Thermal solvent-free synthesis of chromonyl chalcones, pyrazolines and their in vitro antibacterial, antifungal activities

Abstract

A facile and ecofriendly synthesis of new chromonyl chalcones 3a-b from 3-formylchromone 1 and active methyl compounds 2a-b is reported under thermal solvent-free heating condition in good yields. The chromonyl chalcones 3a-b were used as intermediates under green condition for the synthesis of new bioactive pyrazoline derivatives 4a-f. The compounds were tested for antimicrobial activity by disk diffusion assay with slight modifications against Gram-positive, Gram-negative strains of bacteria as well as fungal strains. The investigation of antimicrobial screening revealed that compounds 3a-b and 4a-f showed antibacterial and antifungal activities.

Keywords::

• 3-Formylchromone
• green synthesis
• antimicrobial activity

Acknowledgments

The authors are thankful to University Grants Commission, New Delhi for providing financial assistance in the form of major research project [F.No. 37-15/2009 (SR)], SAIF, CDRI, Lucknow, India for providing analytical, spectral data and Mr Sameer Chaudhary, MD RASA Life Science Informatics, Pune, India for providing drug target identification using BioSpec Module of Raasi Suite.

Declaration of Interest

The authors have declared no conflicts of Interest.