Design and statistical optimization of osmotically driven capsule based on push-pull technology

Abstract

In present investigation attempt was made to develop and statistically optimize osmotically active capsule tailor made from the concept of bilayer (push–pull) osmotic tablet technology. The capsule was comprised of active (drug) and push (osmogen) layer. Active layer was compressed in form of tablet by mixing known amount of drug and formulation excipients. Similarly push layer was made by compressing Mannitol with formulation excipients. Finally, both layers were packed in hard gelatin capsule having small aperture at top and coated with semipermeable membrane to form osmotically active capsule. Formulated and optimized capsules were characterized for Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetric (DSC), scanning electron microscopy, In-vitro drug release study and Release models and kinetics. Statistically optimized formulation showed good correlation between predicted and experimented results, which further confirms the practicability and validity of the model.

Keywords::

• Valsartan
• Mannitol
• statistical optimization
• osmotically activated

Acknowledgements

The authors are grateful to the management, HRPIPER, Shirpur for providing necessary facilities to carry out research work.

Declaration of interest

The authors report no conflicts of interest.