxicity via downregulation of Stathmin 1 | Full Text | References | PDF (4.7 MB) | EPUB
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Article
Phosphocreatine attenuates Gynura segetum-induced hepatocyte apoptosis via a SIRT3-SOD2-mitochondrial reactive oxygen species pathway
Dong-Ping Li, Ying-Ling Chen, Hong-Yue Jiang, Yun Chen, Xiao-Qing Zeng, Li-Li Xu, Yang Ye, Chang-Qiang Ke, Ge Lin, Ji-Yao Wang & Hong Gao
Pages: 2081-2096
Published online: 27 Jun 2019
AbstractforPhosphocreatine attenuates Gynura segetum-induced hepatocyte apoptosis via a SIRT3-SOD2-mitochondrial reactive oxygen species pathway | Full Text | References | PDF (4.5 MB) | EPUB
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Article
Impact of different emulsifiers on biocompatibility and inflammatory potential of Perfluorohexyloctane (F6H8) emulsions for new intravenous drug delivery systems
Charalambos Tsagogiorgas, Friedrich Anger, Grietje Beck, Annette Breedijk, Benito Yard & Simone Hoeger
Pages: 2097-2110
Published online: 27 Jun 2019
AbstractforImpact of different emulsifiers on biocompatibility and inflammatory potential of Perfluorohexyloctane (F6H8) emulsions for new intravenous drug delivery systems | Full Text | References | PDF (1.1 MB) | EPUB
  • 149 Views
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Review

Review Article
Effect of tumor necrosis factor inhibitors on interstitial lung disease in rheumatoid arthritis: angel or demon?
Ying Huang, Weiji Lin, Zhe Chen, Yu Wang, Yao Huang & Shenghao Tu
Pages: 2111-2125
Published online: 01 Jul 2019
AbstractforEffect of tumor necrosis factor inhibitors on interstitial lung disease in rheumatoid arthritis: angel or demon? | Full Text | References | PDF (968.4 KB) | EPUB
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Original Research

Article
Ginsenoside Rb1 pretreatment reverses hippocampal changes in BDNF/TrkB mRNA and protein in rats subjected to acute immobilization stress
Xianhui Kang, Wandong Hong, Kangjie Xie, Hongli Tang, Jingjing Tang, Shan Luo, Wujun Geng & Danyun Jia
Pages: 2127-2134
Published online: 01 Jul 2019
AbstractforGinsenoside Rb1 pretreatment reverses hippocampal changes in BDNF/TrkB mRNA and protein in rats subjected to acute immobilization stress | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Role of GRP78 inhibiting artesunate-induced ferroptosis in KRAS mutant pancreatic cancer cells
Kang Wang, Zhengyang Zhang, Ming Wang, Xiongfeng Cao, Jianchen Qi, Dongqing Wang, Aihua Gong & Haitao Zhu
Pages: 2135-2144
Published online: 02 Jul 2019
AbstractforRole of GRP78 inhibiting artesunate-induced ferroptosis in KRAS mutant pancreatic cancer cells | Full Text | References | PDF (2.6 MB) | EPUB
  • 242 Views
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Article
Preemptive analgesia after lumbar spine surgery by pregabalin and celecoxib: a prospective study
Nguyen Trung Kien, Phillip Geiger, Hoang Van Chuong, Nguyen Manh Cuong, Ngo Van Dinh, Dinh Cong Pho, Vu The Anh & Nguyen Truong Giang
Pages: 2145-2152
Published online: 03 Jul 2019
AbstractforPreemptive analgesia after lumbar spine surgery by pregabalin and celecoxib: a prospective study | Full Text | References | PDF (928.9 KB) | EPUB
  • 251 Views
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Article
Novel peptide myristoly-CM4 induces selective cytotoxicity in leukemia K562/MDR and Jurkat cells by necrosis and/or apoptosis pathway
Huidan Zhang, Dongju Han, Tongtong Lv, Kehang Liu, Yunqing Yang, Xixi Xu & Yuqing Chen
Pages: 2153-2167
Published online: 02 Jul 2019
AbstractforNovel peptide myristoly-CM4 induces selective cytotoxicity in leukemia K562/MDR and Jurkat cells by necrosis and/or apoptosis pathway | Full Text | References | PDF (4.9 MB) | EPUB
  • 130 Views
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Article
Evaluation of novel pyrimidine derivatives as a new class of mushroom tyrosinase inhibitor
S Shohreh Mirmortazavi, Mahdieh Farvandi, Hossein Ghafouri, Asadollah Mohammadi & Mostafa Shourian
Pages: 2169-2178
Published online: 08 Jul 2019
AbstractforEvaluation of novel pyrimidine derivatives as a new class of mushroom tyrosinase inhibitor | Full Text | References | PDF (1.8 MB) | EPUB
  • 146 Views
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Article
Efficacy and safety of tacrolimus vs cyclophosphamide in the therapy of patients with idiopathic membranous nephropathy: a meta-analysis
Wenshan Lin, Hong-Yan Li, Shujun Lin & Tianbiao Zhou
Pages: 2179-2186
Published online: 03 Jul 2019
AbstractforEfficacy and safety of tacrolimus vs cyclophosphamide in the therapy of patients with idiopathic membranous nephropathy: a meta-analysis | Full Text | References | PDF (1.1 MB) | EPUB
  • 86 Views
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Article
Tablet or capsule form of generic mycophenolate mofetil (My-Rept®) after liver transplantation: a prospective randomized trial
Jong Man Kim, Jong Wook Oh, Sangjin Kim, Jinsoo Rhu, Ji Soo Lee, Kyeong Sik Kim, Gyu-Seong Choi & Jae-Won Joh
Pages: 2187-2193
Published online: 02 Jul 2019
AbstractforTablet or capsule form of generic mycophenolate mofetil (My-Rept®) after liver transplantation: a prospective randomized trial | Full Text | References | PDF (995.1 KB) | EPUB
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Article
Activation of the P38/CREB/MMP13 axis is associated with osteoarthritis
Bin Ji, Yan Ma, Haimin Wang, Xiangqian Fang & Peihua Shi
Pages: 2195-2204
Published online: 03 Jul 2019
AbstractforActivation of the P38/CREB/MMP13 axis is associated with osteoarthritis | Full Text | References | PDF (2.2 MB) | EPUB
  • 159 Views
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Article
Delivery of folic acid-modified liposomal curcumin for targeted cervical carcinoma therapy
Wen-Yan Wang, Yun-Xia Cao, Xiao Zhou & Bing Wei
Pages: 2205-2213
Published online: 04 Jul 2019
AbstractforDelivery of folic acid-modified liposomal curcumin for targeted cervical carcinoma therapy | Full Text | References | PDF (2.1 MB) | EPUB
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Review

Review Article
Immune-related adverse events following administration of anti-cytotoxic T-lymphocyte-associated protein-4 drugs: a comprehensive systematic review and meta-analysis
Hang Xu, Ping Tan, Xiaonan Zheng, Yu Huang, Tianhai Lin, Qiang Wei, Jianzhong Ai & Lu Yang
Pages: 2215-2234
Published online: 04 Jul 2019
AbstractforImmune-related adverse events following administration of anti-cytotoxic T-lymphocyte-associated protein-4 drugs: a comprehensive systematic review and meta-analysis | Full Text | References | PDF (5 MB) | EPUB
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Article
Jatrorrhizine inhibits colorectal carcinoma proliferation and metastasis through Wnt/β-catenin signaling pathway and epithelial–mesenchymal transition
Pan Wang, Xiao-Yan Gao, Si-Qian Yang, Zhi-Xin Sun, Lu-Lu Dian, Muhammad Qasim, Aung Thu Phyo, Zong-Suo Liang & Yan-Fang Sun
Pages: 2235-2247
Published online: 08 Jul 2019
AbstractforJatrorrhizine inhibits colorectal carcinoma proliferation and metastasis through Wnt/β-catenin signaling pathway and epithelial–mesenchymal transition | Full Text | References | PDF (5.1 MB) | EPUB
  • 153 Views
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Article
The protective effect and mechanism of the FXR agonist obeticholic acid via targeting gut microbiota in non-alcoholic fatty liver disease
Dan-Ying Zhang, Lin Zhu, Hai-Ning Liu, Yu-Jen Tseng, Shu-Qiang Weng, Tao-Tao Liu, Ling Dong & Xi-Zhong Shen
Pages: 2249-2270
Published online: 05 Jul 2019
AbstractforThe protective effect and mechanism of the FXR agonist obeticholic acid via targeting gut microbiota in non-alcoholic fatty liver disease | Full Text | References | PDF (7.1 MB) | EPUB
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Article
Durability of INI-containing regimens after switching from PI-containing regimens: a single-centre cohort of drug-experienced HIV-infected subjects
Andrea Giacomelli, Alice Ranzani, Letizia Oreni, Elena Gervasi, Angelica Lupo, Anna Lisa Ridolfo, Massimo Galli & Stefano Rusconi
Pages: 2271-2282
Published online: 09 Jul 2019
AbstractforDurability of INI-containing regimens after switching from PI-containing regimens: a single-centre cohort of drug-experienced HIV-infected subjects | Full Text | References | PDF (1,022.7 KB) | EPUB
  • 92 Views
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Article
Comparative study of β-cyclodextrin, γ-cyclodextrin and 4-tert-butylcalix[8]arene ionophores as electroactive materials for the construction of new sensors for trazodone based on host-guest recognition
Haitham Alrabiah, Haya I Aljohar, Ahmed Hassan Bakheit, Atef MA Homoda & Gamal Abdel-Hafiz Mostafa
Pages: 2283-2293
Published online: 11 Jul 2019
AbstractforComparative study of β-cyclodextrin, γ-cyclodextrin and 4-tert-butylcalix[8]arene ionophores as electroactive materials for the construction of new sensors for trazodone based on host-guest recognition | Full Text | References | PDF (1.4 MB) | EPUB
  • 127 Views
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Article
Differences in tolerability of pirfenidone between elderly and younger patients with idiopathic pulmonary fibrosis
Masashi Sakayori, Jiro Terada, Mitsuhiro Abe, Yasutaka Hirasawa, Kenichi Suzuki, Keiichiro Yoshioka, Kenji Tsushima & Koichiro Tatsumi
Pages: 2295-2303
Published online: 11 Jul 2019
AbstractforDifferences in tolerability of pirfenidone between elderly and younger patients with idiopathic pulmonary fibrosis | Full Text | References | PDF (425.8 KB) | EPUB
  • 105 Views
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Article
Efficacy and safety of cyclosporine A in the treatment of idiopathic membranous nephropathy in an Asian population
Shujun Lin, Hong-Yan Li, Tianbiao Zhou & Wenshan Lin
Pages: 2305-2330
Published online: 11 Jul 2019
AbstractforEfficacy and safety of cyclosporine A in the treatment of idiopathic membranous nephropathy in an Asian population | Full Text | References | PDF (4.3 MB) | EPUB
  • 100 Views
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Article
Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening
Xuying Li, Pengyu Jia, Zijun Huang, Shuang Liu, Jiaxin Miao, Yuxuan Guo, Nan Wu & Dalin Jia
Pages: 2331-2342
Published online: 11 Jul 2019
AbstractforLycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening | Full Text | References | PDF (3.4 MB) | EPUB
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Article
Plumbagin promotes human hepatoma SMMC-7721 cell apoptosis via caspase-3/vimentin signal-mediated EMT
Yanfei Wei, Beibei Lv, Jinling Xie, Yuan Zhang, Yuning Lin, Shengshan Wang, Jing Zhong, Yongxin Chen, Yue Peng & Jing Ma
Pages: 2343-2355
Published online: 15 Jul 2019
AbstractforPlumbagin promotes human hepatoma SMMC-7721 cell apoptosis via caspase-3/vimentin signal-mediated EMT | Full Text | References | PDF (3.2 MB) | EPUB
  • 153 Views
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Article
Pharmacokinetics of the Yougui pill in experimental autoimmune encephalomyelitis model rats and its pharmacological activity in vitro
Haolong Liu, Feng Qiu, Xinwei Yang, Haiyu Zhao, Baolin Bian & Lei Wang
Pages: 2357-2370
Published online: 16 Jul 2019
AbstractforPharmacokinetics of the Yougui pill in experimental autoimmune encephalomyelitis model rats and its pharmacological activity in vitro | Full Text | References | PDF (4 MB) | EPUB
  • 119 Views
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Article
MicroRNA-664 suppresses the growth of cervical cancer cells via targeting c-Kit
Mingfen Lv, Rongying Ou, Qianwen Zhang, Fan Lin, Xiangyun Li, Keyu Wang & Yunsheng Xu
Pages: 2371-2379
Published online: 17 Jul 2019
AbstractforMicroRNA-664 suppresses the growth of cervical cancer cells via targeting c-Kit | Full Text | References | PDF (1.3 MB) | EPUB
  • 103 Views
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Article
A new approach of ocular nebulization with vitamin B12 versus oxytocin for the treatment of dry eye disease: an in vivo confocal microscopy study
Jiarui Yang, Yushi Liu, Yanhui Xu, Xiaodan Li, Jiayu Fu, Xiaodan Jiang, Yilin Chou, Jiahui Ma, Ran Hao, Rong Zhang, Weiqiang Qiu & Xuemin Li
Pages: 2381-2391
Published online: 18 Jul 2019
AbstractforA new approach of ocular nebulization with vitamin B12 versus oxytocin for the treatment of dry eye disease: an in vivo confocal microscopy study | Full Text | References | PDF (6.3 MB) | EPUB
  • 209 Views
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Article
Synthesis and antihepatotoxic activity of dihydropyrimidinone derivatives linked with 1,4-benzodioxane
Mashooq Ahmad Bhat, Mohamed A Al-Omar, Azmat Ali Khan, Amer M Alanazi & Ahmed M Naglah
Pages: 2393-2404
Published online: 18 Jul 2019
AbstractforSynthesis and antihepatotoxic activity of dihydropyrimidinone derivatives linked with 1,4-benzodioxane | Full Text | References | PDF (1.7 MB) | EPUB
  • 198 Views
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Review

