Drug Design, Development and Therapy, Volume 15, Issue (2021)

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Drug Design, Development and Therapy, Volume 15, Issue (2021)

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Perspectives

Discussion
Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start?
Qing Yu & Yi Sun
Pages: 1-8
Published online: 06 Jan 2021
AbstractforTargeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start? | Full Text | References | PDF (988.2 KB) | EPUB
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Discussion
Current Status and Perspectives of Protease Inhibitors and Their Combination with Nanosized Drug Delivery Systems for Targeted Cancer Therapy
Magdalena Rudzińska, Cenk Daglioglu, Lyudmila V Savvateeva, Fatma Necmiye Kaci, Rodolphe Antoine & Andrey A Zamyatnin Jr
Pages: 9-20
Published online: 06 Jan 2021
AbstractforCurrent Status and Perspectives of Protease Inhibitors and Their Combination with Nanosized Drug Delivery Systems for Targeted Cancer Therapy | Full Text | References | PDF (2.2 MB) | EPUB
  • 458 Views
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Original Research

Article
RASSF1A Enhances Chemosensitivity of NSCLC Cells Through Activating Autophagy by Regulating MAP1S to Inactivate Keap1-Nrf2 Pathway
Jincai Wang, Xufeng Zhang, Fang Yang, Yuguang Yang, Tianjiao Wang, Wenming Liu, Hongfeng Zhou & Wei Zhao
Pages: 21-35
Published online: 06 Jan 2021
AbstractforRASSF1A Enhances Chemosensitivity of NSCLC Cells Through Activating Autophagy by Regulating MAP1S to Inactivate Keap1-Nrf2 Pathway | Full Text | References | PDF (8 MB) | EPUB
  • 117 Views
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Article
Lactobacillus plantarum KSFY06 Prevents Inflammatory Response and Oxidative Stress in Acute Liver Injury Induced by D-Gal/LPS in Mice
Chong Li, Jun Si, Fang Tan, Kun-Young Park & Xin Zhao
Pages: 37-50
Published online: 06 Jan 2021
AbstractforLactobacillus plantarum KSFY06 Prevents Inflammatory Response and Oxidative Stress in Acute Liver Injury Induced by D-Gal/LPS in Mice | Full Text | References | PDF (7.4 MB) | EPUB
  • 207 Views
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Article
Inhibition of Pre-B Cell Colony Enhancing Factor Reduces Lung Injury in Rats Receiving Cardiopulmonary Bypass
Chao Lu, Wei Yang, Jianliang Zhou, Zulei Zhang, Yi Gong, Fajia Hu, Wenpeng Yu & Xiao Dong
Pages: 51-60
Published online: 07 Jan 2021
AbstractforInhibition of Pre-B Cell Colony Enhancing Factor Reduces Lung Injury in Rats Receiving Cardiopulmonary Bypass | Full Text | References | PDF (5.9 MB) | EPUB
  • 99 Views
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Article
Pristimerin Protects Against OVX-Mediated Bone Loss by Attenuating Osteoclast Formation and Activity via Inhibition of RANKL-Mediated Activation of NF-κB and ERK Signaling Pathways
Xuedong Li, Xixi Lin, Zuoxing Wu, Yuangang Su, Jiamin Liang, Runfeng Chen, Xue Yang, Lei Hou, Jinmin Zhao, Qian Liu & Feng Xu
Pages: 61-74
Published online: 07 Jan 2021
AbstractforPristimerin Protects Against OVX-Mediated Bone Loss by Attenuating Osteoclast Formation and Activity via Inhibition of RANKL-Mediated Activation of NF-κB and ERK Signaling Pathways | Full Text | References | PDF (7.3 MB) | EPUB
  • 150 Views
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Review

Review Article
A Review of Drug Therapy in Vestibular Schwannoma
Jianfei Long, Yu Zhang, Xiang Huang, Junwei Ren, Ping Zhong & Bin Wang
Pages: 75-85
Published online: 08 Jan 2021
AbstractforA Review of Drug Therapy in Vestibular Schwannoma | Full Text | References | PDF (584.2 KB) | EPUB
  • 441 Views
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Original Research

Article
Roflumilast Attenuates Doxorubicin-Induced Cardiotoxicity by Targeting Inflammation and Cellular Senescence in Cardiomyocytes Mediated by SIRT1
Sheng Zhang, Peng Wu, Jiabao Liu, Yingqiang Du & Zhijian Yang
Pages: 87-97
Published online: 11 Jan 2021
AbstractforRoflumilast Attenuates Doxorubicin-Induced Cardiotoxicity by Targeting Inflammation and Cellular Senescence in Cardiomyocytes Mediated by SIRT1 | Full Text | References | PDF (4.3 MB) | EPUB
  • 218 Views
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Article
Network Pharmacology and Experimental Evidence Identify the Mechanism of Astragaloside IV in Oxaliplatin Neurotoxicity
Jingyu Xu, Zhenbiao Guan, Xiaowei Wang, Dazhi Sun, Yongjin Li, Bei Pei, Ye Lu, Liangxi Yuan & Xuan Zhang
Pages: 99-110
Published online: 12 Jan 2021
AbstractforNetwork Pharmacology and Experimental Evidence Identify the Mechanism of Astragaloside IV in Oxaliplatin Neurotoxicity | Full Text | References | PDF (9.2 MB) | EPUB
  • 156 Views
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Review

Review Article
Chronic Obstructive Pulmonary Disease Treatment and Pharmacist-Led Medication Management
Liu-Cheng Li, Yong-Yue Han, Zhi-Hui Zhang, Wen-Cheng Zhou, Hong-Mei Fang, Jiao Qu & Lian-Di Kan
Pages: 111-124
Published online: 12 Jan 2021
AbstractforChronic Obstructive Pulmonary Disease Treatment and Pharmacist-Led Medication Management | Full Text | References | PDF (383.4 KB) | EPUB
  • 770 Views
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Original Research

Article
Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway
Maojian Chen, Chanchan Xiao, Wei Jiang, Weiping Yang, Qinghong Qin, Qixing Tan, Bin Lian, Zhijie Liang & Changyuan Wei
Pages: 125-140
Published online: 12 Jan 2021
AbstractforCapsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway | Full Text | References | PDF (12.2 MB) | EPUB
  • 451 Views
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Article
Preparation and Characterization of Tacrolimus-Loaded SLNs in situ Gel for Ocular Drug Delivery for the Treatment of Immune Conjunctivitis
Kexin Sun & Ke Hu
Pages: 141-150
Published online: 12 Jan 2021
AbstractforPreparation and Characterization of Tacrolimus-Loaded SLNs in situ Gel for Ocular Drug Delivery for the Treatment of Immune Conjunctivitis | Full Text | References | PDF (2.3 MB) | EPUB
  • 435 Views
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Review

Review Article
Spotlight on Pimavanserin Tartrate and Its Therapeutic Potential in the Treatment of Major Depressive Disorder: The Evidence to Date
Vicki Soogrim, Valerie L Ruberto, James Murrough & Manish Kumar Jha
Pages: 151-157
Published online: 13 Jan 2021
AbstractforSpotlight on Pimavanserin Tartrate and Its Therapeutic Potential in the Treatment of Major Depressive Disorder: The Evidence to Date | Full Text | References | PDF (276.2 KB) | EPUB
  • 155 Views
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Review Article
Subcutaneous Delivery of High-Dose/Volume Biologics: Current Status and Prospect for Future Advancements
Advait V Badkar, Rajesh B Gandhi, Shawn P Davis & Michael J LaBarre
Pages: 159-170
Published online: 13 Jan 2021
AbstractforSubcutaneous Delivery of High-Dose/Volume Biologics: Current Status and Prospect for Future Advancements | Full Text | References | PDF (597.8 KB) | EPUB
  • 1412 Views
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Original Research

Article
Combination of Sodium Cantharidinate with Cisplatin Synergistically Hampers Growth of Cervical Cancer
Xiangxun Chen, Mengxi Zhou, Wenjie Fan, Mingwei Yang & Lin Yang
Pages: 171-183
Published online: 13 Jan 2021
AbstractforCombination of Sodium Cantharidinate with Cisplatin Synergistically Hampers Growth of Cervical Cancer | Full Text | References | PDF (10.8 MB) | EPUB
  • 118 Views
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Article
Bioequivalence and Pharmacokinetic Profiles of Generic and Branded Obeticholic Acid in Healthy Chinese Subjects Under Fasting and Fed Conditions
Meng-Na Wang, Hai-Tao Yu, Ya-Qian Li, Yun Zeng, Shuang Yang, Guo-Ping Yang, Qi Pei & Jie Huang
Pages: 185-193
Published online: 14 Jan 2021
AbstractforBioequivalence and Pharmacokinetic Profiles of Generic and Branded Obeticholic Acid in Healthy Chinese Subjects Under Fasting and Fed Conditions | Full Text | References | PDF (1.6 MB) | EPUB
  • 200 Views
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Review

Review Article
Quaternary Lidocaine Derivatives: Past, Present, and Future
Qi Wang, Yujun Zhang, Jin Liu & Wensheng Zhang
Pages: 195-207
Published online: 14 Jan 2021
AbstractforQuaternary Lidocaine Derivatives: Past, Present, and Future | Full Text | References | PDF (585.9 KB) | EPUB
  • 242 Views
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Original Research

Article
H2O2-Inactivated Salmonella typhimurium RE88 Strain as a New Cancer Vaccine Carrier: Evaluation in a Mouse Model of Cancer
Yingzi Fan, Tingting Bai, Yaomei Tian, Bailing Zhou, Yuanda Wang & Li Yang
Pages: 209-222
Published online: 15 Jan 2021
AbstractforH2O2-Inactivated Salmonella typhimurium RE88 Strain as a New Cancer Vaccine Carrier: Evaluation in a Mouse Model of Cancer | Full Text | References | PDF (5.9 MB) | EPUB
  • 151 Views
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Article
Clinical Significance of Continuable Treatment with Nintedanib Over 12 Months for Idiopathic Pulmonary Fibrosis in a Real-World Setting
Motoyasu Kato, Shinichi Sasaki, Misa Tateyama, Yuta Arai, Hiroaki Motomura, Issei Sumiyoshi, Yusuke Ochi, Junko Watanabe, Hiroaki Ihara, Shinsaku Togo & Kazuhisa Takahashi
Pages: 223-230
Published online: 18 Jan 2021
AbstractforClinical Significance of Continuable Treatment with Nintedanib Over 12 Months for Idiopathic Pulmonary Fibrosis in a Real-World Setting | Full Text | References | PDF (374 KB) | EPUB
  • 112 Views
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Corrigendum

Correction
Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy [Corrigendum]
Page: 231
Published online: 20 Jan 2021
CitationforGalangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy [Corrigendum] | Full Text | PDF (162.9 KB) | EPUB
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Original Research

Article
Gracillin Isolated from Reineckia carnea Induces Apoptosis of A549 Cells via the Mitochondrial Pathway
Jianqiong Yang, Ling Cao, Yamei Li, Hai Liu, Minhong Zhang, Huamou Ma, Biao Wang, Xiaoliang Yuan & Qian Liu
Pages: 233-243
Published online: 20 Jan 2021
AbstractforGracillin Isolated from Reineckia carnea Induces Apoptosis of A549 Cells via the Mitochondrial Pathway | Full Text | References | PDF (5.5 MB) | EPUB
  • 191 Views
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Article
Paeoniflorin Sensitizes Breast Cancer Cells to Tamoxifen by Downregulating microRNA-15b via the FOXO1/CCND1/β-Catenin Axis
Yanhong Wang, Qian Wang, Xibei Li, Gongwen Luo, Mou Shen, Jia Shi, Xueliang Wang & Lu Tang
Pages: 245-257
Published online: 22 Jan 2021
AbstractforPaeoniflorin Sensitizes Breast Cancer Cells to Tamoxifen by Downregulating microRNA-15b via the FOXO1/CCND1/β-Catenin Axis | Full Text | References | PDF (8.5 MB) | EPUB
  • 170 Views
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Review

Review Article
Effects of Caffeic Acid and Its Derivatives on Bone: A Systematic Review
Sophia Ogechi Ekeuku, Kok-Lun Pang & Kok-Yong Chin
Pages: 259-275
Published online: 22 Jan 2021
AbstractforEffects of Caffeic Acid and Its Derivatives on Bone: A Systematic Review | Full Text | References | PDF (2 MB) | EPUB
  • 411 Views
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Original Research

Article
Physcion Protects Rats Against Cerebral Ischemia-Reperfusion Injury via Inhibition of TLR4/NF-kB Signaling Pathway
Xiaobo Dong, Lei Wang, Guangrong Song, Xu Cai, Wenxin Wang, Jiaqi Chen & Gesheng Wang
Pages: 277-287
Published online: 25 Jan 2021
AbstractforPhyscion Protects Rats Against Cerebral Ischemia-Reperfusion Injury via Inhibition of TLR4/NF-kB Signaling Pathway | Full Text | References | PDF (4.8 MB) | EPUB
  • 233 Views
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Article
Gypenosides Inhibit Inflammatory Response and Apoptosis of Endothelial and Epithelial Cells in LPS-Induced ALI: A Study Based on Bioinformatic Analysis and in vivo/vitro Experiments
Qing Tu, Yabing Zhu, Yuan Yuan, Long Guo, Lu Liu, Liangfang Yao, Yun Zou, Jinbao Li & Feng Chen
Pages: 289-303
Published online: 25 Jan 2021
AbstractforGypenosides Inhibit Inflammatory Response and Apoptosis of Endothelial and Epithelial Cells in LPS-Induced ALI: A Study Based on Bioinformatic Analysis and in vivo/vitro Experiments | Full Text | References | PDF (11.5 MB) | EPUB
  • 127 Views
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Article
Phenotyping Study of Cyclophosphamide 4-Hydroxylation in Malay Cancer Patients
Yesi Ihdina Fityatal Hasanah, Yahdiana Harahap & Denni Joko Purwanto
Pages: 305-313
Published online: 26 Jan 2021
AbstractforPhenotyping Study of Cyclophosphamide 4-Hydroxylation in Malay Cancer Patients | Full Text | References | PDF (756.3 KB) | EPUB
  • 115 Views
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Article
Administration of Dexmedetomidine Does Not Produce Long-Term Protective Effect on Testicular Damage Post Testicular Ischemia-Reperfusion Injury
Jing Xiao, Wenbo Wan, Ying Zhang, Jun Ma, Lin Yan, Yukun Luo & Jie Tang
Pages: 315-321
Published online: 27 Jan 2021
AbstractforAdministration of Dexmedetomidine Does Not Produce Long-Term Protective Effect on Testicular Damage Post Testicular Ischemia-Reperfusion Injury | Full Text | References | PDF (1.4 MB) | EPUB
  • 111 Views
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Article
CircNRIP1 Modulates the miR-515-5p/IL-25 Axis to Control 5-Fu and Cisplatin Resistance in Nasopharyngeal Carcinoma
Junwu Lin, Hong Qin, Yue Han, Xinghua Li, YuJuan Zhao & Guangsheng Zhai
Pages: 323-330
Published online: 27 Jan 2021
AbstractforCircNRIP1 Modulates the miR-515-5p/IL-25 Axis to Control 5-Fu and Cisplatin Resistance in Nasopharyngeal Carcinoma | Full Text | References | PDF (3.6 MB) | EPUB
  • 99 Views
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Review

Review Article
Tezepelumab as an Emerging Therapeutic Option for the Treatment of Severe Asthma: Evidence to Date
Zachariah L Dorey-Stein & Kartik V Shenoy
Pages: 331-338
Published online: 27 Jan 2021
AbstractforTezepelumab as an Emerging Therapeutic Option for the Treatment of Severe Asthma: Evidence to Date | Full Text | References | PDF (977.2 KB) | EPUB
  • 230 Views
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Original Research

Article
A Retrospective Observational Study of Anlotinib in Patients with Platinum-Resistant or Platinum-Refractory Epithelial Ovarian Cancer
Qingli Cui, Yanhui Hu, Dongyang Ma & Huaimin Liu
Pages: 339-347
Published online: 27 Jan 2021
AbstractforA Retrospective Observational Study of Anlotinib in Patients with Platinum-Resistant or Platinum-Refractory Epithelial Ovarian Cancer | Full Text | References | PDF (1.7 MB) | EPUB
  • 155 Views
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Erratum

Correction
Therapeutic Effects of Modified Gengnianchun Formula on Stress-Induced Diminished Ovarian Reserve Based on Experimental Approaches and Network Pharmacology [Erratum]
Page: 349
Published online: 27 Jan 2021
CitationforTherapeutic Effects of Modified Gengnianchun Formula on Stress-Induced Diminished Ovarian Reserve Based on Experimental Approaches and Network Pharmacology [Erratum] | Full Text | PDF (165.6 KB) | EPUB
  • 87 Views
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Original Research

Article
New Approach in Ocular Drug Delivery: In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations
Tivadar Bíró, Alexandra Bocsik, Bisera Jurišić Dukovski, Ilona Gróf, Jasmina Lovrić, Ildikó Csóka, Mária A Deli & Zoltán Aigner
Pages: 351-360
Published online: 03 Feb 2021
AbstractforNew Approach in Ocular Drug Delivery: In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations | Full Text | References | PDF (2.5 MB) | EPUB
  • 218 Views
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Article
Irisin Protects Against Hind Limb Ischemia Reperfusion Injury
Ayşegül Küçük, Yücel Polat, Aydan Kılıçarslan, Nuran Süngü, Hakan Kartal, Ali Doğan Dursun & Mustafa Arslan
Pages: 361-368
Published online: 04 Feb 2021
AbstractforIrisin Protects Against Hind Limb Ischemia Reperfusion Injury | Full Text | References | PDF (4.3 MB) | EPUB
  • 129 Views
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Article
Thiazolidine Derivatives Attenuate Carrageenan-Induced Inflammatory Pain in Mice
Zulkifal Malik, Muzaffar Abbas, Lina Tariq Al Kury, Fawad Ali Shah, Mahboob Alam, Arif-ullah Khan, Humaira Nadeem, Saad Alghamdi, Muhammad Umar Khayam Sahibzada & Shupeng Li
Pages: 369-384
Published online: 04 Feb 2021
AbstractforThiazolidine Derivatives Attenuate Carrageenan-Induced Inflammatory Pain in Mice | Full Text | References | PDF (5.1 MB) | EPUB
  • 200 Views
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Article
Design, Synthesis, Molecular Modelling, and Biological Evaluation of Oleanolic Acid-Arylidene Derivatives as Potential Anti-Inflammatory Agents
Reyaz Hassan Mir, Goutami Godavari, Nasir Ali Siddiqui, Bilal Ahmad, Ramzi A Mothana, Riaz Ullah, Omer M Almarfadi, Sanjay M Jachak & Mubashir Hussain Masoodi
Pages: 385-397
Published online: 04 Feb 2021
AbstractforDesign, Synthesis, Molecular Modelling, and Biological Evaluation of Oleanolic Acid-Arylidene Derivatives as Potential Anti-Inflammatory Agents | Full Text | References | PDF (2.4 MB) | EPUB
  • 241 Views
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Article
Development and Characterization of PLGA Nanoparticle-Laden Hydrogels for Sustained Ocular Delivery of Norfloxacin in the Treatment of Pseudomonas Keratitis: An Experimental Study
Rana M Gebreel, Noha A Edris, Hala M Elmofty, Mina I Tadros, Mohamed A El-Nabarawi & Doaa H Hassan
Pages: 399-418
Published online: 05 Feb 2021
AbstractforDevelopment and Characterization of PLGA Nanoparticle-Laden Hydrogels for Sustained Ocular Delivery of Norfloxacin in the Treatment of Pseudomonas Keratitis: An Experimental Study | Full Text | References | PDF (8.5 MB) | EPUB
  • 472 Views
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Corrigendum

Correction
Zafirlukast in Combination with Pseudohypericin Attenuates Spinal Cord Injury and Motor Function in Experimental Mice [Corrigendum]
Pages: 419-422
Published online: 09 Feb 2021
First Page PreviewforZafirlukast in Combination with Pseudohypericin Attenuates Spinal Cord Injury and Motor Function in Experimental Mice [Corrigendum] | Full Text | PDF (3.7 MB) | EPUB
  • 85 Views
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Original Research

Article
Individualized Vancomycin Dosing with Therapeutic Drug Monitoring and Pharmacokinetic Consultation Service: A Large-Scale Retrospective Observational Study
Sang-Mi Kim, Hyun-Seung Lee, Na-Young Hwang, Kyunga Kim, Hyung-Doo Park & Soo-Youn Lee
Pages: 423-440
Published online: 04 Mar 2021
AbstractforIndividualized Vancomycin Dosing with Therapeutic Drug Monitoring and Pharmacokinetic Consultation Service: A Large-Scale Retrospective Observational Study | Full Text | References | PDF (2.3 MB) | EPUB
  • 222 Views
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Article
Effect of Evodiamine on Rat Colonic Hypermotility Induced by Water Avoidance Stress and the Underlying Mechanism
HaiXia Ren, FangTing Yuan, Wei Tan, YiJuan Ding, Ping An & HeSheng Luo
Pages: 441-452
Published online: 10 Feb 2021
AbstractforEffect of Evodiamine on Rat Colonic Hypermotility Induced by Water Avoidance Stress and the Underlying Mechanism | Full Text | References | PDF (6.3 MB) | EPUB
  • 91 Views
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Review

Review Article
Profile of Enfortumab Vedotin in the Treatment of Urothelial Carcinoma: The Evidence to Date
Mohamad Moussa, Athanasios Papatsoris, Mohamed Abou Chakra & Athanasios Dellis
Pages: 453-462
Published online: 11 Feb 2021
AbstractforProfile of Enfortumab Vedotin in the Treatment of Urothelial Carcinoma: The Evidence to Date | Full Text | References | PDF (296.3 KB) | EPUB
  • 152 Views
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Original Research

Article
Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry for Simultaneous Determination of Antipsychotic Drugs in Human Plasma and Its Application in Therapeutic Drug Monitoring
Yingjie Qi & Guangxuan Liu
Pages: 463-479
Published online: 12 Feb 2021
AbstractforUltra-Performance Liquid Chromatography-Tandem Mass Spectrometry for Simultaneous Determination of Antipsychotic Drugs in Human Plasma and Its Application in Therapeutic Drug Monitoring | Full Text | References | PDF (10.6 MB) | EPUB
  • 252 Views
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Article
Long Noncoding RNA SOX2-OT Aggravates Doxorubicin-Induced Apoptosis of Cardiomyocyte by Targeting miR-942-5p/DP5
Haining Wang, Xiule Lin, Jilin Li, Guoning Zeng & Tan Xu
Pages: 481-492
Published online: 11 Feb 2021
AbstractforLong Noncoding RNA SOX2-OT Aggravates Doxorubicin-Induced Apoptosis of Cardiomyocyte by Targeting miR-942-5p/DP5 | Full Text | References | PDF (6.3 MB) | EPUB
  • 151 Views
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Article
EGCG Regulates Cell Apoptosis of Human Umbilical Vein Endothelial Cells Grown on 316L Stainless Steel for Stent Implantation
Jinpeng Wang, Yue Wang, Yuyi Zhao, Jinbin Zhao, Beilin Zhang & Kun Xu
Pages: 493-499
Published online: 11 Feb 2021
AbstractforEGCG Regulates Cell Apoptosis of Human Umbilical Vein Endothelial Cells Grown on 316L Stainless Steel for Stent Implantation | Full Text | References | PDF (3.2 MB) | EPUB
  • 104 Views
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Article
Loganin Attenuates Septic Acute Renal Injury with the Participation of AKT and Nrf2/HO-1 Signaling Pathways
Jin Zhang, Changsong Wang, Kai Kang, Haitao Liu, Xiaowei Liu, Xiaonan Jia & Kaijiang Yu
Pages: 501-513
Published online: 11 Feb 2021
AbstractforLoganin Attenuates Septic Acute Renal Injury with the Participation of AKT and Nrf2/HO-1 Signaling Pathways | Full Text | References | PDF (8.4 MB) | EPUB
  • 259 Views
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Corrigendum

Correction
Budesonide/Formoterol Anti-Inflammatory Reliever and Maintenance or Fluticasone Propionate/Salmeterol Plus as-Needed, Short-Acting β2 Agonist: Real-World Effectiveness in patients Without Optimally Controlled asthma (REACT) Study [Corrigendum]
Pages: 515-516
Published online: 12 Feb 2021
CitationforBudesonide/Formoterol Anti-Inflammatory Reliever and Maintenance or Fluticasone Propionate/Salmeterol Plus as-Needed, Short-Acting β2 Agonist: Real-World Effectiveness in patients Without Optimally Controlled asthma (REACT) Study [Corrigendum] | Full Text | PDF (244 KB) | EPUB
  • 92 Views
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Original Research

Article
L-Cysteine Provides Neuroprotection of Hypoxia-Ischemia Injury in Neonatal Mice via a PI3K/Akt-Dependent Mechanism
Tingting Li, Jiangbing Li, Tong Li, Yijing Zhao, Hongfei Ke, Shuanglian Wang, Dexiang Liu & Zhen Wang
Pages: 517-529
Published online: 11 Feb 2021
AbstractforL-Cysteine Provides Neuroprotection of Hypoxia-Ischemia Injury in Neonatal Mice via a PI3K/Akt-Dependent Mechanism | Full Text | References | PDF (17.4 MB) | EPUB
  • 113 Views
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Article
Synergistic Anticancer Strategy of Sonodynamic Therapy Combined with PI-103 Against Hepatocellular Carcinoma
Huajing Yang, Hui Jing, Xue Han, Haoyan Tan & Wen Cheng
Pages: 531-542
Published online: 11 Feb 2021
AbstractforSynergistic Anticancer Strategy of Sonodynamic Therapy Combined with PI-103 Against Hepatocellular Carcinoma | Full Text | References | PDF (8.3 MB) | EPUB
  • 156 Views
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Article
Magnesium Isoglycyrrhizinate Alleviates Arsenic Trioxide-Induced Cardiotoxicity: Contribution of Nrf2 and TLR4/NF-κB Signaling Pathway
Bin Zheng, Yakun Yang, Jinghan Li, Jing Li, Saijie Zuo, Xi Chu, Shan Xu, Donglai Ma & Li Chu
Pages: 543-556
Published online: 12 Feb 2021
AbstractforMagnesium Isoglycyrrhizinate Alleviates Arsenic Trioxide-Induced Cardiotoxicity: Contribution of Nrf2 and TLR4/NF-κB Signaling Pathway | Full Text | References | PDF (9.5 MB) | EPUB
  • 146 Views
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Article
Self-Nanoemulsifying Drug Delivery System of Genkwanin: A Novel Approach for Anti-Colitis-Associated Colorectal Cancer
Hua-Feng Yin, Chun-Ming Yin, Ting Ouyang, Shu-Ding Sun, Wei-Guo Chen, Xiao-Lin Yang, Xin He & Chun-Feng Zhang
Pages: 557-576
Published online: 12 Feb 2021
AbstractforSelf-Nanoemulsifying Drug Delivery System of Genkwanin: A Novel Approach for Anti-Colitis-Associated Colorectal Cancer | Full Text | References | PDF (14.2 MB) | EPUB
  • 356 Views
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Article
Effects of Quercetin on the Efficacy of Various Chemotherapeutic Drugs in Cervical Cancer Cells
Wenbin Xu, Shangdan Xie, Xin Chen, Shuya Pan, Hongfei Qian & Xueqiong Zhu
Pages: 577-588
Published online: 15 Feb 2021
AbstractforEffects of Quercetin on the Efficacy of Various Chemotherapeutic Drugs in Cervical Cancer Cells | Full Text | References | PDF (9.1 MB) | EPUB
  • 564 Views
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Open Access
Article
Nephroprotective Effect of Adropinin Against Streptozotocin-Induced Diabetic Nephropathy in Rats: Inflammatory Mechanism and YAP/TAZ Factor
Ling Guo, Bei Jiang, Dengren Li & Xiaoyan Xiao
Pages: 589-600
Published online: 16 Feb 2021
AbstractforNephroprotective Effect of Adropinin Against Streptozotocin-Induced Diabetic Nephropathy in Rats: Inflammatory Mechanism and YAP/TAZ Factor | Full Text | References | PDF (4.2 MB) | EPUB
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Article
Preparation, Characterization and in vitro/in vivo Evaluation of Lovastatin-Loaded PLGA Microspheres by Local Administration for Femoral Head Necrosis
Yang Sun & Di Long
Pages: 601-610
Published online: 16 Feb 2021
AbstractforPreparation, Characterization and in vitro/in vivo Evaluation of Lovastatin-Loaded PLGA Microspheres by Local Administration for Femoral Head Necrosis | Full Text | References | PDF (4.2 MB) | EPUB
  • 143 Views
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Article
Effect of Different Dosage Frequency of Polymyxin B on Rat Nephrotoxicity
Wenrui Sun, Binchuan Hu, Xiaoshan Zhang, Yuzhen Wang, Zheng Xiang & Guanyang Lin
Pages: 611-616
Published online: 16 Feb 2021
AbstractforEffect of Different Dosage Frequency of Polymyxin B on Rat Nephrotoxicity | Full Text | References | PDF (533.2 KB) | EPUB
  • 150 Views
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Article
Treatment of Severe Acute Bacterial Keratitis in Rabbits Using Continuous Topical Ocular Instillation with Norvancomycin
Wenxiang Lin, Libei Zhao, Qian Tan & Ding Lin
Pages: 617-628
Published online: 16 Feb 2021
AbstractforTreatment of Severe Acute Bacterial Keratitis in Rabbits Using Continuous Topical Ocular Instillation with Norvancomycin | Full Text | References | PDF (3.1 MB) | EPUB
  • 132 Views
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Article
Safety, Tolerability, and Pharmacokinetics of Ibuprofenamine Hydrochloride Spray (NSAIDs), a New Drug for Rheumatoid Arthritis and Osteoarthritis, in Healthy Chinese Subjects
Panpan Xie, Wei Xue, Wenyuan Qi, Yang Li, Lei Yang, Zhaojun Yang & Aixin Shi
Pages: 629-638
Published online: 16 Feb 2021
AbstractforSafety, Tolerability, and Pharmacokinetics of Ibuprofenamine Hydrochloride Spray (NSAIDs), a New Drug for Rheumatoid Arthritis and Osteoarthritis, in Healthy Chinese Subjects | Full Text | References | PDF (1.3 MB) | EPUB
  • 262 Views
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Review

