Drug Design, Development and Therapy, Volume 8, Issue (2014)

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Drug Design, Development and Therapy, Volume 8, Issue (2014)

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Original Research

Article
Therapeutic potentials of naringin on polymethylmethacrylate induced osteoclastogenesis and osteolysis, in vitro and in vivo assessments
Nianhu Li, Zhanwang Xu, Paul H Wooley, Jianxin Zhang & Shang-You Yang
Pages: 1-11
Published online: 10 Dec 2013
AbstractforTherapeutic potentials of naringin on polymethylmethacrylate induced osteoclastogenesis and osteolysis, in vitro and in vivo assessments | Full Text | References | PDF (4.7 MB)
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Open Access

Review

Review Article
Clinical utility of entecavir for chronic hepatitis B in Chinese patients
Jiyao Wang
Pages: 13-24
Published online: 12 Dec 2013
AbstractforClinical utility of entecavir for chronic hepatitis B in Chinese patients | Full Text | References | PDF (343.9 KB)
  • 88 Views
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Open Access
Review Article
Lixisenatide as add-on therapy to basal insulin
Dominique Xavier Brown, Emma Louise Butler & Marc Evans
Pages: 25-38
Published online: 13 Dec 2013
AbstractforLixisenatide as add-on therapy to basal insulin | Full Text | References | PDF (391.6 KB)
  • 59 Views
  • 1 CrossRef citations
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Open Access

Original Research

Article
(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death
Jun-ya Ueda, Sirivan Athikomkulchai, Ryuta Miyatake, Ikuo Saiki, Hiroyasu Esumi & Suresh Awale
Pages: 39-47
Published online: 18 Dec 2013
Abstractfor(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death | Full Text | References | PDF (1.9 MB)
  • 145 Views
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Open Access

Review

Review Article
Development and use of sulodexide in vascular diseases: implications for treatment
Sergio Coccheri & Ferdinando Mannello
Pages: 49-65
Published online: 24 Dec 2013
AbstractforDevelopment and use of sulodexide in vascular diseases: implications for treatment | Full Text | References | PDF (476.4 KB)
  • 371 Views
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Open Access

Original Research

Article
Development and characterization of a gastroretentive dosage form composed of chitosan and hydroxyethyl cellulose for alendronate
Ying-Chen Chen, Hsiu-O Ho, Chiao-Chi Chiu & Ming-Thau Sheu
Pages: 67-78
Published online: 27 Dec 2013
AbstractforDevelopment and characterization of a gastroretentive dosage form composed of chitosan and hydroxyethyl cellulose for alendronate | Full Text | References | PDF (753.6 KB)
  • 136 Views
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Open Access

Review

Review Article
Overview of clinical use and side effect profile of valsartan in Chinese hypertensive patients
Qi-Fang Huang, Yan Li & Ji-Guang Wang
Pages: 79-86
Published online: 30 Dec 2013
AbstractforOverview of clinical use and side effect profile of valsartan in Chinese hypertensive patients | Full Text | References | PDF (323.8 KB)
  • 184 Views
  • 5 CrossRef citations
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Open Access
Review Article
Rituximab for the treatment of rheumatoid arthritis: an update
Chi Chiu Mok
Pages: 87-100
Published online: 29 Sep 2022
AbstractforRituximab for the treatment of rheumatoid arthritis: an update | Full Text | References | PDF (289.8 KB)
  • 857 Views
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Open Access
Review Article
Transdermal testosterone replacement therapy in men
M Iftekhar Ullah, Daniel M Riche & Christian A Koch
Pages: 101-112
Published online: 29 Sep 2022
AbstractforTransdermal testosterone replacement therapy in men | Full Text | References | PDF (501.5 KB)
  • 196 Views
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Open Access
Review Article
Does fesoterodine have a role in the treatment of poorly managed patients with overactive bladder?
Vikky Morris & Adrian Wagg
Pages: 113-119
Published online: 09 Jan 2014
AbstractforDoes fesoterodine have a role in the treatment of poorly managed patients with overactive bladder? | Full Text | References | PDF (193.7 KB)
  • 70 Views
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Open Access

Corrigendum

Correction
Clinical experimentation with aerosol antibiotics: current and future methods of administration [Corrigendum]
Page: 121
Published online: 16 Jan 2014
CitationforClinical experimentation with aerosol antibiotics: current and future methods of administration [Corrigendum] | Full Text | PDF (91.1 KB)
  • 51 Views
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Open Access

Short Report

Brief Report
Comparative steady-state pharmacokinetic study of an extended-release formulation of itopride and its immediate-release reference formulation in healthy volunteers
Seonghae Yoon, Howard Lee, Tae-Eun Kim, SeungHwan Lee, Dong-Hyun Chee, Joo-Youn Cho, Kyung-Sang Yu & In-Jin Jang
Pages: 123-128
Published online: 15 Jan 2014
AbstractforComparative steady-state pharmacokinetic study of an extended-release formulation of itopride and its immediate-release reference formulation in healthy volunteers | Full Text | References | PDF (230.7 KB)
  • 153 Views
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Open Access

Original Research

Article
Novel N-substituted aminobenzamide scaffold derivatives targeting the dipeptidyl peptidase-IV enzyme
Qosay A Al-Balas, Munia F Sowaileh, Mohammad A Hassan, Amjad M Qandil, Karem H Alzoubi, Nizar M Mhaidat, Ammar M Almaaytah & Omar F Khabour
Pages: 129-163
Published online: 16 Jan 2014
AbstractforNovel N-substituted aminobenzamide scaffold derivatives targeting the dipeptidyl peptidase-IV enzyme | Full Text | References | PDF (3.3 MB)
  • 79 Views
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Open Access
Article
Changes in surface expression of N-methyl-D-aspartate receptors in the striatum in a rat model of Parkinson’s disease
Jing Gan, Chen Qi, Li-Min Mao & Zhenguo Liu
Pages: 165-173
Published online: 17 Jan 2014
AbstractforChanges in surface expression of N-methyl-D-aspartate receptors in the striatum in a rat model of Parkinson’s disease | Full Text | References | PDF (833.8 KB)
  • 71 Views
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Open Access

Review

Review Article
Significant roadblocks exist in developing sputum sample libraries for clinical validation of novel in vitro diagnostics
Joshua M Dollow & Justin A Green
Pages: 175-182
Published online: 23 Jan 2014
AbstractforSignificant roadblocks exist in developing sputum sample libraries for clinical validation of novel in vitro diagnostics | Full Text | References | PDF (305.2 KB)
  • 62 Views
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Open Access

Original Research

Article
QSAR and docking studies on xanthone derivatives for anticancer activity targeting DNA topoisomerase IIα
Sarfaraz Alam & Feroz Khan
Pages: 183-195
Published online: 31 Jan 2014
AbstractforQSAR and docking studies on xanthone derivatives for anticancer activity targeting DNA topoisomerase IIα | Full Text | References | PDF (1.1 MB)
  • 361 Views
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Open Access

Review

Review Article
Omalizumab, an anti-immunoglobulin E antibody: state of the art
Cristoforo Incorvaia, Marina Mauro, Marina Russello, Chiara Formigoni, Gian Galeazzo Riario-Sforza & Erminia Ridolo
Pages: 197-207
Published online: 07 Feb 2014
AbstractforOmalizumab, an anti-immunoglobulin E antibody: state of the art | Full Text | References | PDF (871.9 KB)
  • 117 Views
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Open Access

Original Research

Article
Sinonasal inhalation of tobramycin vibrating aerosol in cystic fibrosis patients with upper airway Pseudomonas aeruginosa colonization: results of a randomized, double-blind, placebo-controlled pilot study
Jochen G Mainz, Katja Schädlich, Claudia Schien, Ruth Michl, Petra Schelhorn-Neise, Assen Koitschev, Christiane Koitschev, Peter M Keller, Joachim Riethmüller, Baerbel Wiedemann & James F Beck
Pages: 209-217
Published online: 10 Feb 2014
AbstractforSinonasal inhalation of tobramycin vibrating aerosol in cystic fibrosis patients with upper airway Pseudomonas aeruginosa colonization: results of a randomized, double-blind, placebo-controlled pilot study | Full Text | References | PDF (350.1 KB)
  • 94 Views
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Open Access
Article
Difference in the effects of switching from Candesartan to Olmesartan or Telmisartan to Olmesartan in hypertensive patients with type 2 diabetes: the COTO study
Hiroyuki Daikuhara, Kensaku Fukunaga & Tomie Ohshima
Pages: 219-226
Published online: 17 Feb 2014
AbstractforDifference in the effects of switching from Candesartan to Olmesartan or Telmisartan to Olmesartan in hypertensive patients with type 2 diabetes: the COTO study | Full Text | References | PDF (313.1 KB)
  • 280 Views
  • 2 CrossRef citations
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Open Access
Article
Characterization of renal biomarkers for use in clinical trials: biomarker evaluation in healthy volunteers
David A Brott, Scott H Adler, Ramin Arani, Susan C Lovick, Mark Pinches & Stephen T Furlong
Pages: 227-237
Published online: 13 Feb 2014
AbstractforCharacterization of renal biomarkers for use in clinical trials: biomarker evaluation in healthy volunteers | Full Text | References | PDF (348.5 KB)
  • 75 Views
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Open Access
Article
Effect of vildagliptin add-on treatment to metformin on plasma asymmetric dimethylarginine in type 2 diabetes mellitus patients
Mustafa Cakirca, Cumali Karatoprak, Mehmet Zorlu, Muharrem Kiskac, Mustafa Kanat, Mehmet Ali Cikrikcioglu, Pinar Soysal, Mehmet Hursitoglu, Ahmet Adil Camli, Reha Erkoc & Muhammad Abdul-Ghani
Pages: 239-243
Published online: 14 Feb 2014
AbstractforEffect of vildagliptin add-on treatment to metformin on plasma asymmetric dimethylarginine in type 2 diabetes mellitus patients | Full Text | References | PDF (214.9 KB)
  • 82 Views
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Open Access
Article
Efficacy and safety of febuxostat in the treatment of hyperuricemia in stable kidney transplant recipients
Tadashi Sofue, Masashi Inui, Taiga Hara, Yoko Nishijima, Kumiko Moriwaki, Yushi Hayashida, Nobufumi Ueda, Akira Nishiyama, Yoshiyuki Kakehi & Masakazu Kohno
Pages: 245-253
Published online: 17 Feb 2014
AbstractforEfficacy and safety of febuxostat in the treatment of hyperuricemia in stable kidney transplant recipients | Full Text | References | PDF (508.2 KB)
  • 84 Views
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Open Access
Article
Insulin induces drug resistance in melanoma through activation of the PI3K/Akt pathway
Mengna Chi, Yan Ye, Xu Dong Zhang & Jiezhong Chen
Pages: 255-262
Published online: 17 Feb 2014
AbstractforInsulin induces drug resistance in melanoma through activation of the PI3K/Akt pathway | Full Text | References | PDF (483.1 KB)
  • 88 Views
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Open Access
Article
Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results
Cristina Fernández-Fernández, Luis F Callado, Rocío Girón, Eva Sánchez, Amaia M Erdozain, José Antonio López-Moreno, Paula Morales, Fernando Rodríguez de Fonseca, Javier Fernández-Ruiz, Pilar Goya, J Javier Meana, M Isabel Martín & Nadine Jagerovic
Pages: 263-277
Published online: 20 Feb 2014
AbstractforCombining rimonabant and fentanyl in a single entity: preparation and pharmacological results | Full Text | References | PDF (735.2 KB)
  • 85 Views
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Open Access

Perspectives

Article
Paclitaxel: new uses for an old drug
Dongshan Zhang, Ruhao Yang, Shixuan Wang & Zheng Dong
Pages: 279-284
Published online: 20 Feb 2014
AbstractforPaclitaxel: new uses for an old drug | Full Text | References | PDF (752.6 KB)
  • 982 Views
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Open Access

Review

Review Article
Ulipristal acetate: a novel pharmacological approach for the treatment of uterine fibroids
Nicoletta Biglia, Silvestro Carinelli, Antonio Maiorana, Marta D’Alonzo, Giuseppe Lo Monte & Roberto Marci
Pages: 285-292
Published online: 20 Feb 2014
AbstractforUlipristal acetate: a novel pharmacological approach for the treatment of uterine fibroids | Full Text | References | PDF (229.9 KB)
  • 251 Views
  • 9 CrossRef citations
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Open Access

Original Research

Article
Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells
Yong-Wan Kim, Eun Young Kim, Doin Jeon, Juinn-Lin Liu, Helena Suhyun Kim, Jin Woo Choi & Woong Shick Ahn
Pages: 293-314
Published online: 24 Feb 2014
AbstractforDifferential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells | Full Text | References | PDF (3.7 MB)
  • 146 Views
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Open Access
Article
Genistein suppresses tumor necrosis factor α-induced inflammation via modulating reactive oxygen species/Akt/nuclear factor κB and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells
Jinchao Li, Jun Li, Ye Yue, Yiping Hu, Wenxiang Cheng, Ruoxi Liu, Xiaohua Pan & Peng Zhang
Pages: 315-323
Published online: 17 Mar 2014
AbstractforGenistein suppresses tumor necrosis factor α-induced inflammation via modulating reactive oxygen species/Akt/nuclear factor κB and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells | Full Text | References | PDF (1.6 MB)
  • 128 Views
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Open Access

Corrigendum

Correction
Daclatasvir: potential role in hepatitis C [Corrigendum]
Page: 325
Published online: 20 Mar 2014
CitationforDaclatasvir: potential role in hepatitis C [Corrigendum] | Full Text | PDF (89.7 KB)
  • 48 Views
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Open Access

Original Research

Article
Tetrandrine protects mouse retinal ganglion cells from ischemic injury
Weiyi Li, Chen Yang, Jing Lu, Ping Huang, Colin J Barnstable, Chun Zhang & Samuel S Zhang
Pages: 327-339
Published online: 21 Mar 2014
AbstractforTetrandrine protects mouse retinal ganglion cells from ischemic injury | Full Text | References | PDF (2.8 MB)
  • 70 Views
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Open Access