Article
Lumacaftor-ivacaftor in the treatment of cystic fibrosis: design, development and place in therapy
GJ Connett
Pages: 2405-2412
Published online: 19 Jul 2019
AbstractforLumacaftor-ivacaftor in the treatment of cystic fibrosis: design, development and place in therapy | Full Text | References | PDF (582 KB) | EPUB
  • 433 Views
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Review Article
Complement system and age-related macular degeneration: drugs and challenges
Jiali Wu & Xiaodong Sun
Pages: 2413-2425
Published online: 19 Jul 2019
AbstractforComplement system and age-related macular degeneration: drugs and challenges | Full Text | References | PDF (742.1 KB) | EPUB
  • 252 Views
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Original Research

Article
A randomized controlled trial evaluating the effects of amlodipine on myocardial iron deposition in pediatric patients with thalassemia major
Arwa Khaled, Hoda A Salem, Dina A Ezzat, Hadeel M Seif & Hoda Rabee
Pages: 2427-2436
Published online: 22 Jul 2019
AbstractforA randomized controlled trial evaluating the effects of amlodipine on myocardial iron deposition in pediatric patients with thalassemia major | Full Text | References | PDF (978.6 KB) | EPUB
  • 322 Views
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Article
RETRACTED ARTICLE: Novel purine thioglycoside analogs: synthesis, nanoformulation and biological evaluation in in vitro human liver and breast cancer models
Mamdouh A Abu-Zaied, Samah A Loutfy, Ashraf E Hassan & Galal H Elgemeie
Pages: 2437-2457
Published online: 26 Jul 2019
AbstractforRETRACTED ARTICLE: Novel purine thioglycoside analogs: synthesis, nanoformulation and biological evaluation in in vitro human liver and breast cancer models | PDF (5.2 MB)
  • 67 Views
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Article
Physicochemical properties and drug-release mechanisms of dual-release bilayer tablet containing mirabegron and fesoterodine fumarate
Hong-Goo Lee, Yun-Sang Park, Jin-Hyuk Jeong, Yong-Bin Kwon, Dae Hwan Shin, Ju-Young Kim, Yun-Seok Rhee, Eun-Seok Park, Dong-Wook Kim & Chun-Woong Park
Pages: 2459-2474
Published online: 23 Jul 2019
AbstractforPhysicochemical properties and drug-release mechanisms of dual-release bilayer tablet containing mirabegron and fesoterodine fumarate | Full Text | References | PDF (4.5 MB) | EPUB
  • 391 Views
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Article
Pharmacokinetics of hard micronized progesterone capsules via vaginal or oral route compared with soft micronized capsules in healthy postmenopausal women: a randomized open-label clinical study
Hanbi Wang, Meizhi Liu, Qiang Fu & Chengyan Deng
Pages: 2475-2482
Published online: 23 Jul 2019
AbstractforPharmacokinetics of hard micronized progesterone capsules via vaginal or oral route compared with soft micronized capsules in healthy postmenopausal women: a randomized open-label clinical study | Full Text | References | PDF (1.5 MB) | EPUB
  • 437 Views
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Article
Pharmacokinetics and tolerability of IDP-73152 mesylate after a single oral administration under fasted and fed conditions in healthy volunteers
Dongseong Shin, Sang-In Park, Hong-Sub Lee, Kyung-Mi An, Juyoung Jung, MyongJae Lee & Kyung-Sang Yu
Pages: 2483-2490
Published online: 24 Jul 2019
AbstractforPharmacokinetics and tolerability of IDP-73152 mesylate after a single oral administration under fasted and fed conditions in healthy volunteers | Full Text | References | PDF (969.7 KB) | EPUB
  • 86 Views
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Review

Review Article
Infliximab and biosimilar infliximab in psoriasis: efficacy, loss of efficacy, and adverse events
Smriti Subedi, Yu Gong, Youdong Chen & Yuling Shi
Pages: 2491-2502
Published online: 23 Jul 2019
AbstractforInfliximab and biosimilar infliximab in psoriasis: efficacy, loss of efficacy, and adverse events | Full Text | References | PDF (332.1 KB) | EPUB
  • 370 Views
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Original Research

Article
Downregulation of microRNA-23b-3p alleviates IL-1β-induced injury in chondrogenic CHON-001 cells
Qining Yang, Yongwei Zhou, Pengfei Cai, Weicong Fu, Jinhua Wang, Qiang Wei & Xiaofei Li
Pages: 2503-2512
Published online: 23 Jul 2019
AbstractforDownregulation of microRNA-23b-3p alleviates IL-1β-induced injury in chondrogenic CHON-001 cells | Full Text | References | PDF (2 MB) | EPUB
  • 109 Views
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Article
Thymol polymeric nanoparticle synthesis and its effects on the toxicity of high glucose on OEC cells: involvement of growth factors and integrin‐linked kinase
Elahe Karimi, Shahryar Abbasi & Naser Abbasi
Pages: 2513-2532
Published online: 25 Jul 2019
AbstractforThymol polymeric nanoparticle synthesis and its effects on the toxicity of high glucose on OEC cells: involvement of growth factors and integrin‐linked kinase | Full Text | References | PDF (6 MB) | EPUB
  • 219 Views
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Article
Pharmacokinetic interactions between telmisartan/amlodipine and rosuvastatin after multiple oral administrations in healthy Korean male subjects
Seol Ju Moon, Ji-Young Jeon, Kyungho Jang, Kyung-Sang Yu, Yeji Lim & Min-Gul Kim
Pages: 2533-2542
Published online: 25 Jul 2019
AbstractforPharmacokinetic interactions between telmisartan/amlodipine and rosuvastatin after multiple oral administrations in healthy Korean male subjects | Full Text | References | PDF (337.8 KB) | EPUB
  • 197 Views
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Article
Erythropoietin enhances osteogenic differentiation of human periodontal ligament stem cells via Wnt/β-catenin signaling pathway
De-Hua Zheng, Xu-Xia Wang, Dan Ma, Li-Na Zhang, Qing-Fang Qiao & Jun Zhang
Pages: 2543-2552
Published online: 26 Jul 2019
AbstractforErythropoietin enhances osteogenic differentiation of human periodontal ligament stem cells via Wnt/β-catenin signaling pathway | Full Text | References | PDF (3.7 MB) | EPUB
  • 138 Views
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Article
Neonatal outcomes and congenital malformations in children born after dydrogesterone application in progestin-primed ovarian stimulation protocol for IVF: a retrospective cohort study
Jialyu Huang, Qin Xie, Jiaying Lin, Xuefeng Lu, Ningling Wang, Hongyuan Gao, Renfei Cai & Yanping Kuang
Pages: 2553-2563
Published online: 26 Jul 2019
AbstractforNeonatal outcomes and congenital malformations in children born after dydrogesterone application in progestin-primed ovarian stimulation protocol for IVF: a retrospective cohort study | Full Text | References | PDF (1.9 MB) | EPUB
  • 254 Views
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Review

Article
Glecaprevir/pibrentasvir for the treatment of chronic hepatitis C: design, development, and place in therapy
Thomas G Cotter & Donald M Jensen
Pages: 2565-2577
Published online: 29 Jul 2019
AbstractforGlecaprevir/pibrentasvir for the treatment of chronic hepatitis C: design, development, and place in therapy | Full Text | References | PDF (1.4 MB) | EPUB
  • 217 Views
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Original Research

Article
Astragaloside IV protects endothelial progenitor cells from the damage of ox-LDL via the LOX-1/NLRP3 inflammasome pathway
Weibin Qian, Xinrui Cai, Qiuhai Qian, Qianzhu Zhuang, Wenjun Yang, Xinying Zhang & Lijie Zhao
Pages: 2579-2589
Published online: 29 Sep 2022
AbstractforAstragaloside IV protects endothelial progenitor cells from the damage of ox-LDL via the LOX-1/NLRP3 inflammasome pathway | Full Text | References | PDF (2.9 MB) | EPUB
  • 115 Views
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Article
Nudol, a phenanthrene derivative from Dendrobium nobile, induces cell cycle arrest and apoptosis and inhibits migration in osteosarcoma cells
Yuying Zhang, Qianqian Zhang, Wei Xin, Na Liu & Hua Zhang
Pages: 2591-2601
Published online: 29 Jul 2019
AbstractforNudol, a phenanthrene derivative from Dendrobium nobile, induces cell cycle arrest and apoptosis and inhibits migration in osteosarcoma cells | Full Text | References | PDF (2.3 MB) | EPUB
  • 159 Views
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Article
Effects of losartan and atorvastatin on the development of early posttraumatic joint stiffness in a rat model
Andreas Baranowski, Ludwig Schlemmer, Katharina Förster, Ekaterina Slotina, Tim Mickan, Sebastian Truffel, Anja Klein, Stefan G Mattyasovszky, Alexander Hofmann, Ulrike Ritz & Pol M Rommens
Pages: 2603-2618
Published online: 30 Jul 2019
AbstractforEffects of losartan and atorvastatin on the development of early posttraumatic joint stiffness in a rat model | Full Text | References | PDF (3.2 MB) | EPUB
  • 216 Views
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Article
Role of heat shock protein 22 in the protective effect of geranylgeranylacetone in response to oxidized-LDL
Ren Gong, Xi-Yong Li, Huai-Jing Chen, Cong-Cong Xu, Hai-Yang Fang, Jian Xiang & Yan-Qing Wu
Pages: 2619-2632
Published online: 30 Jul 2019
AbstractforRole of heat shock protein 22 in the protective effect of geranylgeranylacetone in response to oxidized-LDL | Full Text | References | PDF (3.9 MB) | EPUB
  • 87 Views
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Article
Effects of ondansetron and [6]-gingerol on pica and gut microbiota in rats treated with cisplatin
Xiaodi Feng, Qianqian Cheng, Qi Meng, Yanhong Yang & Ke Nie
Pages: 2633-2641
Published online: 01 Aug 2019
AbstractforEffects of ondansetron and [6]-gingerol on pica and gut microbiota in rats treated with cisplatin | Full Text | References | PDF (454 KB) | EPUB
  • 179 Views
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Review

Review Article
Efficacy of chloral hydrate oral solution for sedation in pediatrics: a systematic review and meta-analysis
Zhe Chen, Mao Lin, Zongyao Huang, Linan Zeng, Liang Huang, Dan Yu & Lingli Zhang
Pages: 2643-2653
Published online: 31 Jul 2019
AbstractforEfficacy of chloral hydrate oral solution for sedation in pediatrics: a systematic review and meta-analysis | Full Text | References | PDF (3.4 MB) | EPUB
  • 292 Views
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Original Research

Article
An investigation of the stability of meropenem in elastomeric infusion devices
Finbarr Foy, Giuseppe Luna, Jorge Martinez, Zach Nizich, Jason Seet, Katie Lie, Bruce Sunderland & Petra Czarniak
Pages: 2655-2665
Published online: 01 Aug 2019
AbstractforAn investigation of the stability of meropenem in elastomeric infusion devices | Full Text | References | PDF (1.8 MB) | EPUB
  • 371 Views
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Article
Carvedilol attenuates carbon tetrachloride-induced liver fibrosis and hepatic sinusoidal capillarization in mice
Ying Wu, Zhen Li, Ai-Yuan Xiu, Dong-Xiao Meng, Si-Ning Wang & Chun-Qing Zhang
Pages: 2667-2676
Published online: 01 Aug 2019
AbstractforCarvedilol attenuates carbon tetrachloride-induced liver fibrosis and hepatic sinusoidal capillarization in mice | Full Text | References | PDF (4.8 MB) | EPUB
  • 218 Views
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Article
Dextromethorphan and memantine after ketamine analgesia: a randomized control trial
Elodie Martin, Marc Sorel, Véronique Morel, Fabienne Marcaillou, Pascale Picard, Noémie Delage, Florence Tiberghien, Marie-Christine Crosmary, Mitra Najjar, Renato Colamarino, Christelle Créach, Béatrice Lietar, Géraldine Brumauld de Montgazon, Anne Margot-Duclot, Marie-Anne Loriot, Céline Narjoz, Céline Lambert, Bruno Pereira & Gisèle Pickering
Pages: 2677-2688
Published online: 02 Aug 2019
AbstractforDextromethorphan and memantine after ketamine analgesia: a randomized control trial | Full Text | References | PDF (1.2 MB) | EPUB
  • 262 Views
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Article
Systemic taurine treatment provides neuroprotection against retinal photoreceptor degeneration and visual function impairments
Ye Tao, Miao He, Qinghua Yang, Zhao Ma, Yingxin Qu, Wen Chen, Guanghua Peng & Dengke Teng
Pages: 2689-2702
Published online: 07 Aug 2019
AbstractforSystemic taurine treatment provides neuroprotection against retinal photoreceptor degeneration and visual function impairments | Full Text | References | PDF (2.6 MB) | EPUB
  • 178 Views
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Article
RETRACTED ARTICLE: Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway
Xinying Zhou, Zezheng Liu, Bin Huang, Huibo Yan, Changsheng Yang, Qingchu Li & Dadi Jin
Pages: 2703-2713
Published online: 05 Aug 2019
AbstractforRETRACTED ARTICLE: Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway | PDF (3.3 MB)
  • 48 Views
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Article
Neuroprotective effects of melatonin and celecoxib against ethanol-induced neurodegeneration: a computational and pharmacological approach
Lina T Al Kury, Alam Zeb, Zain Ul Abidin, Nadeem Irshad, Imran Malik, Arooj Mohsin Alvi, Atif Ali Khan Khalil, Sareer Ahmad, Muhammad Faheem, Arif-Ullah Khan, Fawad Ali Shah & Shupeng Li
Pages: 2715-2727
Published online: 02 Aug 2019
AbstractforNeuroprotective effects of melatonin and celecoxib against ethanol-induced neurodegeneration: a computational and pharmacological approach | Full Text | References | PDF (5.1 MB) | EPUB
  • 403 Views
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Review

Case Report
Association between the c.415C > T, c.52G > A, and 36_37insGGAGTC polymorphisms of NUDT 15 and thiopurine-induced leukopenia, thiopurine intolerance, and severe hair loss: an updated meta-analysis
Ruili Wang, Baogang Liu, Jiapeng Li, Jiamin Xu, Xiaoling Wang, Zhigang Zhao & Libo Zhao
Pages: 2729-2744
Published online: 05 Aug 2019
AbstractforAssociation between the c.415C > T, c.52G > A, and 36_37insGGAGTC polymorphisms of NUDT 15 and thiopurine-induced leukopenia, thiopurine intolerance, and severe hair loss: an updated meta-analysis | Full Text | References | PDF (8.4 MB) | EPUB
  • 113 Views
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Original Research

