Synthesis and biological evaluation of novel 6, 7-dimethoxy-3-(4-pyridyl)-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-yl-4-substituted phenylmethanone/ethanone derivatives

Abstract

A series of 6,7-dimethoxy-3-(4-pyridyl)-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-yl-4-substituted phenylmethanone/ethanone derivatives were synthesized and in vitro activity against mycobacterium tuberculosis (MTB) and INHR-MTB were carried out. Among the synthesized compounds, compound (4h) 6,7-dimethoxy-3-(4-pyridyl)-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-yl-4-pyridyl methanone was found to be the most active agent against MTB and INHR-MTB with a minimum inhibitory concentration of 0.22 μM.

Keywords::

• Mycobacterial agents
• pyrazoline
• indanone
• mycobacterium tuberculosis

Acknowledgments

The authors wish to express their thanks to Pharmacogenetic and Pharmacogenomic Research, Institute for Research in Molecular Medicine, Universiti of Sains Malaysia, Pennag, Malaysia and Alwar Pharmacy College, Alwar, Rajasthan, India, for providing research facilities.

Declaration of interest

The authors report no conflicts of interest.