New insights into homopiperazine-based 5-HT_1A/5-HT₇R ligands: synthesis and biological evaluation

Abstract

The synthesis of new N-homopiperazinyl-based ligands is reported. Various structural modifications along with the corresponding biological activities on 5-HT_1A/5-HT₇ receptors give further insights into this class of serotoninergic ligands. Among the tested central heterocyles, the 7-azaindole gave the best results on the above-mentioned receptors.

Keywords::

• Homopiperazinyl
• 7-azaindole
• 5-HT₇
• 5-HT_1A receptor affinity

Declaration of interest: All authors declare that the study has not been funded by external funds or grants and that there is no conflict of interests of any kind.