Article
Liraglutide attenuates cardiac remodeling and improves heart function after abdominal aortic constriction through blocking angiotensin II type 1 receptor in rats
Rong-Hua Zheng, Xiao-Jie Bai, Wei-Wei Zhang, Jing Wang, Feng Bai, Cai-Ping Yan, Erskine A James, Himangshu S Bose, Ning-Ping Wang & Zhi-Qing Zhao
Pages: 2745-2757
Published online: 06 Aug 2019
AbstractforLiraglutide attenuates cardiac remodeling and improves heart function after abdominal aortic constriction through blocking angiotensin II type 1 receptor in rats | Full Text | References | PDF (3 MB) | EPUB
  • 163 Views
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Article
Cerebral protection of epigallocatechin gallate (EGCG) via preservation of mitochondrial function and ERK inhibition in a rat resuscitation model
Sina Qin, Meng-hua Chen, Wei Fang, Xiao-feng Tan, Lu Xie, Ye-gui Yang, Tao Qin & Nuo Li
Pages: 2759-2768
Published online: 07 Aug 2019
AbstractforCerebral protection of epigallocatechin gallate (EGCG) via preservation of mitochondrial function and ERK inhibition in a rat resuscitation model | Full Text | References | PDF (1 MB) | EPUB
  • 141 Views
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Article
Effects of acarbose and metformin on the inflammatory state in newly diagnosed type 2 diabetes patients: a one-year randomized clinical study
Dan Mo, Songfang Liu, Hong Ma, Haoming Tian, Honglin Yu, Xiangxun Zhang, Nanwei Tong, Jiayu Liao & Yan Ren
Pages: 2769-2776
Published online: 09 Aug 2019
AbstractforEffects of acarbose and metformin on the inflammatory state in newly diagnosed type 2 diabetes patients: a one-year randomized clinical study | Full Text | References | PDF (270.2 KB) | EPUB
  • 299 Views
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Review

Review Article
Minoxidil and its use in hair disorders: a review
Poonkiat Suchonwanit, Sasima Thammarucha & Kanchana Leerunyakul
Pages: 2777-2786
Published online: 09 Aug 2019
AbstractforMinoxidil and its use in hair disorders: a review | Full Text | References | PDF (488.9 KB) | EPUB
  • 8726 Views
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Original Research

Article
Thapsigargin induces apoptosis in adrenocortical carcinoma by activating endoplasmic reticulum stress and the JNK signaling pathway: an in vitro and in vivo study
Lili Wu, Xuemei Huang, Yaqi Kuang, Zengmiao Xing, Xiujun Deng & Zuojie Luo
Pages: 2787-2798
Published online: 12 Aug 2019
AbstractforThapsigargin induces apoptosis in adrenocortical carcinoma by activating endoplasmic reticulum stress and the JNK signaling pathway: an in vitro and in vivo study | Full Text | References | PDF (5.1 MB) | EPUB
  • 188 Views
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Article
eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats
Linya Guo, Yanbing Li, Ying Tian, Shaoxin Gong, Xi Chen, Tianhong Peng, Aiping Wang & Zhisheng Jiang
Pages: 2799-2809
Published online: 13 Aug 2019
AbstractforeIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats | Full Text | References | PDF (2.4 MB) | EPUB
  • 131 Views
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Article
Piceatannol inhibits oxidative stress through modification of Nrf2-signaling pathway in testes and attenuates spermatogenesis and steroidogenesis in rats exposed to cadmium during adulthood
Xiaoxue Shi & Lijie Fu
Pages: 2811-2824
Published online: 13 Aug 2019
AbstractforPiceatannol inhibits oxidative stress through modification of Nrf2-signaling pathway in testes and attenuates spermatogenesis and steroidogenesis in rats exposed to cadmium during adulthood | Full Text | References | PDF (3.2 MB) | EPUB
  • 157 Views
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Letter

Article
Nicorandil prior to primary percutaneous coronary intervention improves clinical outcomes in patients with acute myocardial infarction: a meta-analysis of randomized controlled trials [Letter]
Jun Li, Ling Zhang & Aixia Lu
Pages: 2825-2826
Published online: 13 Aug 2019
CitationforNicorandil prior to primary percutaneous coronary intervention improves clinical outcomes in patients with acute myocardial infarction: a meta-analysis of randomized controlled trials [Letter] | Full Text | References | PDF (177.3 KB) | EPUB
  • 72 Views
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Original Research

Article
Protective effects of tiopronin against oxidative stress in severely burned patients
Feng-Jun Qin, Xiao-Hua Hu, Zhong Chen, Xu Chen & Yu-Ming Shen
Pages: 2827-2832
Published online: 13 Aug 2019
AbstractforProtective effects of tiopronin against oxidative stress in severely burned patients | Full Text | References | PDF (242.5 KB) | EPUB
  • 138 Views
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Article
Overexpression of SOX9 alleviates the progression of human osteoarthritis in vitro and in vivo
Yuanming Ouyang, Wei Wang, Bing Tu, Yi Zhu, Cunyi Fan & Yanfeng Li
Pages: 2833-2842
Published online: 13 Aug 2019
AbstractforOverexpression of SOX9 alleviates the progression of human osteoarthritis in vitro and in vivo | Full Text | References | PDF (1.1 MB) | EPUB
  • 294 Views
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Review

Review Article
Denosumab in the treatment of glucocorticoid-induced osteoporosis: a systematic review and meta-analysis
Zeina A Yanbeiy & Karen E Hansen
Pages: 2843-2852
Published online: 14 Aug 2019
AbstractforDenosumab in the treatment of glucocorticoid-induced osteoporosis: a systematic review and meta-analysis | Full Text | References | PDF (910.5 KB) | EPUB
  • 306 Views
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Original Research

Article
Effects of peri-operative intravenous administration of dexmedetomidine on emergence agitation after general anesthesia in adults: a meta-analysis of randomized controlled trials
Jian Zhang, Yang Yu, Shuai Miao, Lu Liu, Shuyuan Gan, Xianhui Kang & Shengmei Zhu
Pages: 2853-2864
Published online: 15 Aug 2019
AbstractforEffects of peri-operative intravenous administration of dexmedetomidine on emergence agitation after general anesthesia in adults: a meta-analysis of randomized controlled trials | Full Text | References | PDF (1.4 MB) | EPUB
  • 247 Views
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Methodology

Article
Validated UPLC-MS/MS method for quantification of fruquintinib in rat plasma and its application to pharmacokinetic study
Yi-Bin Mei, Shun-Bin Luo, Ling-Yan Ye, Qiang Zhang, Jing Guo, Xiang-Jun Qiu & Sai-Li Xie
Pages: 2865-2871
Published online: 15 Aug 2019
AbstractforValidated UPLC-MS/MS method for quantification of fruquintinib in rat plasma and its application to pharmacokinetic study | Full Text | References | PDF (1.6 MB) | EPUB
  • 175 Views
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Original Research

Article
Total extract of Xin Jia Xuan Bai Cheng Qi decoction inhibits pulmonary fibrosis via the TGF-β/Smad signaling pathways in vivo and in vitro
Hui Qin, Hao-Tian Wen, Kai-Juan Gu, Xu-Dong Hu, Tao Yang, Xiao-Feng Yan, Ting-Jie Ye, Jin-Lin Huo & Jing Hu
Pages: 2873-2886
Published online: 19 Aug 2019
AbstractforTotal extract of Xin Jia Xuan Bai Cheng Qi decoction inhibits pulmonary fibrosis via the TGF-β/Smad signaling pathways in vivo and in vitro | Full Text | References | PDF (4.3 MB) | EPUB
  • 127 Views
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Article
Bone marrow mesenchymal stem cell-derived exosomes attenuate D-GaIN/LPS-induced hepatocyte apoptosis by activating autophagy in vitro
Shuxian Zhao, Yan Liu & Zenghui Pu
Pages: 2887-2897
Published online: 19 Aug 2019
AbstractforBone marrow mesenchymal stem cell-derived exosomes attenuate D-GaIN/LPS-induced hepatocyte apoptosis by activating autophagy in vitro | Full Text | References | PDF (2.9 MB) | EPUB
  • 182 Views
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Review

Review Article
Clinical application of obinutuzumab for treating chronic lymphocytic leukemia
Chunyan Luan & Baoan Chen
Pages: 2899-2909
Published online: 19 Aug 2019
AbstractforClinical application of obinutuzumab for treating chronic lymphocytic leukemia | Full Text | References | PDF (1.1 MB) | EPUB
  • 150 Views
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Original Research

Article
RETRACTED ARTICLE: Impact of postoperative dexmedetomidine infusion on incidence of delirium in elderly patients undergoing major elective noncardiac surgery: a randomized clinical trial
Yuanyuan Sun, Mingming Jiang, Yunjing Ji, Yue Sun, Yao Liu & Wen Shen
Pages: 2911-2922
Published online: 19 Aug 2019
AbstractforRETRACTED ARTICLE: Impact of postoperative dexmedetomidine infusion on incidence of delirium in elderly patients undergoing major elective noncardiac surgery: a randomized clinical trial | PDF (633.5 KB)
  • 97 Views
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Article
Rutaecarpine may improve neuronal injury, inhibits apoptosis, inflammation and oxidative stress by regulating the expression of ERK1/2 and Nrf2/HO-1 pathway in rats with cerebral ischemia-reperfusion injury
Meiyu Han, Lin Hu & Yang Chen
Pages: 2923-2931
Published online: 20 Aug 2019
AbstractforRutaecarpine may improve neuronal injury, inhibits apoptosis, inflammation and oxidative stress by regulating the expression of ERK1/2 and Nrf2/HO-1 pathway in rats with cerebral ischemia-reperfusion injury | Full Text | References | PDF (1.6 MB) | EPUB
  • 106 Views
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Article
Effect of intrathecal dexmedetomidine on cesarean section during spinal anesthesia: a meta-analysis of randomized trials
Yun-Qi Wang, Xian-Jie Zhang & Ying Wang
Pages: 2933-2939
Published online: 21 Aug 2019
AbstractforEffect of intrathecal dexmedetomidine on cesarean section during spinal anesthesia: a meta-analysis of randomized trials | Full Text | References | PDF (2.5 MB) | EPUB
  • 275 Views
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Article
Effect of hepatic and renal impairment on the pharmacokinetics of olanzapine and samidorphan given in combination as a bilayer tablet
Lei Sun, Sergey Yagoda, Yangchun Du & Lisa von Moltke
Pages: 2941-2955
Published online: 22 Aug 2019
AbstractforEffect of hepatic and renal impairment on the pharmacokinetics of olanzapine and samidorphan given in combination as a bilayer tablet | Full Text | References | PDF (1.4 MB) | EPUB
  • 182 Views
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Review

Review Article
Attractor – a new turning point in drug discovery
Xucan Hou, Meng Li, Congmin Jia, Xianbao Zhang & Yun Wang
Pages: 2957-2968
Published online: 22 Aug 2019
AbstractforAttractor – a new turning point in drug discovery | Full Text | References | PDF (921.4 KB) | EPUB
  • 130 Views
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Original Research

Article
Esomeprazole alleviates the damage to stress ulcer in rats through not only its antisecretory effect but its antioxidant effect by inactivating the p38 MAPK and NF-κB signaling pathways
Wei Xie, Xielin Huang, Renpin Chen, Ruru Chen, Tang Li, Wei Wu & Zhiming Huang
Pages: 2969-2984
Published online: 22 Aug 2019
AbstractforEsomeprazole alleviates the damage to stress ulcer in rats through not only its antisecretory effect but its antioxidant effect by inactivating the p38 MAPK and NF-κB signaling pathways | Full Text | References | PDF (3.7 MB) | EPUB
  • 314 Views
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Review

Article
The development of an oral GLP-1 receptor agonist for the management of type 2 diabetes: evidence to date
Christina Antza, Krishnarajah Nirantharakumar, Ioannis Doundoulakis, Abd A Tahrani & Konstantinos A Toulis
Pages: 2985-2996
Published online: 22 Aug 2019
AbstractforThe development of an oral GLP-1 receptor agonist for the management of type 2 diabetes: evidence to date | Full Text | References | PDF (445.9 KB) | EPUB
  • 521 Views
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Original Research

Article
A network pharmacology approach to explore active compounds and pharmacological mechanisms of epimedium for treatment of premature ovarian insufficiency
Huishan Zhao, Yinghua Shan, Zhi Ma, Mingwei Yu & Benjiao Gong
Pages: 2997-3007
Published online: 22 Aug 2019
AbstractforA network pharmacology approach to explore active compounds and pharmacological mechanisms of epimedium for treatment of premature ovarian insufficiency | Full Text | References | PDF (8.2 MB) | EPUB
  • 231 Views
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Open Access
Article
Network pharmacology study on the active components of Pterocypsela elata and the mechanism of their effect against cerebral ischemia
Bingxuan Niu, Hui Zhang, Chunyan Li, Fulin Yan, Yu Song, Guangfan Hai, Yunjuan Jiao & Yansheng Feng
Pages: 3009-3019
Published online: 05 Sep 2019
AbstractforNetwork pharmacology study on the active components of Pterocypsela elata and the mechanism of their effect against cerebral ischemia | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Synthesis and antitumor evaluation of neolaxiflorin B inspired compounds
Jing-Ping Liu, Ye-Zhi Xiao, Yu Hu, Xiao-Nian Li, Ming-Jiang Wu, Yong Zhao, Yan Zhao, Ze-Jin Ma & Jing Shen
Pages: 3021-3028
Published online: 23 Aug 2019
AbstractforSynthesis and antitumor evaluation of neolaxiflorin B inspired compounds | Full Text | References | PDF (547.9 KB) | EPUB
  • 114 Views
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Article
Isolation, pharmacological evaluation and molecular docking studies of bioactive compounds from Grewia optiva
Wasim Ul Bari, Mohammad Zahoor, Alam Zeb, Muhammad Umar Khayam Sahibzada, Riaz Ullah, Abdelaaty A Shahat, Hafiz Majid Mahmood & Irfan Khan
Pages: 3029-3036
Published online: 26 Aug 2019
AbstractforIsolation, pharmacological evaluation and molecular docking studies of bioactive compounds from Grewia optiva | Full Text | References | PDF (449.6 KB) | EPUB
  • 450 Views
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Article
Arsenic sulfide induces miR-4665-3p to inhibit gastric cancer cell invasion and migration
Xiuli Zhang, Zhen Tan, Ting Kang, Chuanying Zhu & Siyu Chen
Pages: 3037-3049
Published online: 29 Sep 2022
AbstractforArsenic sulfide induces miR-4665-3p to inhibit gastric cancer cell invasion and migration | Full Text | References | PDF (3 MB) | EPUB
  • 107 Views
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Review

