In situ precise electrospinning of medical glue fibers as nonsuture dural repair with high sealing capability and flexibility

Abstract

Purpose

In this work, we propose an in situ precise electrospinning of medical glue fibers onto dural wound for improving sealing capability, avoiding tissue adhesion, and saving time in dural repair.

Methods

N-octyl-2-cyanoacrylate, a commercial tissue adhesive (medical glue), can be electrospun into ultrathin fibrous film with precise and homogeneous deposition by a gas-assisted electrospinning device.

Results

The self-assembled N-octyl-2-cyanoacrylate film shows high compactness and flexibility owing to its fibrous structure. Simulation experiments on egg membranes and goat meninges demonstrated that this technology can repair small membrane defects quickly and efficiently.

Conclusion

This method may have potential application in dural repair, for example, working as an effective supplementary technique for conventional dura suture.

Keywords:

• cyanoacrylates
• electrospun fibers
• in situ repair dural
• gas-assisted electrospinning apparatus

Acknowledgments

This study was supported by the National Natural Science Foundation of China (51373082), the Taishan Scholars Programme of Shandong Province, People’s Republic of China (ts20120528), and the Postdoctoral Scientific Research Foundation of Qingdao.

Disclosure

The authors report no conflicts of interest in this work.