Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 27, Issue 1 (2012)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 27, Issue 1 (2012)

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Research Article

Article
Chemical constituents of Polygala tenuifolia roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production in BV2 microglia
Namki Cho, Jungmoo Huh, Heejung Yang, Eun Ju Jeong, Young Choong Kim, Jinwoong Kim & Sang Hyun Sung
Pages: 1-4
Published online: 08 Jul 2011
AbstractforChemical constituents of Polygala tenuifolia roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production in BV2 microglia | Full Text | References | PDF (600 KB)
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Article
A screening assay for neuraminidase inhibitors using neuraminidases N1 and N3 from a baculovirus expression system
Jarinrat Kongkamnerd, Adelaide Milani, Giovanni Cattoli, Calogero Terregino, Ilaria Capua, Luca Beneduce, Andrea Gallotta, Paolo Pengo, Giorgio Fassina, Stanislav Miertus & Wanchai De-Eknamkul
Pages: 5-11
Published online: 08 Jul 2011
AbstractforA screening assay for neuraminidase inhibitors using neuraminidases N1 and N3 from a baculovirus expression system | Full Text | References | PDF (667.3 KB)
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Article
Oxidases and oxygenases in regulation of neutrophil redox pathways in Behçet’s disease patients
Meltem A. Melikoglu, Cahit Kacar, Aysegul Cort, Gultekin Yucel & Mutay Aslan
Pages: 12-17
Published online: 24 Jun 2011
AbstractforOxidases and oxygenases in regulation of neutrophil redox pathways in Behçet’s disease patients | Full Text | References | PDF (615 KB)
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Article
In vitro effects of some drugs on human erythrocyte glutathione reductase
Muhammet Karaman, Ebru Akkemik, Harun Budak & Mehmet Ciftci
Pages: 18-23
Published online: 08 Jul 2011
AbstractforIn vitro effects of some drugs on human erythrocyte glutathione reductase | Full Text | References | PDF (705.8 KB)
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Article
Designing modulators of dimethylarginine dimethylaminohydrolase (DDAH): A focus on selectivity over arginase
Juerke Kotthaus, Dennis Schade, Joscha Kotthaus & Bernd Clement
Pages: 24-28
Published online: 08 Jul 2011
AbstractforDesigning modulators of dimethylarginine dimethylaminohydrolase (DDAH): A focus on selectivity over arginase | Full Text | References | PDF (763.4 KB)
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Article
Biochemical characterization of an ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP, E.C. 3.1.4.1) from rat cardiac soluble and microsomal fractions
Daniela Pochmann, Adrine Maria Innocente, Andréia Buffon, João José Freitas Sarkis & Lisiane De Oliveira Porciúncula
Pages: 29-36
Published online: 03 May 2011
AbstractforBiochemical characterization of an ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP, E.C. 3.1.4.1) from rat cardiac soluble and microsomal fractions | Full Text | References | PDF (698.1 KB)
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Article
Evaluation of in vitro effects of some analgesic drugs on erythrocyte and recombinant carbonic anhydrase I and II
Başak Gökçe, Nahit Gençer, Oktay Arslan, Sumeyye Aydogan Turkoğlu, Meltem Alper & Feray Köçkar
Pages: 37-42
Published online: 03 May 2011
AbstractforEvaluation of in vitro effects of some analgesic drugs on erythrocyte and recombinant carbonic anhydrase I and II | Full Text | References | PDF (601.6 KB)
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Article
Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols including natural products
Halis Türker Balaydın, Hakan Soyut, Deniz Ekinci, Süleyman Göksu, Şükrü Beydemir, Abdullah Menzek & Ertan Şahin
Pages: 43-50
Published online: 03 Jun 2011
AbstractforSynthesis and carbonic anhydrase inhibitory properties of novel bromophenols including natural products | Full Text | References | PDF (845.5 KB)
  • 965 Views