Review Article
Ketamine and depression: a narrative review
Alexandrine Corriger & Gisèle Pickering
Pages: 3051-3067
Published online: 27 Aug 2019
AbstractforKetamine and depression: a narrative review | Full Text | References | PDF (1.8 MB) | EPUB
  • 5814 Views
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Original Research

Article
Antiproliferative activity and possible mechanism of action of certain 5-methoxyindole tethered C-5 functionalized isatins
Maha S Almutairi, Eman S Hassan, Adam B Keeton, Gary A Piazza, Ali S Abdelhameed & Mohamed I Attia
Pages: 3069-3078
Published online: 29 Sep 2022
AbstractforAntiproliferative activity and possible mechanism of action of certain 5-methoxyindole tethered C-5 functionalized isatins | Full Text | References | PDF (943.1 KB) | EPUB
  • 100 Views
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Article
Design, synthesis, and biological study of 4-[(2-nitroimidazole-1H-alkyloxyl)aniline]-quinazolines as EGFR inhibitors exerting cytotoxicities both under normoxia and hypoxia
Weiyan Cheng, Suhua Wang, Zhiheng Yang, Xin Tian & Yongzhou Hu
Pages: 3079-3089
Published online: 28 Aug 2019
AbstractforDesign, synthesis, and biological study of 4-[(2-nitroimidazole-1H-alkyloxyl)aniline]-quinazolines as EGFR inhibitors exerting cytotoxicities both under normoxia and hypoxia | Full Text | References | PDF (1.1 MB) | EPUB
  • 128 Views
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Article
Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation
Yong-Liang Yuan, Neng Jiang, Ze-Yun Li, Zhi-Zhen Song, Zhi-Heng Yang, Wen-Hua Xue, Xiao-Jian Zhang & Yue Du
Pages: 3091-3103
Published online: 28 Aug 2019
AbstractforPolyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation | Full Text | References | PDF (3.8 MB) | EPUB
  • 121 Views
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Article
Therapeutic potential of BLT1 antagonist for COPD: involvement of inducing autophagy and ameliorating inflammation
Li Zhang, Jingwen Huang, Ran Dong, Yun Feng & Min Zhou
Pages: 3105-3116
Published online: 04 Sep 2019
AbstractforTherapeutic potential of BLT1 antagonist for COPD: involvement of inducing autophagy and ameliorating inflammation | Full Text | References | PDF (5.9 MB) | EPUB
  • 139 Views
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Article
Silibinin attenuates high-fat diet-induced renal fibrosis of diabetic nephropathy
Kun Liu, Shiju Zhou, Jinyan Liu, Yingying Wang, Fengxian Zhu & Man Liu
Pages: 3117-3126
Published online: 29 Aug 2019
AbstractforSilibinin attenuates high-fat diet-induced renal fibrosis of diabetic nephropathy | Full Text | References | PDF (2.4 MB) | EPUB
  • 169 Views
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Article
Pharmacokinetic and bioequivalence study between two formulations of S-1 in Korean gastric cancer patients
Hae Won Lee, Sook Jin Seong, Woo Youl Kang, Boram Ohk, Mi-Ri Gwon, Bo Kyung Kim, Seungil Cho, Kyunghee Cho, Yong Kyung Sung, Young-Ran Yoon & Jong Gwang Kim
Pages: 3127-3136
Published online: 03 Sep 2019
AbstractforPharmacokinetic and bioequivalence study between two formulations of S-1 in Korean gastric cancer patients | Full Text | References | PDF (807.6 KB) | EPUB
  • 115 Views
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Article
Dexmedetomidine protects H9c2 cardiomyocytes against oxygen-glucose deprivation/reoxygenation-induced intracellular calcium overload and apoptosis through regulating FKBP12.6/RyR2 signaling
Mei Yuan, Xiao-Wen Meng, Jiao Ma, Hong Liu, Shao-Yong Song, Qing-Cai Chen, Hua-Yue Liu, Juan Zhang, Nan Song, Fu-Hai Ji & Ke Peng
Pages: 3137-3149
Published online: 02 Sep 2019
AbstractforDexmedetomidine protects H9c2 cardiomyocytes against oxygen-glucose deprivation/reoxygenation-induced intracellular calcium overload and apoptosis through regulating FKBP12.6/RyR2 signaling | Full Text | References | PDF (8.4 MB) | EPUB
  • 121 Views
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Article
The safety, pharmacodynamics, and pharmacokinetics of immediate-release formulation containing esomeprazole 20 mg/sodium bicarbonate 800 mg in healthy adult male
Dasohm Kim, Min Soo Park, Byung Won Yoo, Taegon Hong, Shin Jung Park & Choon Ok Kim
Pages: 3151-3159
Published online: 03 Sep 2019
AbstractforThe safety, pharmacodynamics, and pharmacokinetics of immediate-release formulation containing esomeprazole 20 mg/sodium bicarbonate 800 mg in healthy adult male | Full Text | References | PDF (932.3 KB) | EPUB
  • 325 Views
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Article
Mifepristone inhibits IGF-1 signaling pathway in the treatment of uterine leiomyomas
Qi Shen, Shuangwei Zou, Bo Sheng, Menghuang Zhao, Lu-Zhe Sun & Xueqiong Zhu
Pages: 3161-3170
Published online: 03 Sep 2019
AbstractforMifepristone inhibits IGF-1 signaling pathway in the treatment of uterine leiomyomas | Full Text | References | PDF (6 MB) | EPUB
  • 112 Views
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Article
Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes
Xiao-yuan Zheng, Shi-ming Yang, Rong Zhang, Su-min Wang, Guo-bing Li & Shi-wen Zhou
Pages: 3171-3180
Published online: 29 Sep 2022
AbstractforEmodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes | Full Text | References | PDF (3.4 MB) | EPUB
  • 181 Views
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Article
Omalizumab for chronic spontaneous urticaria in “complex” patients: data from real-life clinical practice
Laura Vollono, Arianna Piccolo, Caterina Lanna, Maria Esposito, Mauro Bavetta, Elena Campione, Luca Bianchi & Laura Diluvio
Pages: 3181-3186
Published online: 06 Sep 2019
AbstractforOmalizumab for chronic spontaneous urticaria in “complex” patients: data from real-life clinical practice | Full Text | References | PDF (267.3 KB) | EPUB
  • 146 Views
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Review

Article
Clinical evaluation of dacomitinib for the treatment of metastatic non-small cell lung cancer (NSCLC): current perspectives
Daniele Lavacchi, Francesca Mazzoni & Giuseppe Giaccone
Pages: 3187-3198
Published online: 29 Sep 2022
AbstractforClinical evaluation of dacomitinib for the treatment of metastatic non-small cell lung cancer (NSCLC): current perspectives | Full Text | References | PDF (504.2 KB) | EPUB
  • 299 Views
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Original Research

Article
Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats
Cong Hao, Xuewen Wu, Ruoyu Zhou, Hao Zhang, Yulai Zhou, Xinxing Wang, Yong Feng, Lingyun Mei, Chufeng He, Xinzhang Cai & Lisha Wu
Pages: 3199-3206
Published online: 29 Sep 2022
AbstractforDownregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats | Full Text | References | PDF (2.2 MB) | EPUB
  • 135 Views
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Article
Palliative chemotherapy with or without anti-EGFR therapy for de novo metastatic nasopharyngeal carcinoma: a propensity score-matching study
Xue-Song Sun, Yu-Jing Liang, Xiao-Yun Li, Sai-Lan Liu, Qiu-Yan Chen, Lin-Quan Tang & Hai-Qiang Mai
Pages: 3207-3216
Published online: 10 Sep 2019
AbstractforPalliative chemotherapy with or without anti-EGFR therapy for de novo metastatic nasopharyngeal carcinoma: a propensity score-matching study | Full Text | References | PDF (1.6 MB) | EPUB
  • 81 Views
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Article
Ubenimex induces apoptotic and autophagic cell death in rat GH3 and MMQ cells through the ROS/ERK pathway
Yanjun Wang, Bo Pang, Rui Zhang, Yibing Fu & Qi Pang
Pages: 3217-3228
Published online: 12 Sep 2019
AbstractforUbenimex induces apoptotic and autophagic cell death in rat GH3 and MMQ cells through the ROS/ERK pathway | Full Text | References | PDF (9.8 MB) | EPUB
  • 99 Views
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Article
Preclinical pharmacodynamic and pharmacokinetic characterization of the major metabolites of cariprazine
Béla Kiss, Zsolt Némethy, Károly Fazekas, Dalma Kurkó, István Gyertyán, Katalin Sághy, István Laszlovszky, Bence Farkas, Norbert Kirschner, Etelka Bolf-Terjéki, Ottilia Balázs & Balázs Lendvai
Pages: 3229-3248
Published online: 16 Sep 2019
AbstractforPreclinical pharmacodynamic and pharmacokinetic characterization of the major metabolites of cariprazine | Full Text | References | PDF (967.2 KB) | EPUB
  • 411 Views
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Article
Identification of substandard drug products using electronic tongue: cefdinir suspension as a pilot example
Nawaf Abu-Khalaf, Abdel Naser Zaid, Nidal Jaradat, Alaaldin M Alkilany, Samer R Abulateefeh, Rowa Al Ramahi & Mashhour Ghanem
Pages: 3249-3258
Published online: 16 Sep 2019
AbstractforIdentification of substandard drug products using electronic tongue: cefdinir suspension as a pilot example | Full Text | References | PDF (840.1 KB) | EPUB
  • 137 Views
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Article
Carbocisteine inhibits the expression of Muc5b in COPD mouse model
Yan Song, Wei Wang, Yanqing Xie, Bin Xiang, Xuan Huang, Weijie Guan & Jinping Zheng
Pages: 3259-3268
Published online: 16 Sep 2019
AbstractforCarbocisteine inhibits the expression of Muc5b in COPD mouse model | Full Text | References | PDF (5.8 MB) | EPUB
  • 159 Views
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Article
A novel curcumin-loaded composite dressing facilitates wound healing due to its natural antioxidant effect
Yong Zhao, Chuanyu Dai, Zheng Wang, Weimin Chen, Jiaguo Liu, Renxi Zhuo, Aixi Yu & Shiwen Huang
Pages: 3269-3280
Published online: 16 Sep 2019
AbstractforA novel curcumin-loaded composite dressing facilitates wound healing due to its natural antioxidant effect | Full Text | References | PDF (9.4 MB) | EPUB
  • 217 Views
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Article
Gemcitabine-loaded RGD modified liposome for ovarian cancer: preparation, characterization and pharmacodynamic studies
Zhongyuan Tang, Weiwei Feng, Yiqing Yang & Qun Wang
Pages: 3281-3290
Published online: 17 Sep 2019
AbstractforGemcitabine-loaded RGD modified liposome for ovarian cancer: preparation, characterization and pharmacodynamic studies | Full Text | References | PDF (2.1 MB) | EPUB
  • 180 Views
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Article
Muscone Promotes The Adipogenic Differentiation Of Human Gingival Mesenchymal Stem Cells By Inhibiting The Wnt/β-Catenin Signaling Pathway
Wen-Xiu Yuan, Xu-Xia Wang, De-Hua Zheng, Dan Ma, Qun Cui, Fan Yang & Jun Zhang
Pages: 3291-3306
Published online: 18 Sep 2019
AbstractforMuscone Promotes The Adipogenic Differentiation Of Human Gingival Mesenchymal Stem Cells By Inhibiting The Wnt/β-Catenin Signaling Pathway | Full Text | References | PDF (13.1 MB) | EPUB
  • 101 Views
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Article
Topical anesthetic analgesic therapy using the combination of ropivacaine and dexmedetomidine: hyaluronic acid modified long-acting nanostructured lipid carriers containing a skin penetration enhancer
Yongjian Yang, Dahai Qiu, Yajun Liu & Lei Chao
Pages: 3307-3319
Published online: 18 Sep 2019
AbstractforTopical anesthetic analgesic therapy using the combination of ropivacaine and dexmedetomidine: hyaluronic acid modified long-acting nanostructured lipid carriers containing a skin penetration enhancer | Full Text | References | PDF (2.9 MB) | EPUB
  • 165 Views
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Article
Effects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats
Zheen Aorahman Ahmed, Aso Nihad Abtar, Hemn Hassan Othman & Tavga Ahmed Aziz
Pages: 3321-3329
Published online: 20 Sep 2019
AbstractforEffects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats | Full Text | References | PDF (6.9 MB) | EPUB
  • 369 Views
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Article
Bioequivalence Study Of A Fixed-Dose Combination Tablet Containing Melitracen 10 mg And Flupentixol 0.5 mg In Healthy Chinese Volunteers Under Fasted And Fed Conditions
Lihua Wu, Chang Xu, Guolan Wu, Huili Zhou, Duo Lv, You Zhai, Yujie Huang, Wenling Tang, Fangqiong Li & Jianzhong Shentu
Pages: 3331-3342
Published online: 19 Sep 2019
AbstractforBioequivalence Study Of A Fixed-Dose Combination Tablet Containing Melitracen 10 mg And Flupentixol 0.5 mg In Healthy Chinese Volunteers Under Fasted And Fed Conditions | Full Text | References | PDF (5.5 MB) | EPUB
  • 226 Views
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Article
Effect Of Chinese Herb Danzhi Xiaoyao Pills On Pharmacokinetics Of Venlafaxine In Beagles
Yong-liang Zhu, Shuang-long Li, Ke-li Chen, Kun-peng Ma, De-qian Wu & Xiang-jun Qiu
Pages: 3343-3355
Published online: 20 Sep 2019
AbstractforEffect Of Chinese Herb Danzhi Xiaoyao Pills On Pharmacokinetics Of Venlafaxine In Beagles | Full Text | References | PDF (6.8 MB) | EPUB
  • 108 Views
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Article
Effects of loratadine, a histamine H1 receptor antagonist, on the skeletal system of young male rats
Joanna Folwarczna, Natalia Konarek, Karolina Freier, Dawid Karbowniczek, Piotr Londzin & Aleksandra Janas
Pages: 3357-3367
Published online: 23 Sep 2019
AbstractforEffects of loratadine, a histamine H1 receptor antagonist, on the skeletal system of young male rats | Full Text | References | PDF (1.2 MB) | EPUB
  • 214 Views
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Article
Design, Synthesis, And Evaluation Of Cyanopyridines As Anti-Colorectal Cancer Agents Via Inhibiting STAT3 Pathway
Lingyuan Xu, Lingxi Shi, Sensen Qiu, Siyu Chen, Mengsha Lin, Youqun Xiang, Chengguang Zhao, Jiandong Zhu, Liqun Shen & Zhigui Zuo
Pages: 3369-3381
Published online: 24 Sep 2019
AbstractforDesign, Synthesis, And Evaluation Of Cyanopyridines As Anti-Colorectal Cancer Agents Via Inhibiting STAT3 Pathway | Full Text | References | PDF (5.5 MB) | EPUB
  • 157 Views
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Article
Effect Of Bevacizumab On Growth Of Human Nasal Polyposis In Vitro; An Off-Label Use Of Anti-Angiogenic Agent For Nasal Polyposis Treatment
Shadman Nemati, Faeze Keihanian, Amin Saeidinia & Mahdi Bakhshaei
Pages: 3383-3389
Published online: 24 Sep 2019
AbstractforEffect Of Bevacizumab On Growth Of Human Nasal Polyposis In Vitro; An Off-Label Use Of Anti-Angiogenic Agent For Nasal Polyposis Treatment | Full Text | References | PDF (3 MB) | EPUB
  • 118 Views
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Article
Paclitaxel alleviated sepsis-induced acute lung injury by activating MUC1 and suppressing TLR-4/NF-κB pathway
Yu-Ming Wang, Ran Ji, Wei-Wei Chen, Shun-Wei Huang, Yan-Jun Zheng, Zhi-Tao Yang, Hong-Ping Qu, Hao Chen, En-Qiang Mao, Ying Chen & Er-Zhen Chen
Pages: 3391-3404
Published online: 24 Sep 2019
AbstractforPaclitaxel alleviated sepsis-induced acute lung injury by activating MUC1 and suppressing TLR-4/NF-κB pathway | Full Text | References | PDF (7 MB) | EPUB
  • 228 Views
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Review

