Efficacy and safety of tacrolimus in induction therapy of patients with lupus nephritis

Abstract

Background

The purpose of this study was to detect the efficacy and safety of tacrolimus (TAC) in induction therapy of patients with lupus nephritis.

Methods

Associated studies were extracted from the PubMed and the Cochrane Library on July 10, 2018, and applicable investigations were pooled and analyzed by meta-analysis. Data on complete remission (CR), total remission (TR; complete plus partial remission), proteinuria levels, urine erythrocyte number, albumin, glomerular filtration rate, negative rate of ds-DNA, C₃ levels, C₄ levels, systemic lupus erythematosus disease activity index (SLE-DAI), etc, were extracted and pooled using RevMan 5.3.

Results

In the therapeutic regimen of TAC + glucocorticoids (GC) vs cyclophosphamide (CYC) + GC, the results indicated that the TAC group had high values of CR, TR, albumin, and negative rate of ds-DNA, and low values of proteinuria levels and SLE-DAI when compared with those in CYC group (all P<0.05). In the therapeutic regimen comprising TAC + GC vs mycophenolate mofetil (MMF) + GC, the results indicated that the difference of CR, TR, proteinuria levels, and albumin between TAC group and MMF group were not significant (all P>0.05). In the therapeutic regimen comprising TAC + MMF + GC vs CYC + GC, multitarget therapy group showed higher values of CR, TR, urinary protein decline, and rise of serum albumin when compared with CYC group (all P<0.05).

Conclusion

TAC is an effective and safe agent in induction therapy of patients with lupus nephritis.

Keywords:

• tacrolimus
• lupus nephritis
• complete remission
• CR
• total remission
• TR
• meta-analysis

Acknowledgments

This study was supported by the Guangzhou Medical Key Discipline Construction Project, the Natural Science Foundation of the Guangdong Province (no 2015A030310386), and Guangdong Medical Science and Technology Research Fund Project (no A2018336). All authors should be regarded as co-first authors in this study.

Disclosure

The authors report no conflicts of interest in this work.