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Article
Synthesis, antimicrobial activity and cytotoxicity of novel oxadiazole derivatives
Zafer Asim Kaplancikli, Mehlika Dilek Altintop, Gulhan Turan-Zitouni, Ahmet Ozdemir, Rasime Ozic & Gülşen Akalın
Pages: 51-57
Published online: 03 May 2011
AbstractforSynthesis, antimicrobial activity and cytotoxicity of novel oxadiazole derivatives | Full Text | References | PDF (619.6 KB)
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Article
Synthesis, characterization and biological studies of sulfonamide Schiff’s bases and some of their metal derivatives
Zahid H. Chohan, Hazoor A. Shad & Claudiu T. Supuran
Pages: 58-68
Published online: 03 May 2011
AbstractforSynthesis, characterization and biological studies of sulfonamide Schiff’s bases and some of their metal derivatives | Full Text | References | PDF (1.5 MB)
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Article
Synthesis and biological screening of some pyridine derivatives as anti-malarial agents
Adnan A. Bekhit, Ariaya Hymete, Ashenafi Damtew, Abdel Maaboud I. Mohamed & Alaa El-Din A. Bekhit
Pages: 69-77
Published online: 25 May 2011
AbstractforSynthesis and biological screening of some pyridine derivatives as anti-malarial agents | Full Text | References | PDF (860.5 KB)
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Article
The phenylthiourea is a competitive inhibitor of the enzymatic oxidation of DOPA by phenoloxidase
Alexandra D. Ryazanova, Alexander A. Alekseev & Irina A. Slepneva
Pages: 78-83
Published online: 03 May 2011
AbstractforThe phenylthiourea is a competitive inhibitor of the enzymatic oxidation of DOPA by phenoloxidase | Full Text | References | PDF (746.7 KB)
  • 10696 Views
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Article
Thermal solvent-free synthesis of chromonyl chalcones, pyrazolines and their in vitro antibacterial, antifungal activities
Zeba N. Siddiqui, Shagufta Praveen, T.N. Mohammed Musthafa, Anis Ahmad & Asad U. Khan
Pages: 84-91
Published online: 25 May 2011
AbstractforThermal solvent-free synthesis of chromonyl chalcones, pyrazolines and their in vitro antibacterial, antifungal activities | Full Text | References | PDF (644.2 KB)
  • 1122 Views
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Article
Synthesis and biological evaluation of some novel sulfamoylphenyl-pyridazinone as anti-inflammatory agents (Part-II)
Rafia Bashir, Shafiya Yaseen, Syed Ovais, Shamim Ahmad, Hinna Hamid, M.S. Alam, Mohammad Samim & Kalim Javed
Pages: 92-96
Published online: 25 May 2011
AbstractforSynthesis and biological evaluation of some novel sulfamoylphenyl-pyridazinone as anti-inflammatory agents (Part-II) | Full Text | References | PDF (606.8 KB)
  • 799 Views
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Article
Carbonic anhydrase I and II inhibition with natural products: caffeine and piperine
Kalyan K. Sethi, Suvendu K. Sahoo, Jayaprakash N. Pichikala & Padilam Suresh
Pages: 97-100
Published online: 25 May 2011
AbstractforCarbonic anhydrase I and II inhibition with natural products: caffeine and piperine | Full Text | References | PDF (603.5 KB)
  • 842 Views
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Article
Novel furfurylidene N-acylhydrazones derived from natural safrole: discovery of LASSBio-1215, a new potent antiplatelet prototype
Ana Paula C. Rodrigues, Luciana M.M. Costa, Bruna L.R. Santos, Rodolfo C. Maia, Ana L.P. Miranda, Eliezer J. Barreiro & Carlos A.M. Fraga
Pages: 101-109
Published online: 25 May 2011
AbstractforNovel furfurylidene N-acylhydrazones derived from natural safrole: discovery of LASSBio-1215, a new potent antiplatelet prototype | Full Text | References | PDF (768.3 KB) | Supplemental
  • 557 Views
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Article
RETRACTED: Synthesis and evaluation of anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation properties of new 2-(4-isobutylphenyl)propanoic acid derivatives
