Synthesis, characterization and biological studies of sulfonamide Schiff’s bases and some of their metal derivatives

Abstract

A new series of Schiff base ligands derived from sulfonamide and their metal(II) complexes [cobalt(II), copper(II), nickel(II) and zinc(II)] have been synthesized and characterized. The nature of bonding and structure of all the synthesized compounds has been explored by physical, analytical and spectral data of the ligands and their metal(II) complexes. The authors suggest that all the prepared complexes possess an octahedral geometry. The ligands and metal(II) complexes have been screened for their in vitro antibacterial activity against bacterial strains, Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi and for antifungal activity against fungal strains, Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata. These assays enabled the identification of the metal complexes as an effective antimicrobial agent with low cytotoxicity.

Keywords::

• Sulfonamides
• metal(II) complexes
• antibacterial
• antifungal
• cytotoxic

Acknowledgement

HAZ is grateful to Higher Education Commission (HEC), Government of Pakistan for providing Scholarship under Indigenous PhD Program (PIN 042–160410-PS2-117). The authors are also thankful to HEJ research Institute of Chemistry, University of Karachi, Pakistan, for providing help in taking NMR and mass spectra and also antibacterial and antifungal assays.

Declaration of interest

The authors report no conflict of interest. The authors alone are responsible for the content and writing of the article.