Review Article
Progress in Clinical Research on Gonadotropin-Releasing Hormone Receptor Antagonists for the Treatment of Prostate Cancer
Yi-Fu Liu, Sheng-Qiang Fu, Yu-Chang Yan, Bin-Bin Gong, Wen-Jie Xie, Xiao-Rong Yang, Ting Sun & Ming Ma
Pages: 639-649
Published online: 16 Feb 2021
AbstractforProgress in Clinical Research on Gonadotropin-Releasing Hormone Receptor Antagonists for the Treatment of Prostate Cancer | Full Text | References | PDF (720.5 KB) | EPUB
  • 213 Views
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Original Research

Article
Pharmacokinetic and Pharmacodynamic Comparison of Two Formulations of a Fixed-Dose Combination of Gemigliptin/Rosuvastatin 50/20 mg: A Randomized, Open-Label, Single-Dose, Two-Way Crossover Study
Eunsol Yang, Hyounggyoon Yoo, In-Jin Jang, Kyung-Sang Yu & SeungHwan Lee
Pages: 651-658
Published online: 17 Feb 2021
AbstractforPharmacokinetic and Pharmacodynamic Comparison of Two Formulations of a Fixed-Dose Combination of Gemigliptin/Rosuvastatin 50/20 mg: A Randomized, Open-Label, Single-Dose, Two-Way Crossover Study | Full Text | References | PDF (1.9 MB) | EPUB
  • 154 Views
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Article
Thiazole-Based Thiosemicarbazones: Synthesis, Cytotoxicity Evaluation and Molecular Docking Study
Sobhi M Gomha, Hyam A Abdelhady, Doaa Z H Hassain, Aboubakr H Abdelmonsef, Mohamed El-Naggar, Mahmoud M Elaasser & Huda K Mahmoud
Pages: 659-677
Published online: 17 Feb 2021
AbstractforThiazole-Based Thiosemicarbazones: Synthesis, Cytotoxicity Evaluation and Molecular Docking Study | Full Text | References | PDF (6.5 MB) | EPUB
  • 765 Views
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Article
Trans-Cinnamaldehyde Increases Random Pattern Flap Survival Through Activation of the Nitric Oxide Pathway
Xiaobin Luo, Bin Zhao, Baoxia Chen, Hongyu Chen, Tao Han, Najeeb Bassam Najeeb Bsoul & Hede Yan
Pages: 679-688
Published online: 18 Feb 2021
AbstractforTrans-Cinnamaldehyde Increases Random Pattern Flap Survival Through Activation of the Nitric Oxide Pathway | Full Text | References | PDF (10.7 MB) | EPUB
  • 119 Views
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Article
The Effectiveness and Safety of Intravenous Dexmedetomidine of Different Concentrations Combined with Butorphanol for Post-Caesarean Section Analgesia: A Randomized Controlled Trial
Shijiang Liu, Peipei Peng, Youli Hu, Cunming Liu, Xiaofei Cao, Chun Yang & Mei Gao
Pages: 689-698
Published online: 18 Feb 2021
AbstractforThe Effectiveness and Safety of Intravenous Dexmedetomidine of Different Concentrations Combined with Butorphanol for Post-Caesarean Section Analgesia: A Randomized Controlled Trial | Full Text | References | PDF (3.8 MB) | EPUB
  • 190 Views
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Review

Review Article
Glucocorticoid-Like Activity of Escin: A New Mechanism for an Old Drug
Luca Gallelli, Erika Cione, Tian Wang & Leiming Zhang
Pages: 699-704
Published online: 24 Feb 2021
AbstractforGlucocorticoid-Like Activity of Escin: A New Mechanism for an Old Drug | Full Text | References | PDF (845.7 KB) | EPUB
  • 248 Views
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Original Research

Article
Danggui Buxue Decoction in the Treatment of Metastatic Colon Cancer: Network Pharmacology Analysis and Experimental Validation
Shi-Han Feng, Bin Zhao, Xue Zhan, Retsepile Motanyane, Shu-Mei Wang & Ao Li
Pages: 705-720
Published online: 24 Feb 2021
AbstractforDanggui Buxue Decoction in the Treatment of Metastatic Colon Cancer: Network Pharmacology Analysis and Experimental Validation | Full Text | References | PDF (10.2 MB) | EPUB
  • 197 Views
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Review

Review Article
The Risks of miRNA Therapeutics: In a Drug Target Perspective
Song Zhang, Zhujun Cheng, Yanan Wang & Tianyu Han
Pages: 721-733
Published online: 22 Feb 2021
AbstractforThe Risks of miRNA Therapeutics: In a Drug Target Perspective | Full Text | References | PDF (3.5 MB) | EPUB
  • 759 Views
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Original Research

Article
Addition of Celebrex and Pregabalin to Ropivacaine for Posterior Spinal Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial
Ye Zhang, Bin He, Jinqiu Zhao, Muzi Zhang, Qinsong Ren, Wei Zhang, Shuai Xu, Zhengxue Quan & Yunsheng Ou
Pages: 735-742
Published online: 22 Feb 2021
AbstractforAddition of Celebrex and Pregabalin to Ropivacaine for Posterior Spinal Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial | Full Text | References | PDF (731.4 KB) | EPUB
  • 203 Views
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Article
The Effectiveness of Ruxolitinib for Acute/Chronic Graft-versus-Host Disease in Children: A Retrospective Study
Wenli Yang, Guanghua Zhu, Maoquan Qin, Zhigang Li, Bin Wang, Jun Yang & Tianyou Wang
Pages: 743-752
Published online: 22 Feb 2021
AbstractforThe Effectiveness of Ruxolitinib for Acute/Chronic Graft-versus-Host Disease in Children: A Retrospective Study | Full Text | References | PDF (788.5 KB) | EPUB
  • 251 Views
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Article
Mechanism of Action of Xiaoyao San in Treatment of Ischemic Stroke is Related to Anti-Apoptosis and Activation of PI3K/Akt Pathway
Yue Xu, Weiyin Chen, Zeran Chen, Mengyuan Huang, Fang Yang & Yang Zhang
Pages: 753-767
Published online: 22 Feb 2021
AbstractforMechanism of Action of Xiaoyao San in Treatment of Ischemic Stroke is Related to Anti-Apoptosis and Activation of PI3K/Akt Pathway | Full Text | References | PDF (9.4 MB) | EPUB
  • 149 Views
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Article
The Volatile Oil of Zanthoxylum bungeanum Pericarp Improved the Hypothalamic-Pituitary-Adrenal Axis and Gut Microbiota to Attenuate Chronic Unpredictable Stress-Induced Anxiety Behavior in Rats
Daneng Wei, Yafei Zhao, Mengmeng Zhang, Lei Zhu, Li Wang, Xing Yuan & Chunjie Wu
Pages: 769-786
Published online: 22 Feb 2021
AbstractforThe Volatile Oil of Zanthoxylum bungeanum Pericarp Improved the Hypothalamic-Pituitary-Adrenal Axis and Gut Microbiota to Attenuate Chronic Unpredictable Stress-Induced Anxiety Behavior in Rats | Full Text | References | PDF (8.3 MB) | EPUB
  • 233 Views
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Article
Dopamine-Mediated Vanillin Multicomponent Derivative Synthesis via Grindstone Method: Application of Antioxidant, Anti-Tyrosinase, and Cytotoxic Activities
Arunadevi Mani, Anis Ahamed, Daoud Ali, Saud Alarifi & Idhayadhulla Akbar
Pages: 787-802
Published online: 23 Feb 2021
AbstractforDopamine-Mediated Vanillin Multicomponent Derivative Synthesis via Grindstone Method: Application of Antioxidant, Anti-Tyrosinase, and Cytotoxic Activities | Full Text | References | PDF (2.1 MB) | EPUB
  • 309 Views
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Article
Convallatoxin Promotes M2 Macrophage Polarization to Attenuate Atherosclerosis Through PPARγ-Integrin αvβ5 Signaling Pathway
Yi Zhang, Xiujin Shi, Jialun Han, Wenxing Peng, Zhenwei Fang, Yang Zhou, Xiaoyu Xu, Jie Lin, Fucheng Xiao, Limin Zhao & Yang Lin
Pages: 803-812
Published online: 23 Feb 2021
AbstractforConvallatoxin Promotes M2 Macrophage Polarization to Attenuate Atherosclerosis Through PPARγ-Integrin αvβ5 Signaling Pathway | Full Text | References | PDF (7 MB) | EPUB
  • 159 Views
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Corrigendum

Correction
Efficacy and Safety of Retinol Palmitate Ophthalmic Solution in the Treatment of Dry Eye: A Japanese Phase II Clinical Trial [Corrigendum]
Pages: 813-816
Published online: 24 Feb 2021
First Page PreviewforEfficacy and Safety of Retinol Palmitate Ophthalmic Solution in the Treatment of Dry Eye: A Japanese Phase II Clinical Trial [Corrigendum] | Full Text | PDF (1.7 MB) | EPUB
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Original Research

Article
Predicting and Exploring the Mechanisms of Erzhi Pill in Prevention and Treatment of Osteoporosis Based on Network Pharmacology and Zebrafish Experiments
Zhiguo Zhong, Yuyun Li, Yan Chen, Wen Chen, Siyan Li, Xiaohua Lv & Shiying Luo
Pages: 817-827
Published online: 24 Feb 2021
AbstractforPredicting and Exploring the Mechanisms of Erzhi Pill in Prevention and Treatment of Osteoporosis Based on Network Pharmacology and Zebrafish Experiments | Full Text | References | PDF (6.9 MB) | EPUB
  • 243 Views
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Clinical Trial Report

Case Report
Effects of Sugammadex versus Neostigmine on Intraoperative Coagulation Profiles in Patients with Thyroidectomy
Dizhou Zhao, Jieyu Fang, Wei Xiong, Jun Lin, Wanmei Chen & Chujun Wu
Pages: 829-834
Published online: 25 Feb 2021
AbstractforEffects of Sugammadex versus Neostigmine on Intraoperative Coagulation Profiles in Patients with Thyroidectomy | Full Text | References | PDF (957.2 KB) | EPUB
  • 106 Views
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Review

Review Article
Current Understanding on Perioperative Management in Lung Cancer: Implications for Anesthetic Considerations
Jian Wang, Lei Liu, Yuli Song, Jinghua Jiao & Yifan Zhong
Pages: 835-842
Published online: 25 Feb 2021
AbstractforCurrent Understanding on Perioperative Management in Lung Cancer: Implications for Anesthetic Considerations | Full Text | References | PDF (937.1 KB) | EPUB
  • 118 Views
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Original Research

Article
Breviscapine Pretreatment Inhibits Myocardial Inflammation and Apoptosis in Rats After Coronary Microembolization by Activating the PI3K/Akt/GSK-3β Signaling Pathway
Zhi-Qing Chen, You Zhou, Feng Chen, Jun-Wen Huang, Jing Zheng, Hao-Liang Li, Tao Li & Lang Li
Pages: 843-855
Published online: 25 Feb 2021
AbstractforBreviscapine Pretreatment Inhibits Myocardial Inflammation and Apoptosis in Rats After Coronary Microembolization by Activating the PI3K/Akt/GSK-3β Signaling Pathway | Full Text | References | PDF (8.5 MB) | EPUB
  • 131 Views
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Article
Aloperine Inhibits Proliferation and Promotes Apoptosis in Colorectal Cancer Cells by Regulating the circNSUN2/miR-296-5p/STAT3 Pathway
Wei Han, Desong Kong, Qin Lu, Wei Zhang & Zhimin Fan
Pages: 857-870
Published online: 25 Feb 2021
AbstractforAloperine Inhibits Proliferation and Promotes Apoptosis in Colorectal Cancer Cells by Regulating the circNSUN2/miR-296-5p/STAT3 Pathway | Full Text | References | PDF (11.3 MB) | EPUB
  • 106 Views
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Article
Taxifolin, Extracted from Waste Larix olgensis Roots, Attenuates CCl4-Induced Liver Fibrosis by Regulating the PI3K/AKT/mTOR and TGF-β1/Smads Signaling Pathways
Xinglong Liu, Wencong Liu, Chuanbo Ding, Yingchun Zhao, Xueyan Chen, Dong Ling, Yinan Zheng & Zhiqiang Cheng
Pages: 871-887
Published online: 26 Feb 2021
AbstractforTaxifolin, Extracted from Waste Larix olgensis Roots, Attenuates CCl4-Induced Liver Fibrosis by Regulating the PI3K/AKT/mTOR and TGF-β1/Smads Signaling Pathways | Full Text | References | PDF (14.2 MB) | EPUB
  • 183 Views
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Article
Low Frequency of Integrase Inhibitor Resistance Mutations Among Therapy-Naïve HIV Patients in Southeast China
Jinglan Lai, Yuming Liu, Xiao Han, Aiqiong Huang, Jin Lin, Wen Ao, Hanhui Ye & Yahong Chen
Pages: 889-894
Published online: 26 Feb 2021
AbstractforLow Frequency of Integrase Inhibitor Resistance Mutations Among Therapy-Naïve HIV Patients in Southeast China | Full Text | References | PDF (255.1 KB) | EPUB
  • 91 Views
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Hypothesis

Discussion
Bitter Taste Receptor as a Therapeutic Target in Orthopaedic Disorders
Weyland Cheng, Manye Yao & Fangna Liu
Pages: 895-903
Published online: 26 Feb 2021
AbstractforBitter Taste Receptor as a Therapeutic Target in Orthopaedic Disorders | Full Text | References | PDF (1.1 MB) | EPUB
  • 170 Views
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Original Research

Article
Hydroxyapatite Nanoparticles Facilitate Osteoblast Differentiation and Bone Formation Within Sagittal Suture During Expansion in Rats
Wei Liang, Pengbing Ding, Guan Li, Enhang Lu & Zhenmin Zhao
Pages: 905-917
Published online: 01 Mar 2021
AbstractforHydroxyapatite Nanoparticles Facilitate Osteoblast Differentiation and Bone Formation Within Sagittal Suture During Expansion in Rats | Full Text | References | PDF (9.2 MB) | EPUB
  • 209 Views
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Review

Review Article
Zanubrutinib (BGB-3111), a Second-Generation Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase and Its Utility in Treating Chronic Lymphocytic Leukemia
Joanna M Rhodes & Anthony R Mato
Pages: 919-926
Published online: 02 Mar 2021
AbstractforZanubrutinib (BGB-3111), a Second-Generation Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase and Its Utility in Treating Chronic Lymphocytic Leukemia | Full Text | References | PDF (285.3 KB) | EPUB
  • 303 Views
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Original Research

Article
Lidocaine Inhibits Myoblast Cell Migration and Myogenic Differentiation Through Activation of the Notch Pathway
Xiangtian Ling, Xinqi Ma, Xielan Kuang, Yuxiu Zou, Han Zhang, Han Tang, Han Du, Binbin Zhu, Hao Huang, Qing Xia, Minghao Chen, Danyi Mao, Dongli Chen, Huangxuan Shen & Jianhua Yan
Pages: 927-936
Published online: 02 Mar 2021
AbstractforLidocaine Inhibits Myoblast Cell Migration and Myogenic Differentiation Through Activation of the Notch Pathway | Full Text | References | PDF (5.5 MB) | EPUB
  • 102 Views
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Article
Characterization of Oxygenated Heterocyclic Compounds and in vitro Antioxidant Activity of Pomelo Essential Oil
Guijie Li, Yujiao Cheng, Tenghui Zhang, Yingzhuo Li, Leng Han & Guolu Liang
Pages: 937-947
Published online: 02 Mar 2021
AbstractforCharacterization of Oxygenated Heterocyclic Compounds and in vitro Antioxidant Activity of Pomelo Essential Oil | Full Text | References | PDF (895.4 KB) | EPUB
  • 338 Views
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Article
Geniposide from Gardenia jasminoides var. radicans Makino Attenuates Myocardial Injury in Spontaneously Hypertensive Rats via Regulating Apoptotic and Energy Metabolism Signalling Pathway
Ying Hou, Peipei Yuan, Yang Fu, Qi Zhang, Liyuan Gao, Yaxin Wei, Xiaoke Zheng & Weisheng Feng
Pages: 949-962
Published online: 03 Mar 2021
AbstractforGeniposide from Gardenia jasminoides var. radicans Makino Attenuates Myocardial Injury in Spontaneously Hypertensive Rats via Regulating Apoptotic and Energy Metabolism Signalling Pathway | Full Text | References | PDF (8 MB) | EPUB
  • 132 Views
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Article
Method Development and Validation for Measuring O6-Methylguanine in Dried Blood Spot Using Ultra High-Performance Liquid Chromatography Tandem Mass Spectrometry
Yahdiana Harahap, Aurelia Maria Vianney & Herman Suryadi
Pages: 963-971
Published online: 03 Mar 2021
AbstractforMethod Development and Validation for Measuring O6-Methylguanine in Dried Blood Spot Using Ultra High-Performance Liquid Chromatography Tandem Mass Spectrometry | Full Text | References | PDF (3 MB) | EPUB
  • 122 Views
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Article
Dihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon Fibroblasts via Inducing Autophagy
Xiaoyuan Wang, Wuqi Song, Fengmin Zhang & Renping Huang
Pages: 973-981
Published online: 03 Mar 2021
AbstractforDihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon Fibroblasts via Inducing Autophagy | Full Text | References | PDF (3.7 MB) | EPUB
  • 105 Views
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Review

Review Article
Beware of Steroid-Induced Avascular Necrosis of the Femoral Head in the Treatment of COVID-19—Experience and Lessons from the SARS Epidemic
Shenqi Zhang, Chengbin Wang, Lei Shi & Qingyun Xue
Pages: 983-995
Published online: 04 Mar 2021
AbstractforBeware of Steroid-Induced Avascular Necrosis of the Femoral Head in the Treatment of COVID-19—Experience and Lessons from the SARS Epidemic | Full Text | References | PDF (362.4 KB) | EPUB
  • 570 Views
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Original Research

Article
The Effect of Nintedanib on T-Cell Activation, Subsets and Functions
Kenia Ubieta, Matthew James Thomas & Lutz Wollin
Pages: 997-1011
Published online: 08 Mar 2021
AbstractforThe Effect of Nintedanib on T-Cell Activation, Subsets and Functions | Full Text | References | PDF (10.6 MB) | EPUB
  • 219 Views
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Article
Epigallocatechin-3-Gallate Promotes the in vitro Maturation and Embryo Development Following IVF of Porcine Oocytes
Kangfa Huang, Chengde Li, Fenglei Gao, Yushan Fan, Fanwen Zeng, Li Meng, Li Li, Shouquan Zhang & Hengxi Wei
Pages: 1013-1020
Published online: 04 Mar 2021
AbstractforEpigallocatechin-3-Gallate Promotes the in vitro Maturation and Embryo Development Following IVF of Porcine Oocytes | Full Text | References | PDF (1.3 MB) | EPUB
  • 151 Views
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Review

Review Article
Superoxide Dismutase as an Intervention for Radiation Therapy-Associated Toxicities: Review and Profile of Avasopasem Manganese as a Treatment Option for Radiation-Induced Mucositis
Stephen T Sonis
Pages: 1021-1029
Published online: 05 Mar 2021
AbstractforSuperoxide Dismutase as an Intervention for Radiation Therapy-Associated Toxicities: Review and Profile of Avasopasem Manganese as a Treatment Option for Radiation-Induced Mucositis | Full Text | References | PDF (303.5 KB) | EPUB
  • 323 Views
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Original Research

Article
Role of Oxidative Stress and Reduced Endogenous Hydrogen Sulfide in Diabetic Nephropathy
Arslan Hussain Lodhi, Fiaz-ud-Din Ahmad, Kainat Furwa & Asadullah Madni
Pages: 1031-1043
Published online: 05 Mar 2021
AbstractforRole of Oxidative Stress and Reduced Endogenous Hydrogen Sulfide in Diabetic Nephropathy | Full Text | References | PDF (2 MB) | EPUB
  • 251 Views
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Review

Review Article
An Overview of Bimekizumab for the Treatment of Psoriatic Arthritis: The Evidence so Far
Daniel G Oliveira, Raquel Faria & Tiago Torres
Pages: 1045-1053
Published online: 09 Mar 2021
AbstractforAn Overview of Bimekizumab for the Treatment of Psoriatic Arthritis: The Evidence so Far | Full Text | References | PDF (985.2 KB) | EPUB
  • 237 Views
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Original Research

Article
Bioactive Compounds from Germinated Brown Rice Protect Cardiomyocytes Against Simulated Ischemic/Reperfusion Injury by Ameliorating Mitochondrial Dysfunction
Kanokwan Demeekul, Wichit Suthammarak & Soontaree Petchdee
Pages: 1055-1066
Published online: 09 Mar 2021
AbstractforBioactive Compounds from Germinated Brown Rice Protect Cardiomyocytes Against Simulated Ischemic/Reperfusion Injury by Ameliorating Mitochondrial Dysfunction | Full Text | References | PDF (5.5 MB) | EPUB
  • 152 Views
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Article
The Use of Novel Non-Vitamin K Antagonist Oral Anticoagulants Following Closure of the Left Atrial Appendage: Preliminary Results of Clinical Follow-Up
Jing Zhu & Jian Xu
Pages: 1067-1073
Published online: 09 Mar 2021
AbstractforThe Use of Novel Non-Vitamin K Antagonist Oral Anticoagulants Following Closure of the Left Atrial Appendage: Preliminary Results of Clinical Follow-Up | Full Text | References | PDF (370.4 KB) | EPUB
  • 117 Views
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Article
Investigation of the Active Ingredients and Mechanism of Polygonum cuspidatum in Asthma Based on Network Pharmacology and Experimental Verification
Junjie Bi, Yuhua Lin, Yipeng Sun, Mengzhe Zhang, Qingge Chen, Xiayi Miu, Lingling Tang, Jinjin Liu, Linyun Zhu, Zhenhua Ni & Xiongbiao Wang
Pages: 1075-1089
Published online: 09 Mar 2021
AbstractforInvestigation of the Active Ingredients and Mechanism of Polygonum cuspidatum in Asthma Based on Network Pharmacology and Experimental Verification | Full Text | References | PDF (8.7 MB) | EPUB
  • 150 Views
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Article
Pharmacokinetics and Bioequivalence Evaluation of Two Montelukast Sodium Chewable Tablets in Healthy Chinese Volunteers Under Fasted and Fed Conditions
Weihong Li, Yanrong Wang, Yingzi Pei & Yue Xia
Pages: 1091-1099
Published online: 09 Mar 2021
AbstractforPharmacokinetics and Bioequivalence Evaluation of Two Montelukast Sodium Chewable Tablets in Healthy Chinese Volunteers Under Fasted and Fed Conditions | Full Text | References | PDF (2.5 MB) | EPUB
  • 275 Views
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Article
Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Benfotiamine in Healthy Subjects
Lei Sheng, Wei Cao, Pingping Lin, Weili Chen, Hongrong Xu, Chunjiu Zhong, Fei Yuan, Hanjing Chen, Hui Li, Chao Liu, Mengjie Yang & Xuening Li
Pages: 1101-1110
Published online: 09 Mar 2021
AbstractforSafety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Benfotiamine in Healthy Subjects | Full Text | References | PDF (1.5 MB) | EPUB
  • 446 Views
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Article
Withanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model
Acharya Balkrishna, Subarna Pokhrel, Hoshiyar Singh, Monali Joshi, Vallabh Prakash Mulay, Swati Haldar & Anurag Varshney
Pages: 1111-1133
Published online: 11 Mar 2021
AbstractforWithanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model | Full Text | References | PDF (8 MB) | EPUB
  • 345 Views
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Review

Review Article
The Efficacy and Safety of Abrocitinib as a Treatment Option for Atopic Dermatitis: A Short Report of the Clinical Data
Maddalena Napolitano, Gabriella Fabbrocini, Angelo Ruggiero, Vincenzo Marino, Mariateresa Nocerino & Cataldo Patruno
Pages: 1135-1147
Published online: 10 Mar 2021
AbstractforThe Efficacy and Safety of Abrocitinib as a Treatment Option for Atopic Dermatitis: A Short Report of the Clinical Data | Full Text | References | PDF (2 MB) | EPUB
  • 211 Views
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Review Article
Antibacterial and Antimicrobial Effects of Xanthorrhizol in the Prevention of Dental Caries: A Systematic Review
Ghulam Sarwar Khalid, Mohammad Hassan Hamrah, Elaha Somaya Ghafary, Sepideh Hosseini & Fateme Almasi
Pages: 1149-1156
Published online: 11 Mar 2021
AbstractforAntibacterial and Antimicrobial Effects of Xanthorrhizol in the Prevention of Dental Caries: A Systematic Review | Full Text | References | PDF (1.1 MB) | EPUB
  • 493 Views
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Original Research

Article
Repeated Doses of Ketamine Affect the Infant Rat Urogenital System
Hulya Kasıkara, Nuran Sungu, Mustafa Arslan, Aysegul Kucuk, Levent Ozturk, Nigar Afandiyeva & Mustafa Kavutcu
Pages: 1157-1165
Published online: 11 Mar 2021
AbstractforRepeated Doses of Ketamine Affect the Infant Rat Urogenital System | Full Text | References | PDF (8.3 MB) | EPUB
  • 126 Views
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Article
Charge-Transfer Complex of Linifanib with 2,3-dichloro-3,5-dicyano-1,4-benzoquinone: Synthesis, Spectroscopic Characterization, Computational Molecular Modelling and Application in the Development of Novel 96-microwell Spectrophotometric Assay
Ibrahim A Darwish, Nasr Y Khalil, Nawaf A Alsaif, Rashed N Herqash, Ahmed Y A Sayed & Hamdy M Abdel-Rahman
Pages: 1167-1180
Published online: 12 Mar 2021
AbstractforCharge-Transfer Complex of Linifanib with 2,3-dichloro-3,5-dicyano-1,4-benzoquinone: Synthesis, Spectroscopic Characterization, Computational Molecular Modelling and Application in the Development of Novel 96-microwell Spectrophotometric Assay | Full Text | References | PDF (3.8 MB) | EPUB
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Article
Pharmacokinetics, Bioequivalence and Safety Evaluation of Two Ticagrelor Tablets Under Fasting and Fed Conditions in Healthy Chinese Subjects
Jin Wang, Huan Zhang, Rui Wang & Yun Cai
Pages: 1181-1193
Published online: 15 Mar 2021
AbstractforPharmacokinetics, Bioequivalence and Safety Evaluation of Two Ticagrelor Tablets Under Fasting and Fed Conditions in Healthy Chinese Subjects | Full Text | References | PDF (1.6 MB) | EPUB
  • 264 Views
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Article
Development and Evaluation of a Physiologically Based Pharmacokinetic Drug-Disease Model of Propranolol for Suggesting Model Informed Dosing in Liver Cirrhosis Patients
Muhammad Nasir Kalam, Muhammad Fawad Rasool, Faleh Alqahtani, Imran Imran, Asim Ur Rehman & Naveed Ahmed
Pages: 1195-1211
Published online: 17 Mar 2021
AbstractforDevelopment and Evaluation of a Physiologically Based Pharmacokinetic Drug-Disease Model of Propranolol for Suggesting Model Informed Dosing in Liver Cirrhosis Patients | Full Text | References | PDF (7.3 MB) | EPUB
  • 367 Views
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Review

