https://orcid.org/0000-0001-5785-4566
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Abstract
Background
Ulvan is a natural polymer and type of sulfated polysaccharides from green seaweed that could have potential as a candidate for wound dressing material based on the support of its biopolymer characteristics such as antioxidant and antimicrobial activities.
Objective
In this study, we developed and prepared three different hydrogel films to explore the potency of ulvan for wound dressing application.
Methods
Ulvan hydrogel films were prepared by the facile method through ionic crosslinking with boric acid and added glycerol as a plasticizer. The films were evaluated in regard to swelling degree, water vapor transmission (WVTR), Fourier transform infrared (FTIR), powder x-ray diffractometry (P-XRD), scanning electron microscopy (SEM), mechanical properties, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), antimicrobial, and antioxidant activity.
Results
The hydrogel films showed that the different concentration of ulvan in the formula affects the characteristics of the hydrogel film. The higher the concentration of ulvan in UHF, the higher the value of viscosity (201±13.45 to 689±62.23 cps for UHF5 to UHF10), swelling degree (82% to 130% for UHF5 to UHF10 at 1 h), moisture content (24%±1.94% to 18.4%±0.51 for UHF5 to UHF10), and the WVTR were obtained in the range 1856–2590g/m2/24h. Meanwhile, the SEM showed porous hydrogel film. Besides, all hydrogel films can reduce hydroxyl radicals and inhibit gram-positive and negative bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Streptococcus epidermidis).
Conclusion
The swelling behavior and WVTR of these films are great and could have potential as a wound dressing biomaterial, supported by their antimicrobial and antioxidant properties.
Acknowledgments
The authors are thankful to the Ministry of Education and Culture, the Republic of Indonesia, via the grant scheme of Hibah Penelitian Disertasi Doktor with number 1207/UN6.3.1/PT.00/2021 for the financial support.
Disclosure
In this work, the authors declare no conflicts of interest.