The preparation of metal–organic frameworks and their biomedical application

Abstract

The development of a safe and targetable drug carrier is a major challenge. An efficient delivery system should protect cargo from degradation and cleanup, and control of drug release in the target site. Metal–organic frameworks (MOFs), consisting of metal ions and a variety of organic ligands, have been applied for drug delivery due to their distinct structure. In this review, we summarized the synthesis strategies of MOFs, especially emphasizing the methods of pore creation in frameworks, which were based on recent literatures. Subsequently, the controlled size, biocompatibility, drug releasing performances, and imaging of MOFs were discussed, which would pave the road for the application in drug-delivery systems.

Keywords:

• metal-organic frameworks
• pore creation
• the controlled size
• biocompatibility
• drug releasing performances
• imaging

Acknowledgments

This work was supported by the National Natural Science Foundation of China (51203157, 51203177), the National High Technology Research and Development Program of China (SS2014AA020708), and Antibiotics Research and Re-evaluation Key Laboratory Foundation of Sichuan Province (ARRLKF15-04).

Disclosure

The authors report no conflict of interest in this work.