Abstract
Introduction
The presence of cancer stem cells (CSCs) significantly limits the therapeutic efficacy of radiotherapy (RT). Efficient elimination of potential CSCs is crucial for enhancing the effectiveness of RT.
Methods
In this study, we developed a biomimetic hybrid nano-system (PMC) composed of MnCO3 as the inner core and platelet membrane (PM) as the outer shell. By exploiting the specific recognition properties of membrane surface proteins, PMC enables precise targeting of CSCs. Sonodynamic therapy (SDT) was employed using manganese carbonate nanoparticles (MnCO3 NPs), which generate abundant reactive oxygen species (ROS) upon ultrasound (US) irradiation, thereby impairing CSC self-renewal capacity and eradicating CSCs. Subsequent RT effectively eliminates common tumor cells.
Results
Both in vitro cell experiments and in vivo animal studies demonstrate that SDT mediated by PMC synergistically enhances RT to selectively combat CSCs while inhibiting tumor growth without noticeable side effects.
Discussion
Our findings offer novel insights for enhancing the efficacy and safety profiles of RT.
Data Sharing Statement
The detailed experimental steps are provided in the Supporting Information.
Acknowledgments
We are grateful for the financial support from the National Natural Science Foundation of China (No. 82303797) and the Guangxi Natural Science Foundation (No.2023GXNSFBA026137). We appreciate Dr. Wei Ping’s assistance in our project.
Disclosure
The authors declare no competing interest in this work.