Potential Exploration of Biocompatible Carbon-Coated MoSe₂ Nanoparticles for Exploration of the Photothermal Potential in the Treatment of Human Choriocarcinoma

Abstract

Background

Molybdenum diselenide (MoSe₂), as a nano near-infrared absorber, has been widely studied in the field of photothermal therapy of cancer. However, there is little research on its application in the treatment of human choriocarcinoma.

Methods and Results

In this paper, a new type of carbon-coated MoSe₂ (MEC) nanoparticles was prepared by a one-step hydrothermal method. The chemical characterization including SEM, TEM, EDS, XRD, FT-IR, TGA, Roman, and XPS showed that MEC was successfully synthesized. MEC exhibited a high photothermal conversion efficiency (50.97%) and extraordinary photothermal stability under laser irradiation. The cell experiment results showed that MEC had good biocompatibility on normal cells while significant photothermal effect on human choriocarcinoma (JEG-3) cells, achieving a good anticancer effect. The level of reactive oxygen species (ROS) in JEG-3 cells was significantly increased under the combination of MEC nanoparticles and near-infrared radiation. MEC nanoparticles could induce apoptosis of JEG-3 cells in combination with near-infrared radiation. Finally, transcriptomic analysis verified that MEC combined with laser radiation could inhibit DNA replication and induce apoptosis, thus improving its therapeutic effect on human choriocarcinoma.

Conclusion

MEC nanoparticles exert an excellent photothermal effect and may become an important candidate drug for the treatment of human choriocarcinoma.

Keywords:

• MoSe₂
• carbon-coated
• biocompatibility
• human choriocarcinoma
• photothermal therapy

Acknowledgments

This work was supported by the Shaanxi Provincial Key Research and Development Program Project(Program No.2020SF-030).

Author Contributions

All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.

Disclosure

The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported herein.

Additional information

Funding

Shaanxi Provincial Key Research and Development Program Project (Program No.2020SF-030).