Review Article
Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications
Mohsen Doostmohammadi, Atefeh Ameri, Reza Mohammadinejad, Negar Dehghannoudeh, Ibrahim M Banat, Mandana Ohadi & Gholamreza Dehghannoudeh
Pages: 3405-3418
Published online: 26 Sep 2019
AbstractforHydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications | Full Text | References | PDF (864 KB) | EPUB
  • 260 Views
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Original Research

Article
The Efficacy And Safety Of Apatinib Treatment For Patients With Metastatic Or Recurrent Cervical Cancer: A Retrospective Study
Jiangtao Yu, Ziwen Xu, Anyang Li, Jindi Zhang, Yi Wang, Hongqin Zhao & Haiyan Zhu
Pages: 3419-3424
Published online: 26 Sep 2019
AbstractforThe Efficacy And Safety Of Apatinib Treatment For Patients With Metastatic Or Recurrent Cervical Cancer: A Retrospective Study | Full Text | References | PDF (714.4 KB) | EPUB
  • 102 Views
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Review

Review Article
Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties
Luca Gallelli
Pages: 3425-3437
Published online: 27 Sep 2019
AbstractforEscin: a review of its anti-edematous, anti-inflammatory, and venotonic properties | Full Text | References | PDF (4.9 MB) | EPUB
  • 1093 Views
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Original Research

Article
Efficacy, Safety And Feasibility Of Antiemetic Prophylaxis With Fosaprepitant, Granisetron And Dexamethasone In Pediatric Patients With Hemato-Oncological Malignancies
Karin Melanie Cabanillas Stanchi, Martin Ebinger, Ulrike Hartmann, Manon Queudeville, Judith Feucht, Michael Ost, Marie-Sarah Koch, Carmen Malaval, Markus Mezger, Sarah Schober, Simone Weber, Sebastian Michaelis, Veit Lange, Peter Lang, Rupert Handgretinger & Michaela Döring
Pages: 3439-3451
Published online: 30 Sep 2019
AbstractforEfficacy, Safety And Feasibility Of Antiemetic Prophylaxis With Fosaprepitant, Granisetron And Dexamethasone In Pediatric Patients With Hemato-Oncological Malignancies | Full Text | References | PDF (5.7 MB) | EPUB
  • 167 Views
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Article
Efficacy And Safety Of Travoprost Versus Timolol To Treat Early-Onset Ocular Hypertension Secondary To Vitrectomy: A Randomized Trial
Yuan Fang, Hsiangyu Ku, Dekang Gan, Rui Jiang & Xinghuai Sun
Pages: 3453-3463
Published online: 30 Sep 2019
AbstractforEfficacy And Safety Of Travoprost Versus Timolol To Treat Early-Onset Ocular Hypertension Secondary To Vitrectomy: A Randomized Trial | Full Text | References | PDF (8.6 MB) | EPUB
  • 129 Views
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Article
Dexmedetomidine Attenuates Neuroinflammation In LPS-Stimulated BV2 Microglia Cells Through Upregulation Of miR-340
Yang Bao, Yijun Zhu, Guangbao He, Hongwei Ni, Chenxia Liu, Limin Ma, Lifeng Zhang & Dongping Shi
Pages: 3465-3475
Published online: 03 Oct 2019
AbstractforDexmedetomidine Attenuates Neuroinflammation In LPS-Stimulated BV2 Microglia Cells Through Upregulation Of miR-340 | Full Text | References | PDF (6.7 MB) | EPUB
  • 232 Views
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Article
Evaluation of the effect of long-term use of antidepressants in the SSRI group on bone density with dental volumetric tomography
Kamil Serkan Agacayak, Rıdvan Guler & Bekir Ilyasov
Pages: 3477-3484
Published online: 03 Oct 2019
AbstractforEvaluation of the effect of long-term use of antidepressants in the SSRI group on bone density with dental volumetric tomography | Full Text | References | PDF (1.5 MB) | EPUB
  • 317 Views
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Article
Enzyme Inhibitory, Antioxidant And Antibacterial Potentials Of Synthetic Symmetrical And Unsymmetrical Thioureas
Sumaira Naz, Muhammad Zahoor, Muhammad Naveed Umar, Barkat Ali, Riaz Ullah, Abdelaaty A Shahat, Hafiz Majid Mahmood & Muhammad Umar Khayam Sahibzada
Pages: 3485-3495
Published online: 07 Oct 2019
AbstractforEnzyme Inhibitory, Antioxidant And Antibacterial Potentials Of Synthetic Symmetrical And Unsymmetrical Thioureas | Full Text | References | PDF (1.1 MB) | EPUB
  • 200 Views
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Review

Review Article
The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies
Sok Kuan Wong, Kok-Yong Chin & Soelaiman Ima-Nirwana
Pages: 3497-3514
Published online: 07 Oct 2019
AbstractforThe Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies | Full Text | References | PDF (762.2 KB) | EPUB
  • 524 Views
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Original Research

Article
Thrombospondin-1 Serum Levels In Hypertensive Patients With Endothelial Dysfunction After One Year Of Treatment With Perindopril
Valentina Buda, Minodora Andor, Carmen Cristescu, Mirela Cleopatra Tomescu, Danina M Muntean, Dana Emilia Bâibâță, Diana Aurora Bordejevic, Corina Danciu, Olivia Dalleur, Dorina Coricovac, Zorin Crainiceanu, Anca Tudor, Ionut Ledeti & Lucian Petrescu
Pages: 3515-3526
Published online: 29 Sep 2022
AbstractforThrombospondin-1 Serum Levels In Hypertensive Patients With Endothelial Dysfunction After One Year Of Treatment With Perindopril | Full Text | References | PDF (657.2 KB) | EPUB
  • 122 Views
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Corrigendum

Correction
20(S)-Ginsenoside Rg3 Promotes Senescence And Apoptosis In Gallbladder Cancer Cells Via The P53 Pathway [Corrigendum]
Pages: 3527-3528
Published online: 08 Oct 2019
Citationfor20(S)-Ginsenoside Rg3 Promotes Senescence And Apoptosis In Gallbladder Cancer Cells Via The P53 Pathway [Corrigendum] | Full Text | PDF (2 MB) | EPUB
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Original Research

Article
Aucubin Protects Chondrocytes Against IL-1β-Induced Apoptosis In Vitro And Inhibits Osteoarthritis In Mice Model
Bo-wei Wang, Yi Jiang, Zi-long Yao, Pei-sheng Chen, Bin Yu & Sheng-nan Wang
Pages: 3529-3538
Published online: 09 Oct 2019
AbstractforAucubin Protects Chondrocytes Against IL-1β-Induced Apoptosis In Vitro And Inhibits Osteoarthritis In Mice Model | Full Text | References | PDF (6.7 MB) | EPUB
  • 238 Views
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Article
Indole-2-Carboxamide Derivative LG25 Inhibits Triple-Negative Breast Cancer Growth By Suppressing Akt/mTOR/NF-κB Signalling Pathway
Xiaohong Xu, Vinothkumar Rajamanickam, Sheng Shu, Zhoudi Liu, Tao Yan, Jinxin He, Zhiguo Liu, Guilong Guo, Guang Liang & Yi Wang
Pages: 3539-3550
Published online: 11 Oct 2019
AbstractforIndole-2-Carboxamide Derivative LG25 Inhibits Triple-Negative Breast Cancer Growth By Suppressing Akt/mTOR/NF-κB Signalling Pathway | Full Text | References | PDF (9.5 MB) | EPUB
  • 140 Views
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Article
Clinical And Bacteriological Impact Of Clarithromycin In Streptococcal Pharyngitis: Findings From A Meta-Analysis Of Clinical Trials
Daryl J Hoban & Jos Nauta
Pages: 3551-3558
Published online: 16 Oct 2019
AbstractforClinical And Bacteriological Impact Of Clarithromycin In Streptococcal Pharyngitis: Findings From A Meta-Analysis Of Clinical Trials | Full Text | References | PDF (709.4 KB) | EPUB
  • 266 Views
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Article
Tanshinone I Inhibits IL-1β-Induced Apoptosis, Inflammation And Extracellular Matrix Degradation In Chondrocytes CHON-001 Cells And Attenuates Murine Osteoarthritis
Xipeng Wang, Jianbo Fan, Xiaomin Ding, Yuyu Sun, Zhiming Cui & Wei Liu
Pages: 3559-3568
Published online: 15 Oct 2019
AbstractforTanshinone I Inhibits IL-1β-Induced Apoptosis, Inflammation And Extracellular Matrix Degradation In Chondrocytes CHON-001 Cells And Attenuates Murine Osteoarthritis | Full Text | References | PDF (4.4 MB) | EPUB
  • 203 Views
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Article
Formulation, Characterization And Evaluation Of Curcumin- Loaded PLGA- TPGS Nanoparticles For Liver Cancer Treatment
Xiao-ping Chen, Yi Li, Yu Zhang & Gao-wei Li
Pages: 3569-3578
Published online: 16 Oct 2019
AbstractforFormulation, Characterization And Evaluation Of Curcumin- Loaded PLGA- TPGS Nanoparticles For Liver Cancer Treatment | Full Text | References | PDF (5.6 MB) | EPUB
  • 285 Views
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Article
Diammonium Glycyrrhizinate Mitigates Liver Injury Via Inhibiting Proliferation Of NKT Cells And Promoting Proliferation Of Tregs
Meixin Gao, Xiulan Li, Lingling He, Junru Yang, Xiaohui Ye, Fan Xiao & Hongshan Wei
Pages: 3579-3589
Published online: 16 Oct 2019
AbstractforDiammonium Glycyrrhizinate Mitigates Liver Injury Via Inhibiting Proliferation Of NKT Cells And Promoting Proliferation Of Tregs | Full Text | References | PDF (7.5 MB) | EPUB
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Review

Review Article
In-vitro blood-brain barrier models for drug screening and permeation studies: an overview
Sounak Bagchi, Tanya Chhibber, Behnaz Lahooti, Angela Verma, Vivek Borse & Rahul Dev Jayant
Pages: 3591-3605
Published online: 18 Oct 2019
AbstractforIn-vitro blood-brain barrier models for drug screening and permeation studies: an overview | Full Text | References | PDF (4.8 MB) | EPUB
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Original Research

Article
MicroRNA-384-5p/Beclin-1 As Potential Indicators For Epigallocatechin Gallate Against Cardiomyocytes Ischemia Reperfusion Injury By Inhibiting Autophagy Via PI3K/Akt Pathway
Chan Zhang, Ronggan Liang, Xiaowen Gan, Xiufang Yang, LingLin Chen & Jie Jian
Pages: 3607-3623
Published online: 17 Oct 2019
AbstractforMicroRNA-384-5p/Beclin-1 As Potential Indicators For Epigallocatechin Gallate Against Cardiomyocytes Ischemia Reperfusion Injury By Inhibiting Autophagy Via PI3K/Akt Pathway | Full Text | References | PDF (15.3 MB) | EPUB
  • 117 Views
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Article
The Effect Of Food On The Pharmacokinetic Properties And Bioequivalence Of Two Formulations Of Levocetirizine Dihydrochloride In Healthy Chinese Volunteers
Yu Cheng, Bi-Juan Lin, Jin-Hua Guo, Bing-Lin Huang, Lin-Ping Fang, Wan-Cai Que, Mao-Bai Liu, Xin-Feng Chen & Hong-Qiang Qiu
Pages: 3625-3634
Published online: 18 Oct 2019
AbstractforThe Effect Of Food On The Pharmacokinetic Properties And Bioequivalence Of Two Formulations Of Levocetirizine Dihydrochloride In Healthy Chinese Volunteers | Full Text | References | PDF (2.3 MB) | EPUB
  • 287 Views
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Review