Review

Review Article
Anti-TNF therapy for juvenile idiopathic arthritis-related uveitis
Francesco Semeraro, Barbara Arcidiacono, Giuseppe Nascimbeni, Martina Angi, Barbara Parolini & Ciro Costagliola
Pages: 341-348
Published online: 24 Mar 2014
AbstractforAnti-TNF therapy for juvenile idiopathic arthritis-related uveitis | Full Text | References | PDF (799 KB)
  • 105 Views
  • 6 CrossRef citations
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Open Access
Review Article
Tocilizumab in the treatment of rheumatoid arthritis and beyond
Anjali Shetty, Rebekah Hanson, Peter Korsten, Munir Shawagfeh, Shiva Arami, Suncica Volkov, Olga Vila, William Swedler, Abdel Naser Shunaigat, Sameer Smadi, Ray Sawaqed, David Perkins, Shiva Shahrara & Nadera J Sweiss
Pages: 349-364
Published online: 28 Mar 2014
AbstractforTocilizumab in the treatment of rheumatoid arthritis and beyond | Full Text | References | PDF (756.9 KB)
  • 323 Views
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Open Access
Review Article
Fc-fusion technology and recombinant FVIII and FIX in the management of the hemophilias
Maria Elisa Mancuso & Pier Mannuccio Mannucci
Pages: 365-371
Published online: 28 Mar 2014
AbstractforFc-fusion technology and recombinant FVIII and FIX in the management of the hemophilias | Full Text | References | PDF (472.5 KB)
  • 90 Views
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Open Access

Original Research

Article
Discovery and evaluation of asymmetrical monocarbonyl analogs of curcumin as anti-inflammatory agents
Yali Zhang, Chengguang Zhao, Wenfei He, Zhe Wang, Qilu Fang, Bing Xiao, Zhiguo Liu, Guang Liang & Shulin Yang
Pages: 373-382
Published online: 04 Apr 2014
AbstractforDiscovery and evaluation of asymmetrical monocarbonyl analogs of curcumin as anti-inflammatory agents | Full Text | References | PDF (1 MB)
  • 210 Views
  • 6 CrossRef citations
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Open Access
Article
Triazole derivatives with improved in vitro antifungal activity over azole drugs
Shichong Yu, Xiaoyun Chai, Yanwei Wang, Yongbing Cao, Jun Zhang, Qiuye Wu, Dazhi Zhang, Yuanying Jiang, Tianhua Yan & Qingyan Sun
Pages: 383-390
Published online: 10 Apr 2014
AbstractforTriazole derivatives with improved in vitro antifungal activity over azole drugs | Full Text | References | PDF (755.1 KB)
  • 128 Views
  • 20 CrossRef citations
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Open Access
Article
Effects of switching from prandial premixed insulin therapy to basal plus two times bolus insulin therapy on glycemic control and quality of life in patients with type 2 diabetes mellitus
Hiroyuki Ito, Mariko Abe, Shinichi Antoku, Takashi Omoto, Masahiro Shinozaki, Shinya Nishio, Mizuo Mifune & Michiko Togane
Pages: 391-396
Published online: 23 Apr 2014
AbstractforEffects of switching from prandial premixed insulin therapy to basal plus two times bolus insulin therapy on glycemic control and quality of life in patients with type 2 diabetes mellitus | Full Text | References | PDF (265.2 KB)
  • 68 Views
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Open Access
Article
Formulation development for the orexin receptor antagonist almorexant: assessment in two clinical studies
Jasper Dingemanse, Martine Gehin, Hans Gabriel Cruz & Petra Hoever
Pages: 397-403
Published online: 28 Apr 2014
AbstractforFormulation development for the orexin receptor antagonist almorexant: assessment in two clinical studies | Full Text | References | PDF (300.1 KB)
  • 70 Views
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Open Access
Article
Clinical efficacy of Spasmofen® suppository in the emergency treatment of renal colic: a randomized, double-blind, double-dummy comparative trial
Mostafa Yakoot, Amel Salem, Sameh Yousef & Sherine Helmy
Pages: 405-410
Published online: 02 May 2014
AbstractforClinical efficacy of Spasmofen® suppository in the emergency treatment of renal colic: a randomized, double-blind, double-dummy comparative trial | Full Text | References | PDF (367.8 KB)
  • 122 Views
  • 6 CrossRef citations
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Open Access
Article
Combined isosorbide dinitrate and ibuprofen as a novel therapy for muscular dystrophies: evidence from Phase I studies in healthy volunteers
Maria Vittoria Cossu, Dario Cattaneo, Serena Fucile, Paolo Pellegrino, Sara Baldelli, Valeria Cozzi, Amedeo Capetti & Emilio Clementi
Pages: 411-419
Published online: 02 May 2014
AbstractforCombined isosorbide dinitrate and ibuprofen as a novel therapy for muscular dystrophies: evidence from Phase I studies in healthy volunteers | Full Text | References | PDF (1,007.3 KB)
  • 97 Views
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Open Access
Article
Topical infliximab for the suppression of wound healing following experimental glaucoma filtration surgery
Burak Turgut, Kenan Eren, Mehmet Mustafa Akın, Tamer Demir & Sabiha Kobat
Pages: 421-429
Published online: 02 May 2014
AbstractforTopical infliximab for the suppression of wound healing following experimental glaucoma filtration surgery | Full Text | References | PDF (1.9 MB)
  • 85 Views
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Open Access

Review

Review Article
Linagliptin: from bench to bedside
John Doupis
Pages: 431-446
Published online: 05 May 2014
AbstractforLinagliptin: from bench to bedside | Full Text | References | PDF (606 KB)
  • 227 Views
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Open Access

Original Research

Article
Inhibition of B7-1 (CD80) by RhuDex® reduces lipopolysaccharide-mediated inflammation in human atherosclerotic lesions
Andreas O Doesch, Li Zhao, Christian A Gleissner, Mohammadreza Akhavanpoor, David Rohde, Deniz Okuyucu, Maani Hakimi, Thomas J Dengler, Hugo A Katus & Christian Erbel
Pages: 447-457
Published online: 12 May 2014
AbstractforInhibition of B7-1 (CD80) by RhuDex® reduces lipopolysaccharide-mediated inflammation in human atherosclerotic lesions | Full Text | References | PDF (1.9 MB)
  • 70 Views
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Open Access
Article
Improving anticancer efficacy of (–)-epigallocatechin-3-gallate gold nanoparticles in murine B16F10 melanoma cells
Cheng-Cheung Chen, Dar-Shih Hsieh, Kao-Jean Huang, Yi-Lin Chan, Po-Da Hong, Ming-Kung Yeh & Chang-Jer Wu
Pages: 459-474
Published online: 08 May 2014
AbstractforImproving anticancer efficacy of (–)-epigallocatechin-3-gallate gold nanoparticles in murine B16F10 melanoma cells | Full Text | References | PDF (2 MB)
  • 155 Views
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Open Access
Article
P-glycoprotein- and organic anion-transporting polypeptide-mediated transport of periplocin may lead to drug–herb/drug–drug interactions
Sheng Liang, Fengchun Deng, Haiyan Xing, He Wen, Xiaoyan Shi, Orleans Nii Martey, Emmanuel Koomson & Xin He
Pages: 475-483
Published online: 09 May 2014
AbstractforP-glycoprotein- and organic anion-transporting polypeptide-mediated transport of periplocin may lead to drug–herb/drug–drug interactions | Full Text | References | PDF (862.1 KB)
  • 80 Views
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Open Access
Article
Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor
Chengyuan Qian, Mengxia Li, Jiangdong Sui, Tao Ren, Zheng Li, Liang Zhang, Liwei Zhou, Yi Cheng & Dong Wang
Pages: 485-496
Published online: 09 May 2014
AbstractforIdentification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor | Full Text | References | PDF (1.7 MB)
  • 80 Views
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Open Access
Article
Transdermal fentanyl for pain due to chemoradiotherapy-induced oral mucositis in nasopharyngeal cancer patients: evaluating efficacy, safety, and improvement in quality of life
Su-Ping Guo, San-Gang Wu, Juan Zhou, Hui-Xia Feng, Feng-Yan Li, Ying-Jia Wu, Jia-Yuan Sun & Zhen-Yu He
Pages: 497-503
Published online: 12 May 2014
AbstractforTransdermal fentanyl for pain due to chemoradiotherapy-induced oral mucositis in nasopharyngeal cancer patients: evaluating efficacy, safety, and improvement in quality of life | Full Text | References | PDF (292.8 KB)
  • 76 Views
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Open Access
Article
Synthesis, antimicrobial, and anti-inflammatory activity, of novel S-substituted and N-substituted 5-(1-adamantyl)-1,2,4-triazole-3-thiols
Ebtehal S Al-Abdullah, Hanadi H Asiri, Siham Lahsasni, Elsayed E Habib, Tarek M Ibrahim & Ali A El-Emam
Pages: 505-518
Published online: 12 May 2014
AbstractforSynthesis, antimicrobial, and anti-inflammatory activity, of novel S-substituted and N-substituted 5-(1-adamantyl)-1,2,4-triazole-3-thiols | Full Text | References | PDF (1.7 MB)
  • 166 Views
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Open Access
Article
The effects of sulodexide on both clinical and molecular parameters in patients with mixed arterial and venous ulcers of lower limbs
Raffaele Serra, Luca Gallelli, Angela Conti, Giovanni De Caridi, Mafalda Massara, Francesco Spinelli, Gianluca Buffone, Francesco Giuseppe Caliò, Bruno Amato, Simona Ceglia, Giuseppe Spaziano, Luca Scaramuzzino, Alessia Giovanna Ferrarese, Raffaele Grande & Stefano de Franciscis
Pages: 519-527
Published online: 13 May 2014
AbstractforThe effects of sulodexide on both clinical and molecular parameters in patients with mixed arterial and venous ulcers of lower limbs | Full Text | References | PDF (723.1 KB)
  • 118 Views
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Open Access
Article
Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials
David Pierce, Mary Corcoran, Patrick Martin, Karen Barrett, Susi Inglis, Peter Preston, Thomas N Thompson & Sandra K Willsie
Pages: 529-543
Published online: 14 May 2014
AbstractforEffect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials | Full Text | References | PDF (550.6 KB)
  • 110 Views
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Open Access
Article
Protective effect of picroside II on myocardial ischemia reperfusion injury in rats
Nan Wu, Wenna Li, Wenqi Shu & Dalin Jia
Pages: 545-554
Published online: 14 May 2014
AbstractforProtective effect of picroside II on myocardial ischemia reperfusion injury in rats | Full Text | References | PDF (1.2 MB)
  • 64 Views
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Review

Review Article
Molecular pharmacodynamics of new oral drugs used in the treatment of multiple sclerosis
Luigi di Nuzzo, Rosamaria Orlando, Carla Nasca & Ferdinando Nicoletti
Pages: 555-568
Published online: 19 May 2014
AbstractforMolecular pharmacodynamics of new oral drugs used in the treatment of multiple sclerosis | Full Text | References | PDF (793.4 KB)
  • 145 Views
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Open Access

Corrigendum

Correction
Profile of gantenerumab and its potential in the treatment of Alzheimer’s disease [Corrigendum]
Page: 569
Published online: 21 May 2014
CitationforProfile of gantenerumab and its potential in the treatment of Alzheimer’s disease [Corrigendum] | Full Text | PDF (105.4 KB)
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Original Research

Article
Pharmacoinformatics elucidation of potential drug targets against migraine to target ion channel protein KCNK18
Sheikh Arslan Sehgal, Mubashir Hassan & Sajid Rashid
Pages: 571-581
Published online: 21 May 2014
AbstractforPharmacoinformatics elucidation of potential drug targets against migraine to target ion channel protein KCNK18 | Full Text | References | PDF (1.4 MB)
  • 279 Views
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Open Access
Article
Cytoprotective effect of selective small-molecule caspase inhibitors against staurosporine-induced apoptosis
Jianghong Wu, Yuren Wang, Shuguang Liang & Haiching Ma
Pages: 583-600
Published online: 24 May 2014
AbstractforCytoprotective effect of selective small-molecule caspase inhibitors against staurosporine-induced apoptosis | Full Text | References | PDF (1.3 MB)
  • 128 Views
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Open Access
Article
Chronic obstructive pulmonary disease treated with inhaled medium- or high-dose corticosteroids: a prospective and randomized study focusing on clinical efficacy and the risk of pneumonia
Shih-Lung Cheng, Kang-Cheng Su, Hao-Chien Wang, Diahn-Warng Perng & Pan-Chyr Yang
Pages: 601-607
Published online: 28 May 2014
AbstractforChronic obstructive pulmonary disease treated with inhaled medium- or high-dose corticosteroids: a prospective and randomized study focusing on clinical efficacy and the risk of pneumonia | Full Text | References | PDF (386.6 KB)
  • 72 Views
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Open Access
Article
Quinoxaline-substituted chalcones as new inhibitors of breast cancer resistance protein ABCG2: polyspecificity at B-ring position
Evelyn Winter, Gustavo Jabor Gozzi, Louise Domeneghini Chiaradia-Delatorre, Nathalia Daflon-Yunes, Raphael Terreux, Charlotte Gauthier, Alessandra Mascarello, Paulo César Leal, Silvia M Cadena, Rosendo Augusto Yunes, Ricardo José Nunes, Tania Beatriz Creczynski-Pasa & Attilio Di Pietro
Pages: 609-619
Published online: 27 May 2014
AbstractforQuinoxaline-substituted chalcones as new inhibitors of breast cancer resistance protein ABCG2: polyspecificity at B-ring position | Full Text | References | PDF (1 MB)
  • 83 Views
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Open Access
Article
Is increasing the dose of Entecavir effective in partial virological responders?
Ayse Erturk, Remzi Adnan Akdogan, Emine Parlak, Erkan Cure, Medine Cumhur Cure & Cinar Ozturk
Pages: 621-625
Published online: 29 May 2014
AbstractforIs increasing the dose of Entecavir effective in partial virological responders? | Full Text | References | PDF (300.2 KB)
  • 63 Views
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Open Access
Article
Anxiolytic and antidepressant-like activities of the novel and potent non-imidazole histamine H3 receptor antagonist ST-1283
Amine Bahi, Johannes Stephan Schwed, Miriam Walter, Holger Stark & Bassem Sadek
Pages: 627-637
Published online: 28 May 2014
AbstractforAnxiolytic and antidepressant-like activities of the novel and potent non-imidazole histamine H3 receptor antagonist ST-1283 | Full Text | References | PDF (1.2 MB)
  • 179 Views
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Open Access
Article
Neurotherapeutic activity of the recombinant heat shock protein Hsp70 in a model of focal cerebral ischemia in rats
Maxim A Shevtsov, Boris P Nikolaev, Ludmila Y Yakovleva, Anatolii V Dobrodumov, Anastasiy S Dayneko, Alexey A Shmonin, Timur D Vlasov, Elena V Melnikova, Alexander D Vilisov, Irina V Guzhova, Alexander M Ischenko, Anastasiya L Mikhrina, Oleg V Galibin, Igor V Yakovenko & Boris A Margulis
Pages: 639-650
Published online: 29 Sep 2022
AbstractforNeurotherapeutic activity of the recombinant heat shock protein Hsp70 in a model of focal cerebral ischemia in rats | Full Text | References | PDF (2.1 MB)
  • 97 Views
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Open Access
Article
Evaluation of ceftiofur–PHBV microparticles in rats
Cristian Vilos, Luis Constandil, Paula I Rodas, Mario Cantin, Katherine Zepeda, Natalia Herrera & Luis A Velasquez
Pages: 651-666
Published online: 29 May 2014
AbstractforEvaluation of ceftiofur–PHBV microparticles in rats | Full Text | References | PDF (1.9 MB)
  • 73 Views
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Open Access