Review Article
Potential Anti-Coronavirus Agents and the Pharmacologic Mechanisms
Yang Yang, Xiao Cui, Huaying Wei, Caiping Guo & Yulin Zhang
Pages: 1213-1223
Published online: 17 Mar 2021
AbstractforPotential Anti-Coronavirus Agents and the Pharmacologic Mechanisms | Full Text | References | PDF (2.3 MB) | EPUB
  • 107 Views
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Review Article
Drug Discovery and Development in Rare Diseases: Taking a Closer Look at the Tafamidis Story
Arianna Burton, Adam Castaño, Marianna Bruno, Steve Riley, Jennifer Schumacher, Marla B Sultan, Sandi See Tai, Daniel P Judge, Jignesh K Patel & Jeffery W Kelly
Pages: 1225-1243
Published online: 18 Mar 2021
AbstractforDrug Discovery and Development in Rare Diseases: Taking a Closer Look at the Tafamidis Story | Full Text | References | PDF (3.9 MB) | EPUB
  • 641 Views
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Original Research

Article
Study on the Mechanism of Jiawei Shengjiang Powder in Improving Male Asthma-Induced Asthenospermia Based on Network Pharmacology and Bioinformatics
Ji-sheng Wang, Xue-feng Gong, Jun-long Feng, Hai-song Li, Xiao Li, Sheng Deng, Pei-zhong Ren, Jia-mei Wang, Ming-sheng Lv, Rui-feng Jin, Qiu-yi Chen, Bin Wang & Hong-sheng Cui
Pages: 1245-1259
Published online: 19 Mar 2021
AbstractforStudy on the Mechanism of Jiawei Shengjiang Powder in Improving Male Asthma-Induced Asthenospermia Based on Network Pharmacology and Bioinformatics | Full Text | References | PDF (9.4 MB) | EPUB
  • 167 Views
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Article
The Antimicrobial Peptide Melectin Shows Both Antimicrobial and Antitumor Activity via Membrane Interference and DNA Binding
Xiaolei Liang, Jiexi Yan, Yingwei Lu, Shan Liu & Xiaojing Chai
Pages: 1261-1273
Published online: 19 Mar 2021
AbstractforThe Antimicrobial Peptide Melectin Shows Both Antimicrobial and Antitumor Activity via Membrane Interference and DNA Binding | Full Text | References | PDF (4.6 MB) | EPUB
  • 181 Views
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Review

Review Article
Role of p38 Mitogen-Activated Protein Kinase in Asthma and COPD: Pathogenic Aspects and Potential Targeted Therapies
Corrado Pelaia, Alessandro Vatrella, Luca Gallelli, Nicola Lombardo, Angela Sciacqua, Rocco Savino & Girolamo Pelaia
Pages: 1275-1284
Published online: 23 Mar 2021
AbstractforRole of p38 Mitogen-Activated Protein Kinase in Asthma and COPD: Pathogenic Aspects and Potential Targeted Therapies | Full Text | References | PDF (1.9 MB) | EPUB
  • 308 Views
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Review Article
Application of Topical Immunotherapy in the Treatment of Alopecia Areata: A Review and Update
Thipprapai Mahasaksiri, Chaninan Kositkuljorn, Tanaporn Anuntrangsee & Poonkiat Suchonwanit
Pages: 1285-1298
Published online: 23 Mar 2021
AbstractforApplication of Topical Immunotherapy in the Treatment of Alopecia Areata: A Review and Update | Full Text | References | PDF (395.5 KB) | EPUB
  • 398 Views
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Original Research

Article
Synthesis of Michael Adducts as Key Building Blocks for Potential Analgesic Drugs: In vitro, in vivo and in silico Explorations
Sajjad Ahmad, Mater H Mahnashi, Bandar A Alyami, Yahya S Alqahtani, Farhat Ullah, Muhammad Ayaz, Muhammad Tariq, Abdul Sadiq & Umer Rashid
Pages: 1299-1313
Published online: 23 Mar 2021
AbstractforSynthesis of Michael Adducts as Key Building Blocks for Potential Analgesic Drugs: In vitro, in vivo and in silico Explorations | Full Text | References | PDF (2.9 MB) | EPUB
  • 1142 Views
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Article
Nα-1, 3-Benzenedicarbonyl-Bis-(Amino Acid) and Dipeptide Candidates: Synthesis, Cytotoxic, Antimicrobial and Molecular Docking Investigation
Ahmed M Naglah, Gaber O Moustafa, Ahmed A Elhenawy, Marwa M Mounier, Heba El-Sayed, Mohamed A Al-Omar, Abdulrahman A Almehizia & Mashooq A Bhat
Pages: 1315-1332
Published online: 25 Mar 2021
AbstractforNα-1, 3-Benzenedicarbonyl-Bis-(Amino Acid) and Dipeptide Candidates: Synthesis, Cytotoxic, Antimicrobial and Molecular Docking Investigation | Full Text | References | PDF (1.5 MB) | EPUB
  • 166 Views
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Article
Inhibitory Effects of Periplocin on Lymphoma Cells: A Network Pharmacology Approach and Experimental Validation
Riyang Zhao, Chen Han, Suli Dai, Sisi Wei, Xiaohan Xiang, Yaojie Wang, Ruinian Zhao, Lianmei Zhao & Baoen Shan
Pages: 1333-1344
Published online: 26 Mar 2021
AbstractforInhibitory Effects of Periplocin on Lymphoma Cells: A Network Pharmacology Approach and Experimental Validation | Full Text | References | PDF (11 MB) | EPUB
  • 121 Views
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Review

Review Article
Anti-Inflammation, Immunomodulation and Therapeutic Repair in Current Clinical Trials for the Management of COVID-19
Chenghai Li, Hua Zhao, Linna Cheng & Bin Wang
Pages: 1345-1356
Published online: 29 Mar 2021
AbstractforAnti-Inflammation, Immunomodulation and Therapeutic Repair in Current Clinical Trials for the Management of COVID-19 | Full Text | References | PDF (347.8 KB) | EPUB
  • 149 Views
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Original Research

Article
Caspase Cascade Activation During Apoptotic Cell Death of Human Lung Carcinoma Cells A549 Induced by Marine Sponge Callyspongia aerizusa
Yuni Elsa Hadisaputri, Rheza Andika, Iyan Sopyan, Ade Zuhrotun, Rani Maharani, Rachmaniar Rachmat & Rizky Abdulah
Pages: 1357-1368
Published online: 29 Mar 2021
AbstractforCaspase Cascade Activation During Apoptotic Cell Death of Human Lung Carcinoma Cells A549 Induced by Marine Sponge Callyspongia aerizusa | Full Text | References | PDF (2.5 MB) | EPUB
  • 186 Views
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Article
Chlorogenic Acid Inhibits Human Glioma U373 Cell Progression via Regulating the SRC/MAPKs Signal Pathway: Based on Network Pharmacology Analysis
Jiabin Zhou, Fengqi Zhang, Jun Chen, Shilin Zhang & Haijun Wang
Pages: 1369-1383
Published online: 30 Mar 2021
AbstractforChlorogenic Acid Inhibits Human Glioma U373 Cell Progression via Regulating the SRC/MAPKs Signal Pathway: Based on Network Pharmacology Analysis | Full Text | References | PDF (1 MB) | EPUB
  • 157 Views
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Review

Review Article
Progress of Plant Medicine Derived Extracts and Alkaloids on Modulating Viral Infections and Inflammation
Huihui Ti, Zixi Zhuang, Qian Yu & Shumei Wang
Pages: 1385-1408
Published online: 31 Mar 2021
AbstractforProgress of Plant Medicine Derived Extracts and Alkaloids on Modulating Viral Infections and Inflammation | Full Text | References | PDF (12.7 MB) | EPUB
  • 741 Views
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Original Research

Article
Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway
Yangliang Yang, Jing Yi, Mengzhi Pan, Baoji Hu & Hongwei Duan
Pages: 1409-1422
Published online: 30 Mar 2021
AbstractforEdaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway | Full Text | References | PDF (759.8 KB) | EPUB
  • 157 Views
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Erratum

Correction
The Risks of miRNA Therapeutics: In a Drug Target Perspective [Erratum]
Page: 1423
Published online: 30 Mar 2021
CitationforThe Risks of miRNA Therapeutics: In a Drug Target Perspective [Erratum] | Full Text | PDF (153.9 KB) | EPUB
  • 108 Views
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Original Research

Article
Effect of Spray Drying Conditions on Physical Properties of Panax notoginseng Saponin (PNS) Powder and the Intra-Batch Dissolution Variability of PNS Hydrophilic Matrix Tablet
Maorui Yang, Bing Xu, Xin Wang, Wanting Li, Junjie Cao, Wenjing Li & Yanjiang Qiao
Pages: 1425-1440
Published online: 30 Mar 2021
AbstractforEffect of Spray Drying Conditions on Physical Properties of Panax notoginseng Saponin (PNS) Powder and the Intra-Batch Dissolution Variability of PNS Hydrophilic Matrix Tablet | Full Text | References | PDF (5.9 MB) | EPUB
  • 146 Views
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Article
White Tip Silver Needle (Slightly Fermented White Tea) Flavonoids Help Prevent Aging via Antioxidative and Anti-Inflammatory Effects
Chong Li, Jianchun He, Yue Yang, Yuting Gou, Zhiying Wang, Hong Chen & Xin Zhao
Pages: 1441-1457
Published online: 31 Mar 2021
AbstractforWhite Tip Silver Needle (Slightly Fermented White Tea) Flavonoids Help Prevent Aging via Antioxidative and Anti-Inflammatory Effects | Full Text | References | PDF (9.9 MB) | EPUB
  • 295 Views
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Article
Amino Acid Conjugates of Aminothiazole and Aminopyridine as Potential Anticancer Agents: Synthesis, Molecular Docking and in vitro Evaluation
Shagufta Naz, Fawad Ali Shah, Humaira Nadeem, Sadia Sarwar, Zhen Tan, Muhammad Imran, Tahir Ali, Jing Bo Li & Shupeng Li
Pages: 1459-1476
Published online: 01 Apr 2021
AbstractforAmino Acid Conjugates of Aminothiazole and Aminopyridine as Potential Anticancer Agents: Synthesis, Molecular Docking and in vitro Evaluation | Full Text | References | PDF (7.9 MB) | EPUB
  • 172 Views
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Corrigendum

Correction
Low-Dose Triple Antihypertensive Combination Therapy in Patients with Hypertension: A Randomized, Double-Blind, Phase II Study [Corrigendum]
Page: 1477
Published online: 07 Apr 2021
CitationforLow-Dose Triple Antihypertensive Combination Therapy in Patients with Hypertension: A Randomized, Double-Blind, Phase II Study [Corrigendum] | Full Text | PDF (163.5 KB) | EPUB
  • 83 Views
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Original Research

Article
Pelvic Ultrasound Parameters of Long-Acting Depot Formulation of Leuprorelin in the Treatment of Idiopathic Central Precocious Puberty in Girls
Kun Yang, Rui-Fang Qi, Rong-Min Li, Yu Zhang & Jing-Xia Liu
Pages: 1479-1484
Published online: 07 Apr 2021
AbstractforPelvic Ultrasound Parameters of Long-Acting Depot Formulation of Leuprorelin in the Treatment of Idiopathic Central Precocious Puberty in Girls | Full Text | References | PDF (247.5 KB) | EPUB
  • 125 Views
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Clinical Trial Report

Case Report
The Effect of Lidocaine on Postoperative Quality of Recovery and Lung Protection of Patients Undergoing Thoracoscopic Radical Resection of Lung Cancer
Lei Wang, Jing Sun, Xueguang Zhang & Guanglei Wang
Pages: 1485-1493
Published online: 07 Apr 2021
AbstractforThe Effect of Lidocaine on Postoperative Quality of Recovery and Lung Protection of Patients Undergoing Thoracoscopic Radical Resection of Lung Cancer | Full Text | References | PDF (1.3 MB) | EPUB
  • 190 Views
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Original Research

Article
Pharmaceutical Development of 5-Fluorouracil-Eluting Stents for the Potential Treatment of Gastrointestinal Cancers and Related Obstructions
Mohammad Arafat, Yunmei Song, Kyle Brewer, Paris Fouladian, Ankit Parikh, Hugo Albrecht, Anton Blencowe & Sanjay Garg
Pages: 1495-1507
Published online: 09 Apr 2021
AbstractforPharmaceutical Development of 5-Fluorouracil-Eluting Stents for the Potential Treatment of Gastrointestinal Cancers and Related Obstructions | Full Text | References | PDF (2.7 MB) | EPUB
  • 209 Views
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Article
RETRACTED ARTICLE: Solasodine, Isolated from Solanum sisymbriifolium Fruits, Has a Potent Anti-Tumor Activity Against Pancreatic Cancer
Yingchao Fan, Zhumeng Li, Liting Wu, Feng Lin, Jinfeng Shao, Xiaoyan Ma, Yonghua Yao, Wenfang Zhuang & Yuan Wang
Pages: 1509-1519
Published online: 13 Apr 2021
AbstractforRETRACTED ARTICLE: Solasodine, Isolated from Solanum sisymbriifolium Fruits, Has a Potent Anti-Tumor Activity Against Pancreatic Cancer | PDF (6.1 MB)
  • 180 Views
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Article
Effect of Oral versus Vaginal Administration of Estradiol and Dydrogesterone on the Proliferative and Secretory Transformation of Endometrium in Patients with Premature Ovarian Failure and Preparing for Assisted Reproductive Technology
Wenjuan Feng, Longyun Nie, Xiaoyu Wang, Fang Yang, Pan Pan & Xiaohui Deng
Pages: 1521-1529
Published online: 14 Apr 2021
AbstractforEffect of Oral versus Vaginal Administration of Estradiol and Dydrogesterone on the Proliferative and Secretory Transformation of Endometrium in Patients with Premature Ovarian Failure and Preparing for Assisted Reproductive Technology | Full Text | References | PDF (5.9 MB) | EPUB
  • 278 Views
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Article
Preparation Optimization of Bovine Serum Albumin Nanoparticles and Its Application for siRNA Delivery
Yifan Wang, Si Chen, Xin Yang, Shuang Zhang & Chunying Cui
Pages: 1531-1547
Published online: 14 Apr 2021
AbstractforPreparation Optimization of Bovine Serum Albumin Nanoparticles and Its Application for siRNA Delivery | Full Text | References | PDF (10.5 MB) | EPUB
  • 343 Views
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Article
An Ensemble Model for Prediction of Vancomycin Trough Concentrations in Pediatric Patients
Xiaohui Huang, Ze Yu, Shuhong Bu, Zhiyan Lin, Xin Hao, Wenjun He, Peng Yu, Zeyuan Wang, Fei Gao, Jian Zhang & Jihui Chen
Pages: 1549-1559
Published online: 14 Apr 2021
AbstractforAn Ensemble Model for Prediction of Vancomycin Trough Concentrations in Pediatric Patients | Full Text | References | PDF (551.7 KB) | EPUB
  • 248 Views
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Article
Establishment and Verification of UPLC-MS/MS Technique for Pharmacokinetic Drug–Drug Interactions of Selinexor with Posaconazole in Rats
Chen-jian Zhou, Hui-jun Wang, Chun-yan Zhou, Chao-fan Li, Ming-Jia Zhu & Xiang-jun Qiu
Pages: 1561-1568
Published online: 15 Apr 2021
AbstractforEstablishment and Verification of UPLC-MS/MS Technique for Pharmacokinetic Drug–Drug Interactions of Selinexor with Posaconazole in Rats | Full Text | References | PDF (2.6 MB) | EPUB
  • 188 Views
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Clinical Trial Report

Case Report
Comparison of Outcomes in Patients with Obesity Between Two Administration Routes of Omeprazole After Laparoscopic Sleeve Gastrectomy: An Open-Label Randomized Clinical Trial
Qin Tan, Yanding Gao, Pin Zhang, Yan Huo, Yihan Lu & Weifeng Huang
Pages: 1569-1576
Published online: 15 Apr 2021
AbstractforComparison of Outcomes in Patients with Obesity Between Two Administration Routes of Omeprazole After Laparoscopic Sleeve Gastrectomy: An Open-Label Randomized Clinical Trial | Full Text | References | PDF (2.1 MB) | EPUB
  • 125 Views
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Original Research

Article
Network Pharmacology Analysis of ZiShenWan for Diabetic Nephropathy and Experimental Verification of Its Anti-Inflammatory Mechanism
Xiaoyuan Guo, You Wu, Chengfei Zhang, Lili Wu, Lingling Qin & Tonghua Liu
Pages: 1577-1594
Published online: 15 Apr 2021
AbstractforNetwork Pharmacology Analysis of ZiShenWan for Diabetic Nephropathy and Experimental Verification of Its Anti-Inflammatory Mechanism | Full Text | References | PDF (16.9 MB) | EPUB
  • 186 Views
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Article
Immunomodulatory Effect of a New Ingredients Group Extracted from Astragalus Through Membrane Separation Technique
Di Zhang, Yafei Guo & Yingli Wang
Pages: 1595-1607
Published online: 15 Apr 2021
AbstractforImmunomodulatory Effect of a New Ingredients Group Extracted from Astragalus Through Membrane Separation Technique | Full Text | References | PDF (4.8 MB) | EPUB
  • 132 Views
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Review

Review Article
Pharmacological Management of Gastro-Esophageal Reflux Disease: An Update of the State-of-the-Art
Vincenzo Savarino, Elisa Marabotto, Patrizia Zentilin, Maria Giulia Demarzo, Nicola de Bortoli & Edoardo Savarino
Pages: 1609-1621
Published online: 19 Apr 2021
AbstractforPharmacological Management of Gastro-Esophageal Reflux Disease: An Update of the State-of-the-Art | Full Text | References | PDF (999.8 KB) | EPUB
  • 614 Views
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Original Research

Article
RETRACTED ARTICLE: In vitro Preparation and Evaluation of Sustained-Release Microcapsules of Salvianolic Acid
Yun-Hong Wang, Tong Qu, Xue-Lian Wang & Rong-Ping Yang
Pages: 1623-1631
Published online: 21 Apr 2021
AbstractforRETRACTED ARTICLE: In vitro Preparation and Evaluation of Sustained-Release Microcapsules of Salvianolic Acid | PDF (426.5 KB)
  • 21 Views
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Article
Population Pharmacokinetics and Safety of Oral Tetra-Arsenic Tetra-Sulfide Formula in Pediatric Acute Promyelocytic Leukemia
Li Zhang, Xin-Mei Yang, Jing Chen, Lei Hu, Fan Yang, Yue Zhou, Bei-Bei Zhao, Wei Zhao & Xiao-Fan Zhu
Pages: 1633-1640
Published online: 21 Apr 2021
AbstractforPopulation Pharmacokinetics and Safety of Oral Tetra-Arsenic Tetra-Sulfide Formula in Pediatric Acute Promyelocytic Leukemia | Full Text | References | PDF (349.5 KB) | EPUB
  • 186 Views
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Article
Temozolomide-Induced Changes in Gut Microbial Composition in a Mouse Model of Brain Glioma
Xiao-Chong Li, Bang-Sheng Wu, Yi Jiang, Jie Li, Ze-Fen Wang, Chao Ma, Yi-Rong Li, Jie Yao, Xiao-Qing Jin & Zhi-Qiang Li
Pages: 1641-1652
Published online: 21 Apr 2021
AbstractforTemozolomide-Induced Changes in Gut Microbial Composition in a Mouse Model of Brain Glioma | Full Text | References | PDF (4.1 MB) | EPUB
  • 239 Views
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Article
Fasudil Dichloroacetate Alleviates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension by Ameliorating Dysfunction of Pulmonary Arterial Smooth Muscle Cells
Ping Liu, Wen Huang, Yirui Ding, Jianbing Wu, Zhuangzhuang Liang, Zhangjian Huang, Weiping Xie & Hui Kong
Pages: 1653-1666
Published online: 22 Apr 2021
AbstractforFasudil Dichloroacetate Alleviates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension by Ameliorating Dysfunction of Pulmonary Arterial Smooth Muscle Cells | Full Text | References | PDF (12 MB) | EPUB
  • 128 Views
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Article
Lactobacillus plantarum ZS62 Alleviates Alcohol-Induced Gastric Injury in Mice via an Anti-Oxidative Mechanism
Ya Wu, Jing Hu, Xingyao Long, Yanni Pan, Jianfei Mu, Kun-Young Park & Xin Zhao
Pages: 1667-1676
Published online: 22 Apr 2021
AbstractforLactobacillus plantarum ZS62 Alleviates Alcohol-Induced Gastric Injury in Mice via an Anti-Oxidative Mechanism | Full Text | References | PDF (4.9 MB) | EPUB
  • 192 Views
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Article
Rituximab Therapy for Treatment of Pemphigus in Southeast Asians
Silada Kanokrungsee, Tanaporn Anuntrangsee, Jutamas Tankunakorn, Ploychompoo Srisuwanwattana, Poonkiat Suchonwanit & Kumutnart Chanprapaph
Pages: 1677-1690
Published online: 22 Apr 2021
AbstractforRituximab Therapy for Treatment of Pemphigus in Southeast Asians | Full Text | References | PDF (2 MB) | EPUB
  • 158 Views
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Article
Carbon Monoxide Releasing Molecule-3 Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Carbon Monoxide Release
Hui Chen, Yan Dai, Jing Cui, Xiaochun Yin, Wei Feng, Meiyi lv & Hui Song
Pages: 1691-1704
Published online: 22 Apr 2021
AbstractforCarbon Monoxide Releasing Molecule-3 Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Carbon Monoxide Release | Full Text | References | PDF (934.3 KB) | EPUB
  • 155 Views
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Article
Flavopereirine Suppresses the Progression of Human Oral Cancer by Inhibiting the JAK-STAT Signaling Pathway via Targeting LASP1
Junwu Xu, Zhiyuan Wu & Jian Huang
Pages: 1705-1716
Published online: 22 Apr 2021
AbstractforFlavopereirine Suppresses the Progression of Human Oral Cancer by Inhibiting the JAK-STAT Signaling Pathway via Targeting LASP1 | Full Text | References | PDF (723.9 KB) | EPUB
  • 158 Views
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Article
Alendronate Alleviated Femoral Head Necrosis and Upregulated BMP2/EIF2AK3/EIF2A/ATF4 Pathway in Liquid Nitrogen Treated Rats
Ke Rong, Xiaoliu Li, Weimin Jiang, Xuhua Wu, Qingquan Xia, Jie Chen & Xiaofan Yin
Pages: 1717-1724
Published online: 23 Apr 2021
AbstractforAlendronate Alleviated Femoral Head Necrosis and Upregulated BMP2/EIF2AK3/EIF2A/ATF4 Pathway in Liquid Nitrogen Treated Rats | Full Text | References | PDF (476.9 KB) | EPUB
  • 107 Views
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Article
No Relevant Pharmacokinetic Drug–Drug Interaction Between the Sodium-Glucose Co-Transporter-2 Inhibitor Empagliflozin and Lobeglitazone, a Peroxisome Proliferator-Activated Receptor-γ Agonist, in Healthy Subjects
Yu Kyong Kim, Jun Gi Hwang & Min Kyu Park
Pages: 1725-1734
Published online: 28 Apr 2021
AbstractforNo Relevant Pharmacokinetic Drug–Drug Interaction Between the Sodium-Glucose Co-Transporter-2 Inhibitor Empagliflozin and Lobeglitazone, a Peroxisome Proliferator-Activated Receptor-γ Agonist, in Healthy Subjects | Full Text | References | PDF (4.1 MB) | EPUB
  • 262 Views
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Article
Comparison of Pharmacokinetic, Pharmacodynamic and Tolerability Profiles of CKD-11101, Darbepoetin Alfa (NESP®) Biosimilar, to Those of NESP® After a Single Subcutaneous or Intravenous Administration to Healthy Subjects
Inseung Jeon, Jaeseong Oh, Yu-Kyung Kwon, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang, Kyung-Sang Yu & SeungHwan Lee
Pages: 1735-1747
Published online: 28 Apr 2021
AbstractforComparison of Pharmacokinetic, Pharmacodynamic and Tolerability Profiles of CKD-11101, Darbepoetin Alfa (NESP®) Biosimilar, to Those of NESP® After a Single Subcutaneous or Intravenous Administration to Healthy Subjects | Full Text | References | PDF (618.2 KB) | EPUB
  • 297 Views
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Article
MYC/NBS1-Mediated DNA Damage Response is Involved in the Inhibitory Effect of Hydroxysafflor Yellow A on Glioma Cells
Dongfang Tang, Tao Huang, Qilong Tian & Julei Wang
Pages: 1749-1763
Published online: 28 Apr 2021
AbstractforMYC/NBS1-Mediated DNA Damage Response is Involved in the Inhibitory Effect of Hydroxysafflor Yellow A on Glioma Cells | Full Text | References | PDF (1.2 MB) | EPUB
  • 105 Views
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Article
Active-Ingredient Screening and Synergistic Action Mechanism of Shegan Mixture for Anti-Asthma Effects Based on Network Pharmacology in a Mouse Model of Asthma
Qing Ye, Qiqiang Zhang, Huijuan Yao, Ajing Xu, Yan Liu, Jia Qi, Hai Zhang & Jian Zhang
Pages: 1765-1777
Published online: 29 Apr 2021
AbstractforActive-Ingredient Screening and Synergistic Action Mechanism of Shegan Mixture for Anti-Asthma Effects Based on Network Pharmacology in a Mouse Model of Asthma | Full Text | References | PDF (849.9 KB) | EPUB
  • 133 Views
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Article
Integrating Network Pharmacology and Experimental Validation to Decipher the Mechanism of Action of Huanglian Jiedu Decoction in Treating Atherosclerosis
Jiahua Liang, Yingjie Huang, Zhexing Mai, Qunzhang Zhan, Hengchen Lin, Yuxin Xie, Haihao Wang, Yan Liu & Chuanjin Luo
Pages: 1779-1795
Published online: 30 Apr 2021
AbstractforIntegrating Network Pharmacology and Experimental Validation to Decipher the Mechanism of Action of Huanglian Jiedu Decoction in Treating Atherosclerosis | Full Text | References | PDF (12.4 MB) | EPUB
  • 501 Views
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Article
OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo
Leilei Ding, Chenchen Ren, Li Yang, Zimeng Wu, Feiyan Li, Dongyuan Jiang, Yuanhang Zhu & Jie Lu
Pages: 1797-1810
Published online: 30 Apr 2021
AbstractforOSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo | Full Text | References | PDF (11.9 MB) | EPUB
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Review

Review Article
The Application of Zonisamide to Patients Suffering from Dementia with Lewy Bodies: Emerging Clinical Data
Babak Tousi & James B Leverenz
Pages: 1811-1817
Published online: 03 May 2021
AbstractforThe Application of Zonisamide to Patients Suffering from Dementia with Lewy Bodies: Emerging Clinical Data | Full Text | References | PDF (251.5 KB) | EPUB
  • 173 Views
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Review Article
Thymoquinone: A Promising Natural Compound with Potential Benefits for COVID-19 Prevention and Cure
Osama A Badary, Marwa S Hamza & Rajiv Tikamdas
Pages: 1819-1833
Published online: 03 May 2021
AbstractforThymoquinone: A Promising Natural Compound with Potential Benefits for COVID-19 Prevention and Cure | Full Text | References | PDF (460.8 KB) | EPUB
  • 687 Views
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Original Research

Article
Exosomal Circ-XIAP Promotes Docetaxel Resistance in Prostate Cancer by Regulating miR-1182/TPD52 Axis
Hui Zhang, Minghui Li, Jing Zhang, Yanbing Shen & Qi Gui
Pages: 1835-1849
Published online: 03 May 2021
AbstractforExosomal Circ-XIAP Promotes Docetaxel Resistance in Prostate Cancer by Regulating miR-1182/TPD52 Axis | Full Text | References | PDF (1.1 MB) | EPUB
  • 122 Views
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Review

