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Abstract
Nostotrebin 6, a new polyphenolic compound with a fully substituted 2,2′-bis(cyclopent-4-en-1,3-dione) skeleton, was isolated from a methanolic extract of the cyanobacterial strain Nostoc sp. str. Lukešová 27/97. The structure of this compound was determined using X-ray crystallography and further supported by NMR, IR spectroscopy, and MS. Nostotrebin 6 is an S-parabolic I-parabolic noncompetitive inhibitor of acetylcholinesterase (IC50 = 5.5 μM) and an S-parabolic I-parabolic mixed inhibitor of butyrylcholinesterase (IC50 = 6.1–7.5 μM). The inhibitory potency of nostotrebin 6 was compared with that of tacrine and galanthamine.
Declaration of interest: This research was supported by Project ME 874 of the Ministry of Education, Youth, and Sports of the Czech Republic. The Czech Science Foundation further supported this work through Project 522/06/1090. Partial funding was also provided by Project MSM6007665808 of the Ministry of Education, Youth, and Sports of the Czech Republic, and also by Projects AVOZ 50200510 and AVOZ 6060521 of the Czech Academy of Sciences.