Review

Review Article
Progress of clinical research on targeted therapy combined with thoracic radiotherapy for non-small-cell lung cancer
Hongqing Zhuang, Xianzhi Zhao, Lujun Zhao, Joe Y Chang & Ping Wang
Pages: 667-675
Published online: 29 May 2014
AbstractforProgress of clinical research on targeted therapy combined with thoracic radiotherapy for non-small-cell lung cancer | Full Text | References | PDF (239.6 KB)
  • 66 Views
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Open Access
Review Article
GLP-1(28-36)amide, the Glucagon-like peptide-1 metabolite: friend, foe, or pharmacological folly?
Meng-Wong Taing, Felicity J Rose & Jonathan P Whitehead
Pages: 677-688
Published online: 03 Jun 2014
AbstractforGLP-1(28-36)amide, the Glucagon-like peptide-1 metabolite: friend, foe, or pharmacological folly? | Full Text | References | PDF (334.9 KB)
  • 73 Views
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Open Access
Review Article
Ivabradine, coronary artery disease, and heart failure: beyond rhythm control
Pietro Scicchitano, Francesca Cortese, Gabriella Ricci, Santa Carbonara, Michele Moncelli, Massimo Iacoviello, Annagrazia Cecere, Michele Gesualdo, Annapaola Zito, Pasquale Caldarola, Domenico Scrutinio, Rocco Lagioia, Graziano Riccioni & Marco Matteo Ciccone
Pages: 689-700
Published online: 03 Jun 2014
AbstractforIvabradine, coronary artery disease, and heart failure: beyond rhythm control | Full Text | References | PDF (294.7 KB)
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Original Research

Article
Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment
Kosuke Narise, Kensuke Okuda, Yukihiro Enomoto, Tasuku Hirayama & Hideko Nagasawa
Pages: 701-717
Published online: 06 Jun 2014
AbstractforOptimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment | Full Text | References | PDF (2.2 MB)
  • 98 Views
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Open Access
Article
Evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models
Mohammadjavad Paydar, Behnam Kamalidehghan, Yi Li Wong, Won Fen Wong, Chung Yeng Looi & Mohd Rais Mustafa
Pages: 719-733
Published online: 06 Jun 2014
AbstractforEvaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models | Full Text | References | PDF (4.2 MB)
  • 212 Views
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Review

Review Article
The new concepts on overcoming drug resistance in lung cancer
Weisan Zhang, Ping Lei, Xifeng Dong & Cuiping Xu
Pages: 735-744
Published online: 06 Jun 2014
AbstractforThe new concepts on overcoming drug resistance in lung cancer | Full Text | References | PDF (638.7 KB)
  • 102 Views
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Original Research

Article
Mapracorat, a selective glucocorticoid receptor agonist, causes apoptosis of eosinophils infiltrating the conjunctiva in late-phase experimental ocular allergy
Monica Baiula, Andrea Bedini, Jacopo Baldi, Megan E Cavet, Paolo Govoni & Santi Spampinato
Pages: 745-757
Published online: 10 Jun 2014
AbstractforMapracorat, a selective glucocorticoid receptor agonist, causes apoptosis of eosinophils infiltrating the conjunctiva in late-phase experimental ocular allergy | Full Text | References | PDF (3.1 MB)
  • 96 Views
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Open Access
Article
Thrombolytic treatment (alteplase; rt-Pa) in acute massive pulmonary embolism and cardiopulmonary arrest
Adem Dirican, Sevket Ozkaya, Ali Ekber Atas, Esra Kayahan Ulu, Ilknur Kitapci & Ferah Ece
Pages: 759-763
Published online: 12 Jun 2014
AbstractforThrombolytic treatment (alteplase; rt-Pa) in acute massive pulmonary embolism and cardiopulmonary arrest | Full Text | References | PDF (1,012.5 KB)
  • 94 Views
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Review

Review Article
Review of nemonoxacin with special focus on clinical development
Xiaohua Qin & Haihui Huang
Pages: 765-774
Published online: 29 Sep 2022
AbstractforReview of nemonoxacin with special focus on clinical development | Full Text | References | PDF (442.5 KB)
  • 179 Views
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Review Article
Vemurafenib: an evidence-based review of its clinical utility in the treatment of metastatic melanoma
Abhisek Swaika, Jennifer A Crozier & Richard W Joseph
Pages: 775-787
Published online: 16 Jun 2014
AbstractforVemurafenib: an evidence-based review of its clinical utility in the treatment of metastatic melanoma | Full Text | References | PDF (468 KB)
  • 124 Views
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Review Article
New oral anticoagulants in patients with nonvalvular atrial fibrillation: a review of pharmacokinetics, safety, efficacy, quality of life, and cost effectiveness
Helen Mani & Edelgard Lindhoff-Last
Pages: 789-798
Published online: 17 Jun 2014
AbstractforNew oral anticoagulants in patients with nonvalvular atrial fibrillation: a review of pharmacokinetics, safety, efficacy, quality of life, and cost effectiveness | Full Text | References | PDF (339.3 KB)
  • 238 Views
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Original Research

Article
Additive effects of cilnidipine, an L-/N-type calcium channel blocker, and an angiotensin II receptor blocker on reducing cardiorenal damage in Otsuka Long-Evans Tokushima Fatty rats with type 2 diabetes mellitus
Yutaka Mori, Shizuka Aritomi, Kazumi Niinuma, Tarou Nakamura, Kenichi Matsuura, Junichi Yokoyama & Kazunori Utsunomiya
Pages: 799-810
Published online: 17 Jun 2014
AbstractforAdditive effects of cilnidipine, an L-/N-type calcium channel blocker, and an angiotensin II receptor blocker on reducing cardiorenal damage in Otsuka Long-Evans Tokushima Fatty rats with type 2 diabetes mellitus | Full Text | References | PDF (3.6 MB)
  • 85 Views
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Open Access
Article
Use of metformin and vildagliptin for treatment of type 2 diabetes in the elderly
Antoni Sicras-Mainar & Ruth Navarro-Artieda
Pages: 811-818
Published online: 18 Jun 2014
AbstractforUse of metformin and vildagliptin for treatment of type 2 diabetes in the elderly | Full Text | References | PDF (263.3 KB)
  • 95 Views
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Open Access

Hypothesis

Article
Design of a new therapy to treat snake envenomation
Leyla Shahidi Bonjar
Pages: 819-825
Published online: 18 Jun 2014
AbstractforDesign of a new therapy to treat snake envenomation | Full Text | References | PDF (619.6 KB)
  • 80 Views
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Original Research

Article
Quetiapine for acute bipolar depression: a systematic review and meta-analysis
Sirijit Suttajit, Manit Srisurapanont, Narong Maneeton & Benchalak Maneeton
Pages: 827-838
Published online: 25 Jun 2014
AbstractforQuetiapine for acute bipolar depression: a systematic review and meta-analysis | Full Text | References | PDF (759.2 KB)
  • 797 Views
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Review

Review Article
Clinical effectiveness and safety of montelukast in asthma. What are the conclusions from clinical trials and meta-analyses?
Kam Lun Ellis Hon, Ting Fan Leung & Alexander KC Leung
Pages: 839-850
Published online: 26 Jun 2014
AbstractforClinical effectiveness and safety of montelukast in asthma. What are the conclusions from clinical trials and meta-analyses? | Full Text | References | PDF (262.7 KB)
  • 425 Views
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Open Access

Original Research

Article
Novel nanocrystal formulation of megestrol acetate has improved bioavailability compared with the conventional micronized formulation in the fasting state
Kyungho Jang, Seonghae Yoon, Sung-Eun Kim, Joo-Youn Cho, Seo Hyun Yoon, Kyoung Soo Lim, Kyung-Sang Yu, In-Jin Jang & Howard Lee
Pages: 851-858
Published online: 25 Jun 2014
AbstractforNovel nanocrystal formulation of megestrol acetate has improved bioavailability compared with the conventional micronized formulation in the fasting state | Full Text | References | PDF (670.2 KB)
  • 129 Views
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Open Access
Article
Assessing the potential impact of non-proprietary drug copies on quality of medicine and treatment in patients with relapsing multiple sclerosis: the experience with fingolimod
Jorge Correale, Erwin Chiquete, Snezana Milojevic, Nadina Frider & Imre Bajusz
Pages: 859-867
Published online: 25 Jun 2014
AbstractforAssessing the potential impact of non-proprietary drug copies on quality of medicine and treatment in patients with relapsing multiple sclerosis: the experience with fingolimod | Full Text | References | PDF (390.7 KB)
  • 111 Views
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Open Access

Case Report

Case Report
Virologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir
Fumitaka Suzuki, Hitomi Sezaki, Norio Akuta, Yoshiyuki Suzuki, Yusuke Kawamura, Tetsuya Hosaka, Masahiro Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Mariko Kobayashi, Sachiyo Watahiki, Rie Mineta, Yukiko Suzuki & Hiromitsu Kumada
Pages: 869-873
Published online: 30 Jun 2014
AbstractforVirologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir | Full Text | References | PDF (596.6 KB)
  • 79 Views
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Expert Opinion

Editorial
Treatment of pulmonary hypertension in idiopathic pulmonary fibrosis: shortfall in efficacy or trial design?
Steven D Nathan & Christopher S King
Pages: 875-885
Published online: 02 Jul 2014
AbstractforTreatment of pulmonary hypertension in idiopathic pulmonary fibrosis: shortfall in efficacy or trial design? | Full Text | References | PDF (569.1 KB)
  • 74 Views
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Open Access

Review

Review Article
New approaches to the management of schizophrenia: focus on aberrant hippocampal drive of dopamine pathways
Stephanie M Perez & Daniel J Lodge
Pages: 887-896
Published online: 02 Jul 2014
AbstractforNew approaches to the management of schizophrenia: focus on aberrant hippocampal drive of dopamine pathways | Full Text | References | PDF (549.8 KB)
  • 213 Views
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Open Access
Review Article
Design of oral agents for the management of multiple sclerosis: benefit and risk assessment for dimethyl fumarate
Jacqueline Ann Nicholas, Aaron Lee Boster, Jaime Imitola, Colleen O’Connell & Michael Karl Racke
Pages: 897-908
Published online: 07 Jul 2014
AbstractforDesign of oral agents for the management of multiple sclerosis: benefit and risk assessment for dimethyl fumarate | Full Text | References | PDF (367.8 KB)
  • 81 Views
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Open Access

Case Report

Case Report
Dexmedetomidine for awake intubation and an opioid-free general anesthesia in a superobese patient with suspected difficult intubation
Tomasz Gaszynski, Ewelina Gaszynska & Tomasz Szewczyk
Pages: 909-912
Published online: 07 Jul 2014
AbstractforDexmedetomidine for awake intubation and an opioid-free general anesthesia in a superobese patient with suspected difficult intubation | Full Text | References | PDF (477.8 KB)
  • 149 Views
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Review

Review Article
Drug delivery options to increase patient adherence and satisfaction in the management of rheumatoid arthritis – focus on subcutaneous tocilizumab
Yasuharu Nakashima, Masakazu Kondo, Hisaaki Miyahara & Yukihide Iwamoto
Pages: 913-919
Published online: 04 Jul 2014
AbstractforDrug delivery options to increase patient adherence and satisfaction in the management of rheumatoid arthritis – focus on subcutaneous tocilizumab | Full Text | References | PDF (462.1 KB)
  • 73 Views
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Open Access

Retraction

Retraction
Glycyrrhetinic acid-modified chitosan nanoparticles enhanced the effect of 5-fluorouracil in murine liver cancer model via regulatory T-cells [Retraction]
Page: 921
Published online: 08 Jul 2014
CitationforGlycyrrhetinic acid-modified chitosan nanoparticles enhanced the effect of 5-fluorouracil in murine liver cancer model via regulatory T-cells [Retraction] | Full Text | PDF (106.5 KB)
  • 52 Views
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Open Access

Review

Review Article
Profile and potential of ixabepilone in the treatment of pancreatic cancer
Brandon G Smaglo & Michael J Pishvaian
Pages: 923-930
Published online: 14 Jul 2014
AbstractforProfile and potential of ixabepilone in the treatment of pancreatic cancer | Full Text | References | PDF (217.4 KB)
  • 70 Views
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Original Research

Article
A preliminary study of painless and effective transdermal botulinum toxin A delivery by jet nebulization for treatment of primary hyperhidrosis
Tommaso Iannitti, Beniamino Palmieri, Anna Aspiro & Alessandro Di Cerbo
Pages: 931-935
Published online: 14 Jul 2014
AbstractforA preliminary study of painless and effective transdermal botulinum toxin A delivery by jet nebulization for treatment of primary hyperhidrosis | Full Text | References | PDF (437.9 KB)
  • 96 Views
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Open Access
Article
Prostatic urethral angle might be a predictor of treatment efficacy of α-blockers in men with lower urinary tract symptoms
Chen-Pang Hou, Chien-Lun Chen, Yu-Hsiang Lin, Yu-Lun Tsai, Phei-Lang Chang, Horng-Heng Juang & Ke-Hung Tsui
Pages: 937-943
Published online: 15 Jul 2014
AbstractforProstatic urethral angle might be a predictor of treatment efficacy of α-blockers in men with lower urinary tract symptoms | Full Text | References | PDF (903.9 KB)
  • 75 Views
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Open Access
Article
The load and release characteristics on a strong cationic ion-exchange fiber: kinetics, thermodynamics, and influences
Jing Yuan, Yanan Gao, Xinyu Wang, Hongzhuo Liu, Xin Che, Lu Xu, Yang Yang, Qifang Wang, Yan Wang & Sanming Li
Pages: 945-955
Published online: 16 Jul 2014
AbstractforThe load and release characteristics on a strong cationic ion-exchange fiber: kinetics, thermodynamics, and influences | Full Text | References | PDF (2.8 MB)
  • 77 Views
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Case Series

