Influence of a low protein diet on serum transaminases, hepatic enzymes and lipid peroxidation in chloroquine treated rats

Abstract

The influence of a low protein diet (3% protein) on serum transaminases, hepatic enzymes and the hepato-toxicity effect on lipid peroxidation of chloroquine consumption in rat liver was investigated. Rats fed with low protein diet (LPD) were orally treated with chloroquine (CQ) 5 mg/kg body wt for 8 weeks. Results showed that feeding rats with LPD for 8 weeks did not affect the responses of CQ to serum transaminases, while a remarkable increase in lactate dehydrogenase activity was observed. The protein contents of the liver homogenate showed a simultaneous decrease with the liver weights. This was accompanied by the reduction in NADPH-linked and ascorbate-linked lipid peroxidation. There was a decrease in hepatic acid phosphatase activity and a remarkable decrease in the total cholesterol liver. These results confirm the hypothesis that LPD may lead to dysfunction of the liver cells and thus interests in a way to modify the metabolism of CQ.