Review Article
Lanadelumab Injection Treatment For The Prevention Of Hereditary Angioedema (HAE): Design, Development And Place In Therapy
Maria Bova, Anna Valerieva, Maddalena Alessandra Wu, Riccardo Senter & Francesca Perego
Pages: 3635-3646
Published online: 22 Oct 2019
AbstractforLanadelumab Injection Treatment For The Prevention Of Hereditary Angioedema (HAE): Design, Development And Place In Therapy | Full Text | References | PDF (1.4 MB) | EPUB
  • 119 Views
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Original Research

Article
Coenzyme q10 liquid supplementation in dyslipidemic subjects with statin-related clinical symptoms: a double-blind, randomized, placebo-controlled study
Giuseppe Derosa, Angela D'Angelo & Pamela Maffioli
Pages: 3647-3655
Published online: 21 Oct 2019
AbstractforCoenzyme q10 liquid supplementation in dyslipidemic subjects with statin-related clinical symptoms: a double-blind, randomized, placebo-controlled study | Full Text | References | PDF (795.2 KB) | EPUB
  • 337 Views
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Article
Olmesartan Medoxomil, An Angiotensin II-Receptor Blocker, Ameliorates Renal Injury In db/db Mice
Ye Zhu, Ze-Liang Li, Ao Ding, Hui Yang, Wei-Ping Zhu, Tong-Xia Cui, Hui-Tao Zhang & Hua Zhang
Pages: 3657-3667
Published online: 22 Oct 2019
AbstractforOlmesartan Medoxomil, An Angiotensin II-Receptor Blocker, Ameliorates Renal Injury In db/db Mice | Full Text | References | PDF (7.9 MB) | EPUB
  • 128 Views
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Article
A Novel Octapeptide Derived From G Protein-Coupled Receptor 124 Improves Cognitive Function Via Pro-Angiogenesis In A Rat Model Of Chronic Cerebral Hypoperfusion-Induced Vascular Dementia
Ying Xiao, Hong Shen, Rui Li, Xia Zhou, Hong Xiao & Jun Yan
Pages: 3669-3682
Published online: 23 Oct 2019
AbstractforA Novel Octapeptide Derived From G Protein-Coupled Receptor 124 Improves Cognitive Function Via Pro-Angiogenesis In A Rat Model Of Chronic Cerebral Hypoperfusion-Induced Vascular Dementia | Full Text | References | PDF (6.4 MB) | EPUB
  • 97 Views
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Article
Glucoside Derivatives Of Podophyllotoxin: Synthesis, Physicochemical Properties, And Cytotoxicity
Cheng-Ting Zi, Liu Yang, Qing-Hua Kong, Hong-Mei Li, Xing-Zhi Yang, Zhong-Tao Ding, Zi-Hua Jiang, Jiang-Miao Hu & Jun Zhou
Pages: 3683-3692
Published online: 23 Oct 2019
AbstractforGlucoside Derivatives Of Podophyllotoxin: Synthesis, Physicochemical Properties, And Cytotoxicity | Full Text | References | PDF (3.7 MB) | EPUB
  • 154 Views
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Article
Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord Injury
Chuanliang Zhao, Xin Zhou, Jie Qiu, Danqing Xin, Tingting Li, Xili Chu, Hongtao Yuan, Haifeng Wang, Zhen Wang & Dachuan Wang
Pages: 3693-3704
Published online: 24 Oct 2019
AbstractforExosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord Injury | Full Text | References | PDF (4.6 MB) | EPUB
  • 191 Views
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Article
Cardio- Renal Outcomes With Long- Term Agalsidase Alfa Enzyme Replacement Therapy: A 10- Year Fabry Outcome Survey (FOS) Analysis
Uma Ramaswami, Michael Beck, Derralynn Hughes, Christoph Kampmann, Jaco Botha, Guillem Pintos-Morell, Michael L West, Dau-Ming Niu, Kathy Nicholls, Roberto Giugliani & On behalf of the FOS Study Group
Pages: 3705-3715
Published online: 25 Oct 2019
AbstractforCardio- Renal Outcomes With Long- Term Agalsidase Alfa Enzyme Replacement Therapy: A 10- Year Fabry Outcome Survey (FOS) Analysis | Full Text | References | PDF (6 MB) | EPUB
  • 141 Views
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Article
miR- 26a Sensitizes Melanoma Cells To Dabrafenib Via Targeting HMGB1-Dependent Autophagy Pathways
Yan Yu, Niu Xiang, Min Lin, Jin-Wen Huang, Jing Zhang, Bo Cheng & Chao Ji
Pages: 3717-3726
Published online: 29 Oct 2019
AbstractformiR- 26a Sensitizes Melanoma Cells To Dabrafenib Via Targeting HMGB1-Dependent Autophagy Pathways | Full Text | References | PDF (9.5 MB) | EPUB
  • 103 Views
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Article
Baseline Lymphopenia: A Predictor Of Poor Outcomes In HER2 positive Metastatic Breast Cancer Treated With Trastuzumab
Yi-Qun Che, Yue Zhang, Di Wang, Hui-Ying Liu, Di Shen & Yang Luo
Pages: 3727-3734
Published online: 29 Oct 2019
AbstractforBaseline Lymphopenia: A Predictor Of Poor Outcomes In HER2 positive Metastatic Breast Cancer Treated With Trastuzumab | Full Text | References | PDF (934.4 KB) | EPUB
  • 89 Views
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Article
Renoprotective Effects Of Isoliquiritin Against Cationic Bovine Serum Albumin-Induced Membranous Glomerulonephritis In Experimental Rat Model Through Its Anti-Oxidative And Anti-Inflammatory Properties
Yingying Liu, Xiaohua Xu, Ruisi Xu & Siqi Zhang
Pages: 3735-3751
Published online: 30 Oct 2019
AbstractforRenoprotective Effects Of Isoliquiritin Against Cationic Bovine Serum Albumin-Induced Membranous Glomerulonephritis In Experimental Rat Model Through Its Anti-Oxidative And Anti-Inflammatory Properties | Full Text | References | PDF (16.3 MB) | EPUB
  • 152 Views
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Review

Review Article
Smart Targeting To Improve Cancer Therapeutics
Moraima Morales-Cruz, Yamixa Delgado, Betzaida Castillo, Cindy M Figueroa, Anna M Molina, Anamaris Torres, Melissa Milián & Kai Griebenow
Pages: 3753-3772
Published online: 30 Oct 2019
AbstractforSmart Targeting To Improve Cancer Therapeutics | Full Text | References | PDF (3.6 MB) | EPUB
  • 501 Views
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Original Research

Article
Protective Effect Of Vasicine Against Myocardial Infarction In Rats Via Modulation Of Oxidative Stress, Inflammation, And The PI3K/Akt Pathway
Tiechao Jiang, Lirong Zhang, Mei Ding & Min Li
Pages: 3773-3784
Published online: 31 Oct 2019
AbstractforProtective Effect Of Vasicine Against Myocardial Infarction In Rats Via Modulation Of Oxidative Stress, Inflammation, And The PI3K/Akt Pathway | Full Text | References | PDF (4.7 MB) | EPUB
  • 335 Views
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Article
Subarachnoid and epidural dexmedetomidine for the prevention of post-anesthetic shivering: a meta-analysis and systematic review
Yi-Zheng Li, Yi Jiang, Han Lin & Xue-Ping Yang
Pages: 3785-3798
Published online: 01 Nov 2019
AbstractforSubarachnoid and epidural dexmedetomidine for the prevention of post-anesthetic shivering: a meta-analysis and systematic review | Full Text | References | PDF (6.7 MB) | EPUB
  • 177 Views
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Article
Id-1 Promotes Reendothelialization In The Early Phase After Vascular Injury Through Activation Of NFkB/survivin Signaling Pathway
Wei Li, Dayong Du & Yuntian Li
Pages: 3799-3811
Published online: 31 Oct 2019
AbstractforId-1 Promotes Reendothelialization In The Early Phase After Vascular Injury Through Activation Of NFkB/survivin Signaling Pathway | Full Text | References | PDF (8.5 MB) | EPUB
  • 104 Views
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Article
Comparing The Efficacy Of An Anti-Human VEGF-A Neutralizing Antibody Versus Bevacizumab On A Laser-Induced Choroidal Neovascularization (CNV) Rhesus Monkey Model
Oscar Olvera-Montaño, Leopoldo Baiza-Duran, Juan D Quintana-Hau, Mayra G Quiñonez-Alvarado, Wen Zeng, Li Gong & Patricia Muñoz-Villegas
Pages: 3813-3821
Published online: 04 Nov 2019
AbstractforComparing The Efficacy Of An Anti-Human VEGF-A Neutralizing Antibody Versus Bevacizumab On A Laser-Induced Choroidal Neovascularization (CNV) Rhesus Monkey Model | Full Text | References | PDF (3.8 MB) | EPUB
  • 171 Views
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Article
Identification Of Natural Compound Derivative For Inhibition Of XLF And Overcoming Chemoresistance In Colorectal Cancer Cells
Zhuo Liu, Miao Yu, Bingyuan Fei, Jing Sun & Dongxin Wang
Pages: 3823-3834
Published online: 06 Nov 2019
AbstractforIdentification Of Natural Compound Derivative For Inhibition Of XLF And Overcoming Chemoresistance In Colorectal Cancer Cells | Full Text | References | PDF (7.2 MB) | EPUB
  • 91 Views
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Erratum

Correction
The Effect Of Food On The Pharmacokinetic Properties And Bioequivalence Of Two Formulations Of Levocetirizine Dihydrochloride In Healthy Chinese Volunteers [Erratum]
Page: 3835
Published online: 07 Nov 2019
CitationforThe Effect Of Food On The Pharmacokinetic Properties And Bioequivalence Of Two Formulations Of Levocetirizine Dihydrochloride In Healthy Chinese Volunteers [Erratum] | Full Text | PDF (147 KB) | EPUB
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Original Research

Article
Adenosine Inhibits Ovarian Cancer Growth Through Regulating RhoGDI2 Protein Expression
Bing Xia & Jing Wang
Pages: 3837-3844
Published online: 08 Nov 2019
AbstractforAdenosine Inhibits Ovarian Cancer Growth Through Regulating RhoGDI2 Protein Expression | Full Text | References | PDF (3.7 MB) | EPUB
  • 112 Views
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Article
Safety, pharmacokinetics and pharmacodynamics of the selective glucocorticoid receptor modulator AZD7594, following inhalation in healthy Japanese volunteers
Susanne Prothon, Ulrika Wählby Hamrén, Ulrika Tehler, Esther Yoon, Henrik Forsman, Cecilia Arfvidsson, Ajay Aggarwal & Yingxue Chen
Pages: 3845-3853
Published online: 12 Nov 2019
AbstractforSafety, pharmacokinetics and pharmacodynamics of the selective glucocorticoid receptor modulator AZD7594, following inhalation in healthy Japanese volunteers | Full Text | References | PDF (1.3 MB) | EPUB
  • 133 Views
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Review

Review Article
Hesperidin: A Therapeutic Agent For Obesity
Haijun Xiong, Jin Wang, Qian Ran, Guanhua Lou, Chengyi Peng, Qingxia Gan, Ju Hu, Jilin Sun, Renchuan Yao & Qinwan Huang
Pages: 3855-3866
Published online: 12 Nov 2019
AbstractforHesperidin: A Therapeutic Agent For Obesity | Full Text | References | PDF (1,004.9 KB) | EPUB
  • 1486 Views
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Original Research