Pustular drug eruption due to Panax notoginseng saponins
ZhiQiang Yin, LiWen Ma, JiaLi Xu, JiPing Xia & Dan Luo
Pages: 957-961
Published online: 16 Jul 2014
AbstractforPustular drug eruption due to Panax notoginseng saponins | Full Text | References | PDF (1.5 MB)
  • 63 Views
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Original Research

Article
Evaluation of the biological activity of novel monocationic fluoroaryl-2,2′-bichalcophenes and their analogues
Warda A Hussin, Mohamed A Ismail, Abdullah M Alzahrani & Wael M El-Sayed
Pages: 963-972
Published online: 17 Jul 2014
AbstractforEvaluation of the biological activity of novel monocationic fluoroaryl-2,2′-bichalcophenes and their analogues | Full Text | References | PDF (420.8 KB)
  • 75 Views
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Open Access
Article
Sulforaphane reverses glucocorticoid-induced apoptosis in osteoblastic cells through regulation of the Nrf2 pathway
Hao Lin, Bo Wei, Guangsheng Li, Jinchang Zheng, Jiecong Sun, Jiaqi Chu, Rong Zeng & Yanru Niu
Pages: 973-982
Published online: 19 Jul 2014
AbstractforSulforaphane reverses glucocorticoid-induced apoptosis in osteoblastic cells through regulation of the Nrf2 pathway | Full Text | References | PDF (893.6 KB)
  • 110 Views
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Open Access
Article
Efficacy and pharmacokinetic activity of frovatriptan compared to rizatriptan in patients with moderate-to-severe migraine
Lidia Savi, Selene Mogavero & Colin Gerard Egan
Pages: 983-992
Published online: 21 Jul 2014
AbstractforEfficacy and pharmacokinetic activity of frovatriptan compared to rizatriptan in patients with moderate-to-severe migraine | Full Text | References | PDF (1 MB)
  • 121 Views
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Open Access
Article
Carbonic anhydrase IX-directed immunoliposomes for targeted drug delivery to human lung cancer cells in vitro
Blenda Chi Kwan Wong, Hongqi Zhang, Ling Qin, Hubiao Chen, Chen Fang, Aiping Lu & Zhijun Yang
Pages: 993-1001
Published online: 29 Sep 2022
AbstractforCarbonic anhydrase IX-directed immunoliposomes for targeted drug delivery to human lung cancer cells in vitro | Full Text | References | PDF (468.2 KB)
  • 103 Views
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Open Access
Article
Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: a characterization study
Armin Mooranian, Rebecca Negrulj, Nigel Chen-Tan, Hesham S Al-Sallami, Zhongxiang Fang, Trilochan Mukkur, Momir Mikov, Svetlana Golocorbin-Kon, Marc Fakhoury, Frank Arfuso & Hani Al-Salami
Pages: 1003-1012
Published online: 28 Jul 2014
AbstractforNovel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: a characterization study | Full Text | References | PDF (5.2 MB)
  • 155 Views
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Review

Review Article
Potential roles of GPR120 and its agonists in the management of diabetes
Dan Zhang & Po Sing Leung
Pages: 1013-1027
Published online: 29 Jul 2014
AbstractforPotential roles of GPR120 and its agonists in the management of diabetes | Full Text | References | PDF (553 KB)
  • 182 Views
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Open Access

Original Research

Article
Antimycobacterial, antimicrobial, and biocompatibility properties of para-aminosalicylic acid with zinc layered hydroxide and Zn/Al layered double hydroxide nanocomposites
Bullo Saifullah, Mohamed E El Zowalaty, Palanisamy Arulselvan, Sharida Fakurazi, Thomas J Webster, Benjamin M Geilich & Mohd Zobir Hussein
Pages: 1029-1036
Published online: 28 Jul 2014
AbstractforAntimycobacterial, antimicrobial, and biocompatibility properties of para-aminosalicylic acid with zinc layered hydroxide and Zn/Al layered double hydroxide nanocomposites | Full Text | References | PDF (554.5 KB)
  • 94 Views
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Review

Review Article
Clinical utility of erlotinib for the treatment of non-small-cell lung cancer in Japanese patients: current evidence
Yosuke Togashi, Hidetoshi Hayashi, Kazuhiko Nakagawa & Kazuto Nishio
Pages: 1037-1046
Published online: 31 Jul 2014
AbstractforClinical utility of erlotinib for the treatment of non-small-cell lung cancer in Japanese patients: current evidence | Full Text | References | PDF (303.7 KB)
  • 58 Views
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Original Research

Article
Design, synthesis, and anticancer activity of novel berberine derivatives prepared via CuAAC “click” chemistry as potential anticancer agents
Xin Jin, Tian-Hua Yan, Lan Yan, Qian Li, Rui-Lian Wang, Zhen-Lin Hu, Yuan-Ying Jiang, Qing-Yan Sun & Yong-Bing Cao
Pages: 1047-1059
Published online: 06 Aug 2014
AbstractforDesign, synthesis, and anticancer activity of novel berberine derivatives prepared via CuAAC “click” chemistry as potential anticancer agents | Full Text | References | PDF (1.3 MB)
  • 136 Views
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Rapid Communication

Article
Efficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii
Erik PH de Leeuw
Pages: 1061-1064
Published online: 08 Aug 2014
AbstractforEfficacy of the small molecule inhibitor of Lipid II BAS00127538 against Acinetobacter baumannii | Full Text | References | PDF (226.9 KB)
  • 70 Views
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Original Research

Article
Optimization of nebulized delivery of linezolid, daptomycin, and vancomycin aerosol
Paul Zarogoulidis, Ioannis Kioumis, Sofia Lampaki, John Organtzis, Konstantinos Porpodis, Dionysios Spyratos, Georgia Pitsiou, Dimitris Petridis, Athanasia Pataka, Haidong Huang, Qiang Li, Lonny Yarmus, Wolfgang Hohenforst-Schmidt, Nikolaos Pezirkianidis & Konstantinos Zarogoulidis
Pages: 1065-1072
Published online: 12 Aug 2014
AbstractforOptimization of nebulized delivery of linezolid, daptomycin, and vancomycin aerosol | Full Text | References | PDF (2.3 MB)
  • 90 Views
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Article
Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury by suppressing indoxyl sulfate production and restoring renal organic anion transporters
Chika Saigo, Yui Nomura, Yuko Yamamoto, Masataka Sagata, Rika Matsunaga, Hirofumi Jono, Kazuhiko Nishi & Hideyuki Saito
Pages: 1073-1082
Published online: 13 Aug 2014
AbstractforMeclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury by suppressing indoxyl sulfate production and restoring renal organic anion transporters | Full Text | References | PDF (629.9 KB)
  • 91 Views
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Article
Safety and efficacy of S-1 chemotherapy in recurrent and metastatic nasopharyngeal carcinoma patients after failure of platinum-based chemotherapy: multi-institutional retrospective analysis
Pei-Jian Peng, Hua Cheng, Xue-Qing Ou, Lin-Juan Zeng, Xuan Wu, Yu-Meng Liu, Zhong Lin, Yan-Na Tang, Si-Yang Wang, Hong-Yu Zhang & Zhi-Bin Chen
Pages: 1083-1087
Published online: 29 Sep 2022
AbstractforSafety and efficacy of S-1 chemotherapy in recurrent and metastatic nasopharyngeal carcinoma patients after failure of platinum-based chemotherapy: multi-institutional retrospective analysis | Full Text | References | PDF (232.2 KB)
  • 68 Views
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Article
Investigation of aromatase inhibitory activity of metal complexes of 8-hydroxyquinoline and uracil derivatives
Veda Prachayasittikul, Ratchanok Pingaew, Chanin Nantasenamat, Supaluk Prachayasittikul, Somsak Ruchirawat & Virapong Prachayasittikul
Pages: 1089-1096
Published online: 29 Sep 2022
AbstractforInvestigation of aromatase inhibitory activity of metal complexes of 8-hydroxyquinoline and uracil derivatives | Full Text | References | PDF (289.4 KB)
  • 103 Views
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Article
Predictive performance of gentamicin dosing nomograms
Jieon Lee, Seonghae Yoon, Donghoon Shin, HyeKyung Han, Hyungmi An, Jongtae Lee, Kyoung Soo Lim, Kyung-Sang Yu & Howard Lee
Pages: 1097-1106
Published online: 29 Sep 2022
AbstractforPredictive performance of gentamicin dosing nomograms | Full Text | References | PDF (349 KB)
  • 209 Views
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Article
Comparison of effects of anti-angiogenic agents in the zebrafish efficacy–toxicity model for translational anti-angiogenic drug discovery
Geetanjali Chimote, Jayasree Sreenivasan, Nilambari Pawar, Jyothi Subramanian, Hariharan Sivaramakrishnan & Somesh Sharma
Pages: 1107-1123
Published online: 19 Aug 2014
AbstractforComparison of effects of anti-angiogenic agents in the zebrafish efficacy–toxicity model for translational anti-angiogenic drug discovery | Full Text | References | PDF (4.7 MB)
  • 208 Views
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Article
Pharmacokinetics and bioavailability of oxycodone and acetaminophen following single-dose administration of MNK-795, a dual-layer biphasic IR/ER combination formulation, under fed and fasted conditions
Krishna Devarakonda, Terri Morton, Rachel Margulis, Michael Giuliani & Thomas Barrett
Pages: 1125-1134
Published online: 19 Aug 2014
AbstractforPharmacokinetics and bioavailability of oxycodone and acetaminophen following single-dose administration of MNK-795, a dual-layer biphasic IR/ER combination formulation, under fed and fasted conditions | Full Text | References | PDF (433.4 KB)
  • 78 Views
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Letter

Letter
Nasal saline as a placebo in a rhinosinusitis study
Ahmet Karadag & Ferhat Catal
Pages: 1135-1137
Published online: 20 Aug 2014
First Page PreviewforNasal saline as a placebo in a rhinosinusitis study | Full Text | References | PDF (270.9 KB)
  • 65 Views
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Original Research

Article
Design of an epitope-based peptide vaccine against spike protein of human coronavirus: an in silico approach
Arafat Rahman Oany, Abdullah-Al Emran & Tahmina Pervin Jyoti
Pages: 1139-1149
Published online: 29 Sep 2022
AbstractforDesign of an epitope-based peptide vaccine against spike protein of human coronavirus: an in silico approach | Full Text | References | PDF (2.2 MB)
  • 431 Views
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Article
Downregulated microRNA-148b in circulating PBMCs in chronic myeloid leukemia patients with undetectable minimal residual disease: a possible biomarker to discontinue imatinib safely
Junko H Ohyashiki, Kazushige Ohtsuki, Izuru Mizoguchi, Takayuki Yoshimoto, Seiichiro Katagiri, Tomohiro Umezu & Kazuma Ohyashiki
Pages: 1151-1159
Published online: 29 Sep 2022
AbstractforDownregulated microRNA-148b in circulating PBMCs in chronic myeloid leukemia patients with undetectable minimal residual disease: a possible biomarker to discontinue imatinib safely | Full Text | References | PDF (773.9 KB)
  • 80 Views
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Article
Effect of administration of water enriched in O2 by injection or electrolysis on transcutaneous oxygen pressure in anesthetized pigs
Antoine Charton, François Péronnet, Stephane Doutreleau, Evelyne Lonsdorfer, Alexis Klein, Liliana Jimenez, Bernard Geny, Pierre Diemunsch & Ruddy Richard
Pages: 1161-1167
Published online: 26 Aug 2014
AbstractforEffect of administration of water enriched in O2 by injection or electrolysis on transcutaneous oxygen pressure in anesthetized pigs | Full Text | References | PDF (340.2 KB)
  • 80 Views
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Article
The efficacy of ampicillin and Lactobacillus casei rhamnosus in the active management of preterm premature rupture of membranes remote from term
Salih Burcin Kavak, Ebru Kavak, Rasit Ilhan, Remzi Atilgan, Ozgur Arat, Ugur Deveci & Ekrem Sapmaz
Pages: 1169-1173
Published online: 30 Aug 2014
AbstractforThe efficacy of ampicillin and Lactobacillus casei rhamnosus in the active management of preterm premature rupture of membranes remote from term | Full Text | References | PDF (214.9 KB)
  • 95 Views
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Article
Remote ischemic conditioning improves coronary microcirculation in healthy subjects and patients with heart failure
Yasushi Kono, Shota Fukuda, Akihisa Hanatani, Koki Nakanishi, Kenichiro Otsuka, Haruyuki Taguchi & Kenei Shimada
Pages: 1175-1181
Published online: 27 Aug 2014
AbstractforRemote ischemic conditioning improves coronary microcirculation in healthy subjects and patients with heart failure | Full Text | References | PDF (497.7 KB)
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Review

Review Article
Update on the clinical utility of once-daily tacrolimus in the management of transplantation
Maria Aurora Posadas Salas & Titte R Srinivas
Pages: 1183-1194
Published online: 29 Sep 2022
AbstractforUpdate on the clinical utility of once-daily tacrolimus in the management of transplantation | Full Text | References | PDF (295 KB)
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Original Research