Review Article
Forkhead Box Protein O1: Functional Diversity and Post-Translational Modification, a New Therapeutic Target?
Xiaojun Zhang, Lusheng Jiang & Huimin Liu
Pages: 1851-1860
Published online: 03 May 2021
AbstractforForkhead Box Protein O1: Functional Diversity and Post-Translational Modification, a New Therapeutic Target? | Full Text | References | PDF (359.6 KB) | EPUB
  • 159 Views
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Original Research

Article
Effects of Systemic Lidocaine on Postoperative Recovery Quality and Immune Function in Patients Undergoing Laparoscopic Radical Gastrectomy
Xueli Lv, Xiaoxiao Li, Kedi Guo, Tong Li, Yuping Yang, Wensi Lu, Shuting Wang & Su Liu
Pages: 1861-1872
Published online: 03 May 2021
AbstractforEffects of Systemic Lidocaine on Postoperative Recovery Quality and Immune Function in Patients Undergoing Laparoscopic Radical Gastrectomy | Full Text | References | PDF (3.1 MB) | EPUB
  • 157 Views
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Article
Camrelizumab Combined with FOLFOX4 Regimen as First-Line Therapy for Advanced Hepatocellular Carcinomas: A Sub-Cohort of a Multicenter Phase Ib/II Study
Hui Li, Shukui Qin, Ying Liu, Zhendong Chen, Zhenggang Ren, Jianping Xiong, Zhiqiang Meng, Xiao Zhang, Linna Wang, Xiaojing Zhang & Jianjun Zou
Pages: 1873-1882
Published online: 03 May 2021
AbstractforCamrelizumab Combined with FOLFOX4 Regimen as First-Line Therapy for Advanced Hepatocellular Carcinomas: A Sub-Cohort of a Multicenter Phase Ib/II Study | Full Text | References | PDF (511.5 KB) | EPUB
  • 168 Views
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Article
Study on Hepatotoxicity of Rhubarb Based on Metabolomics and Network Pharmacology
Shanze Li, Yuming Wang, Chunyan Li, Na Yang, Hongxin Yu, Wenjie Zhou, Siyu Chen, Shenshen Yang & Yubo Li
Pages: 1883-1902
Published online: 04 May 2021
AbstractforStudy on Hepatotoxicity of Rhubarb Based on Metabolomics and Network Pharmacology | Full Text | References | PDF (16.8 MB) | EPUB
  • 358 Views
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Article
Protective Effects of Silymarin Against D-Gal/LPS-Induced Organ Damage and Inflammation in Mice
Xin Zhao, Haoxiang Wang, Yue Yang, Yuting Gou, Zhiying Wang, Dingyi Yang & Chong Li
Pages: 1903-1914
Published online: 04 May 2021
AbstractforProtective Effects of Silymarin Against D-Gal/LPS-Induced Organ Damage and Inflammation in Mice | Full Text | References | PDF (5.3 MB) | EPUB
  • 211 Views
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Article
Potential Mechanism of S. baicalensis on Lipid Metabolism Explored via Network Pharmacology and Untargeted Lipidomics
Ping-Yuan Ge, Yi-Yu Qi, Shu-Yue Qu, Xin Zhao, Sai-jia Ni, Zeng-Ying Yao, Rui Guo, Nian-Yun Yang, Qi-Chun Zhang & Hua-Xu Zhu
Pages: 1915-1930
Published online: 04 May 2021
AbstractforPotential Mechanism of S. baicalensis on Lipid Metabolism Explored via Network Pharmacology and Untargeted Lipidomics | Full Text | References | PDF (10.1 MB) | EPUB
  • 191 Views
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Article
Body Mass Index Influence on the Clinical Outcomes for Nonvalvular Atrial Fibrillation Patients Admitted to a Hospital Treated with Direct Oral Anticoagulants: A Retrospective Cohort Study
Xiaoye Li, Chengchun Zuo, Qiuyi Ji, Ying Xue, Zi Wang & Qianzhou Lv
Pages: 1931-1943
Published online: 06 May 2021
AbstractforBody Mass Index Influence on the Clinical Outcomes for Nonvalvular Atrial Fibrillation Patients Admitted to a Hospital Treated with Direct Oral Anticoagulants: A Retrospective Cohort Study | Full Text | References | PDF (2 MB) | EPUB
  • 131 Views
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Article
Consolidation Treatment and Long-Term Prognosis of Rituximab in Minimal Change Disease and Focal Segmental Glomerular Sclerosis
Li Lin, Weiming Wang, YiFan Wu, JingYuan Xie, Xiao Li, XiaoXia Pan, Wen Zhang, Jing Xu, YiKai Cai, Hong Ren & Nan Chen
Pages: 1945-1953
Published online: 10 May 2021
AbstractforConsolidation Treatment and Long-Term Prognosis of Rituximab in Minimal Change Disease and Focal Segmental Glomerular Sclerosis | Full Text | References | PDF (343.4 KB) | EPUB
  • 111 Views
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Review

Review Article
Bempedoic Acid for Heterozygous Familial Hypercholesterolemia: From Bench to Bedside
Anandita Agarwala, Renato Quispe, Anne C Goldberg & Erin D Michos
Pages: 1955-1963
Published online: 10 May 2021
AbstractforBempedoic Acid for Heterozygous Familial Hypercholesterolemia: From Bench to Bedside | Full Text | References | PDF (380.3 KB) | EPUB
  • 198 Views
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Review Article
Evaluating Guanfacine Hydrochloride in the Treatment of Attention Deficit Hyperactivity Disorder (ADHD) in Adult Patients: Design, Development and Place in Therapy
Toyosaku Ota, Kazuhiko Yamamuro, Kosuke Okazaki & Toshifumi Kishimoto
Pages: 1965-1969
Published online: 11 May 2021
AbstractforEvaluating Guanfacine Hydrochloride in the Treatment of Attention Deficit Hyperactivity Disorder (ADHD) in Adult Patients: Design, Development and Place in Therapy | Full Text | References | PDF (227.9 KB) | EPUB
  • 1062 Views
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Original Research

Article
Inhibitory Effect of Lactococcus lactis subsp. lactis HFY14 on Diphenoxylate-Induced Constipation in Mice by Regulating the VIP-cAMP-PKA-AQP3 Signaling Pathway
Qian Tan, Jing Hu, Yujing Zhou, Yunxiao Wan, Chuanlan Zhang, Xin Liu, Xingyao Long, Fang Tan & Xin Zhao
Pages: 1971-1980
Published online: 11 May 2021
AbstractforInhibitory Effect of Lactococcus lactis subsp. lactis HFY14 on Diphenoxylate-Induced Constipation in Mice by Regulating the VIP-cAMP-PKA-AQP3 Signaling Pathway | Full Text | References | PDF (1.8 MB) | EPUB
  • 183 Views
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Article
FTY720 Inhibits the Development of Collagen-Induced Arthritis in Mice by Suppressing the Recruitment of CD4+ T Lymphocytes
Chao Zhu, Shuang Wen, Junyong Li, Hongyu Meng, Junzhe Zhang, Kuo Zhao, Ling Wang & Yingze Zhang
Pages: 1981-1992
Published online: 11 May 2021
AbstractforFTY720 Inhibits the Development of Collagen-Induced Arthritis in Mice by Suppressing the Recruitment of CD4+ T Lymphocytes | Full Text | References | PDF (11.1 MB) | EPUB
  • 104 Views
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Review

Review Article
An Overview of the Efficacy and Safety of Ozanimod for the Treatment of Relapsing Multiple Sclerosis
Marzia Fronza, Lorena Lorefice, Jessica Frau & Eleonora Cocco
Pages: 1993-2004
Published online: 11 May 2021
AbstractforAn Overview of the Efficacy and Safety of Ozanimod for the Treatment of Relapsing Multiple Sclerosis | Full Text | References | PDF (329.3 KB) | EPUB
  • 459 Views
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Review Article
Cariprazine as a Treatment Option for Depressive Episodes Associated with Bipolar 1 Disorder in Adults: An Evidence-Based Review of Recent Data
Mauricio Tohen
Pages: 2005-2012
Published online: 12 May 2021
AbstractforCariprazine as a Treatment Option for Depressive Episodes Associated with Bipolar 1 Disorder in Adults: An Evidence-Based Review of Recent Data | Full Text | References | PDF (272.5 KB) | EPUB
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Original Research

Article
Epigallocatechin-3-Gallate Provides Protection Against Alzheimer’s Disease-Induced Learning and Memory Impairments in Rats
Shanji Nan, Peng Wang, Yizhi Zhang & Jia Fan
Pages: 2013-2024
Published online: 13 May 2021
AbstractforEpigallocatechin-3-Gallate Provides Protection Against Alzheimer’s Disease-Induced Learning and Memory Impairments in Rats | Full Text | References | PDF (668.9 KB) | EPUB
  • 288 Views
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Article
PTBP1 Targets ILK to Regulate the Hypoxia-Induced Phenotypic Transformation of Pulmonary Artery Smooth Muscle Cells
Gaoliang Yan, Renhua Sun, Zhongpu Chen, Xiaodong Pan, Zulong Sheng & Chengchun Tang
Pages: 2025-2033
Published online: 13 May 2021
AbstractforPTBP1 Targets ILK to Regulate the Hypoxia-Induced Phenotypic Transformation of Pulmonary Artery Smooth Muscle Cells | Full Text | References | PDF (547.6 KB) | EPUB
  • 97 Views
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Article
Silver Nanoparticle-Coated Ethyl Cellulose Inhibits Tumor Necrosis Factor-α of Breast Cancer Cells
Ahmed A H Abdellatif, Mansour Alsharidah, Osamah Al Rugaie, Hesham M Tawfeek & Nahla Sameh Tolba
Pages: 2035-2046
Published online: 13 May 2021
AbstractforSilver Nanoparticle-Coated Ethyl Cellulose Inhibits Tumor Necrosis Factor-α of Breast Cancer Cells | Full Text | References | PDF (564.7 KB) | EPUB
  • 369 Views
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Article
Protective Effect of Lemon Peel Extract on Oxidative Stress in H9c2 Rat Heart Cell Injury
Jun Wang, Yulin Zhai, Mingguang Ou, Yunfeng Bian, Chenglong Tang, Wanchao Zhang, Yujiao Cheng & Guijie Li
Pages: 2047-2058
Published online: 14 May 2021
AbstractforProtective Effect of Lemon Peel Extract on Oxidative Stress in H9c2 Rat Heart Cell Injury | Full Text | References | PDF (590.9 KB) | EPUB
  • 433 Views
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Article
An Integrated Analysis of Network Pharmacology, Molecular Docking, and Experiment Validation to Explore the New Candidate Active Component and Mechanism of Cuscutae Semen-Mori Fructus Coupled-Herbs in Treating Oligoasthenozoospermia
Xue Bai, Yibo Tang, Qiang Li, Dan Liu, Guimin Liu, Xiaolei Fan, Zhejun Liu, Shujun Yu, Tian Tang, Shuyan Wang, Lingru Li, Kailin Zhou, Yanfei Zheng & Zhenquan Liu
Pages: 2059-2089
Published online: 17 May 2021
AbstractforAn Integrated Analysis of Network Pharmacology, Molecular Docking, and Experiment Validation to Explore the New Candidate Active Component and Mechanism of Cuscutae Semen-Mori Fructus Coupled-Herbs in Treating Oligoasthenozoospermia | Full Text | References | PDF (1.8 MB) | EPUB
  • 274 Views
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Article
Antifungal Efficacy and Safety of Cycloheximide as a Supplement in Optisol-GS
Melissa Dal Pizzol, Eduarda Correa Freitas, Claudete Locatelli, Felipe Guareze, Paula Reginatto, Gabriella Machado, Alexandre Fuentefria & Diane Marinho
Pages: 2091-2098
Published online: 18 May 2021
AbstractforAntifungal Efficacy and Safety of Cycloheximide as a Supplement in Optisol-GS | Full Text | References | PDF (309.7 KB) | EPUB
  • 244 Views
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Article
In vivo and in vitro Evaluation of in situ Gel Formulation of Pemirolast Potassium in Allergic Conjunctivitis
Ting Shen & Zijian Yang
Pages: 2099-2107
Published online: 18 May 2021
AbstractforIn vivo and in vitro Evaluation of in situ Gel Formulation of Pemirolast Potassium in Allergic Conjunctivitis | Full Text | References | PDF (530.8 KB) | EPUB
  • 259 Views
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Article
The Abuse Characteristics of Amphetamine-Type Stimulants in Patients Receiving Methadone Maintenance Treatment and Buprenorphine Maintenance Treatment
Yue Liu, Nina Liu, Wenwen Shen, Longhui Li, Wenhua Zhou & Leiting Xu
Pages: 2109-2116
Published online: 18 May 2021
AbstractforThe Abuse Characteristics of Amphetamine-Type Stimulants in Patients Receiving Methadone Maintenance Treatment and Buprenorphine Maintenance Treatment | Full Text | References | PDF (285.4 KB) | EPUB
  • 127 Views
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Article
Canagliflozin Facilitates Reverse Cholesterol Transport Through Activation of AMPK/ABC Transporter Pathway
Yingnan Zhao, Yanping Li, Qinhui Liu, Qin Tang, Zijing Zhang, Jinhang Zhang, Cuiyuan Huang, Hui Huang, Guorong Zhang, Jian Zhou, Jiamin Yan, Yan Xia, Zhiyong Zhang & Jinhan He
Pages: 2117-2128
Published online: 18 May 2021
AbstractforCanagliflozin Facilitates Reverse Cholesterol Transport Through Activation of AMPK/ABC Transporter Pathway | Full Text | References | PDF (751.7 KB) | EPUB
  • 134 Views
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Article
Pharmacokinetics of Linezolid Dose Adjustment for Creatinine Clearance in Critically Ill Patients: A Multicenter, Prospective, Open-Label, Observational Study
Xipei Wang, Yifan Wang, Fen Yao, Shenglong Chen, Yating Hou, Zhijie Zheng, Jinbiao Luo, Binghui Qiu, Zhanfu Li, Yirong Wang, Zheng Wu, Jinhua Lan & Chunbo Chen
Pages: 2129-2141
Published online: 19 May 2021
AbstractforPharmacokinetics of Linezolid Dose Adjustment for Creatinine Clearance in Critically Ill Patients: A Multicenter, Prospective, Open-Label, Observational Study | Full Text | References | PDF (5.2 MB) | EPUB
  • 317 Views
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Clinical Trial Report

Case Report
Adjuvant Sufentanil Decreased the EC50 of Epidural Ropivacaine for Labor Analgesia in Healthy Term Pregnancy
Bo Xiang, Jian Yang, Xiaofeng Lei & Jin Yu
Pages: 2143-2149
Published online: 18 May 2021
AbstractforAdjuvant Sufentanil Decreased the EC50 of Epidural Ropivacaine for Labor Analgesia in Healthy Term Pregnancy | Full Text | References | PDF (335.7 KB) | EPUB
  • 142 Views
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Original Research

Article
Toxicities and Associated Factors in Patients Receiving Temozolomide-Containing Regimens: A 12-Year Analysis of Hospital Data
Chen Shi, Xiong Wang, Changdong Diao, Haixia Zhu, Qi Yuan, Jinmei Liu, Shijun Li, Ming Gu & Yu Zhang
Pages: 2151-2159
Published online: 20 May 2021
AbstractforToxicities and Associated Factors in Patients Receiving Temozolomide-Containing Regimens: A 12-Year Analysis of Hospital Data | Full Text | References | PDF (299.4 KB) | EPUB
  • 96 Views
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Review

Review Article
Effect of Dexmedetomidine on Postoperative Sleep Quality: A Systematic Review
Xiao Huang, Dandan Lin, Yi Sun, Anshi Wu & Changwei Wei
Pages: 2161-2170
Published online: 21 May 2021
AbstractforEffect of Dexmedetomidine on Postoperative Sleep Quality: A Systematic Review | Full Text | References | PDF (419.5 KB) | EPUB
  • 326 Views
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Article
Development of UPLC-MS/MS Method for Studying the Pharmacokinetic Interaction Between Dasatinib and Posaconazole in Rats
Suili Yang, Xiaoshan Zhang, Yuzhen Wang, Congcong Wen, Chenxiang Wang, Ziye Zhou & Guanyang Lin
Pages: 2171-2178
Published online: 24 May 2021
AbstractforDevelopment of UPLC-MS/MS Method for Studying the Pharmacokinetic Interaction Between Dasatinib and Posaconazole in Rats | Full Text | References | PDF (2.5 MB) | EPUB
  • 258 Views
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Article
Mechanism of Action of Nicotiflorin from Tricyrtis maculata in the Treatment of Acute Myocardial Infarction: From Network Pharmacology to Experimental Pharmacology
Shangshang Yu, Qi Guo, Tianqian Jia, Xiaofei Zhang, Dongyan Guo, Yanzhuo Jia, Jia Li & Jing Sun
Pages: 2179-2191
Published online: 24 May 2021
AbstractforMechanism of Action of Nicotiflorin from Tricyrtis maculata in the Treatment of Acute Myocardial Infarction: From Network Pharmacology to Experimental Pharmacology | Full Text | References | PDF (5.9 MB) | EPUB
  • 301 Views
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Article
Fixed Dose Single Tablet Formulation with Differential Release of Amlodipine Besylate and Simvastatin and Its Pharmacokinetic Profile: QbD and Risk Assessment Approach
Ummarah Kanwal, Shahid Mukhtar, Muzzamil Waheed, Arifa Mehreen, Nasir Abbas, Rahat Shamim, Khalid Hussain, Fatima Rasool, Amjad Hussain & Nadeem Irfan Bukhari
Pages: 2193-2210
Published online: 24 May 2021
AbstractforFixed Dose Single Tablet Formulation with Differential Release of Amlodipine Besylate and Simvastatin and Its Pharmacokinetic Profile: QbD and Risk Assessment Approach | Full Text | References | PDF (678.9 KB) | EPUB
  • 532 Views
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Article
Enhanced Accumulation of Cisplatin in Ovarian Cancer Cells from Combination with Wedelolactone and Resulting Inhibition of Multiple Epigenetic Drivers
Sadia Sarwar, Abir A Alamro, Amani A Alghamdi, Komal Naeem, Salamat Ullah, Muazzam Arif, Jun Qing Yu & Fazlul Huq
Pages: 2211-2227
Published online: 25 May 2021
AbstractforEnhanced Accumulation of Cisplatin in Ovarian Cancer Cells from Combination with Wedelolactone and Resulting Inhibition of Multiple Epigenetic Drivers | Full Text | References | PDF (7.3 MB) | EPUB
  • 171 Views
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Article
Total Glucosides of Paeony Inhibited Autophagy and Improved Acute Kidney Injury Induced by Ischemia-Reperfusion via the lncRNA TUG1/miR-29a/PTEN Axis
Xiaoyan Chang, Pei Zhang, Xing-Xin Xu & Bo Pang
Pages: 2229-2242
Published online: 25 May 2021
AbstractforTotal Glucosides of Paeony Inhibited Autophagy and Improved Acute Kidney Injury Induced by Ischemia-Reperfusion via the lncRNA TUG1/miR-29a/PTEN Axis | Full Text | References | PDF (851.6 KB) | EPUB
  • 137 Views
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Review

Review Article
A Review of Romiplostim Mechanism of Action and Clinical Applicability
James B Bussel, Gerald Soff, Adriana Balduzzi, Nichola Cooper, Tatiana Lawrence & John W Semple
Pages: 2243-2268
Published online: 26 May 2021
AbstractforA Review of Romiplostim Mechanism of Action and Clinical Applicability | Full Text | References | PDF (4.3 MB) | EPUB
  • 836 Views
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Review Article
Clinical Application of Cytokines in Cancer Immunotherapy
Yi Qiu, Mengxi Su, Leyi Liu, Yiqi Tang, Yuan Pan & Jianbo Sun
Pages: 2269-2287
Published online: 27 May 2021
AbstractforClinical Application of Cytokines in Cancer Immunotherapy | Full Text | References | PDF (721.1 KB) | EPUB
  • 973 Views
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Article
Effect of Dezocine on the Ratio of Th1/Th2 Cytokines in Patients Receiving Postoperative Analgesia Following Laparoscopic Radical Gastrectomy: A Prospective Randomised Study
Man Feng, Qinli Feng, Yujie Chen, Ge Liu, Zhuanglei Gao, Juan Xiao & Chang Feng
Pages: 2289-2297
Published online: 27 May 2021
AbstractforEffect of Dezocine on the Ratio of Th1/Th2 Cytokines in Patients Receiving Postoperative Analgesia Following Laparoscopic Radical Gastrectomy: A Prospective Randomised Study | Full Text | References | PDF (2.1 MB) | EPUB
  • 131 Views
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Article
Incidence and Risk Factors of Hepatic Fibrosis in Psoriatic Patients Receiving Methotrexate with Concomitant Acitretin Therapy and Methotrexate Monotherapy
Ploysyne Rattanakaemakorn, Prinpat Pinyowiwat, Wimolsiri Iamsumang, Kumutnart Chanprapaph & Poonkiat Suchonwanit
Pages: 2299-2307
Published online: 28 May 2021
AbstractforIncidence and Risk Factors of Hepatic Fibrosis in Psoriatic Patients Receiving Methotrexate with Concomitant Acitretin Therapy and Methotrexate Monotherapy | Full Text | References | PDF (360.2 KB) | EPUB
  • 152 Views
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Article
Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Attenuates High-Fat Diet-Induced Hepatic Steatosis in Mice
Huashan Li, Jianying Sheng, Jing Wang, Haiting Gao, Jing Yu, Guoxian Ding, Ning Ding, Weiqi He & Juanmin Zha
Pages: 2309-2324
Published online: 31 May 2021
AbstractforSelective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Attenuates High-Fat Diet-Induced Hepatic Steatosis in Mice | Full Text | References | PDF (4.4 MB) | EPUB
  • 128 Views
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Article
Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights
Mohamed A Abdelgawad, Arafa Musa, Atiah H Almalki, Sami I Alzarea, Ehab M Mostafa, Mostafa M Hegazy, Gomaa Mostafa-Hedeab, Mohammed M Ghoneim, Della G T Parambi, Rania B Bakr, Nayef S Al-Muaikel, Abdullah S Alanazi, Metab Alharbi, Waqas Ahmad, Syed N A Bukhari & Mohammad M Al-Sanea
Pages: 2325-2337
Published online: 31 May 2021
AbstractforNovel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights | Full Text | References | PDF (644 KB) | EPUB
  • 434 Views
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Article
Cinnamaldehyde Improves Metabolic Functions in Streptozotocin-Induced Diabetic Mice by Regulating Gut Microbiota
Honglei Zhao, Hongyan Wu, Meitao Duan, Ruixuan Liu, Quanhong Zhu, Kai Zhang & Lili Wang
Pages: 2339-2355
Published online: 01 Jun 2021
AbstractforCinnamaldehyde Improves Metabolic Functions in Streptozotocin-Induced Diabetic Mice by Regulating Gut Microbiota | Full Text | References | PDF (1.7 MB) | EPUB
  • 349 Views
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Article
Topical Delivery of Levocarnitine to the Cornea and Anterior Eye by Thermosensitive in-situ Gel for Dry Eye Disease
Baorui Ma, Linnuo Pang, Pingqing Huang, Jie Bai, Zhiqin Zhang, Huimin Wu, Mengru Cai, Jin Yang, Yuchen Xu, Xingbin Yin, Changhai Qu & Jian Ni
Pages: 2357-2373
Published online: 02 Jun 2021
AbstractforTopical Delivery of Levocarnitine to the Cornea and Anterior Eye by Thermosensitive in-situ Gel for Dry Eye Disease | Full Text | References | PDF (1,021.2 KB) | EPUB
  • 170 Views
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Article
Pharmacokinetics, Tolerability and Pharmacogenetics of DA-8031 After Multiple Ascending Doses in Healthy Male Subjects
Sejung Hwang, Dae Young Lee, Joo-Youn Cho, Jae-Yong Chung, In-Jin Jang, Kyung-Sang Yu & SeungHwan Lee
Pages: 2375-2384
Published online: 01 Jun 2021
AbstractforPharmacokinetics, Tolerability and Pharmacogenetics of DA-8031 After Multiple Ascending Doses in Healthy Male Subjects | Full Text | References | PDF (449.4 KB) | EPUB
  • 121 Views
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Article
Tetramethylpyrazine Improves Cognitive Function of Alzheimer’s Disease Mice by Regulating SSTR4 Ubiquitination
Guohu Weng, Bo Zhou, Tao Liu, Zhengxin Huang & Shixiong Huang
Pages: 2385-2399
Published online: 01 Jun 2021
AbstractforTetramethylpyrazine Improves Cognitive Function of Alzheimer’s Disease Mice by Regulating SSTR4 Ubiquitination | Full Text | References | PDF (827.1 KB) | EPUB
  • 159 Views
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Review

Review Article
Belantamab Mafodotin for the Treatment of Multiple Myeloma: An Overview of the Clinical Efficacy and Safety
Massimo Offidani, Laura Corvatta, Sonia Morè & Attilio Olivieri
Pages: 2401-2415
Published online: 02 Jun 2021
AbstractforBelantamab Mafodotin for the Treatment of Multiple Myeloma: An Overview of the Clinical Efficacy and Safety | Full Text | References | PDF (411.8 KB) | EPUB
  • 446 Views
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Original Research

Article
Volumetric Absorptive Microsampling as a New Biosampling Tool for Monitoring of Tamoxifen, Endoxifen, 4-OH Tamoxifen and N-Desmethyltamoxifen in Breast Cancer Patients
Baitha Palanggatan Maggadani, Harmita, Samuel J Haryono, Marcellino Ryan Rinaldi & Yahdiana Harahap
Pages: 2417-2430
Published online: 04 Jun 2021
AbstractforVolumetric Absorptive Microsampling as a New Biosampling Tool for Monitoring of Tamoxifen, Endoxifen, 4-OH Tamoxifen and N-Desmethyltamoxifen in Breast Cancer Patients | Full Text | References | PDF (508.4 KB) | EPUB
  • 146 Views
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Retraction

Retraction
Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating P53 and RAP2A in vitro and in vivo [Retraction]
Page: 2431
Published online: 08 Jun 2021
CitationforMetformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating P53 and RAP2A in vitro and in vivo [Retraction] | Full Text | PDF (163.7 KB) | EPUB
  • 92 Views
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Original Research

Article
High-Dose Dexmedetomidine Promotes Apoptosis in Fetal Rat Hippocampal Neurons
Qiufeng Wei, Jing Chen, Fei Xiao, Youbing Tu, Yu Zhong & Yubo Xie
Pages: 2433-2444
Published online: 08 Jun 2021
AbstractforHigh-Dose Dexmedetomidine Promotes Apoptosis in Fetal Rat Hippocampal Neurons | Full Text | References | PDF (6 MB) | EPUB
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Review

Review Article
Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives
Jiaxin Yong, Yuan Li, Sihan Lin, Zhenning Wang & Yan Xu
Pages: 2445-2456
Published online: 09 Jun 2021
AbstractforInhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives | Full Text | References | PDF (1.5 MB) | EPUB
  • 248 Views
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Original Research

Article
Cytokine and Chemokine Profile Changes in Patients with Neovascular Age-Related Macular Degeneration After Intravitreal Ranibizumab Injection for Choroidal Neovascularization
Tingting Sun, Qingquan Wei, Peng Gao, Yongjie Zhang & Qing Peng
Pages: 2457-2467
Published online: 09 Jun 2021
AbstractforCytokine and Chemokine Profile Changes in Patients with Neovascular Age-Related Macular Degeneration After Intravitreal Ranibizumab Injection for Choroidal Neovascularization | Full Text | References | PDF (1.8 MB) | EPUB
  • 122 Views
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Article
Factors Associated with Benzodiazepines Prolonged-Term Use in Post-Stroke Subjective Sleep Disturbance: A Single-Centre Retrospective Study from China
Guozhong Ma, Liuqing Sun, Zhiwei Qie, Jinzhao He & Fang Cui
Pages: 2469-2481
Published online: 09 Jun 2021
AbstractforFactors Associated with Benzodiazepines Prolonged-Term Use in Post-Stroke Subjective Sleep Disturbance: A Single-Centre Retrospective Study from China | Full Text | References | PDF (4.4 MB) | EPUB
  • 163 Views
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Corrigendum