Article
Pregnancy And Neonatal Outcomes Of hMG Stimulation With Or Without Letrozole In Endometrial Preparation For Frozen–Thawed Embryo Transfer In Ovulatory Women: A Large Retrospective Cohort Study
Jiaying Lin, Ningling Wang, Jialv Huang, Renfei Cai, Yong Fan, Yanping Kuang & Yun Wang
Pages: 3867-3877
Published online: 14 Nov 2019
AbstractforPregnancy And Neonatal Outcomes Of hMG Stimulation With Or Without Letrozole In Endometrial Preparation For Frozen–Thawed Embryo Transfer In Ovulatory Women: A Large Retrospective Cohort Study | Full Text | References | PDF (1.8 MB) | EPUB
  • 127 Views
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Article
A Fixed-Dose Combination Of Gemigliptin And Rosuvastatin Exhibits Similar Pharmacokinetics, Pharmacodynamics, And Safety Compared To That Of A Loose Combination In Healthy Subjects
Eunwoo Kim, Kyoung Ryun Park, In-Jin Jang, Kyung-Sang Yu & SeungHwan Lee
Pages: 3879-3885
Published online: 13 Nov 2019
AbstractforA Fixed-Dose Combination Of Gemigliptin And Rosuvastatin Exhibits Similar Pharmacokinetics, Pharmacodynamics, And Safety Compared To That Of A Loose Combination In Healthy Subjects | Full Text | References | PDF (446.5 KB) | EPUB
  • 120 Views
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Article
The MAP2K4/JNK/c-Jun Signaling Pathway Plays A Key Role In Dexmedetomidine Protection Against Acetaminophen-Induced Liver Toxicity
An-Hsun Chou, Chia-Chih Liao, Hung-Chen Lee, Jiin-Tarng Liou & Fu-Chao Liu
Pages: 3887-3898
Published online: 14 Nov 2019
AbstractforThe MAP2K4/JNK/c-Jun Signaling Pathway Plays A Key Role In Dexmedetomidine Protection Against Acetaminophen-Induced Liver Toxicity | Full Text | References | PDF (9.4 MB) | EPUB
  • 97 Views
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Article
Luteolin Attenuates Atherosclerosis Via Modulating Signal Transducer And Activator Of Transcription 3-Mediated Inflammatory Response
Xiaoji Ding, Lulu Zheng, Bo Yang, Xiaodong Wang & Yin Ying
Pages: 3899-3911
Published online: 18 Nov 2019
AbstractforLuteolin Attenuates Atherosclerosis Via Modulating Signal Transducer And Activator Of Transcription 3-Mediated Inflammatory Response | Full Text | References | PDF (9.9 MB) | EPUB
  • 153 Views
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Article
Efficacy And Safety Of Apatinib Treatment In Platinum-Resistant Recurrent Epithelial Ovarian Cancer: A Real World Study
Jindi Zhang, Anyang Li, Qi Jiang, Feiyun Zheng & Haiyan Zhu
Pages: 3913-3918
Published online: 15 Nov 2019
AbstractforEfficacy And Safety Of Apatinib Treatment In Platinum-Resistant Recurrent Epithelial Ovarian Cancer: A Real World Study | Full Text | References | PDF (373 KB) | EPUB
  • 115 Views
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Article
The Effects Of Sevoflurane On The Progression And Cisplatinum Sensitivity Of Cervical Cancer Cells
Fang Xue, Yichi Xu, Yizuo Song, Wenwen Zhang, Ruyi Li & Xueqiong Zhu
Pages: 3919-3928
Published online: 18 Nov 2019
AbstractforThe Effects Of Sevoflurane On The Progression And Cisplatinum Sensitivity Of Cervical Cancer Cells | Full Text | References | PDF (5.7 MB) | EPUB
  • 101 Views
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Article
Assessment Of Spanlastic Vesicles Of Zolmitriptan For Treating Migraine In Rats
Nagla Ahmed El-Nabarawy, Mahmoud Hassan Teaima & Doaa Ahmed Helal
Pages: 3929-3937
Published online: 21 Nov 2019
AbstractforAssessment Of Spanlastic Vesicles Of Zolmitriptan For Treating Migraine In Rats | Full Text | References | PDF (2 MB) | EPUB
  • 329 Views
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Article
Alteration of Amino Acid Profiling Influenced by the Active Ingredients of DanHong Injection After Prescription Optimization
Zhili Guo, Yan Zhu, Wenjuan Xu, Kaitao Luo, Hongbin Xiao & Zhong Wang
Pages: 3939-3947
Published online: 29 Sep 2022
AbstractforAlteration of Amino Acid Profiling Influenced by the Active Ingredients of DanHong Injection After Prescription Optimization | Full Text | References | PDF (6 MB) | EPUB
  • 82 Views
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Article
Icariin Alleviates IL-1β-Induced Matrix Degradation By Activating The Nrf2/ARE Pathway In Human Chondrocytes
Shi Zuo, Wei Zou, Rong-Min Wu, Jing Yang, Jian-Nan Fan, Xue-Ke Zhao & Hai-Yang Li
Pages: 3949-3961
Published online: 21 Nov 2019
AbstractforIcariin Alleviates IL-1β-Induced Matrix Degradation By Activating The Nrf2/ARE Pathway In Human Chondrocytes | Full Text | References | PDF (9.5 MB) | EPUB
  • 106 Views
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Article
Effects Of Triptolide On Tooth Movement And Root Resorption In Rats
Fan Yang, Xu Xia Wang, Dan Ma, Qun Cui, De Hua Zheng, Xiao Can Liu & Jun Zhang
Pages: 3963-3975
Published online: 29 Sep 2022
AbstractforEffects Of Triptolide On Tooth Movement And Root Resorption In Rats | Full Text | References | PDF (26 MB) | EPUB
  • 118 Views
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Article
Postconditioning Protection Against Myocardiocyte Anoxia/Reoxygenation Injury From Penehyclidine Hydrochloride
JY Ren, DM Lin, CB Wang, YL Yang, ZQ Wang, BQ Cui & J Ma
Pages: 3977-3988
Published online: 26 Nov 2019
AbstractforPostconditioning Protection Against Myocardiocyte Anoxia/Reoxygenation Injury From Penehyclidine Hydrochloride | Full Text | References | PDF (8.4 MB) | EPUB
  • 78 Views
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Article
A Network Pharmacology-Based Strategy For Predicting Active Ingredients And Potential Targets Of LiuWei DiHuang Pill In Treating Type 2 Diabetes Mellitus
Dan He, Jian-Hua Huang, Zhe-Yu Zhang, Qing Du, Wei-Jun Peng, Rong Yu, Si-Fang Zhang, Shui-Han Zhang & Yu-Hui Qin
Pages: 3989-4005
Published online: 28 Nov 2019
AbstractforA Network Pharmacology-Based Strategy For Predicting Active Ingredients And Potential Targets Of LiuWei DiHuang Pill In Treating Type 2 Diabetes Mellitus | Full Text | References | PDF (9 MB) | EPUB
  • 537 Views
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Article
Transformation of Meloxicam Containing Nanosuspension into Surfactant-Free Solid Compositions to Increase the Product Stability and Drug Bioavailability for Rapid Analgesia
Csaba Bartos, Rita Ambrus, Gábor Katona, Tamás Sovány, Róbert Gáspár, Árpád Márki, Eszter Ducza, Anita Ivanov, Ferenc Tömösi, Tamás Janáky & Piroska Szabó-Révész
Pages: 4007-4020
Published online: 28 Nov 2019
AbstractforTransformation of Meloxicam Containing Nanosuspension into Surfactant-Free Solid Compositions to Increase the Product Stability and Drug Bioavailability for Rapid Analgesia | Full Text | References | PDF (4.8 MB) | EPUB
  • 150 Views
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Article
Delivery Of Curcumin Nanoliposomes Using Surface Modified With CD133 Aptamers For Prostate Cancer
Qi Ma, Wei Qian, Wei Tao, Yanling Zhou & Boxin Xue
Pages: 4021-4033
Published online: 28 Nov 2019
AbstractforDelivery Of Curcumin Nanoliposomes Using Surface Modified With CD133 Aptamers For Prostate Cancer | Full Text | References | PDF (7.3 MB) | EPUB
  • 365 Views
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Article
An Optimized Surfactant-Based PEG-PLCL In Situ Gel Formulation For Enhanced Activity Of Rosuvastatin In Poloxamer-Induced Hyperlipidemic Rats
Tarek A Ahmed, Mohammed A Mussari, Seham El-Sayed Abdel-Hady & Khalid M El-Say
Pages: 4035-4051
Published online: 03 Dec 2019
AbstractforAn Optimized Surfactant-Based PEG-PLCL In Situ Gel Formulation For Enhanced Activity Of Rosuvastatin In Poloxamer-Induced Hyperlipidemic Rats | Full Text | References | PDF (6 MB) | EPUB
  • 113 Views
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Article
Neuroprotective Effect of S-trans, Trans-farnesylthiosalicylic Acid via Inhibition of RAS/ERK Pathway for the Treatment of Alzheimer’s Disease
Xiang Wang, Yu Wang, Yiyi Zhu, Luxia Yan & Liandong Zhao
Pages: 4053-4063
Published online: 29 Nov 2019
AbstractforNeuroprotective Effect of S-trans, Trans-farnesylthiosalicylic Acid via Inhibition of RAS/ERK Pathway for the Treatment of Alzheimer’s Disease | Full Text | References | PDF (7.5 MB) | EPUB
  • 108 Views
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Article
Liraglutide Improves Non-Alcoholic Fatty Liver Disease In Diabetic Mice By Modulating Inflammatory Signaling Pathways
Ying Luo, Pijian Yang, Zhengming Li, Yunchen Luo, Jing Shen, Ruwen Li, Hua Zheng, Yuzhen Liang & Ning Xia
Pages: 4065-4074
Published online: 02 Dec 2019
AbstractforLiraglutide Improves Non-Alcoholic Fatty Liver Disease In Diabetic Mice By Modulating Inflammatory Signaling Pathways | Full Text | References | PDF (7.8 MB) | EPUB
  • 222 Views
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Article
RETRACTED ARTICLE: Cinobufagin Suppresses The Characteristics Of Osteosarcoma Cancer Cells By Inhibiting The IL-6-OPN-STAT3 Pathway
Chuan Zhang, Kun Ma & Wu-Yin Li
Pages: 4075-4090
Published online: 04 Dec 2019
AbstractforRETRACTED ARTICLE: Cinobufagin Suppresses The Characteristics Of Osteosarcoma Cancer Cells By Inhibiting The IL-6-OPN-STAT3 Pathway | PDF (13 MB)
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Review

Review Article
Profile of Tofacitinib in the Treatment of Ulcerative Colitis: An Evidence-Based Review of Recent Data
Fumi Varyani, Konstantinos Argyriou, Frank Phillips, Eirini Tsakiridou & Gordon William Moran
Pages: 4091-4105
Published online: 02 Dec 2019
AbstractforProfile of Tofacitinib in the Treatment of Ulcerative Colitis: An Evidence-Based Review of Recent Data | Full Text | References | PDF (1.9 MB) | EPUB
  • 225 Views
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Original Research

Article
Efficacy and Safety of Combined Vitrectomy with Intravitreal Dexamethasone Implant for Advanced Stage Epiretinal Membrane
Claudio Iovino, Giuseppe Giannaccare, Marco Pellegrini, Federico Bernabei, Mirco Braghiroli, Tomaso Caporossi & Enrico Peiretti
Pages: 4107-4114
Published online: 03 Dec 2019
AbstractforEfficacy and Safety of Combined Vitrectomy with Intravitreal Dexamethasone Implant for Advanced Stage Epiretinal Membrane | Full Text | References | PDF (1.6 MB) | EPUB
  • 112 Views
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Article
Hongjingtian Injection Inhibits Proliferation and Migration and Promotes Apoptosis in High Glucose-Induced Vascular Smooth Muscle Cells
Zhengyuan Fan, Congcong Guo, Yuhan Zhang, Jinming Yao, Lin Liao & Jianjun Dong
Pages: 4115-4126
Published online: 05 Dec 2019
AbstractforHongjingtian Injection Inhibits Proliferation and Migration and Promotes Apoptosis in High Glucose-Induced Vascular Smooth Muscle Cells | Full Text | References | PDF (11.3 MB) | EPUB
  • 96 Views
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Article
Radioprotective Potential of Sulindac Sulfide to Prevent DNA Damage Due to Ionizing Radiation
Seyedeh Atekeh Torabizadeh, Mehdi Rezaeifar, Ali Jomehzadeh, Farzaneh Nabizadeh Haghighi & Mehdi Ansari
Pages: 4127-4134
Published online: 06 Dec 2019
AbstractforRadioprotective Potential of Sulindac Sulfide to Prevent DNA Damage Due to Ionizing Radiation | Full Text | References | PDF (3.9 MB) | EPUB
  • 127 Views
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Article
Pharmacokinetics and Safety of Esketamine in Chinese Patients Undergoing Painless Gastroscopy in Comparison with Ketamine: A Randomized, Open-Label Clinical Study
Jing Wang, Jie Huang, Shuang Yang, Chang Cui, Ling Ye, Sai-ying Wang, Guo-ping Yang & Qi Pei
Pages: 4135-4144
Published online: 06 Dec 2019
AbstractforPharmacokinetics and Safety of Esketamine in Chinese Patients Undergoing Painless Gastroscopy in Comparison with Ketamine: A Randomized, Open-Label Clinical Study | Full Text | References | PDF (3 MB) | EPUB
  • 421 Views
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Article
Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway
Hui-Feng Zhu, Yali Shao, Lei Qin, Jing-Huan Wang, Shan Feng, Yun-Bin Jiang & Dong Wan
Pages: 4145-4157
Published online: 10 Dec 2019
AbstractforCatalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway | Full Text | References | PDF (5.4 MB) | EPUB
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Corrigendum

Correction
A Novel Hybrid Compound LLP2A-Alendronate Accelerates Open Fracture Healing in a Rabbit Model [Corrigendum]
Pages: 4159-4160
Published online: 29 Sep 2022
CitationforA Novel Hybrid Compound LLP2A-Alendronate Accelerates Open Fracture Healing in a Rabbit Model [Corrigendum] | Full Text | PDF (157 KB) | EPUB
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Original Research

