https://orcid.org/0000-0002-2513-764X
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Abstract
Introduction
The synthesis of nanoparticles using naturally occurring reagents such as vitamins, sugars, plant extracts, biodegradable polymers and microorganisms as reductants and capping agents could be considered attractive for nanotechnology. These syntheses have led to the fabrication of limited number of inorganic nanoparticles. Among the reagents mentioned above, plant-based materials seem to be the best candidates, and they are suitable for large-scale biosynthesis of nanoparticles.
Methods
The aqueous extract of Moringa peregrina leaves was used to synthesize silver nanoparticles. The synthesized nanoparticles were characterized by various spectral studies including FT-IR, SEM, HR-TEM and XRD. In addition, the antioxidant activity of the silver nanoparticles was studied viz. DPPH, ABTS, hydroxyl radical scavenging, superoxide radical scavenging, nitric oxide scavenging potential and reducing power with varied concentrations. The anticancer potential of the nanoparticles was also studied against MCF-7 and Caco-2 cancer cell lines.
Results
The results showed that silver nanoparticles displayed strong antioxidant activity compared with gallic acid. Furthermore, the anticancer potential of the nanoparticles against MCF-7 and Caco-2 in comparison with the standard Doxorubicin revealed that the silver nanoparticles produced significant toxic effects against the studied cancer cell lines with the IC50 values of 41.59 (Caco-2) and 26.93 (MCF-7) µg/mL.
Conclusion
In conclusion, the biosynthesized nanoparticles using M. peregrina leaf aqueous extract as a reducing agent showed good antioxidant and anticancer potential on human cancer cells and can be used in biological applications.
Acknowledgments
Author K.S.Y.A.B. as part of his Master of Science in Horticulture Degree in Department of Integrative Agriculture at UAEU, under the major supervision of A.J. and co-supervision of A.S.O.S.A.D. and M.A.M.A. The assistance from staff of Al Foah Experimental Station and E3, F1 labs, CAVM, and UAEU is greatly acknowledged.
Disclosure
This paper is based on the MS Horticulture thesis of Mr. Khaled Saeed Yousef Al Baloushi (first author of this article) under the supervision of Dr. Abdul Jaleel (Corresponding author of this article) and co-supervision of Dr. Mohammed Abdul Muhsen Alyafei and Prof. Ayesha Salem Al Dhaheri (Authors in this article). It has been published on the institutional website: https://scholarworks.uaeu.ac.ae/all_theses/1041/.