Jignesh Priyakant Raval, Ankur Navinchandra Gandhi, Tarunkumar Nanjibhai Akhaja, Kruti Navinbhai Myangar & Nilesh Hasmukhbhai Patel
Pages: 110-116
Published online: 25 May 2011
AbstractforRETRACTED: Synthesis and evaluation of anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation properties of new 2-(4-isobutylphenyl)propanoic acid derivatives | PDF (630.3 KB) | Supplemental
  • 299 Views
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Article
Chemical reactivity and antimicrobial activity of N-substituted maleimides
Natalia Salewska, Joanna Boros-Majewska, Izabela Łącka, Katarzyna Chylińska, Michał Sabisz, Sławomir Milewski & Maria J. Milewska
Pages: 117-124
Published online: 25 May 2011
AbstractforChemical reactivity and antimicrobial activity of N-substituted maleimides | Full Text | References | PDF (701.9 KB)
  • 2576 Views
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Article
In vitro inhibition of polyphenol oxidase by some new diarylureas
Dudu Demir, Nahit Gençer, Oktay Arslan, Hayriye Genç & Mustafa Zengin
Pages: 125-131
Published online: 25 May 2011
AbstractforIn vitro inhibition of polyphenol oxidase by some new diarylureas | Full Text | References | PDF (898.7 KB)
  • 1288 Views
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Article
Rapid screening of enzyme inhibitors using Profiling of Enzyme-Metabolite Assay by HPLC (PREMA-HPLC)
K.Y. Vasantha, C.S. Murugesh & A.P. Sattur
Pages: 132-137
Published online: 25 May 2011
AbstractforRapid screening of enzyme inhibitors using Profiling of Enzyme-Metabolite Assay by HPLC (PREMA-HPLC) | Full Text | References | PDF (650.5 KB)
  • 1573 Views
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Article
A new approach to antiglaucoma drugs: carbonic anhydrase inhibitors with or without NO donating moieties. Mechanism of action and preliminary pharmacology
Francesca Fabrizi, Francesco Mincione, Teresa Somma, Gabriele Scozzafava, Fernando Galassi, Emanuela Masini, Francesco Impagnatiello & Claudiu T. Supuran
Pages: 138-147
Published online: 04 Aug 2011
AbstractforA new approach to antiglaucoma drugs: carbonic anhydrase inhibitors with or without NO donating moieties. Mechanism of action and preliminary pharmacology | Full Text | References | PDF (869.1 KB)
  • 2353 Views
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Article
α-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters
Hüseyin Çavdar, Deniz Ekinci, Oktay Talaz, Nurullah Saraçoğlu, Murat Şentürk & Claudiu T. Supuran
Pages: 148-154
Published online: 03 Nov 2011
Abstractforα-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters | Full Text | References | PDF (721.7 KB)
  • 1127 Views
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Short Communication

Synthesis and biological evaluation of novel 6, 7-dimethoxy-3-(4-pyridyl)-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-yl-4-substituted phenylmethanone/ethanone derivatives
Mohamed Ashraf Ali, Rusli Ismail, Tan Soo Choon, Manogaran Elumalai, Suresh Kumar, Hasnah Osman, Jeyabalan Govidasamy, Rajesh Yadav, Garima Yadav, Ravinder Kour & Swati Vyas
Pages: 155-159
Published online: 03 Jun 2011
AbstractforSynthesis and biological evaluation of novel 6, 7-dimethoxy-3-(4-pyridyl)-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-yl-4-substituted phenylmethanone/ethanone derivatives | Full Text | References | PDF (594.5 KB)
  • 372 Views
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The crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir
Jiří Dostál, Jiří Brynda, Olga Hrušková-Heidingsfeldová, Petr Pachl, Iva Pichová & Pavlína Řezáčová
Pages: 160-165
Published online: 06 Dec 2011
AbstractforThe crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir | Full Text | References | PDF (829.9 KB) | Supplemental
  • 715 Views
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Miscellany

Upcoming conferences of interest
Claudiu T. Supuran
Page: 166
Published online: 03 Dec 2011
CitationforUpcoming conferences of interest | Full Text | PDF (485.5 KB)
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