Synthesis and antihepatotoxic activity of 2-(substituted-phenyl)-5-(2,3-dihydro-1,4-benzodioxane-2-yl)-1,3,4-oxadiazole derivatives

Abstract

Novel 1,3,4-oxadizole derivatives containing the 1,4-dioxane ring system were synthesised starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesised compounds were evaluated for antihepatotoxic activity against CCl₄-induced hepatotoxicity in rats. Some compounds demonstrated a significant antihepatotoxic activity comparable to the standard drug Silymarin.

Keywords::

• 1;4-benzodioxane
• 1;3;4-oxadiazole
• antihepatotoxic activity

Acknowledgements

The authors would like to thank the Head, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India for providing necessary research facilities. We would also like to thank Showkat Ahmad Shah, In charge, Animal House facility, Jamia Hamdard, New Delhi for providing experimental animals for carrying out the antihepatotoxic activity.

Declaration of interest

The authors would like to thank University Grant Commission, New Delhi, for approving the major research project for financial assistance.