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Abstract
The treatment of tuberculosis by chemotherapy is complicated due to multiple drug prescriptions, long treatment duration, and adverse side effects. We report here for the first time an in vitro therapeutic effect of nanocomposites based on para-aminosalicylic acid with zinc layered hydroxide (PAS-ZLH) and zinc-aluminum layered double hydroxides (PAS-Zn/Al LDH), against mycobacteria, Gram-positive bacteria, and Gram-negative bacteria. The nanocomposites demonstrated good antimycobacterial activity and were found to be effective in killing Gram-positive and Gram-negative bacteria. A biocompatibility study revealed good biocompatibility of the PAS-ZLH nanocomposites against normal human MRC-5 lung cells. The para-aminosalicylic acid loading was quantified with high-performance liquid chromatography analysis. In summary, the present preliminary in vitro studies are highly encouraging for further in vivo studies of PAS-ZLH and PAS-Zn/Al LDH nanocomposites to treat tuberculosis.
Acknowledgments
The authors would like to thank the Ministry of Education (MOE), Malaysia, Fundamental Research Grant Scheme, the Malaysian Higher Education Commission, and Northeastern University, Boston, Massachusetts, USA.
Funding for this research was provided by: the Higher Education Commission of Malaysia under the Commonwealth Scholarship and Fellowship Plan (Ref: KPT.B.600-6/3, Vol 68), for Bullo Saifullah; by the Fundamental Research Grant Scheme (FRGS) (FRGS/2/2013/SG06/UPM/01/1 with vote #5524467), for Mohd Zobir B Hussein; and by the Northeastern University in Boston, Massachusetts, USA, for funding the anti-TB experiments, for Thomas J Webster.
Disclosure
The authors report no conflicts of interest in work.