Correction
Ursolic Acid Reduces the Metalloprotease/Anti-Metalloprotease Imbalance in Cerebral Ischemia and Reperfusion Injury [Corrigendum]
Pages: 2483-2484
Published online: 11 Jun 2021
CitationforUrsolic Acid Reduces the Metalloprotease/Anti-Metalloprotease Imbalance in Cerebral Ischemia and Reperfusion Injury [Corrigendum] | Full Text | PDF (1.6 MB) | EPUB
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Original Research

Article
Multiple Administrations of Itraconazole Increase Plasma Exposure to Pyrotinib in Chinese Healthy Adults
Yueyue Liu, Qian Zhang, Chao Lu & Wei Hu
Pages: 2485-2493
Published online: 10 Jun 2021
AbstractforMultiple Administrations of Itraconazole Increase Plasma Exposure to Pyrotinib in Chinese Healthy Adults | Full Text | References | PDF (1.1 MB) | EPUB
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Review

Review Article
High-Impact Clinical Studies That Fomented New Developments in Anesthesia: History of Achievements, 1966–2015
Igor Kissin
Pages: 2495-2505
Published online: 11 Jun 2021
AbstractforHigh-Impact Clinical Studies That Fomented New Developments in Anesthesia: History of Achievements, 1966–2015 | Full Text | References | PDF (269.6 KB) | EPUB
  • 156 Views
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Review Article
The Current Evidence for the Use of Safinamide for the Treatment of Parkinson’s Disease
Giovanni Abbruzzese, Paolo Barone, Leonardo Lopiano & Fabrizio Stocchi
Pages: 2507-2517
Published online: 10 Jun 2021
AbstractforThe Current Evidence for the Use of Safinamide for the Treatment of Parkinson’s Disease | Full Text | References | PDF (309.5 KB) | EPUB
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Original Research

Article
Stability of Aprepitant Injectable Emulsion in Alternate Infusion Bags, in Refrigerated Storage, and Admixed with Dexamethasone and Palonosetron
Thomas Ottoboni, Laura Lerner & Arlene Santhouse
Pages: 2519-2527
Published online: 15 Jun 2021
AbstractforStability of Aprepitant Injectable Emulsion in Alternate Infusion Bags, in Refrigerated Storage, and Admixed with Dexamethasone and Palonosetron | Full Text | References | PDF (1.3 MB) | EPUB
  • 213 Views
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Article
Simultaneous Determination of Celecoxib, Dezocine and Dexmedetomidine in Beagle Plasma Using UPLC-MS/MS Method and the Application in Pharmacokinetics
Jie Hu, Xin-juan Su, Hui-Ling Si, Rui-Xiang Song, Fang Zhang, Xiang-Jun Qiu & Xing-Peng Chen
Pages: 2529-2541
Published online: 15 Jun 2021
AbstractforSimultaneous Determination of Celecoxib, Dezocine and Dexmedetomidine in Beagle Plasma Using UPLC-MS/MS Method and the Application in Pharmacokinetics | Full Text | References | PDF (4.6 MB) | EPUB
  • 141 Views
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Review

Review Article
Estrogen and Preeclampsia: Potential of Estrogens as Therapeutic Agents in Preeclampsia
Chang Shu, Shumei Han, Peng Xu, Ying Wang, Tingting Cheng & Cong Hu
Pages: 2543-2550
Published online: 15 Jun 2021
AbstractforEstrogen and Preeclampsia: Potential of Estrogens as Therapeutic Agents in Preeclampsia | Full Text | References | PDF (600.9 KB) | EPUB
  • 259 Views
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Original Research

Article
Bioequivalence Evaluation of Two Formulations of Tenofovir Alafenamide Tablets in Healthy Subjects Under Fasting and Fed Conditions
Qiuying Li, Lihui Jia, Wenli Hu, Shu Dong & Chaohong Cai
Pages: 2551-2562
Published online: 16 Jun 2021
AbstractforBioequivalence Evaluation of Two Formulations of Tenofovir Alafenamide Tablets in Healthy Subjects Under Fasting and Fed Conditions | Full Text | References | PDF (1.5 MB) | EPUB
  • 291 Views
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Corrigendum

Correction
Sulfasalazine Inhibits Inflammation and Fibrogenesis in Pancreas via NF-κB Signaling Pathway in Rats with Oxidative Stress-Induced Pancreatic Injury [Corrigendum]
Page: 2563
Published online: 16 Jun 2021
CitationforSulfasalazine Inhibits Inflammation and Fibrogenesis in Pancreas via NF-κB Signaling Pathway in Rats with Oxidative Stress-Induced Pancreatic Injury [Corrigendum] | Full Text | PDF (1.1 MB) | EPUB
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Original Research

Article
Metformin in Combination with Malvidin Prevents Progression of Non-Alcoholic Fatty Liver Disease via Improving Lipid and Glucose Metabolisms, and Inhibiting Inflammation in Type 2 Diabetes Rats
Wenlan Zou, Chen Zhang, Xuefang Gu, Xiaohong Li & Huiming Zhu
Pages: 2565-2576
Published online: 17 Jun 2021
AbstractforMetformin in Combination with Malvidin Prevents Progression of Non-Alcoholic Fatty Liver Disease via Improving Lipid and Glucose Metabolisms, and Inhibiting Inflammation in Type 2 Diabetes Rats | Full Text | References | PDF (9.3 MB) | EPUB
  • 150 Views
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Article
Synthesis, Radiolabeling, and Preliminary in vivo Evaluation of [68Ga] IPCAT-NOTA as an Imaging Agent for Dopamine Transporter
Shiou-Shiow Farn, Kang-Wei Chang, Wan-Chi Lin, Hung-Man Yu, Kun-Liang Lin, Yu-Chin Tseng, Yu Chang, Chung-Shan Yu & Wuu-Jyh Lin
Pages: 2577-2591
Published online: 17 Jun 2021
AbstractforSynthesis, Radiolabeling, and Preliminary in vivo Evaluation of [68Ga] IPCAT-NOTA as an Imaging Agent for Dopamine Transporter | Full Text | References | PDF (7.6 MB) | EPUB
  • 96 Views
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Article
Optimal Empiric Polymyxin B Treatment of Patients Infected with Gram-Negative Organisms Detected Using a Blood Antimicrobial Surveillance Network in China
Xingbing Wu, Chen Huang, Hui Wang, Jinru Ji, Chaoqun Ying & Yonghong Xiao
Pages: 2593-2603
Published online: 17 Jun 2021
AbstractforOptimal Empiric Polymyxin B Treatment of Patients Infected with Gram-Negative Organisms Detected Using a Blood Antimicrobial Surveillance Network in China | Full Text | References | PDF (739.8 KB) | EPUB
  • 104 Views
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Article
Effect of a 2-HP-β-Cyclodextrin Formulation on the Biological Transport and Delivery of Chemotherapeutic PLGA Nanoparticles
Kangyu Zheng, Zeju Huang, Jiaying Huang, Xiangmei Liu, Junfeng Ban, Xin Huang, Haosen Luo, Zhicong Chen, Qingchun Xie, Yanzhong Chen & Zhufen Lu
Pages: 2605-2618
Published online: 17 Jun 2021
AbstractforEffect of a 2-HP-β-Cyclodextrin Formulation on the Biological Transport and Delivery of Chemotherapeutic PLGA Nanoparticles | Full Text | References | PDF (7.5 MB) | EPUB
  • 192 Views
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Review

Review Article
The Agonists of Peroxisome Proliferator-Activated Receptor-γ for Liver Fibrosis
Jingjing Li, Chuanyong Guo & Jianye Wu
Pages: 2619-2628
Published online: 18 Jun 2021
AbstractforThe Agonists of Peroxisome Proliferator-Activated Receptor-γ for Liver Fibrosis | Full Text | References | PDF (1.6 MB) | EPUB
  • 237 Views
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Original Research

Article
Immunoregulatory Effect of Acanthopanax trifoliatus (L.) Merr. Polysaccharide on T1DM Mice
Ping Li, Yanli Chen, Luxiang Luo, Huiwen Yang & Yufang Pan
Pages: 2629-2639
Published online: 18 Jun 2021
AbstractforImmunoregulatory Effect of Acanthopanax trifoliatus (L.) Merr. Polysaccharide on T1DM Mice | Full Text | References | PDF (11.1 MB) | EPUB
  • 156 Views
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Article
Curcumol Ameliorates Lung Inflammation and Airway Remodeling via Inhibiting the Abnormal Activation of the Wnt/β-Catenin Pathway in Chronic Asthmatic Mice
Shanshan Jia, Pin Guo, Junhua Lu, Xujun Huang, Laming Deng, Yan Jin, Lanyan Zhao & Xiaofang Fan
Pages: 2641-2651
Published online: 21 Jun 2021
AbstractforCurcumol Ameliorates Lung Inflammation and Airway Remodeling via Inhibiting the Abnormal Activation of the Wnt/β-Catenin Pathway in Chronic Asthmatic Mice | Full Text | References | PDF (7.1 MB) | EPUB
  • 126 Views
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Review

Review Article
Vascular Endothelial Growth Factor Antagonists: Promising Players in the Treatment of Neovascular Age-Related Macular Degeneration
Rehan M Hussain, Bilal A Shaukat, Lauren M Ciulla, Audina M Berrocal & Jayanth Sridhar
Pages: 2653-2665
Published online: 21 Jun 2021
AbstractforVascular Endothelial Growth Factor Antagonists: Promising Players in the Treatment of Neovascular Age-Related Macular Degeneration | Full Text | References | PDF (293 KB) | EPUB
  • 396 Views
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Original Research

Article
A Highly Sensitive Nonextraction-Assisted HPLC Method with Fluorescence Detection for Quantification of Duvelisib in Plasma Samples and its Application to Pharmacokinetic Study in Rats
Ahmed Y Sayed, Nasr Y Khalil, Aliyah Almomen, Nourah Z Alzoman, Abdulrahman A Almehizia & Ibrahim A Darwish
Pages: 2667-2677
Published online: 21 Jun 2021
AbstractforA Highly Sensitive Nonextraction-Assisted HPLC Method with Fluorescence Detection for Quantification of Duvelisib in Plasma Samples and its Application to Pharmacokinetic Study in Rats | Full Text | References | PDF (2.9 MB) | EPUB
  • 172 Views
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Article
Prospective Application of Two New Pyridine-Based Zinc (II) Amide Carboxylate in Management of Alzheimer’s Disease: Synthesis, Characterization, Computational and in vitro Approaches
Rehman Zafar, Humaira Naureen, Muhammad Zubair, Khadija Shahid, Muhammad Saeed Jan, Samar Akhtar, Hammad Ahmad, Wajeeha Waseem, Ali Haider, Saqib Ali, Muhammad Tariq & Abdul Sadiq
Pages: 2679-2694
Published online: 21 Jun 2021
AbstractforProspective Application of Two New Pyridine-Based Zinc (II) Amide Carboxylate in Management of Alzheimer’s Disease: Synthesis, Characterization, Computational and in vitro Approaches | Full Text | References | PDF (8 MB) | EPUB
  • 277 Views
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Review

Review Article
Nanoscale Formulations: Incorporating Curcumin into Combination Strategies for the Treatment of Lung Cancer
Quhui Wu, Huiping Ou, Yan Shang, Xi Zhang, Junyong Wu & Fuyuan Fan
Pages: 2695-2709
Published online: 21 Jun 2021
AbstractforNanoscale Formulations: Incorporating Curcumin into Combination Strategies for the Treatment of Lung Cancer | Full Text | References | PDF (2 MB) | EPUB
  • 324 Views
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Review Article
The Clinical Efficacy and Safety of Neratinib in Combination with Capecitabine for the Treatment of Adult Patients with Advanced or Metastatic HER2-Positive Breast Cancer
Giovanna Chilà, Vincenzo Guarini, Danilo Galizia, Elena Geuna & Filippo Montemurro
Pages: 2711-2720
Published online: 21 Jun 2021
AbstractforThe Clinical Efficacy and Safety of Neratinib in Combination with Capecitabine for the Treatment of Adult Patients with Advanced or Metastatic HER2-Positive Breast Cancer | Full Text | References | PDF (375 KB) | EPUB
  • 211 Views
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Review Article
Chemistry, Pharmacology and Therapeutic Potential of Swertiamarin – A Promising Natural Lead for New Drug Discovery and Development
Nur Sakinah Muhamad Fadzil, Mahendran Sekar, Siew Hua Gan, Srinivasa Reddy Bonam, Yuan Seng Wu, Jaishree Vaijanathappa, Subban Ravi, Pei Teng Lum & Shivsharan B Dhadde
Pages: 2721-2746
Published online: 21 Jun 2021
AbstractforChemistry, Pharmacology and Therapeutic Potential of Swertiamarin – A Promising Natural Lead for New Drug Discovery and Development | Full Text | References | PDF (11.6 MB) | EPUB
  • 411 Views
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Review Article
Progress in Redirecting Antiparasitic Drugs for Cancer Treatment
Haoyang Huang, Qing He, Binghua Guo, Xudong Xu, Yinjuan Wu & Xuerong Li
Pages: 2747-2767
Published online: 22 Jun 2021
AbstractforProgress in Redirecting Antiparasitic Drugs for Cancer Treatment | Full Text | References | PDF (4.4 MB) | EPUB
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Original Research

Article
Study on the Inhibitory Effect of Curcumin on GBM and Its Potential Mechanism
Xiaotao Su, Shaohua Chen, Hongyu Lu, Haoyu Li & Chao Qin
Pages: 2769-2781
Published online: 28 Jun 2021
AbstractforStudy on the Inhibitory Effect of Curcumin on GBM and Its Potential Mechanism | Full Text | References | PDF (10.3 MB) | EPUB
  • 135 Views
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Article
Network Pharmacology Analysis of the Mechanisms of Compound Herba Sarcandrae (Fufang Zhongjiefeng) Aerosol in Chronic Pharyngitis Treatment
Yanping Zhang, Taohua Yuan, Yunsong Li, Ning Wu & Xiaotian Dai
Pages: 2783-2803
Published online: 28 Jun 2021
AbstractforNetwork Pharmacology Analysis of the Mechanisms of Compound Herba Sarcandrae (Fufang Zhongjiefeng) Aerosol in Chronic Pharyngitis Treatment | Full Text | References | PDF (9.4 MB) | EPUB
  • 231 Views
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Article
Comparison of Stimulated Cycles with Low Dose r-FSH versus Hormone Replacement Cycles for Endometrial Preparation Prior to Frozen-Thawed Embryo Transfer in Young Women with Polycystic Ovarian Syndrome: A Single-Center Retrospective Cohort Study from China
Li Li, Dan-Dan Gao, Yi Zhang, Jing-Yan Song & Zhen-Gao Sun
Pages: 2805-2813
Published online: 28 Jun 2021
AbstractforComparison of Stimulated Cycles with Low Dose r-FSH versus Hormone Replacement Cycles for Endometrial Preparation Prior to Frozen-Thawed Embryo Transfer in Young Women with Polycystic Ovarian Syndrome: A Single-Center Retrospective Cohort Study from China | Full Text | References | PDF (259.7 KB) | EPUB
  • 230 Views
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Review

Review Article
Profiling Pretomanid as a Therapeutic Option for TB Infection: Evidence to Date
Stephani L Stancil, Fuad Mirzayev & Susan M Abdel-Rahman
Pages: 2815-2830
Published online: 28 Jun 2021
AbstractforProfiling Pretomanid as a Therapeutic Option for TB Infection: Evidence to Date | Full Text | References | PDF (389.1 KB) | EPUB
  • 580 Views
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Original Research

Article
Exploration of the Effect and Mechanism of Fructus Lycii, Rehmanniae Radix Praeparata, and Paeonia lactiflora in the Treatment of AMD Based on Network Pharmacology and in vitro Experimental Verification
Xi Chen, Jing Zuo, Tianming Hu, Xiaoqing Shi, Yujie Zhu, Hao Wu, Ying Xia, Wei Shi & Wei Wei
Pages: 2831-2842
Published online: 28 Jun 2021
AbstractforExploration of the Effect and Mechanism of Fructus Lycii, Rehmanniae Radix Praeparata, and Paeonia lactiflora in the Treatment of AMD Based on Network Pharmacology and in vitro Experimental Verification | Full Text | References | PDF (7.7 MB) | EPUB
  • 119 Views
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Article
A Novel Folic Acid Receptor-Targeted Drug Delivery System Based on Curcumin-Loaded β-Cyclodextrin Nanoparticles for Cancer Treatment
Weiyong Hong, Fangyuan Guo, Nan Yu, Sanjun Ying, Bang Lou, Jiangqing Wu, Ying Gao, Xugang Ji, Haiying Wang, Aiqin Li, Guoping Wang & Gensheng Yang
Pages: 2843-2855
Published online: 30 Jun 2021
AbstractforA Novel Folic Acid Receptor-Targeted Drug Delivery System Based on Curcumin-Loaded β-Cyclodextrin Nanoparticles for Cancer Treatment | Full Text | References | PDF (9.5 MB) | EPUB
  • 466 Views
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Article
Pentamidine Inhibits Ovarian Cancer Cell Proliferation and Migration by Maintaining Stability of PTEN in vitro
Yi Wu, Zhong Zhang & Zuqiang Kou
Pages: 2857-2868
Published online: 01 Jul 2021
AbstractforPentamidine Inhibits Ovarian Cancer Cell Proliferation and Migration by Maintaining Stability of PTEN in vitro | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Superhydrophobic Surface for Enhancing the Bioavailability of Salbutamol Sulfate from Cross-Linked Microspheres: Formulation, Characterization, and in vivo Evaluation
Dalia Gaber, Siham Abdoun, Ameerah Alfuraihy, Bushra Altasan & Amal Alsubaiyel
Pages: 2869-2884
Published online: 02 Jul 2021
AbstractforSuperhydrophobic Surface for Enhancing the Bioavailability of Salbutamol Sulfate from Cross-Linked Microspheres: Formulation, Characterization, and in vivo Evaluation | Full Text | References | PDF (4.4 MB) | EPUB
  • 133 Views
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Article
Hepatoprotective Effects of Polysaccharide from Anoectochilus roxburghii (Wall.) Lindl. on Rat Liver Injury Induced by CCl4
Xiaoling Yu, Lingyi Huang, Chen You & Liying Huang
Pages: 2885-2897
Published online: 06 Jul 2021
AbstractforHepatoprotective Effects of Polysaccharide from Anoectochilus roxburghii (Wall.) Lindl. on Rat Liver Injury Induced by CCl4 | Full Text | References | PDF (4.2 MB) | EPUB
  • 156 Views
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Article
Evaluation of Ceftazidime/Avibactam Administration in Enterobacteriaceae and Pseudomonas aeruginosa Bloodstream Infections by Monte Carlo Simulation
Yuanyuan Dai, Wenjiao Chang, Xin Zhou, Wei Yu, Chen Huang, Yunbo Chen, Xiaoling Ma, Huaiwei Lu, Rujin Ji, Chaoqun Ying, Peipei Wang, Zhiying Liu, Qingfeng Yuan & Yonghong Xiao
Pages: 2899-2905
Published online: 06 Jul 2021
AbstractforEvaluation of Ceftazidime/Avibactam Administration in Enterobacteriaceae and Pseudomonas aeruginosa Bloodstream Infections by Monte Carlo Simulation | Full Text | References | PDF (1.2 MB) | EPUB
  • 101 Views
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Article
Mechanism of Tetrandrine Against Endometrial Cancer Based on Network Pharmacology
Wenqian Shang, Jing Zhang, Haibo Song, Shunfei Zhu, Aimin Zhang, Yushuang Hua, Shujun Han & Yan Fu
Pages: 2907-2919
Published online: 06 Jul 2021
AbstractforMechanism of Tetrandrine Against Endometrial Cancer Based on Network Pharmacology | Full Text | References | PDF (11.4 MB) | EPUB
  • 271 Views
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Review

Review Article
The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date
Win Min Oo, Christopher Little, Vicky Duong & David J Hunter
Pages: 2921-2945
Published online: 06 Jul 2021
AbstractforThe Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date | Full Text | References | PDF (2 MB) | EPUB
  • 743 Views
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Article
A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects
Hongjie Qian, Qian Chen, Liyu Liang, Yang Zou, Huahua Pu, Liang Xin, Rong Song, Tingting Li, Huijuan Zhu, Yu Wang, Guanghui Tian, Jingshan Shen, Hualiang Jiang, Chen Yu, Zhen Wang & Jingying Jia
Pages: 2947-2959
Published online: 06 Jul 2021
AbstractforA Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects | Full Text | References | PDF (3.3 MB) | EPUB
  • 262 Views
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Article
Pharmacokinetic Study of Frovatriptan Succinate Tablet After Single and Multiple Oral Doses in Chinese Healthy Subjects
Hongquan Zheng, Yan Xia, Shengjun Qu, Lin Fan, Jingjing Zhang, Zhixiang Ma, Yangsheng Chen & Hongwei Fan
Pages: 2961-2968
Published online: 07 Jul 2021
AbstractforPharmacokinetic Study of Frovatriptan Succinate Tablet After Single and Multiple Oral Doses in Chinese Healthy Subjects | Full Text | References | PDF (1.1 MB) | EPUB
  • 147 Views
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Review Article
Spotlight on Melphalan Flufenamide: An Up-and-Coming Therapy for the Treatment of Myeloma
Fortunato Morabito, Giovanni Tripepi, Enrica Antonia Martino, Ernesto Vigna, Francesco Mendicino, Lucio Morabito, Katia Todoerti, Hamdi Al-Janazreh, Graziella D’Arrigo, Filippo Antonio Canale, Giovanna Cutrona, Antonino Neri, Massimo Martino & Massimo Gentile
Pages: 2969-2978
Published online: 08 Jul 2021
AbstractforSpotlight on Melphalan Flufenamide: An Up-and-Coming Therapy for the Treatment of Myeloma | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Assessing Palatability of a New Amphetamine Extended-Release Tablet Formulation for the Treatment of ADHD
Antonio Pardo, Thomas R King, Eman Rafla & Judith C Kando
Pages: 2979-2985
Published online: 08 Jul 2021
AbstractforAssessing Palatability of a New Amphetamine Extended-Release Tablet Formulation for the Treatment of ADHD | Full Text | References | PDF (1.6 MB) | EPUB
  • 151 Views
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Review Article
An Update Review of Biosimilars of Adalimumab in Psoriasis – Bioequivalence and Interchangeability
Xin Zhou, Zhuo Chen & Xinling Bi
Pages: 2987-2998
Published online: 08 Jul 2021
AbstractforAn Update Review of Biosimilars of Adalimumab in Psoriasis – Bioequivalence and Interchangeability | Full Text | References | PDF (259.1 KB) | EPUB
  • 398 Views
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Article
Total Flavone of Abelmoschus manihot Ameliorates Stress-Induced Microbial Alterations Drive Intestinal Barrier Injury in DSS Colitis
Rong Wang, Tuo Chen, Qiong Wang, Xiao-Min Yuan, Zheng-Lan Duan, Ze-Yu Feng, Yang Ding, Fan Bu, Guo-Ping Shi & Yu-Gen Chen
Pages: 2999-3016
Published online: 08 Jul 2021
AbstractforTotal Flavone of Abelmoschus manihot Ameliorates Stress-Induced Microbial Alterations Drive Intestinal Barrier Injury in DSS Colitis | Full Text | References | PDF (15.7 MB) | EPUB
  • 196 Views
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Review Article
Review of Allopregnanolone Agonist Therapy for the Treatment of Depressive Disorders
Autumn Walkery, Lauren D Leader, Emily Cooke & Amy VandenBerg
Pages: 3017-3026
Published online: 09 Jul 2021
AbstractforReview of Allopregnanolone Agonist Therapy for the Treatment of Depressive Disorders | Full Text | References | PDF (298.4 KB) | EPUB
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Article
Effects of Exenatide on Coagulation and Platelet Aggregation in Patients with Type 2 Diabetes
Yaqin Zhang, Ruofei Chen, Yangyang Jia, Mingwei Chen & Zongwen Shuai
Pages: 3027-3040
Published online: 12 Jul 2021
AbstractforEffects of Exenatide on Coagulation and Platelet Aggregation in Patients with Type 2 Diabetes | Full Text | References | PDF (4.6 MB) | EPUB
  • 238 Views
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Review Article
A Call to Action by the Italian Mesotherapy Society on Scientific Research
Massimo Mammucari, Teresa Paolucci, Domenico Russo, Enrica Maggiori, Raffaele Di Marzo, Alberto Migliore, Umberto Massafra, Gianpaolo Ronconi, Paola Emilia Ferrara, Fabio Gori, Barbara Bifarini, Stefano Brauneis, Renato Vellucci, Rocco Domenico Mediati, Bartolomeo Violo, Silvia Natoli, Carmen Pediliggieri, Cristiana Di Campli & Maria Chiara Collina
Pages: 3041-3047
Published online: 12 Jul 2021
AbstractforA Call to Action by the Italian Mesotherapy Society on Scientific Research | Full Text | References | PDF (1.1 MB) | EPUB
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Article
In vitro Antimicrobial Activity of Fosfomycin, Rifampin, Vancomycin, Daptomycin Alone and in Combination Against Vancomycin-Resistant Enterococci
Jiepeng Tong, Yiheng Jiang, Hao Xu, Xuehang Jin, Li Zhang, Shuaibing Ying, Wei Yu & Yunqing Qiu
Pages: 3049-3055
Published online: 12 Jul 2021
AbstractforIn vitro Antimicrobial Activity of Fosfomycin, Rifampin, Vancomycin, Daptomycin Alone and in Combination Against Vancomycin-Resistant Enterococci | Full Text | References | PDF (3.6 MB) | EPUB
  • 146 Views
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Review

Review Article
Profile of Ipragliflozin, an Oral SGLT-2 Inhibitor for the Treatment of Type 2 Diabetes: The Evidence to Date
Wajd Alkabbani & John-Michael Gamble
Pages: 3057-3069
Published online: 14 Jul 2021
AbstractforProfile of Ipragliflozin, an Oral SGLT-2 Inhibitor for the Treatment of Type 2 Diabetes: The Evidence to Date | Full Text | References | PDF (3.8 MB) | EPUB
  • 226 Views
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Original Research