Article
Combining structure-based pharmacophore modeling, virtual screening, and in silico ADMET analysis to discover novel tetrahydro-quinoline based pyruvate kinase isozyme M2 activators with antitumor activity
Can Chen, Ting Wang, Fengbo Wu, Wei Huang, Gu He, Liang Ouyang, Mingli Xiang, Cheng Peng & Qinglin Jiang
Pages: 1195-1210
Published online: 02 Sep 2014
AbstractforCombining structure-based pharmacophore modeling, virtual screening, and in silico ADMET analysis to discover novel tetrahydro-quinoline based pyruvate kinase isozyme M2 activators with antitumor activity | Full Text | References | PDF (6.6 MB)
  • 159 Views
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Article
Combination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients
Seigo Miyoshi, Ryoji Ito, Hitoshi Katayama, Kentaro Dote, Mayuki Aibiki, Hironobu Hamada, Takafumi Okura & Jitsuo Higaki
Pages: 1211-1219
Published online: 02 Sep 2014
AbstractforCombination therapy with sivelestat and recombinant human soluble thrombomodulin for ARDS and DIC patients | Full Text | References | PDF (439.7 KB)
  • 97 Views
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Article
Microencapsulation as a novel delivery method for the potential antidiabetic drug, Probucol
Armin Mooranian, Rebecca Negrulj, Nigel Chen-Tan, Hesham S Al-Sallami, Zhongxiang Fang, TK Mukkur, Momir Mikov, Svetlana Golocorbin-Kon, Marc Fakhoury, Gerald F Watts, Vance Matthews, Frank Arfuso & Hani Al-Salami
Pages: 1221-1230
Published online: 29 Sep 2022
AbstractforMicroencapsulation as a novel delivery method for the potential antidiabetic drug, Probucol | Full Text | References | PDF (4.9 MB)
  • 130 Views
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Case Report

Case Report
Transient hypofibrinogenemia due to allopurinol
ZhiQiang Yin, JiaLi Xu, YongQiang Li, JiPing Xia & Dan Luo
Pages: 1231-1233
Published online: 02 Sep 2014
AbstractforTransient hypofibrinogenemia due to allopurinol | Full Text | References | PDF (378.9 KB)
  • 67 Views
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Original Research

Article
Characterization and evaluation of amine-modified graphene amphotericin B for the treatment of visceral leishmaniasis: in vivo and in vitro studies
Shyam Lal Mudavath, Mahe Talat, Madhukar Rai, Onkar Nath Srivastava & Shyam Sundar
Pages: 1235-1247
Published online: 04 Sep 2014
AbstractforCharacterization and evaluation of amine-modified graphene amphotericin B for the treatment of visceral leishmaniasis: in vivo and in vitro studies | Full Text | References | PDF (4 MB)
  • 115 Views
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Article
Single dose pharmacokinetic equivalence study of two gabapentin preparations in healthy subjects
Raymond R Tjandrawinata, Effi Setiawati, Ratih Sofia Ika Putri, Danang Agung Yunaidi, Fawzia Amalia & Liana W Susanto
Pages: 1249-1255
Published online: 04 Sep 2014
AbstractforSingle dose pharmacokinetic equivalence study of two gabapentin preparations in healthy subjects | Full Text | References | PDF (474 KB)
  • 126 Views
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Article
N-n-butyl haloperidol iodide inhibits H2O2-induced Na+/Ca2+-exchanger activation via the Na+/H+ exchanger in rat ventricular myocytes
Yong-Pan Huang, Fen-Fei Gao, Bin Wang, Fu-Chun Zheng, Yan-Mei Zhang, Yi-Cun Chen, Zhan-Qin Huang, Yan-Shan Zheng, Shu-Ping Zhong & Gang-Gang Shi
Pages: 1257-1267
Published online: 09 Sep 2014
AbstractforN-n-butyl haloperidol iodide inhibits H2O2-induced Na+/Ca2+-exchanger activation via the Na+/H+ exchanger in rat ventricular myocytes | Full Text | References | PDF (1.8 MB)
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Review

Review Article
Update on the clinical utility and practical use of ropivacaine in Chinese patients
Man Li, Li Wan, Wei Mei & Yuke Tian
Pages: 1269-1276
Published online: 09 Sep 2014
AbstractforUpdate on the clinical utility and practical use of ropivacaine in Chinese patients | Full Text | References | PDF (244.9 KB)
  • 121 Views
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Original Research

Article
Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis
Ping Cheng, Kan Chen, Yujing Xia, Weiqi Dai, Fan Wang, Miao Shen, Chengfen Wang, Jing Yang, Rong Zhu, Huawei Zhang, Jingjing Li, Yuanyuan Zheng, Junshan Wang, Yan Zhang, Jie Lu, Yingqun Zhou & Chuanyong Guo
Pages: 1277-1286
Published online: 09 Sep 2014
AbstractforHydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis | Full Text | References | PDF (9 MB)
  • 77 Views
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Article
Synthesis and characterization of a glycine-modified heptamethine indocyanine dye for in vivo cancer-targeted near-infrared imaging
Tao Liu, Shenglin Luo, Yang Wang, Xu Tan, Qingrong Qi & Chunmeng Shi
Pages: 1287-1297
Published online: 09 Sep 2014
AbstractforSynthesis and characterization of a glycine-modified heptamethine indocyanine dye for in vivo cancer-targeted near-infrared imaging | Full Text | References | PDF (2.1 MB)
  • 74 Views
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Article
Efficacy and safety of immunosuppressive therapy in the treatment of seronegative hepatitis associated aplastic anemia
Hai-Fei Chen, Bin-Xian Xu, Hong-Shi Shen, Zheng-Yang Li, Ling-Juan Jin, Jie-Qing Tang, Jing Wang, Jing-Jing Zhu, Long-Mei Qin, Qing-Ya Cui, Yong-Ya Ren & Tian-Qin Wu
Pages: 1299-1305
Published online: 09 Sep 2014
AbstractforEfficacy and safety of immunosuppressive therapy in the treatment of seronegative hepatitis associated aplastic anemia | Full Text | References | PDF (257.7 KB)
  • 73 Views
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Article
Superior rejection profile during the first 24 months after heart transplantation under tacrolimus as baseline immunosuppressive regimen
Matthias Helmschrott, Jan Beckendorf, Ceylan Akyol, Arjang Ruhparwar, Bastian Schmack, Christian Erbel, Christian A Gleissner, Mohammadreza Akhavanpoor, Philipp Ehlermann, Tom Bruckner, Hugo A Katus & Andreas O Doesch
Pages: 1307-1314
Published online: 09 Sep 2014
AbstractforSuperior rejection profile during the first 24 months after heart transplantation under tacrolimus as baseline immunosuppressive regimen | Full Text | References | PDF (466.1 KB)
  • 62 Views
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Article
Novel swellable polymer of orchidaceae family for gastroretentive drug delivery of famotidine
Mahboubeh Razavi, Shaik Nyamathulla, Hamed Karimian & Mohamed Ibrahim Noordin
Pages: 1315-1329
Published online: 09 Sep 2014
AbstractforNovel swellable polymer of orchidaceae family for gastroretentive drug delivery of famotidine | Full Text | References | PDF (4 MB)
  • 146 Views
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Article
Aminaphtone in the control of gingival bleeding in children
José Maria Pereira de Godoy & Mara Lucia Macedo Paizan
Pages: 1331-1334
Published online: 10 Sep 2014
AbstractforAminaphtone in the control of gingival bleeding in children | Full Text | References | PDF (390.2 KB)
  • 57 Views
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Review

Review Article
Update on developments with SGLT2 inhibitors in the management of type 2 diabetes
Michael A Nauck
Page: 1380
Published online: 11 Sep 2014
AbstractforUpdate on developments with SGLT2 inhibitors in the management of type 2 diabetes | Full Text | References | PDF (3.1 MB)
  • 1023 Views
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Review Article
Diverse pathomechanisms leading to the breakdown of cellular estrogen surveillance and breast cancer development: new therapeutic strategies
Zsuzsanna Suba
Pages: 1381-1390
Published online: 11 Sep 2014
AbstractforDiverse pathomechanisms leading to the breakdown of cellular estrogen surveillance and breast cancer development: new therapeutic strategies | Full Text | References | PDF (332.3 KB)
  • 96 Views
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Original Research

Article
Inhibition of urokinase plasminogen activator “uPA” activity alters ethanol consumption and conditioned place preference in mice
Elyazia Al Maamari, Mouza Al Ameri, Shamma Al Mansouri & Amine Bahi
Pages: 1391-1403
Published online: 16 Sep 2014
AbstractforInhibition of urokinase plasminogen activator “uPA” activity alters ethanol consumption and conditioned place preference in mice | Full Text | References | PDF (1.1 MB)
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Article
Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines
Ibrahim Jantan, Syed Nasir Abbas Bukhari, Olayiwola A Adekoya & Ingebrigt Sylte
Pages: 1405-1418
Published online: 16 Sep 2014
AbstractforStudies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines | Full Text | References | PDF (5 MB)
  • 226 Views
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Review

Review Article
Naltrexone sustained-release/bupropion sustained-release for the management of obesity: review of the data to date
Assumpta Caixàs, Lara Albert, Ismael Capel & Mercedes Rigla
Pages: 1419-1427
Published online: 18 Sep 2014
AbstractforNaltrexone sustained-release/bupropion sustained-release for the management of obesity: review of the data to date | Full Text | References | PDF (277.7 KB)
  • 284 Views
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Original Research

Article
Time and dose relationships between schisandrin B- and schisandrae fructus oil-induced hepatotoxicity and the associated elevations in hepatic and serum triglyceride levels in mice
Yi Zhang, Si-Yuan Pan, Shu-Feng Zhou, Xiao-Yan Wang, Nan Sun, Pei-Li Zhu, Zhu-Sheng Chu, Zhi-Ling Yu & Kam-Ming Ko
Pages: 1429-1439
Published online: 19 Sep 2014
AbstractforTime and dose relationships between schisandrin B- and schisandrae fructus oil-induced hepatotoxicity and the associated elevations in hepatic and serum triglyceride levels in mice | Full Text | References | PDF (568.3 KB)
  • 74 Views
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Article
Comparison of dexamethasone intravitreal implant and intravitreal triamcinolone acetonide for the treatment of pseudophakic cystoid macular edema in diabetic patients
Yalong Dang, Yalin Mu, Lin Li, Yahui Mu, Shujing Liu, Chun Zhang, Yu Zhu & Yimin Xu
Pages: 1441-1449
Published online: 18 Sep 2014
AbstractforComparison of dexamethasone intravitreal implant and intravitreal triamcinolone acetonide for the treatment of pseudophakic cystoid macular edema in diabetic patients | Full Text | References | PDF (1.5 MB)
  • 78 Views
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Article
Defensive mechanism in cholangiocarcinoma cells against oxidative stress induced by chlorin e6-based photodynamic therapy
Hye Myeong Lee, Chung-Wook Chung, Cy Hyun Kim, Do Hyung Kim, Tae Won Kwak, Young-Il Jeong & Dae Hwan Kang
Pages: 1451-1462
Published online: 18 Sep 2014
AbstractforDefensive mechanism in cholangiocarcinoma cells against oxidative stress induced by chlorin e6-based photodynamic therapy | Full Text | References | PDF (2.3 MB)
  • 69 Views
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Case Report

Case Report
Pemphigus erythematosus relapse associated with atorvastatin intake
Ada Lo Schiavo, Rosa Valentina Puca, Francesca Romano & Roberto Cozzi
Pages: 1463-1465
Published online: 18 Sep 2014
AbstractforPemphigus erythematosus relapse associated with atorvastatin intake | Full Text | References | PDF (409.7 KB)
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Original Research

Article
Enhanced bioavailability and anthelmintic efficacy of mebendazole in redispersible microparticles with low-substituted hydroxypropylcellulose
Paloma Marina de la Torre-Iglesias, Juan José García-Rodriguez, Guillermo Torrado, Susana Torrado, Santiago Torrado-Santiago & Francisco Bolás-Fernández
Pages: 1467-1479
Published online: 18 Sep 2014
AbstractforEnhanced bioavailability and anthelmintic efficacy of mebendazole in redispersible microparticles with low-substituted hydroxypropylcellulose | Full Text | References | PDF (960.3 KB)
  • 127 Views
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Article
Ferulago angulata activates intrinsic pathway of apoptosis in MCF-7 cells associated with G1 cell cycle arrest via involvement of p21/p27
Hamed Karimian, Soheil Zorofchian Moghadamtousi, Mehran Fadaeinasab, Shahram Golbabapour, Mahboubeh Razavi, Maryam Hajrezaie, Aditya Arya, Mahmood Ameen Abdulla, Syam Mohan, Hapipah Mohd Ali & Mohamad Ibrahim Noordin
Pages: 1481-1497
Published online: 22 Sep 2014
AbstractforFerulago angulata activates intrinsic pathway of apoptosis in MCF-7 cells associated with G1 cell cycle arrest via involvement of p21/p27 | Full Text | References | PDF (8.1 MB)
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Article
Drug-likeness approach of 2-aminopyrimidines as histamine H3 receptor ligands
Bassem Sadek, Annemarie Schreeb, Johannes Stephan Schwed, Lilia Weizel & Holger Stark
Pages: 1499-1513
Published online: 19 Sep 2014
AbstractforDrug-likeness approach of 2-aminopyrimidines as histamine H3 receptor ligands | Full Text | References | PDF (1.5 MB)
  • 72 Views
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Article
Synthesis and antibacterial activities of acylide derivatives bearing an aryl-tetrazolyl chain
Ling-Xing Shan, Ping-Hua Sun, Bao-Qin Guo, Xing-Jun Xu, Zhi-Qiang Li, Jia-Zhi Sun, Shu-Feng Zhou & Wei-Min Chen
Pages: 1515-1525
Published online: 24 Sep 2014
AbstractforSynthesis and antibacterial activities of acylide derivatives bearing an aryl-tetrazolyl chain | Full Text | References | PDF (453.3 KB)
  • 78 Views
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Article
Interferon-γ and celecoxib inhibit lung-tumor growth through modulating M2/M1 macrophage ratio in the tumor microenvironment
Fuqiang Ren, Mingyu Fan, Jiandong Mei, Yongqiang Wu, Chengwu Liu, Qiang Pu, Zongbing You & Lunxu Liu
Pages: 1527-1538
Published online: 23 Sep 2014
AbstractforInterferon-γ and celecoxib inhibit lung-tumor growth through modulating M2/M1 macrophage ratio in the tumor microenvironment | Full Text | References | PDF (9.8 MB)
  • 111 Views
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Article
Cross-sectional and longitudinal analysis of cancer vaccination trials registered on the US Clinical Trials Database demonstrates paucity of immunological trial endpoints and decline in registration since 2008
Liangjian Lu, Haixi Yan, Vijay Shyam-Sundar & Tobias Janowitz
Pages: 1539-1553
Published online: 27 Sep 2014
AbstractforCross-sectional and longitudinal analysis of cancer vaccination trials registered on the US Clinical Trials Database demonstrates paucity of immunological trial endpoints and decline in registration since 2008 | Full Text | References | PDF (1.4 MB)
  • 70 Views
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Review

