Short-term digestive tolerance of high-dose of NUTRIOSE^®FB10 in adult

Abstract

NUTRIOSE^®FB10 is a dextrin considered a dietary fiber. The present study aims to assess the digestive tolerance of a high dose of NUTRIOSE^®FB10 consumed over the day, and its effect on digestive symptoms. In a randomized, double-blind, cross-over trial, 12 healthy men ingested 1 l/day orange juice containing 50 g either NUTRIOSE^®FB10 or placebo (maltodextrin) in three equal doses at breakfast, lunch and 4:00 pm meal. Bloating, borborygmus, flatulence, nausea feelings, stomach ache, transit and stool consistency were evaluated at different times after the first consumption. Questionnaires on well-being and bowel movement were completed at 24 and 48 h. For all data except stool consistency, the area under the curve, the maximum score and the time of this maximum were calculated. For stool consistency, the mean score over 48 h was determined. There was no statistical difference between NUTRIOSE^®FB10 and placebo on each criterion. NUTRIOSE^®FB10 is well tolerated during a single day at 50 g divided into three doses.

Keywords::

• NUTRIOSE^®FB10
• digestive tolerance
• dextrin
• gastrointestinal symptoms

Declarations of interest: The study was performed by Biofortis, Clinical Research Organization, and funded by the Roquette Frères company, which also supplied the experimental products.