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Abstract
Angiogenesis, or the formation of new blood vessels, is a natural defensive mechanism that aids in the restoration of oxygen and nutrition delivery to injured brain tissue after an ischemic stroke. Angiogenesis, by increasing vessel development, may maintain brain perfusion, enabling neuronal survival, brain plasticity, and neurologic recovery. Induction of angiogenesis and the formation of new vessels aid in neurorepair processes such as neurogenesis and synaptogenesis. Advanced nano drug delivery systems hold promise for treatment stroke by facilitating efficient transportation across the the blood-brain barrier and maintaining optimal drug concentrations. Nanoparticle has recently been shown to greatly boost angiogenesis and decrease vascular permeability, as well as improve neuroplasticity and neurological recovery after ischemic stroke. We describe current breakthroughs in the development of nanoparticle-based treatments for better angiogenesis therapy for ischemic stroke employing polymeric nanoparticles, liposomes, inorganic nanoparticles, and biomimetic nanoparticles in this study. We outline new nanoparticles in detail, review the hurdles and strategies for conveying nanoparticle to lesions, and demonstrate the most recent advances in nanoparticle in angiogenesis for stroke treatment.
Graphical Abstract
Acknowledgments
This research was supported by the National Natural Science Foundation of China (82104147 to Guangtian Wang), the China Postdoctoral Special Grant Program (2022T150177 to Guangtian Wang), and the China Postdoctoral Program (2021M693833 to Guangtian Wang and 2020M681120 to Zhihui Li), the Innovative Scientific Research Grant Program of Harbin Medical University (2021-KYYWF-0272 to Guangtian Wang), and the and the Harbin Medical University Youth Fund (2023-KYYWF-0230 to Zhihui Li).
Disclosure
The authors declare no conflicts of interest in this work.