Review Article
Clinical utility and development of the fluticasone/formoterol combination formulation (Flutiform®) for the treatment of asthma
Ricardo Antonio Tan & Jonathan Corren
Pages: 1555-1561
Published online: 30 Sep 2014
AbstractforClinical utility and development of the fluticasone/formoterol combination formulation (Flutiform®) for the treatment of asthma | Full Text | References | PDF (209.7 KB)
  • 80 Views
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Original Research

Article
Provisional in-silico biopharmaceutics classification (BCS) to guide oral drug product development
Omri Wolk, Riad Agbaria & Arik Dahan
Pages: 1563-1575
Published online: 24 Sep 2014
AbstractforProvisional in-silico biopharmaceutics classification (BCS) to guide oral drug product development | Full Text | References | PDF (3 MB)
  • 173 Views
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Article
Phyllostachys edulis extract induces apoptosis signaling in osteosarcoma cells, associated with AMPK activation
Chi-Wen Chou, Ya-Wen Cheng & Chung-Hung Tsai
Pages: 1577-1584
Published online: 24 Sep 2014
AbstractforPhyllostachys edulis extract induces apoptosis signaling in osteosarcoma cells, associated with AMPK activation | Full Text | References | PDF (1.9 MB)
  • 74 Views
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Article
Bioactive protein fraction DLBS1033 containing lumbrokinase isolated from Lumbricus rubellus: ex vivo, in vivo, and pharmaceutic studies
Raymond R Tjandrawinata, Jessica Trisina, Puji Rahayu, Lorentius Agung Prasetya, Aang Hanafiah & Heni Rachmawati
Pages: 1585-1593
Published online: 25 Sep 2014
AbstractforBioactive protein fraction DLBS1033 containing lumbrokinase isolated from Lumbricus rubellus: ex vivo, in vivo, and pharmaceutic studies | Full Text | References | PDF (1.4 MB)
  • 176 Views
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Review

Review Article
EGFR mutations as a prognostic and predictive marker in non-small-cell lung cancer
Shu Fang & Zhehai Wang
Pages: 1595-1611
Published online: 26 Sep 2014
AbstractforEGFR mutations as a prognostic and predictive marker in non-small-cell lung cancer | Full Text | References | PDF (501.2 KB)
  • 203 Views
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Original Research

Article
Pharmacokinetics and tolerability of the new second-generation nonnucleoside reverse- transcriptase inhibitor KM-023 in healthy subjects
Yu-Jung Cha, Kyoung Soo Lim, Min-Kyu Park, Stephen Schneider, Brian Bray, Myung-Chol Kang, Jae-Yong Chung, Seo Hyun Yoon, Joo-Youn Cho & Kyung-Sang Yu
Pages: 1613-1619
Published online: 29 Sep 2022
AbstractforPharmacokinetics and tolerability of the new second-generation nonnucleoside reverse- transcriptase inhibitor KM-023 in healthy subjects | Full Text | References | PDF (645.5 KB)
  • 65 Views
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Article
Buccal acetaminophen provides fast analgesia: two randomized clinical trials in healthy volunteers
Gisèle Pickering, Nicolas Macian, Frédéric Libert, J Michel Cardot, Séverine Coissard, Philippe Perovitch, Marc Maury & Claude Dubray
Pages: 1621-1627
Published online: 26 Sep 2014
AbstractforBuccal acetaminophen provides fast analgesia: two randomized clinical trials in healthy volunteers | Full Text | References | PDF (540 KB)
  • 79 Views
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Article
α-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-κB and Hsp70 protein modulation in vitro, and tumor reduction in vivo
Mohamed Yousif Ibrahim, Najihah Mohd Hashim, Syam Mohan, Mahmood Ameen Abdulla, Behnam Kamalidehghan, Mostafa Ghaderian, Firouzeh Dehghan, Landa Zeenelabdin Ali, Ismail Adam Arbab, Maizatulakmal Yahayu, Gwendoline Ee Cheng Lian, Fatemeh Ahmadipour & Hapipah Mohd Ali
Pages: 1629-1647
Published online: 27 Sep 2014
Abstractforα-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-κB and Hsp70 protein modulation in vitro, and tumor reduction in vivo | Full Text | References | PDF (4.5 MB)
  • 127 Views
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Article
Fusion of cell-penetrating peptides to thermally responsive biopolymer improves tumor accumulation of p21 peptide in a mouse model of pancreatic cancer
Leslie R Walker, Jung Su Ryu, Eddie Perkins, Lacey R McNally & Drazen Raucher
Pages: 1649-1658
Published online: 07 Oct 2014
AbstractforFusion of cell-penetrating peptides to thermally responsive biopolymer improves tumor accumulation of p21 peptide in a mouse model of pancreatic cancer | Full Text | References | PDF (1.1 MB)
  • 101 Views
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Article
Anticancer, antioxidant activities, and DNA affinity of novel monocationic bithiophenes and analogues
Mohamed A Ismail, Reem K Arafa, Magdy M Youssef & Wael M El-Sayed
Pages: 1659-1672
Published online: 29 Sep 2022
AbstractforAnticancer, antioxidant activities, and DNA affinity of novel monocationic bithiophenes and analogues | Full Text | References | PDF (991.4 KB)
  • 93 Views
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Article
An optimized probucol microencapsulated formulation integrating a secondary bile acid (deoxycholic acid) as a permeation enhancer
Armin Mooranian, Rebecca Negrulj, Nigel Chen-Tan, Gerald F Watts, Frank Arfuso & Hani Al-Salami
Pages: 1673-1683
Published online: 29 Sep 2014
AbstractforAn optimized probucol microencapsulated formulation integrating a secondary bile acid (deoxycholic acid) as a permeation enhancer | Full Text | References | PDF (7.4 MB)
  • 92 Views
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Article
Exploratory meta-analysis on lisdexamfetamine versus placebo in adult ADHD
Narong Maneeton, Benchalak Maneeton, Sirijit Suttajit, Jirayu Reungyos, Manit Srisurapanont & Stephen D Martin
Pages: 1685-1693
Published online: 03 Oct 2014
AbstractforExploratory meta-analysis on lisdexamfetamine versus placebo in adult ADHD | Full Text | References | PDF (336.6 KB)
  • 333 Views
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Article
Effects of immunosuppressive treatment on protein expression in rat kidney
Karolina Kędzierska, Katarzyna Sporniak-Tutak, Krzysztof Sindrewicz, Joanna Bober, Leszek Domański, Mirosław Parafiniuk, Elżbieta Urasińska, Andrzej Ciechanowicz, Maciej Domański, Tomasz Smektała, Marek Masiuk, Wiesław Skrzypczak, Małgorzata Ożgo, Joanna Kabat-Koperska & Kazimierz Ciechanowski
Pages: 1695-1708
Published online: 30 Sep 2014
AbstractforEffects of immunosuppressive treatment on protein expression in rat kidney | Full Text | References | PDF (3.1 MB)
  • 63 Views
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Article
Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin (DA-1229), a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers
Namyi Gu, Min Kyu Park, Tae-Eun Kim, Mi Young Bahng, Kyoung Soo Lim, Sang-Heon Cho, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang & Kyung-Sang Yu
Pages: 1709-1721
Published online: 29 Sep 2022
AbstractforMultiple-dose pharmacokinetics and pharmacodynamics of evogliptin (DA-1229), a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers | Full Text | References | PDF (1.7 MB)
  • 165 Views
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Article
Effect of renal function on the pharmacokinetics of fimasartan: a single-dose, open-label, Phase I study
Seokuee Kim, Jongtae Lee, Donghoon Shin, Kyoung Soo Lim, Yon Su Kim, In-Jin Jang & Kyung-Sang Yu
Pages: 1723-1731
Published online: 06 Oct 2014
AbstractforEffect of renal function on the pharmacokinetics of fimasartan: a single-dose, open-label, Phase I study | Full Text | References | PDF (687.4 KB)
  • 112 Views
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Article
The comparative development of elevated resistance to macrolides in community-acquired pneumonia caused by Streptococcus pneumoniae
Josef Yayan
Pages: 1733-1743
Published online: 03 Oct 2014
AbstractforThe comparative development of elevated resistance to macrolides in community-acquired pneumonia caused by Streptococcus pneumoniae | Full Text | References | PDF (314.3 KB)
  • 88 Views
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Review

Review Article
Posttranslational regulation of phosphatase and tensin homolog (PTEN) and its functional impact on cancer behaviors
Wenting Xu, Zhen Yang, Shu-Feng Zhou & Nonghua Lu
Pages: 1745-1751
Published online: 06 Oct 2014
AbstractforPosttranslational regulation of phosphatase and tensin homolog (PTEN) and its functional impact on cancer behaviors | Full Text | References | PDF (694.6 KB)
  • 114 Views
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Article
Inhaled tyrosine kinase inhibitors for pulmonary hypertension: a possible future treatment
Georgia Pitsiou, Paul Zarogoulidis, Dimitris Petridis, Ioannis Kioumis, Sofia Lampaki, John Organtzis, Konstantinos Porpodis, Antonis Papaiwannou, Theodora Tsiouda, Wolfgang Hohenforst-Schmidt, Stylianos Kakolyris, Konstantinos Syrigos, Haidong Huang, Qiang Li, J Francis Turner & Konstantinos Zarogoulidis
Pages: 1753-1763
Published online: 07 Oct 2014
AbstractforInhaled tyrosine kinase inhibitors for pulmonary hypertension: a possible future treatment | Full Text | References | PDF (1.5 MB)
  • 83 Views
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Article
(R)-(+)-α-Lipoic acid protected NG108-15 cells against H2O2-induced cell death through PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines
Muhamad Noor Alfarizal Kamarudin, Nur Afiqah Mohd Raflee, Sharifah Salwa Syed Hussein, Jia Ye Lo, Hadi Supriady & Habsah Abdul Kadir
Pages: 1765-1780
Published online: 08 Oct 2014
Abstractfor(R)-(+)-α-Lipoic acid protected NG108-15 cells against H2O2-induced cell death through PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines | Full Text | References | PDF (4.3 MB)
  • 106 Views
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Article
Evaluation of the pharmacokinetic and pharmacodynamic drug interactions between cilnidipine and valsartan, in healthy volunteers
Jieon Lee, Howard Lee, Kyungho Jang, Kyoung Soo Lim, Dongseong Shin & Kyung-Sang Yu
Pages: 1781-1788
Published online: 08 Oct 2014
AbstractforEvaluation of the pharmacokinetic and pharmacodynamic drug interactions between cilnidipine and valsartan, in healthy volunteers | Full Text | References | PDF (735.1 KB)
  • 217 Views
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Open Access
Article
Purification and in vitro antioxidant activities of tellurium-containing phycobiliproteins from tellurium-enriched Spirulina platensis
Fang Yang, Ka-Hing Wong, Yufeng Yang, Xiaoling Li, Jie Jiang, Wenjie Zheng, Hualian Wu & Tianfeng Chen
Pages: 1789-1800
Published online: 09 Oct 2014
AbstractforPurification and in vitro antioxidant activities of tellurium-containing phycobiliproteins from tellurium-enriched Spirulina platensis | Full Text | References | PDF (1.5 MB)
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Article
Development of polyether urethane intravaginal rings for the sustained delivery of hydroxychloroquine
Yufei Chen, Yannick Leandre Traore, Amanda Li, Keith R Fowke & Emmanuel A Ho
Pages: 1801-1815
Published online: 09 Oct 2014
AbstractforDevelopment of polyether urethane intravaginal rings for the sustained delivery of hydroxychloroquine | Full Text | References | PDF (2 MB)
  • 106 Views
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Article
Topical pimecrolimus inhibits high-dose UVB irradiation-induced epidermal Langerhans cell migration, via regulation of TNF-α and E-cadherin
ZhiQiang Yin, JiaLi Xu, BingRong Zhou, Di Wu, Yang Xu, JiaAn Zhang & Dan Luo
Pages: 1817-1825
Published online: 29 Sep 2022
AbstractforTopical pimecrolimus inhibits high-dose UVB irradiation-induced epidermal Langerhans cell migration, via regulation of TNF-α and E-cadherin | Full Text | References | PDF (2.3 MB)
  • 60 Views
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Article
Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo
Yuan-Yuan Zhao, Ying Tian, Jing Zhang, Fei Xu, Yun-Peng Yang, Yan Huang, Hong-Yun Zhao, Jian-Wei Zhang, Cong Xue, Michael H Lam, Li Yan, Zhi-Huang Hu, Xiao-Xiao Dinglin & Li Zhang
Pages: 1827-1837
Published online: 10 Oct 2014
AbstractforEffects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo | Full Text | References | PDF (5.5 MB)
  • 107 Views
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Article
Potent tumor targeting drug release system comprising MMP-2 specific peptide fragment with self-assembling characteristics
Dan Hua, Weiling Kong, Xuemin Zheng, Zhixing Zhou, Bing Yu, Yazhou Li, Yuli Wang, Xue Yang, Changxiao Liu, Lida Tang, Ying Li & Min Gong
Pages: 1839-1849
Published online: 14 Oct 2014
AbstractforPotent tumor targeting drug release system comprising MMP-2 specific peptide fragment with self-assembling characteristics | Full Text | References | PDF (2.7 MB)
  • 81 Views
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Review

Review Article
Preclinical profile of cabazitaxel
Patricia Vrignaud, Dorothée Semiond, Veronique Benning, Eric Beys, Hervé Bouchard & Sunil Gupta
Pages: 1851-1867
Published online: 13 Oct 2014
AbstractforPreclinical profile of cabazitaxel | Full Text | References | PDF (943 KB)
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Original Research