Article
Inhibition Of JNK Phosphorylation By Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury
Zhongxiang Xiao, Fengli Xu, Xiaona Zhu, Bin Bai, Lu Guo, Guang Liang, Xiaoou Shan, Yali Zhang, Yunjie Zhao & Bing Zhang
Pages: 4161-4171
Published online: 10 Dec 2019
AbstractforInhibition Of JNK Phosphorylation By Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury | Full Text | References | PDF (8.6 MB) | EPUB
  • 118 Views
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Article
Preparation of a Novel One-Armed Anti-c-Met Antibody with Antitumor Activity Against Hepatocellular Carcinoma
Yanxin Yin, Jia Guo, Fei Teng, Lihua Yu, Yun Jiang, Kun Xie, Ming Jiang & Jianmin Fang
Pages: 4173-4184
Published online: 10 Dec 2019
AbstractforPreparation of a Novel One-Armed Anti-c-Met Antibody with Antitumor Activity Against Hepatocellular Carcinoma | Full Text | References | PDF (6.6 MB) | EPUB
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Article
Pharmacological Evaluation of Aldehydic-Pyrrolidinedione Against HCT-116, MDA-MB231, NIH/3T3, MCF-7 Cancer Cell Lines, Antioxidant and Enzyme Inhibition Studies
Ashfaq Ahmad, Farhat Ullah, Abdul Sadiq, Muhammad Ayaz, Haroon Rahim, Umer Rashid, Sajjad Ahmad, Muhammad Saeed Jan, Riaz Ullah, Abdelaaty A Shahat & Hafiz Majid Mahmood
Pages: 4185-4194
Published online: 10 Dec 2019
AbstractforPharmacological Evaluation of Aldehydic-Pyrrolidinedione Against HCT-116, MDA-MB231, NIH/3T3, MCF-7 Cancer Cell Lines, Antioxidant and Enzyme Inhibition Studies | Full Text | References | PDF (3.7 MB) | EPUB
  • 211 Views
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Article
In Silico, Cytotoxic and Antioxidant Potential of Novel Ester, 3-hydroxyoctyl -5- trans-docosenoate Isolated from Anchusa arvensis (L.) M.Bieb. Against HepG-2 Cancer Cells
Sajid Hussain, Farhat Ullah, Muhammad Ayaz, Syed Adnan Ali Shah, Azhar-ul-Haq Ali Shah, Syed Majid Shah, Abdul Wadood, Waqar Aman, Riaz Ullah, Abdelaaty A Shahat & Fahd A Nasr
Pages: 4195-4205
Published online: 10 Dec 2019
AbstractforIn Silico, Cytotoxic and Antioxidant Potential of Novel Ester, 3-hydroxyoctyl -5- trans-docosenoate Isolated from Anchusa arvensis (L.) M.Bieb. Against HepG-2 Cancer Cells | Full Text | References | PDF (7 MB) | EPUB
  • 342 Views
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Article
Drug–Drug Interactions Of Amiodarone And Quinidine On The Pharmacokinetics Of Eliglustat In Rats
Qiong Wang, Haiyun Wang, Youyan Zhong & Qiang Zhang
Pages: 4207-4213
Published online: 29 Sep 2022
AbstractforDrug–Drug Interactions Of Amiodarone And Quinidine On The Pharmacokinetics Of Eliglustat In Rats | Full Text | References | PDF (3.4 MB) | EPUB
  • 126 Views
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Article
The Effect of Glutamine Supplementation on Oxidative Stress and Matrix Metalloproteinase 2 and 9 After Exhaustive Exercise
Ali Nemati, Reza Alipanah-Moghadam, Leila Molazadeh & Abbas Naghizadeh Baghi
Pages: 4215-4223
Published online: 29 Sep 2022
AbstractforThe Effect of Glutamine Supplementation on Oxidative Stress and Matrix Metalloproteinase 2 and 9 After Exhaustive Exercise | Full Text | References | PDF (439.8 KB) | EPUB
  • 232 Views
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Article
Molecular Requirements for the Expression of Antiplatelet Effects by Synthetic Structural Optimized Analogues of the Anticancer Drugs Imatinib and Nilotinib
Despoina Pantazi, Nikoleta Ntemou, Alexios Brentas, Dimitrios Alivertis, Konstantinos Skobridis & Alexandros D Tselepis
Pages: 4225-4238
Published online: 12 Dec 2019
AbstractforMolecular Requirements for the Expression of Antiplatelet Effects by Synthetic Structural Optimized Analogues of the Anticancer Drugs Imatinib and Nilotinib | Full Text | References | PDF (10.5 MB) | EPUB
  • 127 Views
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Article
Synthesis of Novel Xanthone Analogues and Their Growth Inhibitory Activity Against Human Lung Cancer A549 Cells
Junqi Wu, Jinwei Dai, Yuyang Zhang, Jing Wang, Lei Huang, Hongmei Ding, Tiejun Li, Yuefan Zhang, Junqin Mao & Shichong Yu
Pages: 4239-4246
Published online: 13 Dec 2019
AbstractforSynthesis of Novel Xanthone Analogues and Their Growth Inhibitory Activity Against Human Lung Cancer A549 Cells | Full Text | References | PDF (7.6 MB) | EPUB
  • 165 Views
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Article
Small-Molecule Intervention At The Dimerization Interface Of Survivin By Novel Rigidized Scaffolds
Tamer M Ibrahim, Christoph Ernst, Andreas Lange, Susanne Hennig & Frank M Boeckler
Pages: 4247-4263
Published online: 18 Dec 2019
AbstractforSmall-Molecule Intervention At The Dimerization Interface Of Survivin By Novel Rigidized Scaffolds | Full Text | References | PDF (4.9 MB) | EPUB
  • 129 Views
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Article
Valproic Acid Addresses Neuroendocrine Differentiation of LNCaP Cells and Maintains Cell Survival
Francesca Giordano, Giuseppina Daniela Naimo, Alessandra Nigro, Francesco Romeo, Alessandro Paolì, Francesca De Amicis, Adele Vivacqua, Catia Morelli, Loredana Mauro & Maria Luisa Panno
Pages: 4265-4274
Published online: 29 Sep 2022
AbstractforValproic Acid Addresses Neuroendocrine Differentiation of LNCaP Cells and Maintains Cell Survival | Full Text | References | PDF (6.3 MB) | EPUB
  • 87 Views
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Article
The Protective Role of Tanshinone IIA in Silicosis Rat Model via TGF-β1/Smad Signaling Suppression, NOX4 Inhibition and Nrf2/ARE Signaling Activation
Feifei Feng, Peng Cheng, Huanan Zhang, Nannan Li, Yuxin Qi, Hui Wang, Yongbin Wang & Wei Wang
Pages: 4275-4290
Published online: 18 Dec 2019
AbstractforThe Protective Role of Tanshinone IIA in Silicosis Rat Model via TGF-β1/Smad Signaling Suppression, NOX4 Inhibition and Nrf2/ARE Signaling Activation | Full Text | References | PDF (21.7 MB) | EPUB
  • 157 Views
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Review

Review Article
The Role of the Reactive Oxygen Species Scavenger Agent, Astaxanthin, in the Protection of Cisplatin-Treated Patients Against Hearing Loss
Benyu Nan, Xi Gu & Xinsheng Huang
Pages: 4291-4303
Published online: 18 Dec 2019
AbstractforThe Role of the Reactive Oxygen Species Scavenger Agent, Astaxanthin, in the Protection of Cisplatin-Treated Patients Against Hearing Loss | Full Text | References | PDF (3.6 MB) | EPUB
  • 226 Views
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Original Research

Article
A Novel Nanomicellar Combination of Fenretinide and Lenalidomide Shows Marked Antitumor Activity in a Neuroblastoma Xenograft Model
Isabella Orienti, Ferro Nguyen, Peng Guan, Venkatadri Kolla, Natalia Calonghi, Giovanna Farruggia, Michael Chorny & Garrett M Brodeur
Pages: 4305-4319
Published online: 19 Dec 2019
AbstractforA Novel Nanomicellar Combination of Fenretinide and Lenalidomide Shows Marked Antitumor Activity in a Neuroblastoma Xenograft Model | Full Text | References | PDF (7.8 MB) | EPUB
  • 145 Views
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Article
AR-42: A Pan-HDAC Inhibitor with Antitumor and Antiangiogenic Activities in Esophageal Squamous Cell Carcinoma
Yuxuan Zhu, Ting Yuan, Yuan Zhang, Jianyou Shi, Lan Bai, Xingmei Duan, Rongsheng Tong & Lei Zhong
Pages: 4321-4330
Published online: 19 Dec 2019
AbstractforAR-42: A Pan-HDAC Inhibitor with Antitumor and Antiangiogenic Activities in Esophageal Squamous Cell Carcinoma | Full Text | References | PDF (9.2 MB) | EPUB
  • 108 Views
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Article
Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cell Therapy for Rheumatoid Arthritis Patients: A Prospective Phase I/II Study
Liming Wang, Shigao Huang, Shimei Li, Ming Li, Jun Shi, Wen Bai, Qianyun Wang, Libo Zheng & Yongjun Liu
Pages: 4331-4340
Published online: 19 Dec 2019
AbstractforEfficacy and Safety of Umbilical Cord Mesenchymal Stem Cell Therapy for Rheumatoid Arthritis Patients: A Prospective Phase I/II Study | Full Text | References | PDF (12.2 MB) | EPUB
  • 792 Views
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Article
Memory Impairment Induced by Chronic Psychosocial Stress Is Prevented by L-Carnitine
Suzie Y Rababa’h, Karem H Alzoubi, Hana M Hammad, Laiali Alquraan & Khalid El-Salem
Pages: 4341-4350
Published online: 19 Dec 2019
AbstractforMemory Impairment Induced by Chronic Psychosocial Stress Is Prevented by L-Carnitine | Full Text | References | PDF (581.8 KB) | EPUB
  • 134 Views
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Review

Review Article
Levonadifloxacin, a Novel Broad-Spectrum Anti-MRSA Benzoquinolizine Quinolone Agent: Review of Current Evidence
Sachin S Bhagwat, Manohar Nandanwar, Atul Kansagara, Anusuya Patel, Swapna Takalkar, Rajesh Chavan, Hariharan Periasamy, Ravindra Yeole, Prasad K Deshpande, Satish Bhavsar, Ashima Bhatia, Jaishid Ahdal, Rishi Jain & Mahesh Patel
Pages: 4351-4365
Published online: 24 Dec 2019
AbstractforLevonadifloxacin, a Novel Broad-Spectrum Anti-MRSA Benzoquinolizine Quinolone Agent: Review of Current Evidence | Full Text | References | PDF (1 MB) | EPUB
  • 422 Views
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Original Research

Article
Cytokine and Chemokine Profile Changes in Patients After Intravitreal Conbercept Injection for Diabetic Macular Edema
Qingquan Wei, Zhongqi Wan, Yongcheng Hu & Qing Peng
Pages: 4367-4374
Published online: 24 Dec 2019
AbstractforCytokine and Chemokine Profile Changes in Patients After Intravitreal Conbercept Injection for Diabetic Macular Edema | Full Text | References | PDF (2.1 MB) | EPUB
  • 119 Views
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Article
Inhibition of Disruptor of Telomeric Silencing 1-Like Alleviated Renal Ischemia and Reperfusion Injury-Induced Fibrosis by Blocking PI3K/AKT-Mediated Oxidative Stress
Chuan Yang, Zhiyuan Chen, Hua Yu & Xiuheng Liu
Pages: 4375-4387
Published online: 29 Sep 2022
AbstractforInhibition of Disruptor of Telomeric Silencing 1-Like Alleviated Renal Ischemia and Reperfusion Injury-Induced Fibrosis by Blocking PI3K/AKT-Mediated Oxidative Stress | Full Text | References | PDF (12.8 MB) | EPUB
  • 97 Views
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Article
An Efficient, Lung-Targeted, Drug-Delivery System To Treat Asthma Via Microparticles
Nagaraja SreeHarsha, Katharigatta N Venugopala, Anroop B Nair, Teeka S Roopashree, Mahesh Attimarad, Jagadeesh G Hiremath, Bandar E Al-Dhubiab, Chandramouli Ramnarayanan, Pottathil Shinu, Mukund Handral, Micheline Haroun & Christophe Tratrat
Pages: 4389-4403
Published online: 29 Sep 2022
AbstractforAn Efficient, Lung-Targeted, Drug-Delivery System To Treat Asthma Via Microparticles | Full Text | References | PDF (6.3 MB) | EPUB
  • 341 Views
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Article
Developmental Pharmacogenetics of SLCO2B1 on Montelukast Pharmacokinetics in Chinese Children
Qian Li, Kai Wang, Hai-Yan Shi, Yue-E Wu, Yue Zhou, Min Kan, Yi Zheng, Guo-Xiang Hao, Xin-Mei Yang, Yi-Lei Yang, Le-Qun Su, Xiao-Ling Wang, Evelyne Jacqz-Aigrain, Jun Zhou & Wei Zhao
Pages: 4405-4411
Published online: 27 Dec 2019
AbstractforDevelopmental Pharmacogenetics of SLCO2B1 on Montelukast Pharmacokinetics in Chinese Children | Full Text | References | PDF (436.5 KB) | EPUB
  • 124 Views
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Article
RETRACTED ARTICLE: Development and Evaluation of in-situ Nasal Gel Formulations of Nanosized Transferosomal Sumatriptan: Design, Optimization, in vitro and in vivo Evaluation
Mahmoud M Omar, Nermin E Eleraky, Amani M El Sisi & Omiya Ali Hasan
Pages: 4413-4430
Published online: 27 Dec 2019
AbstractforRETRACTED ARTICLE: Development and Evaluation of in-situ Nasal Gel Formulations of Nanosized Transferosomal Sumatriptan: Design, Optimization, in vitro and in vivo Evaluation | PDF (2.9 MB)
  • 585 Views
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Article
Generic Tacrolimus (Tacrobell®) Shows Comparable Outcomes to Brand-Name Tacrolimus in the Long-Term Period After Adult Deceased Donor Liver Transplantation
Jong Man Kim, Jae-Won Joh, Gyu-Seong Choi & Suk-Koo Lee
Pages: 4431-4438
Published online: 29 Sep 2022
AbstractforGeneric Tacrolimus (Tacrobell®) Shows Comparable Outcomes to Brand-Name Tacrolimus in the Long-Term Period After Adult Deceased Donor Liver Transplantation | Full Text | References | PDF (1.9 MB) | EPUB
  • 111 Views
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Article
Dexmedetomidine Promotes Hippocampal Neurogenesis and Improves Spatial Learning and Memory in Neonatal Rats
Yahan Zhang, Qiushi Gao, Ziyi Wu, Hang Xue, Bo Liu & Ping Zhao
Pages: 4439-4449
Published online: 29 Sep 2022
AbstractforDexmedetomidine Promotes Hippocampal Neurogenesis and Improves Spatial Learning and Memory in Neonatal Rats | Full Text | References | PDF (5.8 MB) | EPUB
  • 147 Views
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Article
Sevoflurane Inhibits Proliferation and Invasion of Human Ovarian Cancer Cells by Regulating JNK and p38 MAPK Signaling Pathway
Kai Kang & Yue Wang
Pages: 4451-4460
Published online: 31 Dec 2019
AbstractforSevoflurane Inhibits Proliferation and Invasion of Human Ovarian Cancer Cells by Regulating JNK and p38 MAPK Signaling Pathway | Full Text | References | PDF (5 MB) | EPUB
  • 135 Views
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Article
Progestin-Primed Ovarian Stimulation with Dydrogesterone versus Medroxyprogesterone Acetate in Women with Polycystic Ovarian Syndrome for in vitro Fertilization: A Retrospective Cohort Study
Jialyu Huang, Qin Xie, Jiaying Lin, Xuefeng Lu, Jing Zhu, Hongyuan Gao, Renfei Cai & Yanping Kuang
Pages: 4461-4470
Published online: 29 Sep 2022
AbstractforProgestin-Primed Ovarian Stimulation with Dydrogesterone versus Medroxyprogesterone Acetate in Women with Polycystic Ovarian Syndrome for in vitro Fertilization: A Retrospective Cohort Study | Full Text | References | PDF (382.6 KB) | EPUB
  • 321 Views
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