Article
Starch Nanoparticles for Enhancement of Oral Bioavailability of a Newly Synthesized Thienopyrimidine Derivative with Anti-Proliferative Activity Against Pancreatic Cancer
Ahmed R Gardouh, Ahmed S G Srag El-Din, Mohamed S H Salem, Yasser Moustafa & Shadeed Gad
Pages: 3071-3093
Published online: 16 Jul 2021
AbstractforStarch Nanoparticles for Enhancement of Oral Bioavailability of a Newly Synthesized Thienopyrimidine Derivative with Anti-Proliferative Activity Against Pancreatic Cancer | Full Text | References | PDF (8.8 MB) | EPUB
  • 233 Views
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Article
The Potential Use of Ceftazidime-Avibactam Against Carbapenem Resistant Klebsiella pneumoniae Clinical Isolates Harboring Different Carbapenemase Types in a Thai University Hospital
Worapong Nasomsong, Parnrada Nulsopapon, Dhitiwat Changpradub, Manat Pongchaidecha, Supanun Pungcharoenkijkul, Piraporn Juntanawiwat, Waristha Simsiriporn & Wichai Santimaleeworagun
Pages: 3095-3104
Published online: 16 Jul 2021
AbstractforThe Potential Use of Ceftazidime-Avibactam Against Carbapenem Resistant Klebsiella pneumoniae Clinical Isolates Harboring Different Carbapenemase Types in a Thai University Hospital | Full Text | References | PDF (407.3 KB) | EPUB
  • 181 Views
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Article
Qing-Luo-Yin Alleviated Monocytes/Macrophages-Mediated Inflammation in Rats with Adjuvant-Induced Arthritis by Disrupting Their Interaction with (Pre)-Adipocytes Through PPAR-γ Signaling
Rui Wang, Dan-Feng Li, Yi-Fang Hu, Qiang Liao, Tian-Tian Jiang, Opeyemi Joshua Olatunji, Kui Yang & Jian Zuo
Pages: 3105-3118
Published online: 16 Jul 2021
AbstractforQing-Luo-Yin Alleviated Monocytes/Macrophages-Mediated Inflammation in Rats with Adjuvant-Induced Arthritis by Disrupting Their Interaction with (Pre)-Adipocytes Through PPAR-γ Signaling | Full Text | References | PDF (9.3 MB) | EPUB
  • 146 Views
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Article
Design, Synthesis, Characterization and in vivo Antidiabetic Activity Evaluation of Some Chalcone Derivatives
Semere Welday Kahssay, Gebremedhin Solomon Hailu & Kebede Taye Desta
Pages: 3119-3129
Published online: 17 Jul 2021
AbstractforDesign, Synthesis, Characterization and in vivo Antidiabetic Activity Evaluation of Some Chalcone Derivatives | Full Text | References | PDF (3.9 MB) | EPUB
  • 864 Views
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Article
Wogonin Alleviates Kidney Tubular Epithelial Injury in Diabetic Nephropathy by Inhibiting PI3K/Akt/NF-κB Signaling Pathways
Lei Lei, Jing Zhao, Xue-Qi Liu, Juan Chen, Xiang-Ming Qi, Ling-Ling Xia & Yong-Gui Wu
Pages: 3131-3150
Published online: 16 Jul 2021
AbstractforWogonin Alleviates Kidney Tubular Epithelial Injury in Diabetic Nephropathy by Inhibiting PI3K/Akt/NF-κB Signaling Pathways | Full Text | References | PDF (21.4 MB) | EPUB
  • 205 Views
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Article
RETRACTED ARTICLE: Evaluation of Natural Bioactive-Derived Punicalagin Niosomes in Skin-Aging Processes Accelerated by Oxidant and Ultraviolet Radiation
Ebtesam A Mohamad, Aya A Aly, Aya A Khalaf, Mona I Ahmed, Reham M Kamel, Sherouk M Abdelnaby, Yasmine H Abdelzaher, Marize G Sedrak & Shaker A Mousa
Pages: 3151-3162
Published online: 17 Jul 2021
AbstractforRETRACTED ARTICLE: Evaluation of Natural Bioactive-Derived Punicalagin Niosomes in Skin-Aging Processes Accelerated by Oxidant and Ultraviolet Radiation | PDF (4.4 MB)
  • 94 Views
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Article
Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats
Jiali Yang, Zhixia Jia, Zhigang Xiao, Jing Zhao, Ye Lu, Li Chu, Hui Shao, Lin Pei, Shaodan Zhang & Yuan Chen
Pages: 3163-3180
Published online: 20 Jul 2021
AbstractforBaicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats | Full Text | References | PDF (11.1 MB) | EPUB
  • 254 Views
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Article
Analysis of Clinical Trials of New Drugs for Liver Diseases in China
Longfei Lin & Hui Li
Pages: 3181-3191
Published online: 20 Jul 2021
AbstractforAnalysis of Clinical Trials of New Drugs for Liver Diseases in China | Full Text | References | PDF (2.8 MB) | EPUB
  • 216 Views
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Article
A Network Pharmacology-Based Investigation to the Pharmacodynamic Material Basis and Mechanisms of the Anti-Inflammatory and Anti-Viral Effect of Isatis indigotica
Jiuling Deng, Ying Ma, Yuqiong He, Hong Yang, Yanhong Chen, Liang Wang, Doudou Huang, Shi Qiu, Xia Tao & Wansheng Chen
Pages: 3193-3206
Published online: 20 Jul 2021
AbstractforA Network Pharmacology-Based Investigation to the Pharmacodynamic Material Basis and Mechanisms of the Anti-Inflammatory and Anti-Viral Effect of Isatis indigotica | Full Text | References | PDF (12.5 MB) | EPUB
  • 342 Views
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Article
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway
Leyi Ma, Fan Wu, Qingqing Shao, Guang Chen, Lijun Xu & Fuer Lu
Pages: 3207-3221
Published online: 21 Jul 2021
AbstractforBaicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway | Full Text | References | PDF (7.1 MB) | EPUB
  • 438 Views
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Article
Dual-Functional Peptide Driven Liposome Codelivery System for Efficient Treatment of Doxorubicin-Resistant Breast Cancer
Kamel S Ahmed, Shenhuan Liu, Jing Mao, Jie Zhang & Lipeng Qiu
Pages: 3223-3239
Published online: 27 Jul 2021
AbstractforDual-Functional Peptide Driven Liposome Codelivery System for Efficient Treatment of Doxorubicin-Resistant Breast Cancer | Full Text | References | PDF (9.2 MB) | EPUB
  • 178 Views
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Article
Effect of Berberine on Hyperuricemia and Kidney Injury: A Network Pharmacology Analysis and Experimental Validation in a Mouse Model
Qiaoping Li, Ziwei Huang, Defu Liu, Jingna Zheng, Jianhui Xie, Jiannan Chen, Huifang Zeng, Ziren Su & Yucui Li
Pages: 3241-3254
Published online: 27 Jul 2021
AbstractforEffect of Berberine on Hyperuricemia and Kidney Injury: A Network Pharmacology Analysis and Experimental Validation in a Mouse Model | Full Text | References | PDF (11 MB) | EPUB
  • 389 Views
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Article
Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Huai Hua San Against Ulcerative Colitis
Jiaqin Liu, Jian Liu, Xiaoliang Tong, Weijun Peng, Shanshan Wei, Taoli Sun, Yikun Wang, Bikui Zhang & Wenqun Li
Pages: 3255-3276
Published online: 28 Jul 2021
AbstractforNetwork Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Huai Hua San Against Ulcerative Colitis | Full Text | References | PDF (17.7 MB) | EPUB
  • 1157 Views
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Clinical Trial Report

Case Report
Bioequivalence and Pharmacokinetic Evaluation of Two Oral Formulations of Regorafenib: An Open-Label, Randomised, Single-Dose, Two-Period, Two-Way Crossover Clinical Trial in Healthy Chinese Volunteers Under Fasting and Fed Conditions
Qian Zhang, Zhiqiang Wang, Jingying Wu, Zhen Zhou, Renpeng Zhou & Wei Hu
Pages: 3277-3288
Published online: 29 Jul 2021
AbstractforBioequivalence and Pharmacokinetic Evaluation of Two Oral Formulations of Regorafenib: An Open-Label, Randomised, Single-Dose, Two-Period, Two-Way Crossover Clinical Trial in Healthy Chinese Volunteers Under Fasting and Fed Conditions | Full Text | References | PDF (4.7 MB) | EPUB
  • 282 Views
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Review

Review Article
Imidazole as a Promising Medicinal Scaffold: Current Status and Future Direction
Sahar S Alghamdi, Rasha S Suliman, Khlood Almutairi, Khawla Kahtani & Dimah Aljatli
Pages: 3289-3312
Published online: 29 Jul 2021
AbstractforImidazole as a Promising Medicinal Scaffold: Current Status and Future Direction | Full Text | References | PDF (2.6 MB) | EPUB
  • 1017 Views
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Review Article
COVID-19: Vaccine Delivery System, Drug Repurposing and Application of Molecular Modeling Approach
Soha R Abd El Hadi, Esmat E Zien El-Deen, Mostafa M Bahaa, Abdelfattah A Sadakah & Heba A Yassin
Pages: 3313-3330
Published online: 30 Jul 2021
AbstractforCOVID-19: Vaccine Delivery System, Drug Repurposing and Application of Molecular Modeling Approach | Full Text | References | PDF (8.5 MB) | EPUB
  • 350 Views
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Original Research

Article
Qilin Pill Exerts Therapeutic Effect on Resection-Induced Premature Ovarian Insufficiency Rats by Inhibiting the MAPK and PI3K-AKT Signaling Pathways
Debao Li, Yuling Jia, Yiwen Hou, Dingshi Chen, Chiyang Zheng, Lifen Chen, Li Zhou & Zuyue Sun
Pages: 3331-3345
Published online: 30 Jul 2021
AbstractforQilin Pill Exerts Therapeutic Effect on Resection-Induced Premature Ovarian Insufficiency Rats by Inhibiting the MAPK and PI3K-AKT Signaling Pathways | Full Text | References | PDF (12.2 MB) | EPUB
  • 220 Views
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Corrigendum

Correction
Hydroxyapatite Nanoparticles Facilitate Osteoblast Differentiation and Bone Formation Within Sagittal Suture During Expansion in Rats [Corrigendum]
Pages: 3347-3348
Published online: 02 Aug 2021
CitationforHydroxyapatite Nanoparticles Facilitate Osteoblast Differentiation and Bone Formation Within Sagittal Suture During Expansion in Rats [Corrigendum] | Full Text | PDF (1.6 MB) | EPUB
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Review

Review Article
Real-World Use of Dalbavancin in the Era of Empowerment of Outpatient Antimicrobial Treatment: A Careful Appraisal Beyond Approved Indications Focusing on Unmet Clinical Needs
Milo Gatti, Massimo Andreoni, Federico Pea & Pierluigi Viale
Pages: 3349-3378
Published online: 03 Aug 2021
AbstractforReal-World Use of Dalbavancin in the Era of Empowerment of Outpatient Antimicrobial Treatment: A Careful Appraisal Beyond Approved Indications Focusing on Unmet Clinical Needs | Full Text | References | PDF (2.3 MB) | EPUB
  • 464 Views
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Clinical Trial Report

Case Report
Effect of Intravenous Lidocaine on Serum Interleukin-17 After Video-Assisted Thoracic Surgery for Non-Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial
Yong-heng Hou, Wen-cheng Shi, Shu Cai, Hong Liu, Zhong Zheng, Fu-wei Qi, Chang Li, Xiao-mei Feng, Ke Peng & Fu-hai Ji
Pages: 3379-3390
Published online: 03 Aug 2021
AbstractforEffect of Intravenous Lidocaine on Serum Interleukin-17 After Video-Assisted Thoracic Surgery for Non-Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial | Full Text | References | PDF (4.8 MB) | EPUB
  • 179 Views
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Review

Review Article
Evidence and Current Use of Levosimendan in the Treatment of Heart Failure: Filling the Gap
Nicolina Conti, Milo Gatti, Emanuel Raschi, Igor Diemberger & Luciano Potena
Pages: 3391-3409
Published online: 04 Aug 2021
AbstractforEvidence and Current Use of Levosimendan in the Treatment of Heart Failure: Filling the Gap | Full Text | References | PDF (2 MB) | EPUB
  • 290 Views
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Original Research

Article
What to Do About Missed Doses? A Retrospective Study of Olanzapine in the Elderly
Tao Xiao, Zhanzhang Wang, Guanlie Li, Shanqing Huang, Xiuqing Zhu, Shujing Liu, Xiaolin Li, Jinqing Hu, Dewei Shang & Yuguan Wen
Pages: 3411-3423
Published online: 04 Aug 2021
AbstractforWhat to Do About Missed Doses? A Retrospective Study of Olanzapine in the Elderly | Full Text | References | PDF (3.3 MB) | EPUB
  • 405 Views
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Article
Network Pharmacology and Experimental Evidence: PI3K/AKT Signaling Pathway is Involved in the Antidepressive Roles of Chaihu Shugan San
Shan Zhang, Yujia Lu, Wei Chen, Wei Shi, Qian Zhao, Jingjie Zhao & Li Li
Pages: 3425-3441
Published online: 05 Aug 2021
AbstractforNetwork Pharmacology and Experimental Evidence: PI3K/AKT Signaling Pathway is Involved in the Antidepressive Roles of Chaihu Shugan San | Full Text | References | PDF (13 MB) | EPUB
  • 280 Views
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Article
Hearing Protection Outcomes of Analog Electrode Arrays Coated with Different Drug-Eluting Polymer Films Implanted into Guinea Pig Cochleae
Yuyu Huang, Haoran Yu, Min Liang, Shule Hou, Junmin Chen, Fan Zhang, Xiayu Sun, Huan Jia & Jun Yang
Pages: 3443-3450
Published online: 11 Aug 2021
AbstractforHearing Protection Outcomes of Analog Electrode Arrays Coated with Different Drug-Eluting Polymer Films Implanted into Guinea Pig Cochleae | Full Text | References | PDF (2.7 MB) | EPUB
  • 119 Views
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Article
Ecust004 Suppresses Breast Cancer Cell Growth, Invasion, and Migration via EMT Regulation
Ziyu Liu, Leilei Huang, Liwei Sun, Hui Nie, Yuqi Liang, Jinwen Huang, Fanhong Wu & Xin Hu
Pages: 3451-3461
Published online: 10 Aug 2021
AbstractforEcust004 Suppresses Breast Cancer Cell Growth, Invasion, and Migration via EMT Regulation | Full Text | References | PDF (9.1 MB) | EPUB
  • 114 Views
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Article
Establishment of Prognostic Nomograms for Predicting the Survival of HR-Positive, HER2-Negative Metastatic Breast Cancer Patients Treated with Everolimus
Fangfang Duan, Chenge Song, Yuyu Ma, Kuikui Jiang, Fei Xu, Xiwen Bi, Jiajia Huang, Ruoxi Hong, Zhangzan Huang, Qianyi Lu, Zhongyu Yuan, Shusen Wang & Wen Xia
Pages: 3463-3473
Published online: 10 Aug 2021
AbstractforEstablishment of Prognostic Nomograms for Predicting the Survival of HR-Positive, HER2-Negative Metastatic Breast Cancer Patients Treated with Everolimus | Full Text | References | PDF (2.7 MB) | EPUB
  • 117 Views
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Article
Transferrin-Decorated Protein-Lipid Hybrid Nanoparticle Efficiently Delivers Cisplatin and Docetaxel for Targeted Lung Cancer Treatment
Kaiping Mao, Weina Zhang, Lan Yu, Yi Yu, Haixia Liu & Xiaotao Zhang
Pages: 3475-3486
Published online: 10 Aug 2021
AbstractforTransferrin-Decorated Protein-Lipid Hybrid Nanoparticle Efficiently Delivers Cisplatin and Docetaxel for Targeted Lung Cancer Treatment | Full Text | References | PDF (6.9 MB) | EPUB
  • 222 Views
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Article
Efficacy, Pharmacokinetics, Biodistribution and Excretion of a Novel Acylated Long-Acting Insulin Analogue INS061 in Rats
Kai Pan, Xiaolei Shi, Kai Liu, Ju Wang & Yijun Chen
Pages: 3487-3498
Published online: 10 Aug 2021
AbstractforEfficacy, Pharmacokinetics, Biodistribution and Excretion of a Novel Acylated Long-Acting Insulin Analogue INS061 in Rats | Full Text | References | PDF (3.8 MB) | EPUB
  • 122 Views
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Article
The Reproductive Toxicity of Monosodium Glutamate by Damaging GnRH Neurons Cannot Be Relieved Spontaneously Over Time
Cheng-Xiang Wang, Yue Zhang, Qing-Feng Li, Hong-Liang Sun, Hai-Ling Chong, Jian-Xi Jiang & Qing-Chun Li
Pages: 3499-3508
Published online: 12 Aug 2021
AbstractforThe Reproductive Toxicity of Monosodium Glutamate by Damaging GnRH Neurons Cannot Be Relieved Spontaneously Over Time | Full Text | References | PDF (4.5 MB) | EPUB
  • 178 Views
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Article
Quercetin Prevents Oxidative Stress-Induced Injury of Periodontal Ligament Cells and Alveolar Bone Loss in Periodontitis
Yu Wei, Jiayao Fu, Wenjing Wu, Pengfei Ma, Le Ren, Zimei Yi & Junhua Wu
Pages: 3509-3522
Published online: 12 Aug 2021
AbstractforQuercetin Prevents Oxidative Stress-Induced Injury of Periodontal Ligament Cells and Alveolar Bone Loss in Periodontitis | Full Text | References | PDF (10.3 MB) | EPUB
  • 332 Views
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Article
Effectiveness and Anticancer Activity of a Novel Phenolic Compound from Garcinia porrecta Against the MCF-7 Breast Cancer Cell Line in vitro and in silico
Darwati Darwati, Ayu Nadila Safitri, Nurul Ambardhani, Tri Mayanti, Nurlelasari Nurlelasari & Dikdik Kurnia
Pages: 3523-3533
Published online: 12 Aug 2021
AbstractforEffectiveness and Anticancer Activity of a Novel Phenolic Compound from Garcinia porrecta Against the MCF-7 Breast Cancer Cell Line in vitro and in silico | Full Text | References | PDF (4.5 MB) | EPUB
  • 470 Views
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Clinical Trial Report

Case Report
Lower Background Infusion of Oxycodone for Patient-Controlled Intravenous Analgesia, Combined with Ropivacaine Intercostal Nerve Block, in Patients Undergoing Thoracoscopic Lobectomy for Lung Cancer: A Randomized, Double-Blind, Controlled Clinical Trial
Yunxiao Zhang, Wanpu Yan, Yanyun Chen, Zhiyi Fan & Jiheng Chen
Pages: 3535-3542
Published online: 13 Aug 2021
AbstractforLower Background Infusion of Oxycodone for Patient-Controlled Intravenous Analgesia, Combined with Ropivacaine Intercostal Nerve Block, in Patients Undergoing Thoracoscopic Lobectomy for Lung Cancer: A Randomized, Double-Blind, Controlled Clinical Trial | Full Text | References | PDF (2.2 MB) | EPUB
  • 139 Views
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Original Research

Article
The Synergistic Effect of Ginkgo biloba Extract 50 and Aspirin Against Platelet Aggregation
Jia Ke, Meng-Ting Li, Ya-Jing Huo, Yan-Qiong Cheng, Shu-Fen Guo, Yang Wu, Lei Zhang, Jianpeng Ma, Ai-Jun Liu & Yan Han
Pages: 3543-3560
Published online: 14 Aug 2021
AbstractforThe Synergistic Effect of Ginkgo biloba Extract 50 and Aspirin Against Platelet Aggregation | Full Text | References | PDF (9.7 MB) | EPUB
  • 612 Views
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Article
Prompt Agalsidase Alfa Therapy Initiation is Associated with Improved Renal and Cardiovascular Outcomes in a Fabry Outcome Survey Analysis
Derralynn Hughes, Aleš Linhart, Andrey Gurevich, Vasiliki Kalampoki, Dalia Jazukeviciene, Sandro Feriozzi & On behalf of the FOS Study Group
Pages: 3561-3572
Published online: 16 Aug 2021
AbstractforPrompt Agalsidase Alfa Therapy Initiation is Associated with Improved Renal and Cardiovascular Outcomes in a Fabry Outcome Survey Analysis | Full Text | References | PDF (595.4 KB) | EPUB
  • 111 Views
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Article
The Clinical Efficacy of Three Different Follicle-Stimulating Hormones for Follicle Growth and Development in Long-Protocol Controlled Ovarian Hyperstimulation Treatment
Xi-Qian Zhang, Li-Jia Zhang, Xiu-Lan Zhu, Hong Xu, Yan-Qun Luo, Li Yao, Qian-Wen Huang, Ying-Qi Nong, Wen-Juan Liu & Feng-Hua Liu
Pages: 3573-3580
Published online: 16 Aug 2021
AbstractforThe Clinical Efficacy of Three Different Follicle-Stimulating Hormones for Follicle Growth and Development in Long-Protocol Controlled Ovarian Hyperstimulation Treatment | Full Text | References | PDF (914.6 KB) | EPUB
  • 105 Views
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Article
Gene Therapy for Rdh12-Associated Retinal Diseases Helps to Delay Retinal Degeneration and Vision Loss
Jiaxin Bian, Hongyu Chen, Junhui Sun, Yuqing Cao, Jianhong An, Qing Pan & Ming Qi
Pages: 3581-3591
Published online: 17 Aug 2021
AbstractforGene Therapy for Rdh12-Associated Retinal Diseases Helps to Delay Retinal Degeneration and Vision Loss | Full Text | References | PDF (7.8 MB) | EPUB
  • 183 Views
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Article
Bi-aryl Analogues of Salicylic Acids: Design, Synthesis and SAR Study to Ameliorate Endoplasmic Reticulum Stress
Ye Eun Kim, Dong Hwan Kim, Ami Choi, Seoul Jang, Kwiwan Jeong, Young-mi Kim & Tae-gyu Nam
Pages: 3593-3604
Published online: 17 Aug 2021
AbstractforBi-aryl Analogues of Salicylic Acids: Design, Synthesis and SAR Study to Ameliorate Endoplasmic Reticulum Stress | Full Text | References | PDF (4.2 MB) | EPUB
  • 139 Views
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Article
Combination Therapy of Metastatic Castration-Recurrent Prostate Cancer: Hyaluronic Acid Decorated, Cabazitaxel-Prodrug and Orlistat Co-Loaded Nano-System
Zhen Qu, Yuning Ren, Hongyu Shen, Huihui Wang, Lijie Shi & Deyong Tong
Pages: 3605-3616
Published online: 20 Aug 2021
AbstractforCombination Therapy of Metastatic Castration-Recurrent Prostate Cancer: Hyaluronic Acid Decorated, Cabazitaxel-Prodrug and Orlistat Co-Loaded Nano-System | Full Text | References | PDF (4.8 MB) | EPUB
  • 172 Views
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Corrigendum

Correction
Hydroxyapatite Nanoparticles Facilitate Osteoblast Differentiation and Bone Formation Within Sagittal Suture During Expansion in Rats [Corrigendum]
Pages: 3617-3618
Published online: 20 Aug 2021
CitationforHydroxyapatite Nanoparticles Facilitate Osteoblast Differentiation and Bone Formation Within Sagittal Suture During Expansion in Rats [Corrigendum] | Full Text | PDF (2.1 MB) | EPUB
  • 76 Views
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Review

Review Article
Icariin, an Up-and-Coming Bioactive Compound Against Neurological Diseases: Network Pharmacology-Based Study and Literature Review
Shuangqiu Wang, Jiarui Ma, Yanqi Zeng, Guowei Zhou, Yuxuan Wang, Wenjuan Zhou, Xiaohe Sun & Minghua Wu
Pages: 3619-3641
Published online: 20 Aug 2021
AbstractforIcariin, an Up-and-Coming Bioactive Compound Against Neurological Diseases: Network Pharmacology-Based Study and Literature Review | Full Text | References | PDF (14.1 MB) | EPUB
  • 398 Views
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Original Research

Article
Doxazosin Attenuates Liver Fibrosis by Inhibiting Autophagy in Hepatic Stellate Cells via Activation of the PI3K/Akt/mTOR Signaling Pathway
Ai-Yuan Xiu, Qian Ding, Zhen Li & Chun-Qing Zhang
Pages: 3643-3659
Published online: 21 Aug 2021
AbstractforDoxazosin Attenuates Liver Fibrosis by Inhibiting Autophagy in Hepatic Stellate Cells via Activation of the PI3K/Akt/mTOR Signaling Pathway | Full Text | References | PDF (13.2 MB) | EPUB
  • 396 Views
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Article
Effects of Avitinib on CYP450 Enzyme Activity in vitro and in vivo in Rats
Yong Shi, Deru Meng, Shuanghu Wang, Peiwu Geng, Tao Xu, Quan Zhou, Yunfang Zhou, Wanshu Li & Xugao Chen
Pages: 3661-3673
Published online: 21 Aug 2021
AbstractforEffects of Avitinib on CYP450 Enzyme Activity in vitro and in vivo in Rats | Full Text | References | PDF (8.5 MB) | EPUB
  • 106 Views
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Article
Multivariate Assessment for Bioequivalence Based on the Correlation of Random Effect
Hyungmi An & Dongseong Shin
Pages: 3675-3683
Published online: 23 Aug 2021
AbstractforMultivariate Assessment for Bioequivalence Based on the Correlation of Random Effect | Full Text | References | PDF (473.9 KB) | EPUB
  • 134 Views
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Article
Oleanolic Acid Attenuates Morphine Withdrawal Symptoms in Rodents: Association with Regulation of Dopamine Function
Zhiqi Shi, Shugang Pan, Luolin Wang & Sha Li
Pages: 3685-3696
Published online: 24 Aug 2021
AbstractforOleanolic Acid Attenuates Morphine Withdrawal Symptoms in Rodents: Association with Regulation of Dopamine Function | Full Text | References | PDF (2.7 MB) | EPUB
  • 237 Views
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Article
Puerarin Alleviates UUO-Induced Inflammation and Fibrosis by Regulating the NF-κB P65/STAT3 and TGFβ1/Smads Signaling Pathways
Jingyu Wang, Shuke Ge, Yaqing Wang, Yi Liu, Lihua Qiu, Junying Li, Xin Huang & Li Sun
Pages: 3697-3708
Published online: 24 Aug 2021
AbstractforPuerarin Alleviates UUO-Induced Inflammation and Fibrosis by Regulating the NF-κB P65/STAT3 and TGFβ1/Smads Signaling Pathways | Full Text | References | PDF (9.6 MB) | EPUB
  • 155 Views
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Letter

Letter
Role of Folate, Cobalamin, and Probiotics in COVID-19 Disease Management [Letter]
Dayab Asad & Syed Hasan Shuja
Pages: 3709-3710
Published online: 25 Aug 2021
CitationforRole of Folate, Cobalamin, and Probiotics in COVID-19 Disease Management [Letter] | Full Text | References | PDF (195.8 KB) | EPUB
  • 95 Views
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Original Research

Article
Retrospective Study of the Effects of Zoledronic Acid on Muscle Mass in Osteoporosis Patients
Chun-Feng Huang, Ming-Shi Shiao & Tso-Yen Mao
Pages: 3711-3715
Published online: 27 Aug 2021
AbstractforRetrospective Study of the Effects of Zoledronic Acid on Muscle Mass in Osteoporosis Patients | Full Text | References | PDF (941.5 KB) | EPUB
  • 208 Views
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Perspectives

Discussion
The Legislative Approach and System Improvement of China’s Compulsory Licensing for Drug Patents
Zhang Cao, Yichao Chen, Wenjie Jiang & Wei Li
Pages: 3717-3731
Published online: 01 Sep 2021
AbstractforThe Legislative Approach and System Improvement of China’s Compulsory Licensing for Drug Patents | Full Text | References | PDF (372.5 KB) | EPUB
  • 212 Views
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Retraction

Retraction
A Novel Bispecific Immunotoxin Delivered by Human Bone Marrow-Derived Mesenchymal Stem Cells to Target Blood Vessels and Vasculogenic Mimicry of Malignant Gliomas [Retraction]
Pages: 3733-3734
Published online: 02 Sep 2021
CitationforA Novel Bispecific Immunotoxin Delivered by Human Bone Marrow-Derived Mesenchymal Stem Cells to Target Blood Vessels and Vasculogenic Mimicry of Malignant Gliomas [Retraction] | Full Text | PDF (136.7 KB) | EPUB
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Original Research

Article
Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo
Zhiying Pang, Zengxin Jiang, Runwen Zhu, Chunfeng Song, Han Tang, Lu Cao & Changan Guo
Pages: 3735-3747
Published online: 04 Sep 2021
AbstractforBardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo | Full Text | References | PDF (10.3 MB) | EPUB
  • 166 Views
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Article
Integrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment
Kunpeng Wang, Xiongying Miao, Fanhua Kong, Siqi Huang, Jinggang Mo, Chong Jin & Yanwen Zheng
Pages: 3749-3764
Published online: 04 Sep 2021
AbstractforIntegrating Network Pharmacology and Experimental Verification to Explore the Mechanism of Effect of Zuojin Pills in Pancreatic Cancer Treatment | Full Text | References | PDF (15.2 MB) | EPUB
  • 177 Views
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Article
Determination of the 90% Effective Dose of Phenylephrine Boluses to Treat Spinal Anesthesia-Induced Hypotension in Patients with Severe Preeclampsia during Cesarean Delivery: A Pilot Study
Jin-Ping Liu, Zheng-Bin Pan, Miao Zhu, Guo-Wei Zhu, Da-Bing Song, Xin-Zhong Chen & Xiao-Wei Qian
Pages: 3765-3772
Published online: 07 Sep 2021
AbstractforDetermination of the 90% Effective Dose of Phenylephrine Boluses to Treat Spinal Anesthesia-Induced Hypotension in Patients with Severe Preeclampsia during Cesarean Delivery: A Pilot Study | Full Text | References | PDF (2.1 MB) | EPUB
  • 138 Views
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Review

Review Article
Pore-Forming Toxins During Bacterial Infection: Molecular Mechanisms and Potential Therapeutic Targets
Haijie Hu, Min Liu & Shuang Sun
Pages: 3773-3781
Published online: 07 Sep 2021
AbstractforPore-Forming Toxins During Bacterial Infection: Molecular Mechanisms and Potential Therapeutic Targets | Full Text | References | PDF (1.1 MB) | EPUB
  • 221 Views
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Original Research

