Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 26, Issue 2 (2011)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 26, Issue 2 (2011)

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Research Article

Article
Unusual activity pattern of leucine aminopeptidase inhibitors based on phosphorus containing derivatives of methionine and norleucine
Jan Pícha, Radek Liboska, Miloš Buděšínský, Jiři Jiráček, Małgorzata Pawełczak & Artur Mucha
Pages: 155-161
Published online: 28 Jun 2010
AbstractforUnusual activity pattern of leucine aminopeptidase inhibitors based on phosphorus containing derivatives of methionine and norleucine | Full Text | References | PDF (774.1 KB)
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Article
Evaluating how rimantadines control the proton gating of the influenza A M2-proton port via allosteric binding outside of the M2-channel: MD simulations
Pathumwadee Intharathep, , Thanyada Rungrotmongkol, , Panita Decha, , Nadtanet Nunthaboot, , Nopphorn Kaiyawet, , Teerakiat Kerdcharoen, , Pornthep Sompornpisut & Supot Hannongbua
Pages: 162-168
Published online: 28 Jun 2010
AbstractforEvaluating how rimantadines control the proton gating of the influenza A M2-proton port via allosteric binding outside of the M2-channel: MD simulations | Full Text | References | PDF (1.2 MB)
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Article
Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-β-lactam inhibitor of human leukocyte elastase
Jalmira Mulchande, Sandra I. Simões, Maria M. Gaspar, Carla V. Eleutério, Rudi Oliveira, Maria E.M. Cruz, Rui Moreira & Jim Iley
Pages: 169-175
Published online: 14 Jun 2010
AbstractforSynthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-β-lactam inhibitor of human leukocyte elastase | Full Text | References | PDF (1.1 MB)
  • 618 Views
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Article
Anti-hyperglycaemic effects of the Japanese red maple Acer pycnanthum and its constituents the ginnalins B and C
Atsushi Honma, Tomoyuki Koyama & Kazunaga Yazawa
Pages: 176-180
Published online: 21 Jun 2010
AbstractforAnti-hyperglycaemic effects of the Japanese red maple Acer pycnanthum and its constituents the ginnalins B and C | Full Text | References | PDF (857.6 KB)
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Article
The evaluation of inhibitive effectiveness of the tumour necrosis factor-α converting enzyme selective inhibitors by HPLC
Yunbin Zhao, Jin Yu, Jiuling Gu & Wei Huang
Pages: 181-187
Published online: 15 Mar 2011
AbstractforThe evaluation of inhibitive effectiveness of the tumour necrosis factor-α converting enzyme selective inhibitors by HPLC | Full Text | References | PDF (983.2 KB)
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Article
Third generation fluoroquinolones antibacterial drug based mixed-ligand Cu(II) complexes: structure, antibacterial activity, superoxide dismutase activity and DNA–interaction approach
Mohan N. Patel, Pradhuman A. Parmar & Deepen S. Gandhi
Pages: 188-197
Published online: 28 Jun 2010
AbstractforThird generation fluoroquinolones antibacterial drug based mixed-ligand Cu(II) complexes: structure, antibacterial activity, superoxide dismutase activity and DNA–interaction approach | Full Text | References | PDF (1.3 MB) | Supplemental
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Article
Synthesis of some novel 2,5-disubstituted thiazolidinones from a long chain fatty acid as possible anti-inflammatory, analgesic and hydrogen peroxide scavenging agents
Vipin Kumar, Archana Sharma & Prabodh Chander Sharma
Pages: 198-203
Published online: 28 Jun 2010
AbstractforSynthesis of some novel 2,5-disubstituted thiazolidinones from a long chain fatty acid as possible anti-inflammatory, analgesic and hydrogen peroxide scavenging agents | Full Text | References | PDF (831.1 KB)
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Article
Antiproliferative effect on HepaRG cell cultures of new calix[4]arenes. Part II
Laurent Latxague, François Gaboriau, Olivier Chassande, Jean-Michel Leger, Viviane Pires, Pascal Rouge, Alexandra Dassonville-Klimpt, Sylvain Fardeau, Christian Jarry, Gerard Lescoat, Jean Guillon & Pascal Sonnet
Pages: 204-215
Published online: 14 Jun 2010
AbstractforAntiproliferative effect on HepaRG cell cultures of new calix[4]arenes. Part II | Full Text | References | PDF (1.9 MB)
  • 577 Views
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Article
Synthesis and antihepatotoxic activity of 2-(substituted-phenyl)-5-(2,3-dihydro-1,4-benzodioxane-2-yl)-1,3,4-oxadiazole derivatives
Bahar Ahmed, Habibullah & Shamshir Khan
Pages: 216-221
Published online: 01 Jul 2010
AbstractforSynthesis and antihepatotoxic activity of 2-(substituted-phenyl)-5-(2,3-dihydro-1,4-benzodioxane-2-yl)-1,3,4-oxadiazole derivatives | Full Text | References | PDF (1,016.9 KB)
  • 616 Views
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Article
Design, synthesis and biological evaluation of CB1 cannabinoid receptor ligands derived from the 1,5-diarylpyrazole scaffold
GuoGang Tu, Fang Xiong, HuiMing Huang, BinHai Kuang & ShaoHua Li
Pages: 222-230
Published online: 22 Jun 2010
AbstractforDesign, synthesis and biological evaluation of CB1 cannabinoid receptor ligands derived from the 1,5-diarylpyrazole scaffold | Full Text | References | PDF (1.1 MB)
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Article
Synthesis of 5-amino-1,3,4-thiadiazole-2-sulphonamide derivatives and their inhibition effects on human carbonic anhydrase isozymes
Rahmi Kasımoğulları, Metin Bülbül, Samet Mert & Hülya Güleryüz
Pages: 231-237
Published online: 16 Jun 2010
AbstractforSynthesis of 5-amino-1,3,4-thiadiazole-2-sulphonamide derivatives and their inhibition effects on human carbonic anhydrase isozymes | Full Text | References | PDF (850.3 KB)
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Article
Synthesis and SAR comparative studies of 2-allyl-4-methoxy-1-alkoxybenzenes as 15-lipoxygenase inhibitors
Hamid Sadeghian, Seyed Mohammad Seyedi, Neda Attaran, Atena Jabbari & Zeinab Jafari
Pages: 238-244
Published online: 13 Oct 2010
AbstractforSynthesis and SAR comparative studies of 2-allyl-4-methoxy-1-alkoxybenzenes as 15-lipoxygenase inhibitors | Full Text | References | PDF (2 MB)
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Article
The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage
Kamil Musilek, Ruzena Pavlikova, Jan Marek, Marketa Komloova, Ondrej Holas, Martina Hrabinova, Miroslav Pohanka, Vlastimil Dohnal, Martin Dolezal, Frank Gunn-Moore & Kamil Kuca
Pages: 245-253
Published online: 15 Mar 2011
AbstractforThe preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage | Full Text | References | PDF (976.6 KB)
  • 765 Views
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Article
The chemical constituents of Piper kadsura and their cytotoxic and anti-neuroinflammtaory activities
Ki Hyun Kim, Jung Wook Choi, Sang Un Choi, Sang Keun Ha, Sun Yeou Kim, Hee-Juhn Park & Kang Ro Lee
Pages: 254-260
Published online: 05 Aug 2010
AbstractforThe chemical constituents of Piper kadsura and their cytotoxic and anti-neuroinflammtaory activities | Full Text | References | PDF (1.1 MB)
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Original Article

