Efficacy and toxicity of cladribine for the treatment of refractory acute myeloid leukemia: a meta-analysis

Abstract

Purpose:

To investigate the overall efficacy and toxicity of cladribine and cladribine-based chemotherapy in the treatment of patients with refractory acute myeloid leukemia (AML) based on meta-analysis.

Methods:

PubMed, EMBASE database, and the Cochrane Library were searched for relevant studies. Eligible studies were clinical trials of refractory AML assigned to cladribine with data on efficacy including complete remission (CR) rate, overall response rate (ORR) and overall survival. Toxicity was evaluated based on the early death rate and the incidence of grade 3 and 4 adverse events (AEs).

Results:

A total of 10 clinical trials including 422 refractory AML patients were analyzed. The overall CR rate was 42.2% (95% CI: 31.0–54.3%). And the ORR of seven trials including 235 patients was 49.7% (95% CI: 33.5–66.0%). The overall early death rate of 260 patients enrolled in five trials was 6.8% (95% CI: 4.3–10.6%). Thrombocytopenia, anemia, neutropenia, and infection were the most common grade 3 and 4 AEs.

Conclusion:

Cladribine is effective for refractory AML, and its efficacy can be increased with the combination of cladribine, cytarabine, and granulocyte-colony stimulating factor regimen.

Keywords:

• cladribine
• acute myeloid leukemia
• refractory AML
• meta-analysis

Acknowledgments

This work is supported in part by The National Natural Science Foundation of China (81770172); Key Research & Technology Projects in Jiangsu Province (BE2017747); Milstein Medical Asian American Partnership (MMAAP) Foundation Research Project Award in Hematology (2017).

Disclosure

The authors report no conflicts of interest in this work.