Article
An Integrated Analysis of Network Pharmacology and Experimental Validation to Reveal the Mechanism of Chinese Medicine Formula Naotaifang in Treating Cerebral Ischemia-Reperfusion Injury
Tong Yang, Xiangyu Chen, Zhigang Mei, Xiaolu Liu, Zhitao Feng, Jun Liao, Yihui Deng & Jinwen Ge
Pages: 3783-3808
Published online: 07 Sep 2021
AbstractforAn Integrated Analysis of Network Pharmacology and Experimental Validation to Reveal the Mechanism of Chinese Medicine Formula Naotaifang in Treating Cerebral Ischemia-Reperfusion Injury | Full Text | References | PDF (22.8 MB) | EPUB
  • 235 Views
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Review

Review Article
An Overview of Lenalidomide in Combination with Rituximab for the Treatment of Adult Patients with Follicular Lymphoma: The Evidence to Date
Umut Yilmaz, Ayse Salihoglu & Teoman Soysal
Pages: 3809-3820
Published online: 07 Sep 2021
AbstractforAn Overview of Lenalidomide in Combination with Rituximab for the Treatment of Adult Patients with Follicular Lymphoma: The Evidence to Date | Full Text | References | PDF (351.3 KB) | EPUB
  • 179 Views
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Original Research

Article
Resveratrol Pretreatment Inhibits Myocardial Apoptosis in Rats Following Coronary Microembolization via Inducing the PI3K/Akt/GSK-3β Signaling Cascade
Tao Li, Zhiqing Chen, You Zhou, Haoliang Li, Jian Xie & Lang Li
Pages: 3821-3834
Published online: 07 Sep 2021
AbstractforResveratrol Pretreatment Inhibits Myocardial Apoptosis in Rats Following Coronary Microembolization via Inducing the PI3K/Akt/GSK-3β Signaling Cascade | Full Text | References | PDF (13.6 MB) | EPUB
  • 96 Views
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Article
In vitro Comparison of Pancreatic Enzyme Preparations Available in the Indian Market
Shailesh V Shrikhande, V G Mohan Prasad, J Enrique Domínguez-Muñoz, Kevin E Weigl & Kushal D Sarda
Pages: 3835-3843
Published online: 07 Sep 2021
AbstractforIn vitro Comparison of Pancreatic Enzyme Preparations Available in the Indian Market | Full Text | References | PDF (2.3 MB) | EPUB
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Article
The Jieduan-Niwan (JDNW) Formula Ameliorates Hepatocyte Apoptosis: A Study of the Inhibition of E2F1-Mediated Apoptosis Signaling Pathways in Acute-on-Chronic Liver Failure (ACLF) Using Rats
Weixin Hou, Yulin Hao, Wenlong Yang, Tian Tian, Peng Fang, Yuqiong Du, Lianyin Gao, Yanbin Gao & Qiuyun Zhang
Pages: 3845-3862
Published online: 08 Sep 2021
AbstractforThe Jieduan-Niwan (JDNW) Formula Ameliorates Hepatocyte Apoptosis: A Study of the Inhibition of E2F1-Mediated Apoptosis Signaling Pathways in Acute-on-Chronic Liver Failure (ACLF) Using Rats | Full Text | References | PDF (10.7 MB) | EPUB
  • 133 Views
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Review

Review Article
The Anticancer Potential of Maslinic Acid and Its Derivatives: A Review
Lei Yu, Xiaofang Xie, Xiaoyu Cao, Junren Chen, Guanru Chen, Yan Chen, Gangmin Li, Junyuan Qin, Fu Peng & Cheng Peng
Pages: 3863-3879
Published online: 09 Sep 2021
AbstractforThe Anticancer Potential of Maslinic Acid and Its Derivatives: A Review | Full Text | References | PDF (5.3 MB) | EPUB
  • 276 Views
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Review Article
Recent Advances of Microfluidic Platforms for Controlled Drug Delivery in Nanomedicine
Fikadu Ejeta
Pages: 3881-3891
Published online: 10 Sep 2021
AbstractforRecent Advances of Microfluidic Platforms for Controlled Drug Delivery in Nanomedicine | Full Text | References | PDF (429 KB) | EPUB
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Review Article
Sugammadex, the Guardian of Deep Muscle Relaxation During Conventional and Robot-Assisted Laparoscopic Surgery: A Narrative Review
Yan Sun, Zhilin Wu, Qi Wang, Rui Chen, Shujun Sun & Yun Lin
Pages: 3893-3901
Published online: 14 Sep 2021
AbstractforSugammadex, the Guardian of Deep Muscle Relaxation During Conventional and Robot-Assisted Laparoscopic Surgery: A Narrative Review | Full Text | References | PDF (396.6 KB) | EPUB
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Original Research

Article
Modeling and Simulation for Individualized Therapy of Amisulpride in Chinese Patients with Schizophrenia: Focus on Interindividual Variability, Therapeutic Reference Range and the Laboratory Alert Level
Shanqing Huang, Lu Li, Zhanzhang Wang, Tao Xiao, Xiaolin Li, Shujing Liu, Ming Zhang, Haoyang Lu, Yuguan Wen & Dewei Shang
Pages: 3903-3913
Published online: 14 Sep 2021
AbstractforModeling and Simulation for Individualized Therapy of Amisulpride in Chinese Patients with Schizophrenia: Focus on Interindividual Variability, Therapeutic Reference Range and the Laboratory Alert Level | Full Text | References | PDF (6.2 MB) | EPUB
  • 158 Views
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Article
LC–MS/MS Estimation of Rociletinib Levels in Human Liver Microsomes: Application to Metabolic Stability Estimation
Mohamed W Attwa, Ali S Abdelhameed & Adnan A Kadi
Pages: 3915-3925
Published online: 15 Sep 2021
AbstractforLC–MS/MS Estimation of Rociletinib Levels in Human Liver Microsomes: Application to Metabolic Stability Estimation | Full Text | References | PDF (4.3 MB) | EPUB
  • 177 Views
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Review

Review Article
Umbilical Cord Mesenchymal Stem Cell Therapy for Regenerative Treatment of Rheumatoid Arthritis: Opportunities and Challenges
Xiaolan Lv, Liming Wang, XiaoRong Zou & Shigao Huang
Pages: 3927-3936
Published online: 15 Sep 2021
AbstractforUmbilical Cord Mesenchymal Stem Cell Therapy for Regenerative Treatment of Rheumatoid Arthritis: Opportunities and Challenges | Full Text | References | PDF (1.1 MB) | EPUB
  • 638 Views
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Original Research

Article
Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis
Aiqin Li, Ifrah Nabi Khan, Ikram Ullah Khan, Abid Mehmood Yousaf & Yasser Shahzad
Pages: 3937-3952
Published online: 16 Sep 2021
AbstractforGellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis | Full Text | References | PDF (6.6 MB) | EPUB
  • 596 Views
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Article
CpG Oligodeoxynucleotide Developed to Activate Primate Immune Responses Promotes Antitumoral Effects in Combination with a Neoantigen-Based mRNA Cancer Vaccine
Qin Li, Jie Ren, Wei Liu, Guoqin Jiang & Rongkuan Hu
Pages: 3953-3963
Published online: 18 Sep 2021
AbstractforCpG Oligodeoxynucleotide Developed to Activate Primate Immune Responses Promotes Antitumoral Effects in Combination with a Neoantigen-Based mRNA Cancer Vaccine | Full Text | References | PDF (7.6 MB) | EPUB
  • 322 Views
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Article
Ketamine Induces Ferroptosis of Liver Cancer Cells by Targeting lncRNA PVT1/miR-214-3p/GPX4
Guan-Nan He, Na-Ren Bao, Shuang Wang, Man Xi, Tian-Hao Zhang & Feng-Shou Chen
Pages: 3965-3978
Published online: 18 Sep 2021
AbstractforKetamine Induces Ferroptosis of Liver Cancer Cells by Targeting lncRNA PVT1/miR-214-3p/GPX4 | Full Text | References | PDF (11.6 MB) | EPUB
  • 268 Views
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Article
Stability of Amoxicillin and Clavulanic Acid in Separate Containers for Administration via a Y-Site
Sarah Fawaz, Mahboub Merzouk, Stephen Barton & Shereen Nabhani-Gebara
Pages: 3979-3984
Published online: 21 Sep 2021
AbstractforStability of Amoxicillin and Clavulanic Acid in Separate Containers for Administration via a Y-Site | Full Text | References | PDF (1.5 MB) | EPUB
  • 335 Views
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Article
Selection of DNA Aptamers Recognizing EpCAM-Positive Prostate Cancer by Cell-SELEX for in vitro and in vivo MR Imaging
Jinman Zhong, Jianke Ding, Lei Deng, Ying Xiang, Duoduo Liu, Yanyan Zhang, Xin Chen & Quanxin Yang
Pages: 3985-3996
Published online: 21 Sep 2021
AbstractforSelection of DNA Aptamers Recognizing EpCAM-Positive Prostate Cancer by Cell-SELEX for in vitro and in vivo MR Imaging | Full Text | References | PDF (3.8 MB) | EPUB
  • 186 Views
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Review

Review Article
Non-Alcoholic Steatohepatitis (NASH) – A Review of a Crowded Clinical Landscape, Driven by a Complex Disease
Julia M Fraile, Soumya Palliyil, Caroline Barelle, Andrew J Porter & Marina Kovaleva
Pages: 3997-4009
Published online: 22 Sep 2021
AbstractforNon-Alcoholic Steatohepatitis (NASH) – A Review of a Crowded Clinical Landscape, Driven by a Complex Disease | Full Text | References | PDF (2.9 MB) | EPUB
  • 831 Views
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Original Research

Article
A Network Pharmacology Study on the Molecular Mechanism of Protocatechualdehyde in the Treatment of Diabetic Cataract
Xiao Cheng, Zhihui Song, Xin Wang, Shanshan Xu, Liming Dong, Jie Bai, Guangyao Li & Chao Zhang
Pages: 4011-4023
Published online: 23 Sep 2021
AbstractforA Network Pharmacology Study on the Molecular Mechanism of Protocatechualdehyde in the Treatment of Diabetic Cataract | Full Text | References | PDF (11.4 MB) | EPUB
  • 148 Views
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Article
Antioxidant, Anti-Aging and Organ Protective Effects of Total Saponins from Aralia taibaiensis
Huan Li, Bingtao Zhai, Jing Sun, Yu Fan, Junbo Zou, Jiangxue Cheng, Xiaofei Zhang, Yajun Shi & Dongyan Guo
Pages: 4025-4042
Published online: 23 Sep 2021
AbstractforAntioxidant, Anti-Aging and Organ Protective Effects of Total Saponins from Aralia taibaiensis | Full Text | References | PDF (12.4 MB) | EPUB
  • 396 Views
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Article
Synergistic Dose Permutation of Isolated Alkaloid and Sterol for Anticancer Effect on Young Swiss Albino Mice
Nada H Aljarba, Huma Ali & Saad Alkahtani
Pages: 4043-4052
Published online: 23 Sep 2021
AbstractforSynergistic Dose Permutation of Isolated Alkaloid and Sterol for Anticancer Effect on Young Swiss Albino Mice | Full Text | References | PDF (1.3 MB) | EPUB
  • 233 Views
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Article
The Synergistic Effects of Astragalus mongholicus and Salvia miltiorrhiza on Coronary Heart Disease Identified by Network Pharmacology and Experiment
Yun Zhang, Jie Wang, Yong-Mei Liu, Yin-Ying Chen, Xiao-Chen Yang & Lian Duan
Pages: 4053-4069
Published online: 27 Sep 2021
AbstractforThe Synergistic Effects of Astragalus mongholicus and Salvia miltiorrhiza on Coronary Heart Disease Identified by Network Pharmacology and Experiment | Full Text | References | PDF (12.8 MB) | EPUB
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Review

Review Article
Evolution of Drug Delivery Systems for Recurrent Aphthous Stomatitis
Ine Suharyani, Ahmed Fouad Abdelwahab Mohammed, Muchtaridi Muchtaridi, Nasrul Wathoni & Marline Abdassah
Pages: 4071-4089
Published online: 27 Sep 2021
AbstractforEvolution of Drug Delivery Systems for Recurrent Aphthous Stomatitis | Full Text | References | PDF (4.2 MB) | EPUB
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Review Article
Topical Lidocaine for Chronic Pain Treatment
Marion Voute, Véronique Morel & Gisèle Pickering
Pages: 4091-4103
Published online: 29 Sep 2021
AbstractforTopical Lidocaine for Chronic Pain Treatment | Full Text | References | PDF (1.2 MB) | EPUB
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Original Research

Article
Orally Deliverable Dual-Targeted Pellets for the Synergistic Treatment of Ulcerative Colitis
Xiaomeng Tang, Meng Yang, Yongwei Gu, Liangdi Jiang, Yue Du & Jiyong Liu
Pages: 4105-4123
Published online: 29 Sep 2021
AbstractforOrally Deliverable Dual-Targeted Pellets for the Synergistic Treatment of Ulcerative Colitis | Full Text | References | PDF (17.1 MB) | EPUB
  • 225 Views
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Article
Identification of Active Compounds and Mechanism of Huangtu Decoction for the Treatment of Ulcerative Colitis by Network Pharmacology Combined with Experimental Verification
Wenwen Chen, Lin He, Lian Zhong, Jiayi Sun, Lilin Zhang, Daneng Wei & Chunjie Wu
Pages: 4125-4140
Published online: 29 Sep 2021
AbstractforIdentification of Active Compounds and Mechanism of Huangtu Decoction for the Treatment of Ulcerative Colitis by Network Pharmacology Combined with Experimental Verification | Full Text | References | PDF (12.2 MB) | EPUB
  • 208 Views
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Article
Transcriptome-Based Analysis Reveals Therapeutic Effects of Resveratrol on Endometriosis in aRat Model
Chunyan Wang, Zhengyun Chen, Xianlei Zhao, Cuicui Lin, Shenghui Hong, Yuhan Lou, Xiaomeng Shi, Mengdan Zhao, Xiaohang Yang, Min-Xin Guan & Yongmei Xi
Pages: 4141-4155
Published online: 29 Sep 2021
AbstractforTranscriptome-Based Analysis Reveals Therapeutic Effects of Resveratrol on Endometriosis in aRat Model | Full Text | References | PDF (12.1 MB) | EPUB
  • 240 Views
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Article
The Role of Pretreatment 18F-FDG PET/CT for Early Prediction of Neoadjuvant Chemotherapy Response in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma
Jijin Yao, Ying Wang, Yujing Lin, Yingying Yang, Jingjing Wan, Xiaohua Gong, Fanwei Zhang, Wangjian Zhang, Tia Marks, Siyang Wang, Hongjun Jin & Hong Shan
Pages: 4157-4166
Published online: 01 Oct 2021
AbstractforThe Role of Pretreatment 18F-FDG PET/CT for Early Prediction of Neoadjuvant Chemotherapy Response in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma | Full Text | References | PDF (4.6 MB) | EPUB
  • 107 Views
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Methodology

Article
Development of an UPLC-MS/MS Method for the Quantitative Analysis of Upadacitinib in Beagle Dog Plasma and Pharmacokinetics Study
Meng-Jie Wang, Yu-Hang Zhao, Chen Fan, Ying-Jie Wang, Xin-Qi Wang, Xiang-Jun Qiu & Rui-Le Shen
Pages: 4167-4175
Published online: 02 Oct 2021
AbstractforDevelopment of an UPLC-MS/MS Method for the Quantitative Analysis of Upadacitinib in Beagle Dog Plasma and Pharmacokinetics Study | Full Text | References | PDF (2.9 MB) | EPUB
  • 259 Views
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Original Research

Article
Synthesis of Novel Pinocembrin Amino Acid Derivatives and Their Antiaging Effect on Caenorhabditis elegans via the Modulating DAF-16/FOXO
Wenqi Wang, Xin Feng, Yu Du, Cen Liu, Xinxin Pang, Kunxiu Jiang, Xirui Wang & Yonggang Liu
Pages: 4177-4193
Published online: 05 Oct 2021
AbstractforSynthesis of Novel Pinocembrin Amino Acid Derivatives and Their Antiaging Effect on Caenorhabditis elegans via the Modulating DAF-16/FOXO | Full Text | References | PDF (11.4 MB) | EPUB
  • 148 Views
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Article
Novel Anti-Tubulin Compounds from Trigonella foenum-graecum Seeds; Insights into In-vitro and Molecular Docking Studies
Sahar Saleh Alghamdi, Rasha Saad Suliman, Amjad Sulaiman Alsaeed, Khlood Khaled Almutairi, Norah Abdulaziz Aljammaz, Abdulelah Altolayyan, Rizwan Ali & Alshaimaa Alhallaj
Pages: 4195-4211
Published online: 05 Oct 2021
AbstractforNovel Anti-Tubulin Compounds from Trigonella foenum-graecum Seeds; Insights into In-vitro and Molecular Docking Studies | Full Text | References | PDF (11.7 MB) | EPUB
  • 252 Views
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Article
Development and Characterization of Ulvan Polysaccharides-Based Hydrogel Films for Potential Wound Dressing Applications
Evi Sulastri, Muhammad Sulaiman Zubair, Ronny Lesmana, Ahmed Fouad Abdelwahab Mohammed & Nasrul Wathoni
Pages: 4213-4226
Published online: 05 Oct 2021
AbstractforDevelopment and Characterization of Ulvan Polysaccharides-Based Hydrogel Films for Potential Wound Dressing Applications | Full Text | References | PDF (6.4 MB) | EPUB
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Letter

Letter
Saroglitazar – A Potential Therapeutic Option in Treating NASH? [Letter]
Syed Hasan Shuja, Farea Eqbal & Hafsa Rehman
Pages: 4227-4228
Published online: 08 Oct 2021
CitationforSaroglitazar – A Potential Therapeutic Option in Treating NASH? [Letter] | Full Text | References | PDF (193.5 KB) | EPUB
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Original Research

Article
A Promising Single Oral Disintegrating Tablet for Co-Delivery of Pitavastatin Calcium and Lornoxicam Using Co-Processed Excipients: Formulation, Characterization and Pharmacokinetic Study
Mahmoud H Teaima, Khaled M Abdel-Haleem, Rewan Osama, Mohamed A El-Nabarawi & Osama S Elnahas
Pages: 4229-4242
Published online: 07 Oct 2021
AbstractforA Promising Single Oral Disintegrating Tablet for Co-Delivery of Pitavastatin Calcium and Lornoxicam Using Co-Processed Excipients: Formulation, Characterization and Pharmacokinetic Study | Full Text | References | PDF (5.9 MB) | EPUB
  • 409 Views
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Article
The Therapeutic Effects of Curcumin in Early Septic Acute Kidney Injury: An Experimental Study
Shuo Wang, Ping Zhao, Ying Zhang, Lianhua Zhu, Jianing Zhu, Yukun Luo & Qiuyang Li
Pages: 4243-4255
Published online: 07 Oct 2021
AbstractforThe Therapeutic Effects of Curcumin in Early Septic Acute Kidney Injury: An Experimental Study | Full Text | References | PDF (9.6 MB) | EPUB
  • 121 Views
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Corrigendum

Correction
Synthesis of Novel Pinocembrin Amino Acid Derivatives and Their Antiaging Effect on Caenorhabditis elegans via the Modulating DAF-16/FOXO [Corrigendum]
Pages: 4257-4258
Published online: 11 Oct 2021
CitationforSynthesis of Novel Pinocembrin Amino Acid Derivatives and Their Antiaging Effect on Caenorhabditis elegans via the Modulating DAF-16/FOXO [Corrigendum] | Full Text | PDF (139.4 KB) | EPUB
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Original Research

Article
Investigation of the Active Ingredients and Mechanism of Hudi Enteric-Coated Capsules in DSS-Induced Ulcerative Colitis Mice Based on Network Pharmacology and Experimental Verification
Panghua Ding, Jiajing Liu, Qiuyi Li, Qiongqiong Lu, Junxiang Li, Rui Shi, Lei Shi, Tangyou Mao, Dongyu Ge, HaiJun Niu, Guiying Peng & Zhibin Wang
Pages: 4259-4273
Published online: 08 Oct 2021
AbstractforInvestigation of the Active Ingredients and Mechanism of Hudi Enteric-Coated Capsules in DSS-Induced Ulcerative Colitis Mice Based on Network Pharmacology and Experimental Verification | Full Text | References | PDF (10.9 MB) | EPUB
  • 196 Views
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Article
Triptolide is a Promising Therapeutic Approach in Treating Thyroid Cancer Based on in silico and in vitro Experiment
Fang Wang, Shu-Jing An, Yirong Yin, Juan-Juan Li, Chun-Hui Sun, Jie Lan, Wen-Juan Zhao & Cheng-Qian Li
Pages: 4275-4287
Published online: 11 Oct 2021
AbstractforTriptolide is a Promising Therapeutic Approach in Treating Thyroid Cancer Based on in silico and in vitro Experiment | Full Text | References | PDF (11.1 MB) | EPUB
  • 157 Views
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Review

Review Article
The Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug Design
Yong Ling, Zhi-You Hao, Dong Liang, Chun-Lei Zhang, Yan-Fei Liu & Yan Wang
Pages: 4289-4338
Published online: 13 Oct 2021
AbstractforThe Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug Design | Full Text | References | PDF (31.6 MB) | EPUB
  • 2236 Views
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Original Research

Article
Maackiain Protects the Kidneys of Type 2 Diabetic Rats via Modulating the Nrf2/HO-1 and TLR4/NF-κB/Caspase-3 Pathways
Jiahong Guo, Junying Li, Hua Wei & Zhaozhi Liang
Pages: 4339-4358
Published online: 14 Oct 2021
AbstractforMaackiain Protects the Kidneys of Type 2 Diabetic Rats via Modulating the Nrf2/HO-1 and TLR4/NF-κB/Caspase-3 Pathways | Full Text | References | PDF (18.3 MB) | EPUB
  • 245 Views
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Review

Review Article
Translational Regulation in Hepatocellular Carcinogenesis
Suzana Bracic Tomazic, Christoph Schatz & Johannes Haybaeck
Pages: 4359-4369
Published online: 14 Oct 2021
AbstractforTranslational Regulation in Hepatocellular Carcinogenesis | Full Text | References | PDF (4.1 MB) | EPUB
  • 107 Views
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Original Research

Article
The Steady-State Comparative Bioavailability of Intramuscular Risperidone ISM and Oral Risperidone: An Open-Label, One-Sequence Study
David P Walling, Howard A Hassman, Lourdes Anta, Lourdes Ochoa, Ignacio Ayani, Javier Martínez & Ibon Gutierro
Pages: 4371-4382
Published online: 15 Oct 2021
AbstractforThe Steady-State Comparative Bioavailability of Intramuscular Risperidone ISM and Oral Risperidone: An Open-Label, One-Sequence Study | Full Text | References | PDF (1.3 MB) | EPUB
  • 419 Views
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Article
Formulation and Evaluation of Baclofen-Meloxicam Orally Disintegrating Tablets (ODTs) Using Co-Processed Excipients and Improvement of ODTs Performance Using Six Sigma Method
Rehab Abdelmonem, Menna M Abdellatif, Inas Essam Ibrahim Al-Samadi & Mohamed A El-Nabarawi
Pages: 4383-4402
Published online: 16 Oct 2021
AbstractforFormulation and Evaluation of Baclofen-Meloxicam Orally Disintegrating Tablets (ODTs) Using Co-Processed Excipients and Improvement of ODTs Performance Using Six Sigma Method | Full Text | References | PDF (13.1 MB) | EPUB
  • 769 Views
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Article
Unravelling the Protective Effects of Emodin Against Cyclophosphamide Induced Gonadotoxicity in Male Wistar Rats
Yinhua Wang, Zhaoling Zou, Amit Jaisi & Opeyemi Joshua Olatunji
Pages: 4403-4411
Published online: 19 Oct 2021
AbstractforUnravelling the Protective Effects of Emodin Against Cyclophosphamide Induced Gonadotoxicity in Male Wistar Rats | Full Text | References | PDF (6.2 MB) | EPUB
  • 199 Views
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Article
Mechanism of Yinqin Oral Liquid in the Treatment of Chronic Pharyngitis Based on Network Pharmacology
Shiliang Ji, Fei Xu, Ruifang Zhu, Cheng Wang, Dongkai Guo & Yiguo Jiang
Pages: 4413-4421
Published online: 20 Oct 2021
AbstractforMechanism of Yinqin Oral Liquid in the Treatment of Chronic Pharyngitis Based on Network Pharmacology | Full Text | References | PDF (4.4 MB) | EPUB
  • 127 Views
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Article
The Effects of Primary Unconjugated Bile Acids on Nanoencapsulated Pharmaceutical Formulation of Hydrophilic Drugs: Pharmacological Implications
Armin Mooranian, Thomas Foster, Corina M Ionescu, Louise Carey, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Edan Johnstone, Jafri Kuthubutheen, Daniel Brown, Marcus D Atlas, Momir Mikov & Hani Al-Salami
Pages: 4423-4434
Published online: 23 Oct 2021
AbstractforThe Effects of Primary Unconjugated Bile Acids on Nanoencapsulated Pharmaceutical Formulation of Hydrophilic Drugs: Pharmacological Implications | Full Text | References | PDF (6 MB) | EPUB
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Clinical Trial Report

Case Report
Effect of 2% Hyaluronic Acid on the Rate of Healing of Corneal Epithelial Defect After Pterygium Surgery: A Randomized Controlled Trial
Winai Chaidaroon, Narudom Satayawut & Napaporn Tananuvat
Pages: 4435-4443
Published online: 27 Oct 2021
AbstractforEffect of 2% Hyaluronic Acid on the Rate of Healing of Corneal Epithelial Defect After Pterygium Surgery: A Randomized Controlled Trial | Full Text | References | PDF (2.9 MB) | EPUB
  • 255 Views
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Retraction

Retraction
Cinobufagin Suppresses the Characteristics of Osteosarcoma Cancer Cells by Inhibiting the IL-6-OPN-STAT3 Pathway [Retraction]
Pages: 4445-4446
Published online: 27 Oct 2021
CitationforCinobufagin Suppresses the Characteristics of Osteosarcoma Cancer Cells by Inhibiting the IL-6-OPN-STAT3 Pathway [Retraction] | Full Text | PDF (137.7 KB) | EPUB
  • 85 Views
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Review

Review Article
An Overview on the Potential Roles of EGCG in the Treatment of COVID-19 Infection
Sabrina Bimonte, Cira Antonietta Forte, Massimiliano Cuomo, Gennaro Esposito, Marco Cascella & Arturo Cuomo
Pages: 4447-4454
Published online: 28 Oct 2021
AbstractforAn Overview on the Potential Roles of EGCG in the Treatment of COVID-19 Infection | Full Text | References | PDF (1.2 MB) | EPUB
  • 269 Views
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Original Research

Article
Enhancement of Cancer Chemotherapeutic Efficacy via Bone-Targeted Drug Delivery Carrier in Bone Metastases
Xinghe Xue, Jiachen Yu, Fengfeng Lu, Hongyi Jiang & Xiangyang Wang
Pages: 4455-4468
Published online: 28 Oct 2021
AbstractforEnhancement of Cancer Chemotherapeutic Efficacy via Bone-Targeted Drug Delivery Carrier in Bone Metastases | Full Text | References | PDF (9.4 MB) | EPUB
  • 153 Views
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Article
An Industrial Procedure for Pharmacodynamic Improvement of Metformin HCl via Granulation with Its Paracellular Pathway Enhancer Using Factorial Experimental Design
Omar Y Mady, Adam A Al-Shoubki & Ahmed A Donia
Pages: 4469-4487
Published online: 02 Nov 2021
AbstractforAn Industrial Procedure for Pharmacodynamic Improvement of Metformin HCl via Granulation with Its Paracellular Pathway Enhancer Using Factorial Experimental Design | Full Text | References | PDF (7.7 MB) | EPUB
  • 193 Views
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Article
Artemisinin Improves Acetylcholine-Induced Vasodilatation in Rats with Primary Hypertension
Xuanxuan Liu, Xingxing Wang, Yan Pan, Li Zhao, Shuo Sun, Ang Luo, Changlei Bao, Haiyang Tang & Ying Han
Pages: 4489-4502
Published online: 02 Nov 2021
AbstractforArtemisinin Improves Acetylcholine-Induced Vasodilatation in Rats with Primary Hypertension | Full Text | References | PDF (10.1 MB) | EPUB
  • 455 Views
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Review