Article
Synthesis and in vitro antifungal evaluation of 2-(2,4-difluorophenyl)-1-[(1H-indol-3-ylmethyl)methylamino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols
Rémi Guillon, Cédric Logé, Fabrice Pagniez, Véronique Ferchaud-Roucher, Muriel Duflos, Carine Picot & Patrice Le Pape
Pages: 261-269
Published online: 09 Aug 2010
AbstractforSynthesis and in vitro antifungal evaluation of 2-(2,4-difluorophenyl)-1-[(1H-indol-3-ylmethyl)methylamino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols | Full Text | References | PDF (733.8 KB)
  • 703 Views
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Article
Molecular modelling studies of new potential human DNA polymerase α inhibitors
Barbara Zdrazil, Anja Schwanke, Birte Schmitz, Monika Schäfer-Korting & Hans-Dieter Höltje
Pages: 270-279
Published online: 20 Oct 2010
AbstractforMolecular modelling studies of new potential human DNA polymerase α inhibitors | Full Text | References | PDF (1 MB)
  • 474 Views
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Article
Activated fly ash catalyzed facile synthesis of novel spiro imidazolidine derivatives as potential antibacterial and antifungal agents
V. Kanagarajan, J. Thanusu & M. Gopalakrishnan
Pages: 280-287
Published online: 05 Aug 2010
AbstractforActivated fly ash catalyzed facile synthesis of novel spiro imidazolidine derivatives as potential antibacterial and antifungal agents | Full Text | References | PDF (630.9 KB)
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Short Communications

Prediction of HIV-1 protease inhibitory activity of 4-hydroxy-5,6-dihydropyran-2-ones: QSAR study
V. Ravichandran, V. K. Mourya & R. K. Agrawal
Pages: 288-294
Published online: 24 Aug 2010
AbstractforPrediction of HIV-1 protease inhibitory activity of 4-hydroxy-5,6-dihydropyran-2-ones: QSAR study | Full Text | References | PDF (944 KB)
  • 453 Views
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Dimeric bisbenzimidazoles inhibit the DNA methylation catalyzed by the murine Dnmt3a catalytic domain
N. A. Cherepanova, A. A. Ivanov, D. V. Maltseva, A. S. Minero, A. V. Gromyko, S. A. Streltsov, A. L. Zhuze & E. S. Gromova
Pages: 295-300
Published online: 08 Jul 2010
AbstractforDimeric bisbenzimidazoles inhibit the DNA methylation catalyzed by the murine Dnmt3a catalytic domain | Full Text | References | PDF (900.8 KB)
  • 507 Views
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