Abstract
Seven novel 6-aryl-2-(p-sulfamoylphenyl)-4,5-dihydropyridazin-3(2H)-ones (2a-g) were synthesized by the condensation of appropriate aroylpropionic acid and 4-hydrazinobenzenesulfonamide hydrochloride in ethanol. Structure of all compounds have been elucidated by elemental analysis, IR, 1H NMR, 13C NMR, DEPT and MS spectrscopy. These compounds were tested for their anti-inflammatory activity in carrageenan-induced rat paw edema model. Compound 2b exhibited anti-inflammatory activity comparable to that of celecoxib (at 5 h). Two other compounds 2d and 2g showed promising anti-inflammatory activity (edema reduction more than 80% at 5 h). These compounds (2b, 2d and 2g) did not produce any ulceration in gastric region.
Acknowledgments
This work was supported by Grant No. 32–228/2006 (SR) from the University Grants Commission, New Delhi, India. One of the authors, Rafia Bashir is thankful to UGC for fellowship. Thanks are due to SAIF, CDRI, Lucknow, for providing Mass spectra.
Declaration of interest
The authors report no conflict of interest. The authors alone are responsible for the content and writing of the article.