Review Article
Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures
Ying Peng, Mingyue Ao, Baohua Dong, Yunxiu Jiang, Lingying Yu, Zhimin Chen, Changjiang Hu & Runchun Xu
Pages: 4503-4525
Published online: 02 Nov 2021
AbstractforAnti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures | Full Text | References | PDF (3.1 MB) | EPUB
  • 3533 Views
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Review Article
Chemistry, Biosynthesis, Physicochemical and Biological Properties of Rubiadin: A Promising Natural Anthraquinone for New Drug Discovery and Development
Mohd Nasarudin Watroly, Mahendran Sekar, Shivkanya Fuloria, Siew Hua Gan, Srikanth Jeyabalan, Yuan Seng Wu, Vetriselvan Subramaniyan, Kathiresan V Sathasivam, Subban Ravi, Nur Najihah Izzati Mat Rani, Pei Teng Lum, Jaishree Vaijanathappa, Dhanalekshmi Unnikrishnan Meenakshi, Shankar Mani & Neeraj Kumar Fuloria
Pages: 4527-4549
Published online: 03 Nov 2021
AbstractforChemistry, Biosynthesis, Physicochemical and Biological Properties of Rubiadin: A Promising Natural Anthraquinone for New Drug Discovery and Development | Full Text | References | PDF (14.5 MB) | EPUB
  • 1262 Views
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Original Research

Article
Efficacy of Pre-Treatment with Remimazolam on Prevention of Propofol-Induced Injection Pain in Patients Undergoing Abortion or Curettage: A Prospective, Double-Blinded, Randomized and Placebo-Controlled Clinical Trial
Xuehai Guan, Ziyin Jiao, Xiaofang Gong, Huiyu Cao, Susu Liu, Hongmeng Lan, Xiaofang Huang, Yanmeng Tan, Bing Xu & Chengxin Lin
Pages: 4551-4558
Published online: 04 Nov 2021
AbstractforEfficacy of Pre-Treatment with Remimazolam on Prevention of Propofol-Induced Injection Pain in Patients Undergoing Abortion or Curettage: A Prospective, Double-Blinded, Randomized and Placebo-Controlled Clinical Trial | Full Text | References | PDF (1.9 MB) | EPUB
  • 149 Views
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Article
Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling
Qingling Guo, Haili Qu, Hong Zhang & Xia Zhong
Pages: 4559-4574
Published online: 04 Nov 2021
AbstractforPrunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling | Full Text | References | PDF (12.7 MB) | EPUB
  • 163 Views
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Article
A Validated HPLC-MS/MS Method for Quantification of Methotrexate and Application for Therapeutic Drug Monitoring in Children and Adults with Non-Hodgkin Lymphoma
Zhangying Feng, Jinglin Gao, Xiaonan Gao, Li Hua, Xuyang Nie, Yaqi Sun & Mingxia Wang
Pages: 4575-4583
Published online: 05 Nov 2021
AbstractforA Validated HPLC-MS/MS Method for Quantification of Methotrexate and Application for Therapeutic Drug Monitoring in Children and Adults with Non-Hodgkin Lymphoma | Full Text | References | PDF (2.8 MB) | EPUB
  • 175 Views
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Article
Exploring the Underlying Mechanism of Shenyankangfu Tablet in the Treatment of Glomerulonephritis Through Network Pharmacology, Machine Learning, Molecular Docking, and Experimental Validation
Meiling Jin, Wenwen Ren, Weiguang Zhang, Linchang Liu, Zhiwei Yin & Diangeng Li
Pages: 4585-4601
Published online: 09 Nov 2021
AbstractforExploring the Underlying Mechanism of Shenyankangfu Tablet in the Treatment of Glomerulonephritis Through Network Pharmacology, Machine Learning, Molecular Docking, and Experimental Validation | Full Text | References | PDF (13.4 MB) | EPUB
  • 136 Views
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Article
Transdermal Delivery of Telmisartan: Formulation, in vitro, ex vivo, Iontophoretic Permeation Enhancement and Comparative Pharmacokinetic Study in Rats
Mahmoud Teaima, Rehab Abdelmonem, Yomna A Adel, Mohamed A El-Nabarawi & Tayseer M El-Nawawy
Pages: 4603-4614
Published online: 10 Nov 2021
AbstractforTransdermal Delivery of Telmisartan: Formulation, in vitro, ex vivo, Iontophoretic Permeation Enhancement and Comparative Pharmacokinetic Study in Rats | Full Text | References | PDF (4 MB) | EPUB
  • 432 Views
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Review

Review Article
A review on the molecular basis underlying the protective effects of Andrographis paniculata and andrographolide against myocardial injury
Sok Kuan Wong, Kok-Yong Chin & Soelaiman Ima-Nirwana
Pages: 4615-4632
Published online: 10 Nov 2021
AbstractforA review on the molecular basis underlying the protective effects of Andrographis paniculata and andrographolide against myocardial injury | Full Text | References | PDF (4.8 MB) | EPUB
  • 293 Views
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Original Research

Article
The Effect of Metformin on the Proliferation, Apoptosis and CD133 mRNA Expression of Colon Cancer Stem Cells by Upregulation of miR 342-3p
Yaqin Zhang, Ruofei Chen, Lili Deng, Zongwen Shuai & Mingwei Chen
Pages: 4633-4647
Published online: 11 Nov 2021
AbstractforThe Effect of Metformin on the Proliferation, Apoptosis and CD133 mRNA Expression of Colon Cancer Stem Cells by Upregulation of miR 342-3p | Full Text | References | PDF (6.2 MB) | EPUB
  • 158 Views
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Article
A New Strategy for the Rapid Identification and Validation of the Direct Targets of Aconitine-Induced Cardiotoxicity
Jinxia Wei, Simiao Fan, Hongxin Yu, Lexin Shu & Yubo Li
Pages: 4649-4664
Published online: 13 Nov 2021
AbstractforA New Strategy for the Rapid Identification and Validation of the Direct Targets of Aconitine-Induced Cardiotoxicity | Full Text | References | PDF (8.7 MB) | EPUB
  • 131 Views
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Article
A Retrospective Cohort Study Evaluates Clinical Value of Anlotinib in Persistent, Metastatic, or Recurrent Cervical Cancer After Failure of First-Line Therapy
Hui Yang, Shaoxing Sun, Zijie Mei, Qingming Xiang, Chunxu Yang, Min Chen, Conghua Xie, Yunfeng Zhou & Hui Qiu
Pages: 4665-4674
Published online: 16 Nov 2021
AbstractforA Retrospective Cohort Study Evaluates Clinical Value of Anlotinib in Persistent, Metastatic, or Recurrent Cervical Cancer After Failure of First-Line Therapy | Full Text | References | PDF (414 KB) | EPUB
  • 124 Views
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Article
The Efficacy and Safety of Remimazolam Tosilate versus Etomidate-Propofol in Elderly Outpatients Undergoing Colonoscopy: A Prospective, Randomized, Single-Blind, Non-Inferiority Trial
Xianwen Liu, Baofeng Ding, Fu Shi, Yang Zhang, Lei Liu, Yongwei Sha & Tonghang Zhao
Pages: 4675-4685
Published online: 16 Nov 2021
AbstractforThe Efficacy and Safety of Remimazolam Tosilate versus Etomidate-Propofol in Elderly Outpatients Undergoing Colonoscopy: A Prospective, Randomized, Single-Blind, Non-Inferiority Trial | Full Text | References | PDF (4.6 MB) | EPUB
  • 221 Views
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Article
Activation of GPR18 by Resolvin D2 Relieves Pain and Improves Bladder Function in Cyclophosphamide-Induced Cystitis Through Inhibiting TRPV1
Qudong Lu, Yang Yang, Hengshuai Zhang, Cheng Chen, Jiang Zhao, Zhenxing Yang, Yi Fan, Longkun Li, Huan Feng, Jingzhen Zhu & Shanhong Yi
Pages: 4687-4699
Published online: 15 Nov 2021
AbstractforActivation of GPR18 by Resolvin D2 Relieves Pain and Improves Bladder Function in Cyclophosphamide-Induced Cystitis Through Inhibiting TRPV1 | Full Text | References | PDF (9.2 MB) | EPUB
  • 151 Views
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Article
Antifungal Effects and Potential Mechanisms of Benserazide Hydrochloride Alone and in Combination with Fluconazole Against Candida albicans
Xueqi Chen, Jiyong Wu, Lei Sun, Jing Nie, Shan Su & Shujuan Sun
Pages: 4701-4711
Published online: 16 Nov 2021
AbstractforAntifungal Effects and Potential Mechanisms of Benserazide Hydrochloride Alone and in Combination with Fluconazole Against Candida albicans | Full Text | References | PDF (1.9 MB) | EPUB
  • 113 Views
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Review

Review Article
Therapeutic Effects and Safe Uses of Plant-Derived Polyphenolic Compounds in Cardiovascular Diseases: A Review
Badriyah Shadid Alotaibi, Munazza Ijaz, Manal Buabeid, Zelal Jaber Kharaba, Hafiza Sidra Yaseen & Ghulam Murtaza
Pages: 4713-4732
Published online: 20 Nov 2021
AbstractforTherapeutic Effects and Safe Uses of Plant-Derived Polyphenolic Compounds in Cardiovascular Diseases: A Review | Full Text | References | PDF (4.3 MB) | EPUB
  • 1096 Views
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Original Research

Article
Clinical Effect of Doxycycline Combined with Compound Sulfamethoxazole and Rifampicin in the Treatment of Brucellosis Spondylitis
Xin-Ming Yang, Yong-Li Jia, Ying Zhang, Pei-Nan Zhang, Yao Yao, Yan-Lin Yin & Ye Tian
Pages: 4733-4740
Published online: 23 Nov 2021
AbstractforClinical Effect of Doxycycline Combined with Compound Sulfamethoxazole and Rifampicin in the Treatment of Brucellosis Spondylitis | Full Text | References | PDF (1.4 MB) | EPUB
  • 200 Views
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Article
Inhibition of Lipopolysaccharide-Induced Inflammatory Bone Loss by Saikosaponin D is Associated with Regulation of the RANKL/RANK Pathway
Xinhui Wu, Kangxian Zhao, Xiaoxin Fang, Feng Lu, Weikang Zhang, Xiaoting Song, Lihua Chen, Jiacheng Sun & Haixiao Chen
Pages: 4741-4757
Published online: 23 Nov 2021
AbstractforInhibition of Lipopolysaccharide-Induced Inflammatory Bone Loss by Saikosaponin D is Associated with Regulation of the RANKL/RANK Pathway | Full Text | References | PDF (13.3 MB) | EPUB
  • 147 Views
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Corrigendum

Correction
Hearing Protection Outcomes of Analog Electrode Arrays Coated with Different Drug-Eluting Polymer Films Implanted into Guinea Pig Cochleae [Corrigendum]
Pages: 4759-4760
Published online: 24 Nov 2021
CitationforHearing Protection Outcomes of Analog Electrode Arrays Coated with Different Drug-Eluting Polymer Films Implanted into Guinea Pig Cochleae [Corrigendum] | Full Text | PDF (156 KB) | EPUB
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Original Research

Article
Toxicological Evaluation of a Probiotic-Based Delivery System for P8 Protein as an Anti-Colorectal Cancer Drug
Byung Chull An, Yeo-Sang Yoon, Ho Jin Park, Sangkyun Park, Tai Yeub Kim, Jun Young Ahn, Daebeom Kwon, Oksik Choi, Jin Young Heo, Yongku Ryu, Joong-Hyun Kim, Heejong Eom & Myung Jun Chung
Pages: 4761-4793
Published online: 27 Nov 2021
AbstractforToxicological Evaluation of a Probiotic-Based Delivery System for P8 Protein as an Anti-Colorectal Cancer Drug | Full Text | References | PDF (5.6 MB) | EPUB
  • 193 Views
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Article
Berberine Influences the Survival of Fat Grafting by Inhibiting Autophagy and Apoptosis of Human Adipose Derived Mesenchymal Stem Cells
Hao Pang, Yongting Zhou, Jie Wang, Hao Wu, Xueyi Liu, Feng Gao & Zhibo Xiao
Pages: 4795-4809
Published online: 30 Nov 2021
AbstractforBerberine Influences the Survival of Fat Grafting by Inhibiting Autophagy and Apoptosis of Human Adipose Derived Mesenchymal Stem Cells | Full Text | References | PDF (12.7 MB) | EPUB
  • 135 Views
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Article
Oroxin B Attenuates Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Formation and Activity
Jun-ming Huang, Chen-zhong Wang, Shun-yi Lu, Zhe Wang & Zuo-qin Yan
Pages: 4811-4825
Published online: 30 Nov 2021
AbstractforOroxin B Attenuates Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Formation and Activity | Full Text | References | PDF (16.1 MB) | EPUB
  • 125 Views
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Article
UPLC–MS/MS and Network Pharmacology-Based Analysis of Bioactive Anti-Depression Compounds in Betel Nut
Yunjia Yang, Hairong Huang, Zeying Cui, Jun Chu & Guankui Du
Pages: 4827-4836
Published online: 30 Nov 2021
AbstractforUPLC–MS/MS and Network Pharmacology-Based Analysis of Bioactive Anti-Depression Compounds in Betel Nut | Full Text | References | PDF (6.3 MB) | EPUB
  • 345 Views
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Article
Methylcobalamin Protects Melanocytes from H2O2-Induced Oxidative Stress by Activating the Nrf2/HO-1 Pathway
Ran An, Dong Li, Yingying Dong, Qiuyun She, Ting Zhou, Xiaoqi Nie, Ronghua Pan & Yunhua Deng
Pages: 4837-4848
Published online: 30 Nov 2021
AbstractforMethylcobalamin Protects Melanocytes from H2O2-Induced Oxidative Stress by Activating the Nrf2/HO-1 Pathway | Full Text | References | PDF (6.9 MB) | EPUB
  • 187 Views
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Review

Review Article
New Insights of Anti-Hyperglycemic Agents and Traditional Chinese Medicine on Gut Microbiota in Type 2 Diabetes
Yanxia Chen & Mian Wang
Pages: 4849-4863
Published online: 30 Nov 2021
AbstractforNew Insights of Anti-Hyperglycemic Agents and Traditional Chinese Medicine on Gut Microbiota in Type 2 Diabetes | Full Text | References | PDF (1.9 MB) | EPUB
  • 228 Views
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Original Research

Article
The Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique
Hui-jun Wang, Chun-yan Zhou, Yan-ding Su, Kai-feng Gou, Xiao-nan Geng & Xiang-jun Qiu
Pages: 4865-4873
Published online: 30 Nov 2021
AbstractforThe Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique | Full Text | References | PDF (3.1 MB) | EPUB
  • 194 Views
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Article
Ruxolitinib for Treatment of Steroid-Refractory Graft-versus-Host Disease: Real-World Data from Chinese Patients
Cong Wei, Xiaoting Zhang, Dan Liang, Jilong Yang, Jingwen Du, Chunyan Yue & Lan Deng
Pages: 4875-4883
Published online: 30 Nov 2021
AbstractforRuxolitinib for Treatment of Steroid-Refractory Graft-versus-Host Disease: Real-World Data from Chinese Patients | Full Text | References | PDF (2 MB) | EPUB
  • 147 Views
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Article
Ventilagolin Suppresses Migration, Invasion and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells by Downregulating Pim-1
Ying Liu, Dao-Hai Cheng, Ke-Dao Lai, Hua Su, Guo-Shou Lu, Li Wang & Ji-Hua Lv
Pages: 4885-4899
Published online: 01 Dec 2021
AbstractforVentilagolin Suppresses Migration, Invasion and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells by Downregulating Pim-1 | Full Text | References | PDF (11.2 MB) | EPUB
  • 114 Views
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Article
Protective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts
Qiuting Mo, Hao Fu, Dan Zhao, Jiachan Zhang, Changtao Wang, Dongdong Wang & Meng Li
Pages: 4901-4909
Published online: 01 Dec 2021
AbstractforProtective Effects of Mogroside V on Oxidative Stress Induced by H2O2 in Skin Fibroblasts | Full Text | References | PDF (5.4 MB) | EPUB
  • 327 Views
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Article
Network Pharmacology and Experimental Validation to Reveal the Pharmacological Mechanisms of Liuwei Dihuang Decoction Against Intervertebral Disc Degeneration
Huihao Zhang, Sai Yao, Zhiguo Zhang, Chengcong Zhou, Fangda Fu, Yishan Bian, Huan Luo, Yan Li, Shuxin Yan, Yuying Ge, Yuying Chen, Kunyu Zhan, Yanzhi Ge, Zuxiang Chen, Ming Yue, Xiaofeng Li, Weibin Du, Hongting Jin, Peijian Tong, Hongfeng Ruan & Chengliang Wu
Pages: 4911-4924
Published online: 02 Dec 2021
AbstractforNetwork Pharmacology and Experimental Validation to Reveal the Pharmacological Mechanisms of Liuwei Dihuang Decoction Against Intervertebral Disc Degeneration | Full Text | References | PDF (8.8 MB) | EPUB
  • 148 Views
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Article
Effects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery
Xudong Hu, Bing Luo, Qing Wu, Qingbiao Chen, Penghui Lu, Jie Huang, Xiaoxia Liang, Cheng Ling & Yiqun Li
Pages: 4925-4938
Published online: 02 Dec 2021
AbstractforEffects of Dezocine and Sufentanil on Th1/Th2 Balance in Breast Cancer Patients Undergoing Surgery | Full Text | References | PDF (3 MB) | EPUB
  • 123 Views
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Review

Review Article
New Progress in Improving the Delivery Methods of Bisphosphonates in the Treatment of Bone Tumors
Yu Zhong & Su Li
Pages: 4939-4959
Published online: 10 Dec 2021
AbstractforNew Progress in Improving the Delivery Methods of Bisphosphonates in the Treatment of Bone Tumors | Full Text | References | PDF (2 MB) | EPUB
  • 280 Views
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Original Research

Article
Cell-Penetrating Peptide-Modified Graphene Oxide Nanoparticles Loaded with Rictor siRNA for the Treatment of Triple-Negative Breast Cancer
Yun-Yun Yang, Wei Zhang, Hui Liu, Jun-Jie Jiang, Wen-Jie Wang & Zheng-Yan Jia
Pages: 4961-4972
Published online: 10 Dec 2021
AbstractforCell-Penetrating Peptide-Modified Graphene Oxide Nanoparticles Loaded with Rictor siRNA for the Treatment of Triple-Negative Breast Cancer | Full Text | References | PDF (7.4 MB) | EPUB
  • 209 Views
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Article
Knockdown of TRIM8 Protects HK-2 Cells Against Hypoxia/Reoxygenation-Induced Injury by Inhibiting Oxidative Stress-Mediated Apoptosis and Pyroptosis via PI3K/Akt Signal Pathway
Bang-Hua Zhang, Hao Liu, Yan Yuan, Xiao-Dong Weng, Yang Du, Hui Chen, Zhi-Yuan Chen, Lei Wang & Xiu-Heng Liu
Pages: 4973-4983
Published online: 10 Dec 2021
AbstractforKnockdown of TRIM8 Protects HK-2 Cells Against Hypoxia/Reoxygenation-Induced Injury by Inhibiting Oxidative Stress-Mediated Apoptosis and Pyroptosis via PI3K/Akt Signal Pathway | Full Text | References | PDF (4.6 MB) | EPUB
  • 142 Views
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Article
Pro-Angiogenic Effects of Essential Oil from Perilla frutescens and Its Main Component (Perillaldehyde) on Zebrafish Embryos and Human Umbilical Vein Endothelial Cells
Fei Zhou, Ou Dai, Cheng Peng, Liang Xiong, Hui Ao, Fei Liu & Qin-Mei Zhou
Pages: 4985-4999
Published online: 11 Dec 2021
AbstractforPro-Angiogenic Effects of Essential Oil from Perilla frutescens and Its Main Component (Perillaldehyde) on Zebrafish Embryos and Human Umbilical Vein Endothelial Cells | Full Text | References | PDF (11.7 MB) | EPUB
  • 156 Views
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Article
Bio-Guided Isolation of Two New Hypoglycemic Triterpenoid Saponins from Polygonum capitatum
Doudou Huang, Zenan Du, Yanhong Chen, Zhiying Dong, Xiujuan Wang, Mengshuang Li, Feng Zhang, Wansheng Chen & Lianna Sun
Pages: 5001-5010
Published online: 14 Dec 2021
AbstractforBio-Guided Isolation of Two New Hypoglycemic Triterpenoid Saponins from Polygonum capitatum | Full Text | References | PDF (2.9 MB) | EPUB
  • 149 Views
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Article
(Rose Bengal)/(Eosin Yellow)-Gold-Polypyrrole Hybrids: A Design for Dual Photo-Active Nano-System with Ultra-High Loading Capacity
Abdullah I El-Kholy, Doaa Abdel Fadeel, Maha Nasr, Ibrahim El-Sherbiny & Maha Fadel
Pages: 5011-5023
Published online: 14 Dec 2021
Abstractfor(Rose Bengal)/(Eosin Yellow)-Gold-Polypyrrole Hybrids: A Design for Dual Photo-Active Nano-System with Ultra-High Loading Capacity | Full Text | References | PDF (8.6 MB) | EPUB
  • 148 Views
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Article
Effect of Different Concentrations of Esmolol on Perioperative Hemodynamics and Analgesia in Patients Undergoing Colectomy: A Prospective, Randomized Controlled Study
Fuxi Song, Yanwu Jin, Peng Li, Chao Zheng & Xin Zhao
Pages: 5025-5033
Published online: 14 Dec 2021
AbstractforEffect of Different Concentrations of Esmolol on Perioperative Hemodynamics and Analgesia in Patients Undergoing Colectomy: A Prospective, Randomized Controlled Study | Full Text | References | PDF (1.7 MB) | EPUB
  • 96 Views
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Article
Drug Repurposing: Deferasirox Inhibits the Anti-Apoptotic Activity of Mcl-1
Asma Bourafai-Aziez, Mohammed Benabderrahmane, Hippolyte Paysant, Louis-Bastien Weiswald, Laurent Poulain, Ludovic Carlier, Delphine Ravault, Marie Jouanne, Gaël Coadou, Hassan Oulyadi, Anne-Sophie Voisin-Chiret, Jana Sopková-de Oliveira Santos & Muriel Sebban
Pages: 5035-5059
Published online: 15 Dec 2021
AbstractforDrug Repurposing: Deferasirox Inhibits the Anti-Apoptotic Activity of Mcl-1 | Full Text | References | PDF (25 MB) | EPUB
  • 173 Views
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Article
Establishment of Sunitinib-Resistant Xenograft Model of Renal Cell Carcinoma and the Identification of Drug-Resistant Hub Genes and Pathways
Yingwei Xie, Wentai Shangguan, Zhiliang Chen, Zaosong Zheng, Yuqing Chen, Qiyu Zhong, Yishan Zhang, Jingying Yang, Dingjun Zhu & Wenlian Xie
Pages: 5061-5074
Published online: 16 Dec 2021
AbstractforEstablishment of Sunitinib-Resistant Xenograft Model of Renal Cell Carcinoma and the Identification of Drug-Resistant Hub Genes and Pathways | Full Text | References | PDF (12.3 MB) | EPUB
  • 127 Views
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Article
Val109Asp Polymorphism of the Omentin-1 Gene and Incidence of Knee Osteoarthritis in a Chinese Han Population: A Correlation Analysis
Ruofei Chen, Yaqin Zhang, Honggang Xu, Huaqing Hu, Mingwei Chen & Zongwen Shuai
Pages: 5075-5086
Published online: 21 Dec 2021
AbstractforVal109Asp Polymorphism of the Omentin-1 Gene and Incidence of Knee Osteoarthritis in a Chinese Han Population: A Correlation Analysis | Full Text | References | PDF (831.3 KB) | EPUB
  • 121 Views
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Article
Progestin-Primed Ovarian Stimulation with Clomiphene Citrate Supplementation May Be More Feasible for Young Women with Diminished Ovarian Reserve Compared with Standard Progestin-Primed Ovarian Stimulation: A Retrospective Study
Yue Lin, Qianqian Chen, Jing Zhu, Yili Teng, Xuefeng Huang & Xia Chen
Pages: 5087-5097
Published online: 21 Dec 2021
AbstractforProgestin-Primed Ovarian Stimulation with Clomiphene Citrate Supplementation May Be More Feasible for Young Women with Diminished Ovarian Reserve Compared with Standard Progestin-Primed Ovarian Stimulation: A Retrospective Study | Full Text | References | PDF (3.2 MB) | EPUB
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Article
Comparative Pharmacokinetics/Pharmacodynamics of Fixed-Dose Combination of Esomeprazole and Calcium Carbonate (AD-206) to the Conventional Esomeprazole
Sungyeun Bae, Jihoon Kwon, Si-Beum Lee, In-Jin Jang, Kyung-Sang Yu & SeungHwan Lee
Pages: 5099-5108
Published online: 21 Dec 2021
AbstractforComparative Pharmacokinetics/Pharmacodynamics of Fixed-Dose Combination of Esomeprazole and Calcium Carbonate (AD-206) to the Conventional Esomeprazole | Full Text | References | PDF (3.4 MB) | EPUB
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Article
Simultaneous Determination of Loratadine and Its Metabolite Desloratadine in Beagle Plasma by LC-MS/MS and Application for Pharmacokinetics Study of Loratadine Tablets and Omeprazole‑Induced Drug–Drug Interaction
Yu Zhang, Jiaming Zhang, Qiuchi Xu, Yimeng Wang, Wenying Wu, Weiping Wang, Xiaoting Li & Tianhong Zhang
Pages: 5109-5122
Published online: 22 Dec 2021
AbstractforSimultaneous Determination of Loratadine and Its Metabolite Desloratadine in Beagle Plasma by LC-MS/MS and Application for Pharmacokinetics Study of Loratadine Tablets and Omeprazole‑Induced Drug–Drug Interaction | Full Text | References | PDF (4.7 MB) | EPUB
  • 527 Views
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Article
Downregulation of IRF2 Alleviates Sepsis-Related Acute Kidney Injury in vitro and in vivo
Yanyan Zhang, Yun Zhang, Aixiang Yang & Fei Xia
Pages: 5123-5132
Published online: 22 Dec 2021
AbstractforDownregulation of IRF2 Alleviates Sepsis-Related Acute Kidney Injury in vitro and in vivo | Full Text | References | PDF (5.6 MB) | EPUB
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Retraction

Retraction
In vitro Preparation and Evaluation of Sustained-Release Microcapsules of Salvianolic Acid [Retraction]
Pages: 5133-5134
Published online: 23 Dec 2021
CitationforIn vitro Preparation and Evaluation of Sustained-Release Microcapsules of Salvianolic Acid [Retraction] | Full Text | PDF (138.6 KB) | EPUB
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Original Research

Article
Dynamics of Endocytosis and Degradation of Antibody-Drug Conjugate T-DM1 in HER2 Positive Cancer Cells
Keying Liang, Shengsheng Mei, Xiangzheng Gao, Shanshan Peng & Jinbiao Zhan
Pages: 5135-5150
Published online: 24 Dec 2021
AbstractforDynamics of Endocytosis and Degradation of Antibody-Drug Conjugate T-DM1 in HER2 Positive Cancer Cells | Full Text | References | PDF (10 MB) | EPUB
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Lactobacillus fermentum CQPC08 Attenuates Exercise-Induced Fatigue in Mice Through Its Antioxidant Effects and Effective Intervention of Galactooligosaccharide
Dong Liu, Da Chuan Liu, Hao Fan & Yu Wang
Pages: 5151-5164
Published online: 24 Dec 2021
AbstractforLactobacillus fermentum CQPC08 Attenuates Exercise-Induced Fatigue in Mice Through Its Antioxidant Effects and Effective Intervention of Galactooligosaccharide | Full Text | References | PDF (6.3 MB) | EPUB
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Article
Identification of Active Ingredients of Huangqi Guizhi Wuwu Decoction for Promoting Nerve Function Recovery After Ischemic Stroke Using HT22 Live-Cell-Based Affinity Chromatography Combined with HPLC-MS/MS
Yingying He, Haozhen Zheng, Lanying Zhong, Nijun Zhong, Guiqing Wen, Lisheng Wang & Ying Zhang
Pages: 5165-5178
Published online: 30 Dec 2021
AbstractforIdentification of Active Ingredients of Huangqi Guizhi Wuwu Decoction for Promoting Nerve Function Recovery After Ischemic Stroke Using HT22 Live-Cell-Based Affinity Chromatography Combined with HPLC-MS/MS | Full Text | References | PDF (13.6 MB) | EPUB
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