Synthesis, biological screening and molecular modeling studies of novel 3-chloro-4-substituted-1-(2-(1H-benzimidazol-2-yl)phenyl))-azetidin-2-ones

Abstract

In the present investigation synthesis of some novel 1-(2-(1H-benzimidazol-2-yl)phenyl)-3-chloro-4-(Un/substitutedphenyl)azetidin-2-one (3a-3h) antibacterial are reported. Structures of synthesized compounds were confirmed by spectral techniques (IR, Mass, ¹H-NMR) All reactions were monitored with analytical thin layer chromatography. Synthesized compounds were docked in to the active site of enzyme transpeptidase. Compounds 3a, 3b, 3d and 3g were found to have good affinity for transpeptidase with potent antibacterial activity. A good correlation is found between in silico docking analysis and in vitro antibacterial activity.

Keywords::

• Azetidinones
• benzimidazole
• molecular docking

Acknowledgements

We acknowledge our thanks to SAIF Chandigarh, Punjab for spectral analysis. We are grateful to SAIF Punjab University, Chandigarh for the help in undertaking NMR and Mass spectra.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.