Article
Synthesis and biological evaluation of novel indole-2-one and 7-aza-2-oxindole derivatives as anti-inflammatory agents
Gaozhi Chen, Lili Jiang, Lili Dong, Zhe Wang, Fengli Xu, Ting Ding, Lili Fu, Qilu Fang, Zhiguo Liu, Xiaoou Shan & Guang Liang
Pages: 1869-1892
Published online: 13 Oct 2014
AbstractforSynthesis and biological evaluation of novel indole-2-one and 7-aza-2-oxindole derivatives as anti-inflammatory agents | Full Text | References | PDF (1.8 MB)
  • 102 Views
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Open Access
Article
Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids
Oscar M Bautista-Aguilera, Gerard Esteban, Mourad Chioua, Katarina Nikolic, Danica Agbaba, Ignacio Moraleda, Isabel Iriepa, Elena Soriano, Abdelouahid Samadi, Mercedes Unzeta & José Marco-Contelles
Pages: 1893-1910
Published online: 13 Oct 2014
AbstractforMultipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids | Full Text | References | PDF (2.9 MB)
  • 203 Views
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Review

Review Article
Animal models and therapeutic molecular targets of cancer: utility and limitations
Maria Cekanova & Kusum Rathore
Pages: 1911-1922
Published online: 14 Oct 2014
AbstractforAnimal models and therapeutic molecular targets of cancer: utility and limitations | Full Text | References | PDF (500.6 KB)
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Original Research

Article
Influence of caffeine and hyaluronic acid on collagen biosynthesis in human skin fibroblasts
Magdalena Donejko, Andrzej Przylipiak, Edyta Rysiak, Katarzyna Głuszuk & Arkadiusz Surażyński
Pages: 1923-1928
Published online: 15 Oct 2014
AbstractforInfluence of caffeine and hyaluronic acid on collagen biosynthesis in human skin fibroblasts | Full Text | References | PDF (512 KB)
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Article
Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models
Pin-Jui Kung, Yu-Chen Tao, Ho-Chiang Hsu, Wan-Ling Chen, Te-Hsien Lin, Donala Janreddy, Ching-Fa Yao, Kuo-Hsuan Chang, Jung-Yaw Lin, Ming-Tsan Su, Chung-Hsin Wu, Guey-Jen Lee-Chen & Hsiu-Mei Hsieh-Li
Pages: 1929-1939
Published online: 16 Oct 2014
AbstractforIndole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models | Full Text | References | PDF (5.4 MB)
  • 83 Views
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Article
Anti-inflammatory effects of cordycepin in lipopolysaccharide-stimulated RAW 264.7 macrophages through Toll-like receptor 4-mediated suppression of mitogen-activated protein kinases and NF-κB signaling pathways
Yung Hyun Choi, Gi-Young Kim & Hye Hyeon Lee
Pages: 1941-1953
Published online: 16 Oct 2014
AbstractforAnti-inflammatory effects of cordycepin in lipopolysaccharide-stimulated RAW 264.7 macrophages through Toll-like receptor 4-mediated suppression of mitogen-activated protein kinases and NF-κB signaling pathways | Full Text | References | PDF (1.9 MB)
  • 266 Views
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Article
Intestinal absorption, organ distribution, and urinary excretion of the rare sugar D-psicose
Ikuko Tsukamoto, Akram Hossain, Fuminori Yamaguchi, Yuko Hirata, Youyi Dong, Kazuyo Kamitori, Li Sui, Machiko Nonaka, Masaki Ueno, Kazuyuki Nishimoto, Hirofumi Suda, Kenji Morimoto, Tsuyoshi Shimonishi, Madoka Saito, Tao Song, Ryoji Konishi & Masaaki Tokuda
Pages: 1955-1964
Published online: 17 Oct 2014
AbstractforIntestinal absorption, organ distribution, and urinary excretion of the rare sugar D-psicose | Full Text | References | PDF (400.2 KB)
  • 189 Views
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Article
Anticancer efficacy and absorption, distribution, metabolism, and toxicity studies of Aspergiolide A in early drug development
Yuanyuan Wang, Xin Qi, Dehai Li, Tianjiao Zhu, Xiaomei Mo & Jing Li
Pages: 1965-1977
Published online: 17 Oct 2014
AbstractforAnticancer efficacy and absorption, distribution, metabolism, and toxicity studies of Aspergiolide A in early drug development | Full Text | References | PDF (1.4 MB)
  • 74 Views
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Short Report

Brief Report
Efficacy of short novel antimicrobial and anti-inflammatory peptides in a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) skin infection
Mohamed F Mohamed & Mohamed N Seleem
Pages: 1979-1983
Published online: 17 Oct 2014
AbstractforEfficacy of short novel antimicrobial and anti-inflammatory peptides in a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) skin infection | Full Text | References | PDF (590.5 KB)
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Original Research

Article
Risk factors associated with ineligibility of adjuvant cisplatin-based chemotherapy after nephroureterectomy
I-Hung Shao, Yu-Hsiang Lin, Chen-Pang Hou, Horng-Heng Juang, Chien-Lun Chen, Phei-Lang Chang & Ke-Hung Tsui
Pages: 1985-1991
Published online: 21 Oct 2014
AbstractforRisk factors associated with ineligibility of adjuvant cisplatin-based chemotherapy after nephroureterectomy | Full Text | References | PDF (243.5 KB)
  • 55 Views
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Article
Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs: involvement of MAPK and NF-κB pathways
Mouna Achoui, Karen Heyninck, Chung Yeng Looi, Ali Mohd Mustafa, Guy Haegeman & Mohd Rais Mustafa
Pages: 1993-2007
Published online: 20 Oct 2014
AbstractforImmunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs: involvement of MAPK and NF-κB pathways | Full Text | References | PDF (4.1 MB)
  • 65 Views
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Review

Review Article
Decision-making in product portfolios of pharmaceutical research and development – managing streams of innovation in highly regulated markets
Antti Jekunen
Pages: 2009-2016
Published online: 21 Oct 2014
AbstractforDecision-making in product portfolios of pharmaceutical research and development – managing streams of innovation in highly regulated markets | Full Text | References | PDF (307.7 KB)
  • 436 Views
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Review Article
Safety and efficacy of peramivir for influenza treatment
Atsuko Hata, Ryoko Akashi-Ueda, Kazufumi Takamatsu & Takuro Matsumura
Pages: 2017-2038
Published online: 29 Sep 2022
AbstractforSafety and efficacy of peramivir for influenza treatment | Full Text | References | PDF (536.7 KB)
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Original Research

Article
The doripenem serum concentrations in intensive care patients suffering from acute kidney injury, sepsis, and multi organ dysfunction syndrome undergoing continuous renal replacement therapy slow low-efficiency dialysis
Andrzej Wieczorek, Andrzej Tokarz, Wojciech Gaszynski & Tomasz Gaszynski
Pages: 2039-2044
Published online: 29 Sep 2022
AbstractforThe doripenem serum concentrations in intensive care patients suffering from acute kidney injury, sepsis, and multi organ dysfunction syndrome undergoing continuous renal replacement therapy slow low-efficiency dialysis | Full Text | References | PDF (426.3 KB)
  • 65 Views
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Article
Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer’s drugs: a computational investigation
Faizul Azam, Abdualrahman M Amer, Abdullah R Abulifa & Mustafa M Elzwawi
Pages: 2045-2059
Published online: 29 Sep 2022
AbstractforGinger components as new leads for the design and development of novel multi-targeted anti-Alzheimer’s drugs: a computational investigation | Full Text | References | PDF (3.8 MB)
  • 538 Views
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Article
Clinical efficacy of second-generation tyrosine kinase inhibitors in imatinib-resistant gastrointestinal stromal tumors: a meta-analysis of recent clinical trials
Lile Wu, Zhongqiang Zhang, Hongliang Yao, Kuijie Liu, Yu Wen & Li Xiong
Pages: 2061-2067
Published online: 30 Oct 2014
AbstractforClinical efficacy of second-generation tyrosine kinase inhibitors in imatinib-resistant gastrointestinal stromal tumors: a meta-analysis of recent clinical trials | Full Text | References | PDF (312.3 KB)
  • 65 Views
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Article
Effects of caffeic acid phenethyl ester on palatal mucosal defects and tooth extraction sockets
Ahmet Günay, Osman Fatih Arpağ, Serhat Atilgan, Ferhan Yaman, Yusuf Atalay & İzzet Acikan
Pages: 2069-2074
Published online: 23 Oct 2014
AbstractforEffects of caffeic acid phenethyl ester on palatal mucosal defects and tooth extraction sockets | Full Text | References | PDF (1.9 MB)
  • 90 Views
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Review

Review Article
Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties
Yan-Yang Wang, Yin-Xue Yang, Hong Zhe, Zhi-Xu He & Shu-Feng Zhou
Pages: 2075-2088
Published online: 23 Oct 2014
AbstractforBardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties | Full Text | References | PDF (1,005.3 KB)
  • 389 Views
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Original Research

Article
The role of ketotifen in the prevention of testicular damage in rats with experimental unilateral undescended testes
Abdullah Acikgoz, Ramazan Asci, Oguz Aydin, Hikmet Çavuş, Gamze Donmez & Recep Buyukalpelli
Pages: 2089-2097
Published online: 23 Oct 2014
AbstractforThe role of ketotifen in the prevention of testicular damage in rats with experimental unilateral undescended testes | Full Text | References | PDF (2.7 MB)
  • 94 Views
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Article
Gastroprotective activity of Annona muricata leaves against ethanol-induced gastric injury in rats via Hsp70/Bax involvement
Soheil Zorofchian Moghadamtousi, Elham Rouhollahi, Hamed Karimian, Mehran Fadaeinasab, Mahmood Ameen Abdulla & Habsah Abdul Kadir
Pages: 2099-2111
Published online: 28 Oct 2014
AbstractforGastroprotective activity of Annona muricata leaves against ethanol-induced gastric injury in rats via Hsp70/Bax involvement | Full Text | References | PDF (10.5 MB)
  • 264 Views
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Article
RETRACTED: The influence of goal-directed fluid therapy on the prognosis of elderly patients with hypertension and gastric cancer surgery
Kai Zeng, Yanzhen Li, Min Liang, Youguang Gao, Hongda Cai & Caizhu Lin
Pages: 2113-2119
Published online: 29 Oct 2014
AbstractforRETRACTED: The influence of goal-directed fluid therapy on the prognosis of elderly patients with hypertension and gastric cancer surgery | PDF (907.2 KB)
  • 14 Views
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Article
Curcumin could reduce the monomer of TTR with Tyr114Cys mutation via autophagy in cell model of familial amyloid polyneuropathy
Hui Li, Yu Zhang, Li Cao, Ran Xiong, Bei Zhang, Li Wu, Zongbo Zhao & Sheng-Di Chen
Pages: 2121-2128
Published online: 31 Oct 2014
AbstractforCurcumin could reduce the monomer of TTR with Tyr114Cys mutation via autophagy in cell model of familial amyloid polyneuropathy | Full Text | References | PDF (1.9 MB)
  • 100 Views
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Article
Clinicopathological significance and potential drug target of p15INK4B in multiple myeloma
Jun Li, Lintao Bi, Yumei Lin, Zhenxia Lu & Gang Hou
Pages: 2129-2136
Published online: 29 Sep 2022
AbstractforClinicopathological significance and potential drug target of p15INK4B in multiple myeloma | Full Text | References | PDF (519.5 KB)
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Article
Effect of honokiol on the induction of drug-metabolizing enzymes in human hepatocytes
Yong-Yeon Cho, Hyeon-Uk Jeong, Jeong-Han Kim & Hye Suk Lee
Pages: 2137-2145
Published online: 03 Nov 2014
AbstractforEffect of honokiol on the induction of drug-metabolizing enzymes in human hepatocytes | Full Text | References | PDF (465.6 KB)
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Article
Functional analysis of tanshinone IIA that blocks the redox function of human apurinic/apyrimidinic endonuclease 1/redox factor-1
Jiangdong Sui, Mengxia Li, Chengyuan Qian, Shufeng Wang, Yi Cheng, Benjamin PC Chen & Dong Wang
Pages: 2147-2160
Published online: 29 Sep 2022
AbstractforFunctional analysis of tanshinone IIA that blocks the redox function of human apurinic/apyrimidinic endonuclease 1/redox factor-1 | Full Text | References | PDF (3.7 MB)
  • 76 Views
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Article
Discovery and evaluation of novel anti-inflammatory derivatives of natural bioactive curcumin
Yali Zhang, Xin Jiang, Kesong Peng, Chengwei Chen, Lili Fu, Zhe Wang, Jianpeng Feng, Zhiguo Liu, Huajie Zhang, Guang Liang & Zheer Pan
Pages: 2161-2171
Published online: 04 Nov 2014
AbstractforDiscovery and evaluation of novel anti-inflammatory derivatives of natural bioactive curcumin | Full Text | References | PDF (3.6 MB)
  • 100 Views
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Article
The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1/2 phosphorylation in 6-OHDA-lesioned rats
Lu Song, Xinxin Yang, Yaping Ma, Na Wu & Zhenguo Liu
Pages: 2173-2180
Published online: 04 Nov 2014
AbstractforThe CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1/2 phosphorylation in 6-OHDA-lesioned rats | Full Text | References | PDF (680.7 KB)
  • 65 Views
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Review

Review Article
Clinical utility of apixaban in the prevention and treatment of venous thromboembolism: current evidence
Ali Zalpour & Thein Hlaing Oo
Pages: 2181-2191
Published online: 29 Sep 2022
AbstractforClinical utility of apixaban in the prevention and treatment of venous thromboembolism: current evidence | Full Text | References | PDF (771.2 KB)
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Original Research

Article
RETRACTED: Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens
Mohamed Yousif Ibrahim, Najihah Mohd Hashim, Syam Mohan, Mahmood Ameen Abdulla, Siddig Ibrahim Abdelwahab, Behnam Kamalidehghan, Mostafa Ghaderian, Firouzeh Dehghan, Landa Zeenelabdin Ali, Hamed Karimian, Maizatulakmal Yahayu, Gwendoline Cheng Lian Ee, Abdoreza Soleimani Farjam & Hapipah Mohd Ali
Pages: 2193-2211
Published online: 06 Nov 2014
AbstractforRETRACTED: Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens | PDF (6.7 MB)
  • 24 Views
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Article
Caval filters in intensive care: a retrospective study
F Ferraro, TL Di Gennaro, A Torino, J Petruzzi, A d’Elia, P Fusco, R Marfella & B Lettieri
Pages: 2213-2219
Published online: 06 Nov 2014
AbstractforCaval filters in intensive care: a retrospective study | Full Text | References | PDF (312.2 KB)
  • 57 Views
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Review

