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Abstract
The impact of classic cardiovascular risk factors on oxidative stress status in a high-risk cardiovascular Mediterranean population of 527 subjects was estimated. Oxidative stress markers (malondialdehyde, 8-oxo-7′8′-dihydro-2′-deoxyguanosine, oxidized/reduced glutathione ratio) together with the activity of antioxidant enzyme triad (superoxide dismutase, catalase, glutathione peroxidase) were analysed in circulating mononuclear blood cells. Malondialdehyde, oxidized glutathione and the ratio of oxidized to reduced glutathione were significantly higher while catalase and glutathione peroxidase activities were significantly lower in high cardiovascular risk participants than in controls. Statistically significant differences were obtained after additional multivariate control for sex, age, obesity, diabetes, lipids and medications. Among the main cardiovascular risk factors, hypertension was the strongest determinant of oxidative stress in high risk subjects studied at a primary prevention stage.
Acknowledgements
Sources of Funding: Instituto de Salud Carlos III (FIS PI070240, PI052368, PI051458, PI042234, RD06/0045/0006 and CIBER06/03); Consellería de Sanitat Valencia (GRUPOS 03/101, GRUPOS2004-43 and ACOMP06109).
Declaration of interest: The author reports no conflicts of interest. The author alone is responsible for the content and writing of the paper.
This paper was first published online on Early Online on 30 September 2009.