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Abstract
Purpose
To prepare a novel wound dressing to facilitate cutaneous wound healing.
Methods
Curcumin (Cur) was added to the ring-shaped β-cyclodextrin (CD) to form a β-CD–Cur inclusion complex (CD-Cur). CD-Cur was then integrated into a composite chitosan–alginate (CA) mix. Finally, CA-CD-Cur was generated with a freeze-drying technique. Water-uptake capacity, degradation rate, and drug-release kinetics of the newly formed dressing were investigated in vitro. In animal studies, cutaneous wounds in rats were created, treated with CA-CD-Cur, then compared to CA-Cur, CA, and gauze.
Results
CA-CD-Cur–treated wounds showed accelerated closure rates, improved histopathological results, and lower SOD, lipid peroxidation, pI3K, and pAktkt levels than other groups. On the contrary, catalase, IκBα, and TGFβ1 levels were higher than others.
Conclusion
CA-CD-Cur may facilitate cutaneous wound dressing that facilitate wound healing.
Acknowledgment
This work was financially supported by the National Natural Science Foundation of China (81572163), the Fundamental Research Fund for the Central Universities, and the Zhongnan Hospital of Wuhan University Science, Technology, and Innovation Seed Fund (cxpy20160014). YZ and CYD share joint first authorship, as they contributed equally to this work.
Disclosure
The authors report no conflicts of interest in this work.