Review Article
Studies of selective TNF inhibitors in the treatment of brain injury from stroke and trauma: a review of the evidence to date
Antonino Tuttolomondo, Rosaria Pecoraro & Antonio Pinto
Pages: 2221-2239
Published online: 29 Sep 2022
AbstractforStudies of selective TNF inhibitors in the treatment of brain injury from stroke and trauma: a review of the evidence to date | Full Text | References | PDF (4.6 MB)
  • 473 Views
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Original Research

Article
Early non-steady-state population pharmacokinetics of oral cyclosporine in renal transplant recipients
Hyunjeong Baek, Seunghoon Han, Dong-Seok Yim, Sung Joo Kim, Soo-Youn Lee, Hye Ryoun Jang, Jung Eun Lee, Dae Joong Kim, Yoon-Goo Kim, Ha Young Oh & Wooseong Huh
Pages: 2241-2249
Published online: 07 Nov 2014
AbstractforEarly non-steady-state population pharmacokinetics of oral cyclosporine in renal transplant recipients | Full Text | References | PDF (1.4 MB)
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Commentary

Article Commentary
Women taking the “blue pill” (sildenafil citrate): such a big deal?
Giuseppe Lo Monte, Angela Graziano, Isabella Piva & Roberto Marci
Pages: 2251-2254
Published online: 07 Nov 2014
AbstractforWomen taking the “blue pill” (sildenafil citrate): such a big deal? | Full Text | References | PDF (395.3 KB)
  • 168 Views
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Original Research

Article
Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone
Xue-Jiao Wang, Jun Zhang, Shu-Qing Wang, Wei-Ren Xu, Xian-Chao Cheng & Run-Ling Wang
Pages: 2255-2262
Published online: 29 Sep 2022
AbstractforIdentification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone | Full Text | References | PDF (1.7 MB)
  • 121 Views
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Article
Inhibition of cardiac Kv1.5 potassium current by the anesthetic midazolam: mode of action
Nadine Vonderlin, Fathima Fischer, Edgar Zitron, Claudia Seyler, Daniel Scherer, Dierk Thomas, Hugo A Katus & Eberhard P Scholz
Pages: 2263-2271
Published online: 07 Nov 2014
AbstractforInhibition of cardiac Kv1.5 potassium current by the anesthetic midazolam: mode of action | Full Text | References | PDF (486.8 KB)
  • 69 Views
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Review

Review Article
The role of health technology assessment bodies in shaping drug development
Oriana Ciani & Claudio Jommi
Pages: 2273-2281
Published online: 10 Nov 2014
AbstractforThe role of health technology assessment bodies in shaping drug development | Full Text | References | PDF (467.5 KB)
  • 331 Views
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Original Research

Article
Risk of diarrhea in patients with type 2 diabetes mellitus treated with sitagliptin: a meta-analysis of 30 randomized clinical trials
Qingwei Zhao, Dongsheng Hong, Dongsheng Zheng, Yao Xiao & Baohua Wu
Pages: 2283-2294
Published online: 11 Nov 2014
AbstractforRisk of diarrhea in patients with type 2 diabetes mellitus treated with sitagliptin: a meta-analysis of 30 randomized clinical trials | Full Text | References | PDF (558.7 KB)
  • 65 Views
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Review

Review Article
Leptin signaling molecular actions and drug target in hepatocellular carcinoma
Nan Jiang, Rongtong Sun & Qing Sun
Pages: 2295-2302
Published online: 14 Nov 2014
AbstractforLeptin signaling molecular actions and drug target in hepatocellular carcinoma | Full Text | References | PDF (737.2 KB)
  • 122 Views
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Review Article
Profile of epratuzumab and its potential in the treatment of systemic lupus erythematosus
Hanan Al Rayes & Zahi Touma
Pages: 2303-2310
Published online: 29 Sep 2022
AbstractforProfile of epratuzumab and its potential in the treatment of systemic lupus erythematosus | Full Text | References | PDF (220.5 KB)
  • 88 Views
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Review Article
Choosing preclinical study models of diabetic retinopathy: key problems for consideration
Xue-Song Mi, Ti-Fei Yuan, Yong Ding, Jing-Xiang Zhong & Kwok-Fai So
Pages: 2311-2319
Published online: 18 Nov 2014
AbstractforChoosing preclinical study models of diabetic retinopathy: key problems for consideration | Full Text | References | PDF (275.4 KB)
  • 100 Views
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Original Research

Article
Pilot Phase II study of mazindol in children with attention deficit/hyperactivity disorder
Eric Konofal, Wei Zhao, Cédric Laouénan, Michel Lecendreux, Florentia Kaguelidou, Lila Benadjaoud, France Mentré & Evelyne Jacqz-Aigrain
Pages: 2321-2332
Published online: 11 Dec 2014
AbstractforPilot Phase II study of mazindol in children with attention deficit/hyperactivity disorder | Full Text | References | PDF (1 MB)
  • 89 Views
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Article
Characterization and in vitro studies of the anticancer effect of oxidized carbon nanotubes functionalized with betulinic acid
Julia M Tan, Govindarajan Karthivashan, Palanisamy Arulselvan, Sharida Fakurazi & Mohd Zobir Hussein
Pages: 2333-2343
Published online: 20 Nov 2014
AbstractforCharacterization and in vitro studies of the anticancer effect of oxidized carbon nanotubes functionalized with betulinic acid | Full Text | References | PDF (1.2 MB)
  • 140 Views
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Review

Review Article
Interleukin 1 inhibition with anakinra in adult-onset Still disease: a meta-analysis of its efficacy and safety
Dongsheng Hong, Zhihai Yang, Shuyin Han, Xingguang Liang, Kuifen Ma & Xingguo Zhang
Pages: 2345-2357
Published online: 25 Nov 2014
AbstractforInterleukin 1 inhibition with anakinra in adult-onset Still disease: a meta-analysis of its efficacy and safety | Full Text | References | PDF (991.2 KB)
  • 112 Views
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Original Research

Article
CCL19 and CCL21 modulate the inflammatory milieu in atherosclerotic lesions
Mohammadreza Akhavanpoor, Christian A Gleissner, Stephanie Gorbatsch, Andreas O Doesch, Hamidreza Akhavanpoor, Susanne Wangler, Frederik Jahn, Felix Lasitschka, Hugo A Katus & Christian Erbel
Pages: 2359-2371
Published online: 27 Nov 2014
AbstractforCCL19 and CCL21 modulate the inflammatory milieu in atherosclerotic lesions | Full Text | References | PDF (9.4 MB)
  • 112 Views
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Case Report

Case Report
Scleral melt following Retisert intravitreal fluocinolone implant
Ilias Georgalas, Chrysanthi Koutsandrea, Dimitrios Papaconstantinou, Dimitrios Mpouritis & Petros Petrou
Pages: 2373-2375
Published online: 28 Nov 2014
AbstractforScleral melt following Retisert intravitreal fluocinolone implant | Full Text | References | PDF (1.1 MB)
  • 57 Views
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Original Research

Article
Discovery of potential drugs for human-infecting H7N9 virus containing R294K mutation
Jiao-Yu He, Cheng Li & Guo Wu
Pages: 2377-2390
Published online: 29 Sep 2022
AbstractforDiscovery of potential drugs for human-infecting H7N9 virus containing R294K mutation | Full Text | References | PDF (8.9 MB)
  • 71 Views
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Review

Review Article
Drug development strategies for the treatment of obesity: how to ensure efficacy, safety, and sustainable weight loss
S Barja-Fernandez, R Leis, FF Casanueva & LM Seoane
Pages: 2391-2400
Published online: 01 Dec 2014
AbstractforDrug development strategies for the treatment of obesity: how to ensure efficacy, safety, and sustainable weight loss | Full Text | References | PDF (1.2 MB)
  • 176 Views
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Original Research

Article
Cisplatin-induced hyponatremia in malignancy: comparison between brand-name and generic formulation
Nobuaki Ochi, Hiromichi Yamane, Katsuyuki Hotta, Hiromi Fujii, Hideko Isozaki, Yoshihiro Honda, Tomoko Yamagishi, Toshio Kubo, Mitsune Tanimoto, Katsuyuki Kiura & Nagio Takigawa
Pages: 2401-2408
Published online: 03 Dec 2014
AbstractforCisplatin-induced hyponatremia in malignancy: comparison between brand-name and generic formulation | Full Text | References | PDF (748.3 KB)
  • 80 Views
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Article
Functional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation
Mythily Srinivasan, Corinne Blackburn & Debomoy K Lahiri
Pages: 2409-2421
Published online: 03 Dec 2014
AbstractforFunctional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation | Full Text | References | PDF (2 MB)
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Article
Clinicopathological significance and potential drug target of RUNX3 in breast cancer
Ying-Ying Yu, Chao Chen, Fan-fei Kong & Wei Zhang
Pages: 2423-2430
Published online: 05 Dec 2014
AbstractforClinicopathological significance and potential drug target of RUNX3 in breast cancer | Full Text | References | PDF (1.7 MB)
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Article
Design real-time reversal of tumor multidrug resistance cleverly with shortened carbon nanotubes
Pingping Wu, Shang Li & Haijun Zhang
Pages: 2431-2438
Published online: 05 Dec 2014
AbstractforDesign real-time reversal of tumor multidrug resistance cleverly with shortened carbon nanotubes | Full Text | References | PDF (1.2 MB)
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Article
Matrix-induced autologous chondrocyte implantation for the treatment of chondral defects of the knees in Chinese patients
Zhongwen Zhang, Xin Zhong, Huiru Ji, Zibin Tang, Jianpeng Bai, Minmin Yao, Jianlei Hou, Minghao Zheng, David J Wood, Jiazhi Sun, Shu-Feng Zhou & Aibing Liu
Pages: 2439-2448
Published online: 05 Dec 2014
AbstractforMatrix-induced autologous chondrocyte implantation for the treatment of chondral defects of the knees in Chinese patients | Full Text | References | PDF (1.6 MB)
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Article
Mesenchymal stem cell-based NK4 gene therapy in nude mice bearing gastric cancer xenografts
Yin Zhu, Ming Cheng, Zhen Yang, Chun-Yan Zeng, Jiang Chen, Yong Xie, Shi-Wen Luo, Kun-He Zhang, Shu-Feng Zhou & Nong-Hua Lu
Pages: 2449-2462
Published online: 09 Dec 2014
AbstractforMesenchymal stem cell-based NK4 gene therapy in nude mice bearing gastric cancer xenografts | Full Text | References | PDF (3.8 MB)
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Article
Scientometrics of anesthetic drugs and their techniques of administration, 1984–2013
Kamen V Vlassakov & Igor Kissin
Pages: 2463-2473
Published online: 09 Dec 2014
AbstractforScientometrics of anesthetic drugs and their techniques of administration, 1984–2013 | Full Text | References | PDF (511.4 KB)
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Review

Review Article
Optimizing iron delivery in the management of anemia: patient considerations and the role of ferric carboxymaltose
Jorge Eduardo Toblli & Margarita Angerosa
Pages: 2475-2491
Published online: 11 Dec 2014
AbstractforOptimizing iron delivery in the management of anemia: patient considerations and the role of ferric carboxymaltose | Full Text | References | PDF (2.9 MB)
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Review Article
Dapagliflozin for the treatment of type 2 diabetes: a review of the literature
Mujahid A Saeed & Parth Narendran
Pages: 2493-2505
Published online: 10 Dec 2014
AbstractforDapagliflozin for the treatment of type 2 diabetes: a review of the literature | Full Text | References | PDF (506.7 KB)
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Review Article
A new recombinant factor VIII: from genetics to clinical use
Elena Santagostino
Pages: 2507-2515
Published online: 29 Sep 2022
AbstractforA new recombinant factor VIII: from genetics to clinical use | Full Text | References | PDF (338.1 KB)
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Original Research

Article
Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway
Tao Ren, Jinlu Shan, Yi Qing, Chengyuan Qian, Qing Li, Guoshou Lu, Mengxia Li, Chongyi Li, Yu Peng, Hao Luo, Shiheng Zhang, Weiwei Zhang, Dong Wang & Shu-Feng Zhou
Pages: 2517-2529
Published online: 29 Sep 2022
AbstractforSequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway | Full Text | References | PDF (2.7 MB)
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Article
Treatment of port wine stains with pulsed dye laser: a retrospective study of 848 cases in Shandong Province, People’s Republic of China
Wenhao Shi, Jinliang Wang, Yan Lin, Jianhui Geng, Haixia Wang, Yueqin Gong, Huaxu Liu & Furen Zhang
Pages: 2531-2538
Published online: 12 Dec 2014
AbstractforTreatment of port wine stains with pulsed dye laser: a retrospective study of 848 cases in Shandong Province, People’s Republic of China | Full Text | References | PDF (696 KB)
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Article
Stevens–Johnson Syndrome and toxic epidermal necrolysis: a multi-aspect comparative 7-year study from the People’s Republic of China
Jie Sun, Jin Liu, Qing-Li Gong, Gao-Zhong Ding, Li-Wen Ma, Li-Chao Zhang & Yan Lu
Pages: 2539-2547
Published online: 12 Dec 2014
AbstractforStevens–Johnson Syndrome and toxic epidermal necrolysis: a multi-aspect comparative 7-year study from the People’s Republic of China | Full Text | References | PDF (1.2 MB)
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Article
Curative treatment can be an option for patients with metastatic squamous cell cancer of the head and neck
Clémence Guenne, Jérôme Fayette, Alain Cosmidis, Carine Fuchsmann, Sophie Tartas, Véronique Favrel & Philippe Céruse
Pages: 2549-2553
Published online: 29 Sep 2022
AbstractforCurative treatment can be an option for patients with metastatic squamous cell cancer of the head and neck | Full Text | References | PDF (329.1 KB)
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Article
Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study
Junhui Su, Cui Chang, Qi Xiang, Zhi-Wei Zhou, Rong Luo, Lun Yang, Zhi-Xu He, Hongtu Yang, Jianan Li, Yu Bei, Jinmei Xu, Minjing Zhang, Qihao Zhang, Zhijian Su, Yadong Huang, Jiyan Pang & Shu-Feng Zhou
Pages: 2555-2602
Published online: 12 Dec 2014
AbstractforXyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study | Full Text | References | PDF (4.5 MB)
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